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3.4.22.38: cathepsin K

This is an abbreviated version!
For detailed information about cathepsin K, go to the full flat file.

Word Map on EC 3.4.22.38

Reaction

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg =

Synonyms

Cat K, Cat-K, cath K, cathepsin K, cathepsin O, Cathepsin O2, cathepsin-K, catK, Ctk, CTSK, Human osteoclast cathepsin K, More, OC-2 protein, rhCK

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.38 cathepsin K

Activating Compound

Activating Compound on EC 3.4.22.38 - cathepsin K

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Brij 35
245.48% relative activity at 0.01% (v/v)
chondroitin 4-sulfate
chondroitin 6-sulfate
-
activates 2.5fold in 24 h
chondroitin sulfate
-
non-essential activator in assays using low-molecular-mass substrates, 4fold stimulation of activity at 0.2 mM
dermatan sulfate
-
non-essential activator in assays using low-molecular-mass substrates, 4fold stimulation of activity at 0.2 mM
dithiothreitol
-
DMSO
-
-
EDTA
-
-
heparin
-
12fold stimulation of activity at 0.2 mM
L-cysteine
-
NaCl
-
300 mM NaCl stimulates enzyme activity
SDS
135.84% relative activity at 0.01% (w/v)
Triton X-100
218.51% relative activity at 0.05% (v/v)
Tween 20
218.04% relative activity at 0.05% (v/v)
additional information
-