Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.38 extracted from

  • Lecaille, F.; Vandier, C.; Godat, E.; Herve-Grepinet, V.; Broemme, D.; Lalmanach, G.
    Modulation of hypotensive effects of kinins by cathepsin K (2007), Arch. Biochem. Biophys., 459, 129-136.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
DTT
-
Homo sapiens
DTT
-
Rattus norvegicus

Application

Application Comment Organism
medicine it is shown that cathepsin K acts as a potent kinin-degrading enzyme in bloodstream. Contrary to cathepsin L, cathepsin K attenuates kallikrein-induced decrease of rat blood pressure, and reduces the hypotensive effect of bradykinin in a dose-dependant manner Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Pichia pastoris Homo sapiens
expressed in Pichia pastoris Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
Y67L/L205A this mutant fails to degrade bradykinin, indicating that Tyr67 and Leu205 are key active site residues for the kinin degrading activity of cathepsin Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
Homo sapiens
-
plasma
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bradykinin + H2O
-
Homo sapiens bradykinin(1-4) + bradykinin(5-9)
-
?
bradykinin + H2O
-
Rattus norvegicus bradykinin(1-4) + bradykinin(5-9)
-
?
desArg-bradykinin + H2O
-
Homo sapiens ?
-
?
desArg-bradykinin + H2O
-
Rattus norvegicus ?
-
?
Lys-bradykinin + H2O
-
Homo sapiens ?
-
?
Lys-bradykinin + H2O
-
Rattus norvegicus ?
-
?
o-aminobenzoyl-bradykinin-(3-NO2-Tyr) + H2O
-
Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
cathepsin K
-
Homo sapiens
cathepsin K
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
28
-
assay at Homo sapiens
28
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
assay at Homo sapiens
5.5
-
assay at Rattus norvegicus