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3.4.22.38: cathepsin K

This is an abbreviated version!
For detailed information about cathepsin K, go to the full flat file.

Word Map on EC 3.4.22.38

Reaction

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg =

Synonyms

Cat K, Cat-K, cath K, cathepsin K, cathepsin O, Cathepsin O2, cathepsin-K, catK, Ctk, CTSK, Human osteoclast cathepsin K, More, OC-2 protein, rhCK

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.38 cathepsin K

Purification

Purification on EC 3.4.22.38 - cathepsin K

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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
cathepsin O2 precursor, which can be processed to mature enzyme at 4 C
-
glutathione-Sepharose column chromatography
Ni-NTA agarose column chromatography and Sephacryl S-100 gel filtration
recombinant procathepsin K from Pichia pastoris, processed to the mature form and purified
-
recombinant procathepsin K, expressed in baculovirus infected SF21 cells, processed to cathepsin K
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Superdex 75 gel filtration