3.4.22.38: cathepsin K
This is an abbreviated version!
For detailed information about cathepsin K, go to the full flat file.
Word Map on EC 3.4.22.38
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3.4.22.38
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resorption
-
osteoporosis
-
osteoclastogenesis
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rankl
-
tartrate-resistant
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osteoblast
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collagen
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nfatc1
-
rankl-induced
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multinucleated
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mmp-9
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c-fos
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fracture
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trabecular
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pi
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calcitonin
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osteocalcin
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osteoprotegerin
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osteolytic
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resorb
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m-csf
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collagenolytic
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bisphosphonates
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osteoclast-mediated
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trap-positive
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osteoclast-specific
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odanacatib
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oscar
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antiresorptive
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tracp
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lacuna
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ovariectomy-induced
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rankl-mediated
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dc-stamp
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bone-resorbing
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sclerostin
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osteoclast-related
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telopeptide
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osteoclast-like
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osteoclastogenic
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denosumab
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preosteoclasts
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teriparatide
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pharmacology
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anti-osteoclastogenic
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osteosclerosis
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anti-osteoporotic
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atp6v0d2
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medicine
-
ranelate
-
drug development
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deoxypyridinoline
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rankl-stimulated
-
diagnostics
- 3.4.22.38
- resorption
- osteoporosis
-
osteoclastogenesis
- rankl
-
tartrate-resistant
- osteoblast
- collagen
- nfatc1
-
rankl-induced
-
multinucleated
- mmp-9
- c-fos
-
fracture
-
trabecular
- pi
- calcitonin
- osteocalcin
- osteoprotegerin
-
osteolytic
-
resorb
- m-csf
-
collagenolytic
- bisphosphonates
-
osteoclast-mediated
-
trap-positive
-
osteoclast-specific
- odanacatib
- oscar
-
antiresorptive
- tracp
- lacuna
-
ovariectomy-induced
-
rankl-mediated
-
dc-stamp
-
bone-resorbing
-
sclerostin
-
osteoclast-related
-
telopeptide
-
osteoclast-like
-
osteoclastogenic
-
denosumab
-
preosteoclasts
-
teriparatide
- pharmacology
-
anti-osteoclastogenic
- osteosclerosis
-
anti-osteoporotic
- atp6v0d2
- medicine
-
ranelate
- drug development
-
deoxypyridinoline
-
rankl-stimulated
- diagnostics
Reaction
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg =
Synonyms
Cat K, Cat-K, cath K, cathepsin K, cathepsin O, Cathepsin O2, cathepsin-K, catK, Ctk, CTSK, Human osteoclast cathepsin K, More, OC-2 protein, rhCK
ECTree
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KCat KM Value
KCat KM Value on EC 3.4.22.38 - cathepsin K
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118.8
benzyloxycarbonyl-Gly-L-Pro-L-Arg-7-amido-4-methylcoumarin
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pH and temperature not specified in the publication
4300
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enzyme in the absence of NaCl, in 50 mM HEPES, pH 7.4, containing 1 mM EDTA and 2.5 mM dithiothreitol, at 25°C
7600
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin
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enzyme in the presence of 300 mM NaCl, in 50 mM HEPES, pH 7.4, containing 1 mM EDTA and 2.5 mM dithiothreitol, at 25°C
48
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enzyme in the absence of NaCl, in 50 mM HEPES, pH 7.4, containing 1 mM EDTA and 2.5 mM dithiothreitol, at 25°C
59
benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin
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enzyme in the presence of 300 mM NaCl, in 50 mM HEPES, pH 7.4, containing 1 mM EDTA and 2.5 mM dithiothreitol, at 25°C
4400
mutant enzyme K9E/N190M/K191G/L195K, in 100 mM sodium acetate buffer, pH 5.5, containing 2.5 mM dithiothreitol, and 2.5 mM EDTA, at 28°C
5700
Z-Gly-Pro-Arg-7-amido-4-methylcoumarin
mutant enzyme K9E/I171E/Q172S, in 100 mM sodium acetate buffer, pH 5.5, containing 2.5 mM dithiothreitol, and 2.5 mM EDTA, at 28°C
5900
Z-Gly-Pro-Arg-7-amido-4-methylcoumarin
mutant enzyme K9E, in 100 mM sodium acetate buffer, pH 5.5, containing 2.5 mM dithiothreitol, and 2.5 mM EDTA, at 28°C
6000
Z-Gly-Pro-Arg-7-amido-4-methylcoumarin
wild type enzyme, in 100 mM sodium acetate buffer, pH 5.5, containing 2.5 mM dithiothreitol, and 2.5 mM EDTA, at 28°C
6200
Z-Gly-Pro-Arg-7-amido-4-methylcoumarin
mutant enzyme K9E/I171E/Q172S/N190M/K191G/L195K, in 100 mM sodium acetate buffer, pH 5.5, containing 2.5 mM dithiothreitol, and 2.5 mM EDTA, at 28°C
9700
Z-Gly-Pro-Arg-7-amido-4-methylcoumarin
mutant enzyme N190M/K191G/L195K, in 100 mM sodium acetate buffer, pH 5.5, containing 2.5 mM dithiothreitol, and 2.5 mM EDTA, at 28°C
1500
mutant enzyme K9E/I171E/Q172S/N190M/K191G/L195K, in 100 mM sodium acetate buffer, pH 5.5, containing 2.5 mM dithiothreitol, and 2.5 mM EDTA, at 28°C
1600
Z-Leu-Arg-7-amido-4-methylcoumarin
mutant enzyme K9E, in 100 mM sodium acetate buffer, pH 5.5, containing 2.5 mM dithiothreitol, and 2.5 mM EDTA, at 28°C
1900
Z-Leu-Arg-7-amido-4-methylcoumarin
wild type enzyme, in 100 mM sodium acetate buffer, pH 5.5, containing 2.5 mM dithiothreitol, and 2.5 mM EDTA, at 28°C
2000
Z-Leu-Arg-7-amido-4-methylcoumarin
mutant enzyme N190M/K191G/L195K, in 100 mM sodium acetate buffer, pH 5.5, containing 2.5 mM dithiothreitol, and 2.5 mM EDTA, at 28°C
2100
Z-Leu-Arg-7-amido-4-methylcoumarin
mutant enzyme K9E/N190M/K191G/L195K, in 100 mM sodium acetate buffer, pH 5.5, containing 2.5 mM dithiothreitol, and 2.5 mM EDTA, at 28°C
2700
Z-Leu-Arg-7-amido-4-methylcoumarin
mutant enzyme K9E/I171E/Q172S, in 100 mM sodium acetate buffer, pH 5.5, containing 2.5 mM dithiothreitol, and 2.5 mM EDTA, at 28°C