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3.4.22.38: cathepsin K

This is an abbreviated version!
For detailed information about cathepsin K, go to the full flat file.

Word Map on EC 3.4.22.38

Reaction

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg =

Synonyms

Cat K, Cat-K, cath K, cathepsin K, cathepsin O, Cathepsin O2, cathepsin-K, catK, Ctk, CTSK, Human osteoclast cathepsin K, More, OC-2 protein, rhCK

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.38 cathepsin K

Molecular Weight

Molecular Weight on EC 3.4.22.38 - cathepsin K

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
23500
23590
-
electrospray mass spectrometry of Ala115-terminated enzyme
23650
-
electropspray mass spectrometry of Arg114-terminated enzyme
24000
-
-
27000
-
1 * 37000, procathepsin K, 1 * 27000, mature enzyme, SDS-PAGE
28000
-
x * 28000, mature CatK, SDS-PAGE
29000
32000
-
x * 32000, about, proenzyme
35000
-
procathepsin K, mature enzyme produced by incubation at pH 4.0, 24 h, 4°C, gel filtration
35300
36370
-
procathepsin K, MALDI-Mass spectromety, procathepsin K is autocatalytically activated at 4 C, pH 4, the activation is enhanced by 1% mature cathepsin K, cleavage of procathepsin K after Ala15
37000
37600
x * 37600, recombinant His-tagged enzyme, SDS-PAGE
38000
-
x * 38000, SDS-PAGE
43000
-
precursor cathepsin O2, SDS-PAGE
50000
His6-tagged fusion protein, SDS-PAGE