Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | cathepsin K is activated by proteolytic cleavage | Mus musculus | |
additional information | cathepsin K is activated by proteolytic cleavage | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,3-bis(CBZ-Leu-NH)-2-propanone | - |
Homo sapiens | |
1,3-bis(CBZ-Leu-NH)-2-propanone | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secereted by osteoclasts | Mus musculus | - |
- |
extracellular | the enzyme is secereted by osteoclasts | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen I + H2O | Mus musculus | osteoclasts degrade bone matrix by demineralization followed by degradation of type I collagen through secretion of the cysteine protease, cathepsin K | ? | - |
? | |
collagen I + H2O | Homo sapiens | osteoclasts degrade bone matrix by demineralization followed by degradation of type I collagen through secretion of the cysteine protease, cathepsin K | ? | - |
? | |
additional information | Mus musculus | media from cells on plastic show higher CatK activation than cells on dentin, consistent with cellular expression of cathepsin K mRNA, 2fold upregulation of cathepsin K mRNA from cells cultured on plastic correlates with increased cathepsin K activation, overview | ? | - |
? | |
additional information | Homo sapiens | media from cells on plastic show higher CatK activation than cells on dentin, consistent with cellular expression of cathepsin K mRNA, 2fold upregulation of cathepsin K mRNA from cells cultured on plastic correlates with increased cathepsin K activation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
female BALB/c mice | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | trypsin cleaves at the cathepsin K recognition site activating cathepsin K | Mus musculus |
proteolytic modification | trypsin cleaves at the cathepsin K recognition site activating cathepsin K | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone | cathepsin K probe localizes adjacent to newly mineralizing bone in vivo | Mus musculus | - |
bone | cathepsin K probe localizes adjacent to newly mineralizing bone in vivo | Homo sapiens | - |
additional information | media from cells on plastic show higher CatK activation than cells on dentin, consistent with cellular expression of cathepsin K mRNA, 2fold upregulation of cathepsin K mRNA from cells cultured on plastic correlates with increased cathepsin K activation, overview | Mus musculus | - |
additional information | media from cells on plastic show higher CatK activation than cells on dentin, consistent with cellular expression of cathepsin K mRNA, 2fold upregulation of cathepsin K mRNA from cells cultured on plastic correlates with increased cathepsin K activation, overview | Homo sapiens | - |
osteoclast | - |
Mus musculus | - |
osteoclast | - |
Homo sapiens | - |
RAW-264.7 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen I + H2O | - |
Mus musculus | ? | - |
? | |
collagen I + H2O | - |
Homo sapiens | ? | - |
? | |
collagen I + H2O | osteoclasts degrade bone matrix by demineralization followed by degradation of type I collagen through secretion of the cysteine protease, cathepsin K | Mus musculus | ? | - |
? | |
collagen I + H2O | osteoclasts degrade bone matrix by demineralization followed by degradation of type I collagen through secretion of the cysteine protease, cathepsin K | Homo sapiens | ? | - |
? | |
additional information | media from cells on plastic show higher CatK activation than cells on dentin, consistent with cellular expression of cathepsin K mRNA, 2fold upregulation of cathepsin K mRNA from cells cultured on plastic correlates with increased cathepsin K activation, overview | Mus musculus | ? | - |
? | |
additional information | media from cells on plastic show higher CatK activation than cells on dentin, consistent with cellular expression of cathepsin K mRNA, 2fold upregulation of cathepsin K mRNA from cells cultured on plastic correlates with increased cathepsin K activation, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
catK | - |
Mus musculus |
catK | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
- |
Mus musculus |
5.5 | - |
- |
Homo sapiens |