3.4.22.38: cathepsin K
This is an abbreviated version!
For detailed information about cathepsin K, go to the full flat file.
Word Map on EC 3.4.22.38
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3.4.22.38
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resorption
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osteoporosis
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osteoclastogenesis
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rankl
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tartrate-resistant
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osteoblast
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collagen
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nfatc1
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rankl-induced
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multinucleated
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mmp-9
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c-fos
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fracture
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trabecular
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pi
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calcitonin
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osteocalcin
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osteoprotegerin
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osteolytic
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resorb
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m-csf
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collagenolytic
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bisphosphonates
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osteoclast-mediated
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trap-positive
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osteoclast-specific
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odanacatib
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oscar
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antiresorptive
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tracp
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lacuna
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ovariectomy-induced
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rankl-mediated
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dc-stamp
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bone-resorbing
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sclerostin
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osteoclast-related
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telopeptide
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osteoclast-like
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osteoclastogenic
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denosumab
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preosteoclasts
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teriparatide
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pharmacology
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anti-osteoclastogenic
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osteosclerosis
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anti-osteoporotic
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atp6v0d2
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medicine
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ranelate
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drug development
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deoxypyridinoline
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rankl-stimulated
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diagnostics
- 3.4.22.38
- resorption
- osteoporosis
-
osteoclastogenesis
- rankl
-
tartrate-resistant
- osteoblast
- collagen
- nfatc1
-
rankl-induced
-
multinucleated
- mmp-9
- c-fos
-
fracture
-
trabecular
- pi
- calcitonin
- osteocalcin
- osteoprotegerin
-
osteolytic
-
resorb
- m-csf
-
collagenolytic
- bisphosphonates
-
osteoclast-mediated
-
trap-positive
-
osteoclast-specific
- odanacatib
- oscar
-
antiresorptive
- tracp
- lacuna
-
ovariectomy-induced
-
rankl-mediated
-
dc-stamp
-
bone-resorbing
-
sclerostin
-
osteoclast-related
-
telopeptide
-
osteoclast-like
-
osteoclastogenic
-
denosumab
-
preosteoclasts
-
teriparatide
- pharmacology
-
anti-osteoclastogenic
- osteosclerosis
-
anti-osteoporotic
- atp6v0d2
- medicine
-
ranelate
- drug development
-
deoxypyridinoline
-
rankl-stimulated
- diagnostics
Reaction
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg =
Synonyms
Cat K, Cat-K, cath K, cathepsin K, cathepsin O, Cathepsin O2, cathepsin-K, catK, Ctk, CTSK, Human osteoclast cathepsin K, More, OC-2 protein, rhCK
ECTree
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Expression
Expression on EC 3.4.22.38 - cathepsin K
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a marked increase in cathepsin K expression is seen in the lungs of patients with emphysema compared to normal subjects
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cathepsin K becomes up-regulated in its cerebral expression by neuroleptic treatment
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cathepsin K expression level is decreased in all tissues at 12 h post-infection with Aeromonas hydrophila
cathepsin K gene and protein expression is significantly up-regulated in synovium at the initial stage of osteoarthritis in rabbits
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cathepsins K is elevated in endothelial cells by tumor necrosis factor-alpha stimulation
CtK expression is significantly increased in the muscle and gill at 3-24 h post-injection with bacterial lipopolysaccharide
CTSK expression is stimulated by nuclear factor kappaB ligand. Both, nuclear factor kappaB ligand treatment and overexpression of nuclear factor of activated T-cells c1 dramatically enhances CTSK promoter activity. Proximal nuclear factor of activated T-cells binding sites play a significant role in the nuclear factor of activated T-cells c1-mediated stimulation of CTSK gene expression by nuclear factor kappaB ligand
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expression of cathepsin K is significantly increased (2.7-1.6fold) in the low-energy laser irradiated group on days 2-7 compared with those in the non-irradiated group
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in fibroblasts, interleukin-1alpha and cellular confluence upregulate cathepsin K expression
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in osteosarcoma cells, tissue growth factor beta1 induces the secretion of cathepsin K by about 3fold
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increased expression of cathepsin K in tumors and tumor-associated cells may be a direct result of transcriptional regulation by ETS family members
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induction of cathepsin K expression in fibroblasts from young donors but not from old donors is observed both in vitro and in vivo after exposure to longwave UV-A (100-500 kJ/m2) in a time-dependent manner with a maximum 2 days after exposure. Induction of active cathepsin K is also seen 1 day after irradiation with UV-B and less so after exposure to ionizing radiation followed by decreased levels on the following days
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inhibiting calcineurin or chelation of intracellular Ca2+, prevents the stimulation of CTSK expression by nuclear factor kappaB ligand
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ligand of receptor activator of nuclear factor-kappaB does not induce cathepsin K expression in fibroblasts
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receptor activator of nuclear factor-kappaB or small GTPase Rab do not mediate cathepsin K induction
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serum cathepsin K decreases gradually after alendronate treatment (17% at 3 months, 22% at 6 months and 41% at 12 months)
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serum cathepsin K levels are higher in postmenopausal women with osteoporosis compared with healthy postmenopausal women and premenopausal women
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significantly down-regulated in intestine following Gram-negative bacteria Vibrio anguillarum immersion challenge
SM934-testosterone inhibits proliferation and metastasis ability of breast cancer cells via inhibiting the expression of cathepsin K followed by the inhibition of Bcl-xL
the levels of Cath K in serum of non-small cell lung cancer are comparable to those in controls
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there is a 3fold increase in cathepsin K activity in the lungs of guinea pigs after 12 weeks smoke exposure
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upregulated in three tissues (gill, skin and intestine) following Gram-positive bacteria Streptococcus iniae immersion challenge
vasoprotective shear stress inhibits cathepsin K protein expression and activation downstream of TNFalpha stimulation via reduced NF-kappaB activation and expression. TNFalpha stimulation activates JNK/c-jun phosphorylation, but reduction of NF-kappaB protein prevents induction of cathepsin K transcription under vasoprotective shear stress conditions