3.4.22.38: cathepsin K

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For detailed information about cathepsin K, go to the full flat file.

Word Map on EC 3.4.22.38

3.4.22.38

resorption

osteoporosis

osteoclastogenesis

rankl

tartrate-resistant

osteoblast

collagen

nfatc1

rankl-induced

multinucleated

mmp-9

c-fos

fracture

trabecular

pi

calcitonin

osteocalcin

osteoprotegerin

osteolytic

resorb

m-csf

collagenolytic

bisphosphonates

osteoclast-mediated

trap-positive

osteoclast-specific

odanacatib

oscar

antiresorptive

tracp

lacuna

ovariectomy-induced

rankl-mediated

dc-stamp

bone-resorbing

sclerostin

osteoclast-related

telopeptide

osteoclast-like

osteoclastogenic

denosumab

preosteoclasts

teriparatide

pharmacology

anti-osteoclastogenic

osteosclerosis

anti-osteoporotic

atp6v0d2

medicine

ranelate

drug development

deoxypyridinoline

rankl-stimulated

diagnostics

Reaction

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg =

Synonyms

Cat K, Cat-K, cath K, cathepsin K, cathepsin O, Cathepsin O2, cathepsin-K, catK, Ctk, CTSK, Human osteoclast cathepsin K, More, OC-2 protein, rhCK

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.38 cathepsin K

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Results	in table
32	Activating Compound
603	AA Sequence
40	Application
1	CAS Registry Number
34	Cloned(Commentary)
12	Crystallization (Commentary)
3576	Disease/ Diagnostics
26	Expression
23	General Information
1	General Stability
659	IC50 Value
1154	Inhibitors
18	kcat/KM [mM/s]
211	Ki Value [mM]
50	KM Value [mM]
42	Localization
3	Metals/Ions
25	Molecular Weight [Da]
105	Natural Substrates/ Products (Substrates)
340	Organism
93	PDB ID
32	pH Optimum
5	pH Range
5	pH Stability
12	Posttranslational Modification
35	Protein Variants
18	Purification (Commentary)
1	Reaction
6	Reaction Type
195	Reference
2	Renatured (Commentary)
300	Source Tissue
4	Specific Activity [micromol/min/mg]
254	Substrates and Products (Substrate)
16	Subunits
108	Synonyms
15	Temperature Optimum [°C]
2	Temperature Stability [°C]
47	Turnover Number [1/s]

Organism

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Organism on EC 3.4.22.38 - cathepsin K

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Canis lupus familiaris

UniProt

C57BL/6 mice

Mus musculus C57Bl6/J

C57Bl6/J mice

DBA/1J mice

FVB/N mice

Oryctolagus cuniculus

2 entries

Paralichthys olivaceus

olive flounder

UniProt

UniProt

Italian Duroc and Italian Large White breeds

709888