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3.4.22.38: cathepsin K

This is an abbreviated version!
For detailed information about cathepsin K, go to the full flat file.

Word Map on EC 3.4.22.38

Reaction

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg =

Synonyms

Cat K, Cat-K, cath K, cathepsin K, cathepsin O, Cathepsin O2, cathepsin-K, catK, Ctk, CTSK, Human osteoclast cathepsin K, More, OC-2 protein, rhCK

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.38 cathepsin K

Renatured

Renatured on EC 3.4.22.38 - cathepsin K

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RENATURED/Commentary
ORGANISM
UNIPROT
LITERATURE
otimal pH for renaturation is 9.8, renaturation in the range 7.5-12
-
using 50 mM Tris-HCl pH 8.0, 500 mM NaCl, 0.5 M urea, 0.7 M arginine, 5 mM EDTA, 1% CHAPS, 15% (v/v) glycerol, 10 mM GSH and 1 mM GSSG