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Literature summary for 3.4.22.38 extracted from
- Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption (2009), J. Biol. Chem., 284, 2584-2592.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | catK-deficient cells show a similar suppression of actin rings as wild-type osteoclasts treated with inhibitor LHVS | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| LHVS | a cell-permeable broad spectrum cathepsin inhibitor | Homo sapiens |  |
| LHVS | a cell-permeable broad spectrum cathepsin inhibitor | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| collagen I + H2O | Mus musculus | cathepsin K is responsible for the degradation of type I collagen in osteoclast-mediated bone resorption. Cathepsin K interaction with type I collagen is required for 1. the release of cryptic Arg-Gly-Asp motifs during the initial attachment of osteoclasts and 2. termination of resorption via the creation of autocrine signals originating from type I collagen degradation, overview | ? | - |
? | |
| collagen I + H2O | Homo sapiens | cathepsin K is responsible for the degradation of type I collagen in osteoclast-mediated bone resorption. Cathepsin K interaction with type I collagen is required for 1. the release of cryptic Arg-Gly-Asp motifs during the initial attachment of osteoclasts and 2. termination of resorption via the creation of autocrine signals originating from type I collagen degradation, overview | ? | - |
? | |
| collagen I + H2O | Mus musculus C57BL/6 | cathepsin K is responsible for the degradation of type I collagen in osteoclast-mediated bone resorption. Cathepsin K interaction with type I collagen is required for 1. the release of cryptic Arg-Gly-Asp motifs during the initial attachment of osteoclasts and 2. termination of resorption via the creation of autocrine signals originating from type I collagen degradation, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
C57BL/6 mice | - |
| Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone | - |
Mus musculus | - |
| commercial preparation | recombinant enzyme | Mus musculus | - |
| commercial preparation | recombinant enzyme | Homo sapiens | - |
| osteoclast | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| collagen I + H2O | - |
Mus musculus | ? | - |
? | |
| collagen I + H2O | - |
Homo sapiens | ? | - |
? | |
| collagen I + H2O | cathepsin K is responsible for the degradation of type I collagen in osteoclast-mediated bone resorption. Cathepsin K interaction with type I collagen is required for 1. the release of cryptic Arg-Gly-Asp motifs during the initial attachment of osteoclasts and 2. termination of resorption via the creation of autocrine signals originating from type I collagen degradation, overview | Mus musculus | ? | - |
? | |
| collagen I + H2O | cathepsin K is responsible for the degradation of type I collagen in osteoclast-mediated bone resorption. Cathepsin K interaction with type I collagen is required for 1. the release of cryptic Arg-Gly-Asp motifs during the initial attachment of osteoclasts and 2. termination of resorption via the creation of autocrine signals originating from type I collagen degradation, overview | Homo sapiens | ? | - |
? | |
| collagen I + H2O | - |
Mus musculus C57BL/6 | ? | - |
? | |
| collagen I + H2O | cathepsin K is responsible for the degradation of type I collagen in osteoclast-mediated bone resorption. Cathepsin K interaction with type I collagen is required for 1. the release of cryptic Arg-Gly-Asp motifs during the initial attachment of osteoclasts and 2. termination of resorption via the creation of autocrine signals originating from type I collagen degradation, overview | Mus musculus C57BL/6 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| catK | - |
Mus musculus |
| catK | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 28 | - |
assay at | Mus musculus |
| 28 | - |
assay at | Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
2 min, soluble bone fraction, inactivation at pH 7.2 and 50°C | Mus musculus |
| 50 | - |
2 min, soluble bone fraction, inactivation at pH 7.2 and 50°C | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | - |
assay at | Mus musculus |
| 5.5 | - |
assay at | Homo sapiens |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
2 min, soluble bone fraction, inactivation at pH 7.2 and 50°C | Mus musculus |
| 7.2 | - |
2 min, soluble bone fraction, inactivation at pH 7.2 and 50°C | Homo sapiens |
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