Literature summary for 3.4.22.38 extracted from

Quintanilla-Dieck, M.J.; Codriansky, K.; Keady, M.; Bhawan, J.; Ruenger, T.M.
Cathepsin K in Melanoma Invasion (2008), J. Invest. Dermatol., 128, 2281-2288.

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Application

Application	Comment	Organism
medicine	catK plays an important role in melanoma invasion and metastasis by mediating intracellular degradation of matrix proteins after phagocytosis. Clinical use of catK inhibitors may be promising for the treatment of melanoma	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Boc-I	lysosomotropic, water-soluble polymer selective catK inhibitor. Inhibition of catK greatly reduces melanoma cell invasion through Matrigel basement membrane matrix and increases detection of internalized collagen	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
melanoma cell	immunostaining reveals strong catK expression in most primary melanomas and all cutaneous melanoma metastases. Melanocytic nevi also demonstrates catK expression, but it is less intense than in melanomas. Melanoma lines express both the pro- and the active form of catK	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
cathepsin K	-	Homo sapiens
catK	-	Homo sapiens

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Release 2023.1 (January 2023)