Literature summary for 3.4.22.38 extracted from

Keegan, P.M.; Anbazhakan, S.; Kang, B.; Pace, B.S.; Platt, M.O.
Biomechanical and biochemical regulation of cathepsin K expression in endothelial cells converge at AP-1 and NF-kappaB (2016), Biol. Chem., 397, 459-468 .

Search for more literature for 3.4.22.38

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P43235	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
aortic endothelial cell	-	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	vasoprotective shear stress inhibits cathepsin K protein expression and activation downstream of TNFalpha stimulation via reduced NF-kappaB activation and expression. TNFalpha stimulation activates JNK/c-jun phosphorylation, but reduction of NF-kappaB protein prevents induction of cathepsin K transcription under vasoprotective shear stress conditions	down
Homo sapiens	cathepsins K is elevated in endothelial cells by tumor necrosis factor-alpha stimulation	up

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Release 2023.1 (January 2023)