Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
type I collagen + H2O | Homo sapiens | - |
C-terminal telopeptide of type I collagen + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
coronary artery | left anterior descending coronary arteries with different degrees of atherosclerotic lesions, cathepsin K co-localizes with collagen type I in advanced atherosclerotic lesions especially at the plaque shoulders | Homo sapiens | - |
macrophage foam cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
type I collagen + H2O | - |
Homo sapiens | C-terminal telopeptide of type I collagen + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cathepsin-K | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | human macrophage foam cells degrade atherosclerotic plaques though cathepsin K-mediated processes, resulting in increase in levels of C-terminal fragments of type I collagen | Homo sapiens |