Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | retinoic acid stimulates cathepsin K expression | Homo sapiens |
Application | Comment | Organism |
---|---|---|
pharmacology | cathepsin K is a therapeutic target for bone diseases | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
genotyping | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | determination of six naturally occuring mutations in cathepsin K: an A-G transition at cDNA position 1095, a G-C transition at nucleotide 541, a C-T transition at nucleotide, a C-T transition at nucleotide 935, a G-A transition at nucleotide 236, and a T-C transition at nucleotide 926, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AAE581 | - |
Homo sapiens | |
CID444556 | - |
Homo sapiens | |
CRA-013783 | - |
Homo sapiens | |
L-006235 | - |
Homo sapiens | |
MK-0822 | - |
Homo sapiens | |
MK-1256 | - |
Homo sapiens | |
additional information | physiological inhibitors of osteoclast differentiation and activation, such as osteoprotegerin, interleukin-6, INF-gamma, can also directly suppress cathepsin K expression | Homo sapiens | |
N-cyano-tetrahydro-pyridazine compounds | - |
Homo sapiens | |
SB462595 | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | important role of cathepsin K in osteoclast function, overview. The human disorder pycnodysostosis is a rare, autosomal, recessive, skeletal disorder caused by mutations in cathepsin K, the enzyme might be also involved in the pathological mechanism of osteolysis causing aseptic loosening of total hip replacement implants. In diseases such as arthritis and osteoporosis, the release of cathepsin K likely causes tissue injury. Regulation of cathepsin K expression, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | cathepsin K is synthesized as an inactive pre-proenzyme | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone | - |
Homo sapiens | - |
colon | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
osteoclast | giant multinucleated cells,high expression level | Homo sapiens | - |
ovary | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
skeletal muscle | - |
Homo sapiens | - |
small intestine | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | important role of cathepsin K in osteoclast function, overview. The human disorder pycnodysostosis is a rare, autosomal, recessive, skeletal disorder caused by mutations in cathepsin K, the enzyme might be also involved in the pathological mechanism of osteolysis causing aseptic loosening of total hip replacement implants. In diseases such as arthritis and osteoporosis, the release of cathepsin K likely causes tissue injury. Regulation of cathepsin K expression, overview | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | cathepsin K tertiary structure, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
More | cathepsin K is a member of the papain family of cysteine proteases | Homo sapiens |