Literature summary for 3.4.22.38 extracted from

Takahashi, D.; Iwasaki, N.; Kon, S.; Matsui, Y.; Majima, T.; Minami, A.; Uede, T.
Down-regulation of cathepsin K in synovium leads to progression of osteoarthritis in rabbits (2009), Arthritis Rheum., 60, 2372-2380.

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Organism

Organism	UniProt	Comment	Textmining
Oryctolagus cuniculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
synovium	-	Oryctolagus cuniculus	-

Expression

Organism	Comment	Expression
Oryctolagus cuniculus	cathepsin K gene and protein expression is significantly up-regulated in synovium at the initial stage of osteoarthritis in rabbits	up

General Information

General Information	Comment	Organism
malfunction	down-regulation of cathepsin K in synovium at the initial stage of osteoarthritis significantly accelerates cartilage degeneration	Oryctolagus cuniculus
physiological function	cathepsin K plays a protective role in cartilage degeneration at the initial stage of osteoarthritis	Oryctolagus cuniculus

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Release 2023.1 (January 2023)