Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | expression of cathepsin K indicates persistent osteodestructive activity in longstanding ankylosing spondylitis, a frequent largely genetically determined rheumatic disease that is characterised by spinal inflammation and new bone formation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone | from ankylosing spondylitis and degenerative disc disease patients, strong expression in the different regions of the spine. Cathepsin K-positive multinucleated cells are located at sites of bone destruction, overview | Homo sapiens | - |
mononuclear cell | in intervertebral disks | Homo sapiens | - |
additional information | fibroblast-like cell | Homo sapiens | - |
osteoclast | strong expression in ankylosing spondylitis patients | Homo sapiens | - |
synovium | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | expression of cathepsin K indicates persistent osteodestructive activity in longstanding ankylosing spondylitis, a frequent largely genetically determined rheumatic disease that is characterised by spinal inflammation and new bone formation | Homo sapiens | ? | - |
? |