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Literature summary for 3.4.22.38 extracted from

  • Boskey, A.L.; Gelb, B.D.; Pourmand, E.; Kudrashov, V.; Doty, S.B.; Spevak, L.; Schaffler, M.B.
    Ablation of cathepsin K activity in the young mouse causes hypermineralization of long bone and growth plates (2009), Calcif. Tissue Int., 84, 229-239.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.38

Protein Variants

Protein Variants Comment Organism
additional information 10-week-old male cathepsin K-deficient knockout mice show bones that are mechanically more brittle, while both osteoclasts and osteoblasts show impaired activity relative to the wild type, phenotype with significant hypercalcification of the calcified cartilage and cortices, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
cathepsin K inhibitor II
-
 Mus musculus
additional information no inhibition of cathepsin K inhibitor III Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Mus musculus 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus cathepsin K plays a role in bone tissue development as well as skeletal remodeling, overview ?
-
 ?
additional information Mus musculus C57Bl6/J cathepsin K plays a role in bone tissue development as well as skeletal remodeling, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57Bl6/J mice
-
Mus musculus C57Bl6/J
-
 C57Bl6/J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
bone
-
 Mus musculus
-
bone cancer cell skeletal and nonskeletal tumor cell Mus musculus
-
chondroclast
-
 Mus musculus
-
chondrocyte
-
 Mus musculus
-
endothelial cell
-
 Mus musculus
-
gastric cancer cell
-
 Mus musculus
-
osteoblast
-
 Mus musculus
-
osteoclast
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cathepsin K plays a role in bone tissue development as well as skeletal remodeling, overview Mus musculus ?
-
 ?
additional information cathepsin K plays a role in bone tissue development as well as skeletal remodeling, overview Mus musculus C57Bl6/J ?
-
 ?