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3.4.22.38: cathepsin K

This is an abbreviated version!
For detailed information about cathepsin K, go to the full flat file.

Word Map on EC 3.4.22.38

Reaction

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg =

Synonyms

Cat K, Cat-K, cath K, cathepsin K, cathepsin O, Cathepsin O2, cathepsin-K, catK, Ctk, CTSK, Human osteoclast cathepsin K, More, OC-2 protein, rhCK

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.38 cathepsin K

pH Optimum

pH Optimum on EC 3.4.22.38 - cathepsin K

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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3.8
-
assay at
4 - 7
-
substrate gelatin
5 - 6
6 - 6.5
-
-
6 - 7.4
-
kcat/Km with 2-aminobenzoyl-RPPGFSPFR-(3-nitrotyrosine) is 1.4fold higher at pH 6.0 than at pH 7.4
7.5
-
assay at
additional information
-
CatK is a lysosomal cysteine protease that degrades type I collagen at neutral and acidic pH