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Literature summary for 3.4.22.38 extracted from

  • Sun, Y.; Ishibashi, M.; Seimon, T.; Lee, M.; Sharma, S.M.; Fitzgerald, K.A.; Samokhin, A.O.; Wang, Y.; Sayers, S.; Aikawa, M.; Jerome, W.G.; Ostrowski, M.C.; Bromme, D.; Libby, P.; Tabas, I.A.; Welch, C.L.; Tall, A.R.
    Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K (2009), Circ. Res., 104, 455-465.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Elastin + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta in the macrophage-rich regions of atherosclerotic plaques Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Elastin + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
catK
-
 Mus musculus
CTSK
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus receptor activator of nuclear factor-kappaB or small GTPase Rab do not mediate cathepsin K induction additional information
Mus musculus free cholesterol accumulation in macrophage membranes induces cathepsin K up