Application | Comment | Organism |
---|---|---|
medicine | inhibition of CTSK activity may decrease the risk of breast tumor progression | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
CTSK expression analysis in healthy, benign tumor and malign tumor breast tissues, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cystatin | different types, expression analysis in various cell types isolated from normal and neoplastic breast tissue, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme may play a role in tumor progression, coculture of CTSK+ fibroblasts enhances the invasion of CTSK-breast tumor epithelial cells, whichis blocked by CTSK inhibitors, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene Ctsk | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast | high expression level | Homo sapiens | - |
breast cancer cell | biopsy sites, benign lesions, ductal carcinoma in situ, and invasive breast tumors of different stages. Neither epithelial nor stromal expression of CTSK is significantly associated with recurrence-free or overall survival | Homo sapiens | - |
BT-549 cell | - |
Homo sapiens | - |
epithelial cell | - |
Homo sapiens | - |
fibroblast | tumor, stromal myofibroblasts, high expression level | Homo sapiens | - |
MDA-MB-435 cell | - |
Homo sapiens | - |
MDA-MB-468 cell | - |
Homo sapiens | - |
stromal cell | stromal CTSK expression is significantly higher in invasive compared to in situ carcinomas | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme may play a role in tumor progression, coculture of CTSK+ fibroblasts enhances the invasion of CTSK-breast tumor epithelial cells, whichis blocked by CTSK inhibitors, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CTSK | - |
Homo sapiens |