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Literature summary for 3.4.22.38 extracted from

  • Neidhart, M.; Baraliakos, X.; Seemayer, C.; Zelder, C.; Gay, R.E.; Michel, B.A.; Boehm, H.; Gay, S.; Braun, J.
    Expression of cathepsin K and MMP-1 indicate persistent osteodestruktive activity in longstanding ankylosing spondylitis (2008), Ann. Rheum. Dis., 68, 1334-1339.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens expression of cathepsin K indicates persistent osteodestructive activity in longstanding ankylosing spondylitis, a frequent largely genetically determined rheumatic disease that is characterised by spinal inflammation and new bone formation ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
bone from ankylosing spondylitis and degenerative disc disease patients, strong expression in the different regions of the spine. Cathepsin K-positive multinucleated cells are located at sites of bone destruction, overview Homo sapiens
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mononuclear cell in intervertebral disks Homo sapiens
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additional information fibroblast-like cell Homo sapiens
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osteoclast strong expression in ankylosing spondylitis patients Homo sapiens
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synovium
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information expression of cathepsin K indicates persistent osteodestructive activity in longstanding ankylosing spondylitis, a frequent largely genetically determined rheumatic disease that is characterised by spinal inflammation and new bone formation Homo sapiens ?
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?