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Literature summary for 3.4.22.38 extracted from

  • Schurigt, U.; Hummel, K.M.; Petrow, P.K.; Gajda, M.; Stoeckigt, R.; Middel, P.; Zwerina, J.; Janik, T.; Bernhardt, R.; Schueler, S.; Scharnweber, D.; Beckmann, F.; Saftig, P.; Kollias, G.; Schett, G.; Wiederanders, B.; Braeuer, R.
    Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor-transgenic mice (2008), Arthritis Rheum., 58, 422-434.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
genotyping of C57BL/6 mice either wild-type for cathepsin K, CK+/+, heterozygous for cathepsin K, CK+/-, or deficient in cathepsin K, CK-/-, overview Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information phenotype comparisons of C57BL/6 mice either wild-type for cathepsin K, CK+/+, heterozygous for cathepsin K, CK+/-, or deficient in cathepsin K, CK-/-, no influence of cathepsin K deficiency on the severity of inflammation in arthritic knee joints, overview, Maintenance of the osteopetrosis phenotype of cathepsin K-deficient mice in arthritic mice Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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 C57BL/6 mice either wild-type for cathepsin K, CK+/+, heterozygous for cathepsin K, CK+/-, or deficient in cathepsin K, CK-/-, all transgenically expressing human tumor necrosis factor
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Source Tissue

Source Tissue Comment Organism Textmining
bone
-
 Mus musculus
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osteoclast from either wild-type for cathepsin K, CK+/+, heterozygous for cathepsin K, CK+/-, or deficient in cathepsin K, CK-/-, mice, phenotypes, overview Mus musculus
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