3.4.22.38: cathepsin K
This is an abbreviated version!
For detailed information about cathepsin K, go to the full flat file.
Word Map on EC 3.4.22.38
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3.4.22.38
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resorption
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osteoporosis
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osteoclastogenesis
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rankl
-
tartrate-resistant
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osteoblast
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collagen
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nfatc1
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rankl-induced
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multinucleated
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mmp-9
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c-fos
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fracture
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trabecular
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pi
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calcitonin
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osteocalcin
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osteoprotegerin
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osteolytic
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resorb
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m-csf
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collagenolytic
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bisphosphonates
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osteoclast-mediated
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trap-positive
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osteoclast-specific
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odanacatib
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oscar
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antiresorptive
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tracp
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lacuna
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ovariectomy-induced
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rankl-mediated
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dc-stamp
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bone-resorbing
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sclerostin
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osteoclast-related
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telopeptide
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osteoclast-like
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osteoclastogenic
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denosumab
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preosteoclasts
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teriparatide
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pharmacology
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anti-osteoclastogenic
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osteosclerosis
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anti-osteoporotic
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atp6v0d2
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medicine
-
ranelate
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drug development
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deoxypyridinoline
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rankl-stimulated
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diagnostics
- 3.4.22.38
- resorption
- osteoporosis
-
osteoclastogenesis
- rankl
-
tartrate-resistant
- osteoblast
- collagen
- nfatc1
-
rankl-induced
-
multinucleated
- mmp-9
- c-fos
-
fracture
-
trabecular
- pi
- calcitonin
- osteocalcin
- osteoprotegerin
-
osteolytic
-
resorb
- m-csf
-
collagenolytic
- bisphosphonates
-
osteoclast-mediated
-
trap-positive
-
osteoclast-specific
- odanacatib
- oscar
-
antiresorptive
- tracp
- lacuna
-
ovariectomy-induced
-
rankl-mediated
-
dc-stamp
-
bone-resorbing
-
sclerostin
-
osteoclast-related
-
telopeptide
-
osteoclast-like
-
osteoclastogenic
-
denosumab
-
preosteoclasts
-
teriparatide
- pharmacology
-
anti-osteoclastogenic
- osteosclerosis
-
anti-osteoporotic
- atp6v0d2
- medicine
-
ranelate
- drug development
-
deoxypyridinoline
-
rankl-stimulated
- diagnostics
Reaction
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg =
Synonyms
Cat K, Cat-K, cath K, cathepsin K, cathepsin O, Cathepsin O2, cathepsin-K, catK, Ctk, CTSK, Human osteoclast cathepsin K, More, OC-2 protein, rhCK
ECTree
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Subunits
Subunits on EC 3.4.22.38 - cathepsin K
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monomer
additional information
monomer
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1 * 35300, procathepsin K, 1 * 23500, mature enzyme, calculation from amino acid sequence without sugar chains
additional information
the human sequence contains Asp and Tyr at S3 positions 61 and 67, and residues Met, Ala, Leu, Ala and Leu at S2 positions 68, 134, 160, 163, and 209, respectively, comparison with the rat enzyme
additional information
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the human sequence contains Asp and Tyr at S3 positions 61 and 67, and residues Met, Ala, Leu, Ala and Leu at S2 positions 68, 134, 160, 163, and 209, respectively, comparison with the rat enzyme
additional information
the human sequence contains Tyr at S3 positions 61 and 67, and residues Met, Ser, Val, Ala, and Leu at S2 positions 68, 134, 160, 163, and 209, respectively, comparison with the human enzyme