Reference on EC 3.4.22.27 - cathepsin S
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schick, C.; Pemberton, P.A.; Shi, G.P.; Kamachi, Y.; Cataltepe, S.; Bartuski, A.J.; Gornstein, E.R.; Brömme, D.; Chapman, H.A.; Silverman, G.A.
Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen I: a kinetic analysis
Biochemistry
37
5258-5266
1998
Homo sapiens
Maciewicz, R.A.; Etherington, D.J.
A comparison of four cathepsins (B, L, N and S) with collagenolytic activity from rabbit spleen
Biochem. J.
256
433-440
1988
Oryctolagus cuniculus
Baker, S.M.; Karlsson, L.; Thurmond, R.L.
Cloning, expression, purification, and activity of dog (Canis familiaris) and monkey (Saimiri boliviensis) cathepsin S
Protein Expr. Purif.
28
93-101
2003
Bos taurus, Canis lupus familiaris, Homo sapiens, Mus musculus, Saimiri boliviensis
Bania, J.; Gatti, E.; Lelouard, H.; David, A.; Cappello, F.; Weber, E.; Camosseto, V.; Pierre, P.
Human cathepsin S, but not cathepsin L, degrades efficiently MHC class II-associated invariant chain in nonprofessional APCs
Proc. Natl. Acad. Sci. USA
100
6664-6669
2003
Homo sapiens
Cywin, C.L.; Firestone, R.A.; McNeil, D.W.; Grygon, C.A.; Crane, K.M.; White, D.M.; Kinkade, P.R.; Hopkins, J.L.; Davidson, W.; Labadia, M.E.; Wildeson, J.; Morelock, M.M.; Peterson, J.D.; Raymond, E.L.; Brown, M.L.; Spero, D.M.
The design of potent hydrazones and disulfides as cathepsin S inhibitors
Bioorg. Med. Chem.
11
733-740
2003
Homo sapiens
Dahl, S.W.; Halkier, T.; Lauritzen, C.; Dolenc, I.; Pedersen, J.; Turk, V.; Turk, B.
Human recombinant Pro-dipeptidyl peptidase I (cathepsin C) can be activated by cathepsins L and S but not by autocatalytic processing
Biochemistry
40
1671-1678
2001
Homo sapiens
Walker, B.; Lynas, J.F.; Meighan, M.A.; Bromme, D.
Evaluation of dipeptide alpha-keto-beta-aldehydes as new inhibitors of cathepsin S
Biochem. Biophys. Res. Commun.
275
401-405
2000
Homo sapiens
Katunuma, N.; Murata, E.; Kakegawa, H.; Matsui, A.; Tsuzuki, H.; Tsuge, H.; Turk, D.; Turk, V.; Fukushima, M.; Tada, Y.; Asao, T.
Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivo
FEBS Lett.
458
6-10
1999
Homo sapiens
Marquis, R.W.; Ru, Y.; LoCastro, S.M.; Zeng, J.; et al.
Azepanone-based Inhibitors of human and rat cathepsin K
J. Med. Chem.
44
1380-1395
2001
Homo sapiens
Guo, Y.L.; Kurz, U.; Schultz, J.E.; Lim, C.C.; Wiederanders, B.; Schilling, K.
The a 1/2 helical backbone of the prodomains defines the intrinsic inhibitory specificity in the cathepsin L-like cysteine protease subfamily
FEBS Lett.
469
203-207
2000
Homo sapiens
Katunuma, N.; Matsui, A.; Kakegawa, T.; Murata, E.; Asao, T.; Ohba, Y.
Study of the functional share of lysosomal cathepsins by the development of specific inhibitors
Adv. Enzyme Regul.
39
247-260
1999
Homo sapiens
Mason, C.S.; Lamers, M.B.; Henderson, I.M.; Monk, T.; Williams, D.H.
Baculoviral expression and characterization of rodent cathepsin S
Protein Expr. Purif.
23
45-54
2001
Homo sapiens, Mus musculus, Rattus norvegicus
Mason, R.W.; Sol-Church, K.; Abrahamson, M.
Amino acid substitutions in the N-terminal segment of cystatin C create selective protein inhibitors of lysosomal cysteine proteinases
Biochem. J.
330
833-838
1998
Bos taurus
-
Maubach, G.; Schilling, K.; Rommerskirch, W.; Wenz, I.; Schultz, J.E.; Weber, E.; Wiederanders, B.
The inhibition of cathepsin S by its propeptide-specificity and mechanism of action
Eur. J. Biochem.
250
745-750
1997
Homo sapiens
McGrath, M.E.; Palmer, J.T.; Bromme, D.; Somoza, J.R.
Crystal structure of human cathepsin S
Protein Sci.
7
1294-1302
1998
Homo sapiens
Pauly, T.A.; Sulea, T.; Ammirati, M.; Sivaraman, J.; Danley, D.E.; Griffor, M.C.; Kamath, A.V.; Wang, I.K.; Laird, E.R.; Seddon, A.P.; Menard, R.; Cygler, M.; Rath, V.L.
Specificity determinants of human cathepsin s revealed by crystal structures of complexes
Biochemistry
42
3203-3213
2003
Homo sapiens (P25774), Homo sapiens
Pietschmann, S.; Fehn, M.; Kaulmann, G.; Wenz, I.; Wiederanders, B.; Schilling, K.
Foldase function of the cathepsin S proregion is strictly based upon its domain structure
J. Biol. Chem.
383
1453-1458
2002
Homo sapiens
Quraishi, O.; Storer, A.C.
Identification of internal autoproteolytic cleavage sites within the prosegments of recombinant procathepsin B and procathepsin S. Contribution of a plausible unimolecular autoproteolytic event for the processing of zymogens belonging to the papain family
J. Biol. Chem.
276
8118-8124
2001
Homo sapiens
Rydzewski, R.M.; Bryant, C.; Oballa, R.; Wesolowski, G.; Rodan, S.B.; Bass, K.E.; Wong, D.H.
Peptidic 1-cyanopyrrolidines: synthesis and SAR of a series of potent, selective cathepsin inhibitors
Bioorg. Med. Chem.
10
3277-3284
2002
Homo sapiens
Robichaud, J.; Oballa, R.; Prasit, P.; Falgueyret, J.P.; Percival, M.D.; Wesolowski, G.; Rodan, S.B.; Kimmel, D.; Johnson, C.; Bryant, C.; Venkatraman, S.; Setti, E.; Mendonca, R.; Palmer, J.T.
A novel class of nonpeptidic biaryl inhibitors of human cathepsin K
J. Med. Chem.
46
3709-3727
2003
Homo sapiens
Wiederanders, B.
The function of propeptide domains of cysteine proteinases
Adv. Exp. Med. Biol.
477
261-270
2000
Homo sapiens
Ward, Y.D.; Thomson, D.S.; Frye, L.L.; Cywin, C.L.; Morwick, T.; Emmanuel, M.J.; Zindell, R.; McNeil, D.; Bekkali, Y.; Girardot, M.; Hrapchak, M.; DeTuri, M.; Crane, K.; White, D.; Pav, S.; Wang, Y.; Hao, M.H.; Grygon, C.A.; Labadia, M.E.; Freeman, D.M.; Davidson, W.; Hopkins, J.L.; Brown, M.L.; Spero, D.M.; Giradot, M.
Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors
J. Med. Chem.
45
5471-5482
2002
Homo sapiens
Schmid, H.; Koop, M.; Utermann, S.; Lambacher, L.; Mayer, P.; Schaefer, L.
Specific catalytic activity of cathepsin S in comparison to cathepsins B and L along the rat nephron
Biol. Chem.
378
61-69
1997
Rattus norvegicus
Shindo, K.; Suzuki, H.; Okuda, T.
Paecilopeptin, a new cathepsin S inhibitor produced by Paecilomyces carneus
Biosci. Biotechnol. Biochem.
66
2444-2448
2002
Homo sapiens
Thurmond, R.L.; Sun, S.; Sehon, C.A.; Baker, S.M.; Cai, H.; Gu, Y.; Jiang, W.; Riley, J.P.; Williams, K.N.; Edwards, J.P.; Karlsson, L.
Identification of a potent and selective noncovalent cathepsin S inhibitor
J. Pharmacol. Exp. Ther.
308
268-276
2004
Bos taurus, Canis lupus familiaris, Homo sapiens, Platyrrhini, Mus musculus
Tobbell, D.A.; Middleton, B.J.; Raines, S.; Needham, M.R.; Taylor, I.W.; Beveridge, J.Y.; Abbott, W.M.
Identification of in vitro folding conditions for procathepsin S and cathepsin S using fractional factorial screens
Protein Expr. Purif.
24
242-254
2002
Homo sapiens
Guay, J.; Falgueyret, J.P.; Ducret, A.; Percival, M.D.; Mancini, J.A.
Potency and selectivity of inhibition of cathepsin K, L and S by their respective propeptides
Eur. J. Biochem.
267
6311-6318
2000
Homo sapiens
Kirschke, H.; Schmidt, I.; Wiederanders, B.
Cathepsin S. The cysteine proteinase from bovine lymphoid tissue is distinct from cathepsin L (EC 3.4.22.15)
Biochem. J.
240
455-459
1986
Bos taurus
Cookson, E.J.; Beynon, R.J.
Pyridoxal phosphate as a specific label for fragments of glycogen phosphorylase
Biochem. Soc. Trans.
13
1168-1170
1985
Oryctolagus cuniculus
-
Brömme, D.; Steinert, A.; Friebe, S.; Fittkau, S.; Wiederanders, B.; Kirschke, H.
The specificity of bovine spleen cathepsin S. A comparison with rat liver cathepsins L and B
Biochem. J.
264
475-481
1989
Bos taurus
Wiederanders, B.; Brömme, D.; Kirschke, H.; Von Figura, K.; Schmidt, B.; Peters, C.
Phylogenetic conservation of cysteine proteinases. Cloning and expression of a cDNA coding for human cathepsin S
J. Biol. Chem.
267
13708-13713
1992
Homo sapiens
Kirschke, H.; Wiederanders, B.; Brömme, D.; Rinne, A.
Cathepsin S from bovine spleen. Purification, distribution, intracellular localization and action on proteins
Biochem. J.
264
467-473
1989
Bos taurus
Wiederanders, B.; Brömme, D.; Kirschke, H.; Kalkkinen, N.; Rinne, A.; Paquette, T.; Toothman, P.
Primary structure of bovine cathepsin S. Comparison to cathepsins L, H, B and papain
FEBS Lett.
286
189-192
1991
Bos taurus
Brömme, D.; McGrath, M.E.
High level expression and crystallization of recombinant human cathepsin S
Protein Sci.
5
789-791
1996
Homo sapiens
Shi, G.P.; Munger, J.S.; Meara, J.P.; Rich, D.H.; Chapman, H.A.
Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease
J. Biol. Chem.
267
7258-7262
1992
Homo sapiens
Petanceska, S.; Devi, L.
Sequence analysis, tissue distribution, and expression of rat cathepsin S
J. Biol. Chem.
267
26038-26043
1992
Rattus norvegicus
Shaw, E.; Mohanty, S.; Colic, A.; Stoka, V.; Turk, V.
The affinity-labelling of cathepsin S with peptidyl diazomethyl ketones. Comparison with the inhibition of cathepsin L and calpain
FEBS Lett.
334
340-342
1993
Bos taurus
Turk, B.; Colic, A.; Stoka, V.; Turk, V.
Kinetics of inhibition of bovine cathepsin S by bovine stefin B
FEBS Lett.
339
155-159
1994
Bos taurus
Kopitar, G.; Dolinar, M.; Strukelj, B.; Pungercar, B.; Turk, V.
Folding and activation of human procathepsin S from inclusion bodies produced in Escherichia coli
Eur. J. Biochem.
236
558-562
1996
Homo sapiens
Brömme, D.; Bonneau, P.R.; Lachance, P.; Wiederanders, B.; Kirschke, H.; Peters, C.; Thomas, D.Y.; Storer, A.C.; Vernet, T.
Functional expression of human cathepsin S in Saccharomyces cerevisiae. Purification and characterization of the recombinant enzyme
J. Biol. Chem.
268
4832-4838
1993
Homo sapiens
Brömme, D.; Kirschke, H.; Rinne, R.
Tight-binding inhibition of cathepsin S by cystatins
Biomed. Biochim. Acta
50
631-635
1991
Bos taurus
Ritonja, A.; Colic, A.; Dolenc, I.; Ogrinc, T.; Podobnik, M.; Turk, V.
The complete amino acid sequence of bovine cathepsin S and a partial sequence of bovine cathepsin L
FEBS Lett.
283
329-331
1991
Bos taurus
Dolenc, I.; Ritonja, A.; Colic, A.; Podobnik, M.; Ogrinc, T.; Turk, V.
Bovine cathepsins S and L: isolation and amino acid sequences
Biol. Chem. Hoppe-Seyler
373
407-412
1992
Bos taurus
Brömme, D.; Smith, R.A.; Coles, P.J.; Kirschke, H.; Storer, A.C.; Krantz, A.
Potent inactivation of cathepsins S and L by peptidyl (acyloxy)methyl ketones
Biol. Chem. Hoppe-Seyler
375
343-347
1994
Homo sapiens
Leonardi, A.; Turk, B.; Turk, V.
Inhibition of bovine cathepsins L and S by stefins and cystatins
Biol. Chem. Hoppe-Seyler
377
319-321
1996
Bos taurus
Xin, X.Q.; Gunesekera, B.; Mason, R.W.
The specificity and elastinolytic activities of bovine cathepsins S and H
Arch. Biochem. Biophys.
299
334-339
1994
Bos taurus
Gour-Salin, B.J.; Lachance, P.; Bonneau, P.R.; Storer, A.C.; Kirschke, H.; Broemme, D.
E-64 analogs as inhibitors of cathepsin S: Importance of the S2-P2 intercations for potency and selectivity
Bioorg. Chem.
22
227-241
1994
Homo sapiens
-
Cheng, X.W.; Kuzuya, M.; Nakamura, K.; Di, Q.; Liu, Z.; Sasaki, T.; Kanda, S.; Jin, H.; Shi, G.P.; Murohara, T.; Yokota, M.; Iguchi, A.
Localization of cysteine protease, cathepsin S, to the surface of vascular smooth muscle cells by association with integrin alphanubeta3
Am. J. Pathol.
168
685-694
2006
Homo sapiens
Liu, J.; Ma, L.; Yang, J.; Ren, A.; Sun, Z.; Yan, G.; Sun, J.; Fu, H.; Xu, W.; Hu, C.; Shi, G.P.
Increased serum cathepsin S in patients with atherosclerosis and diabetes
Atherosclerosis
186
411-419
2006
Homo sapiens
Gustin, D.J.; Sehon, C.A.; Wei, J.; Cai, H.; Meduna, S.P.; Khatuya, H.; Sun, S.; Gu, Y.; Jiang, W.; Thurmond, R.L.; Karlsson, L.; Edwards, J.P.
Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors
Bioorg. Med. Chem. Lett.
15
1687-1691
2005
Homo sapiens
Liu, H.; Tully, D.C.; Epple, R.; Bursulaya, B.; Li, J.; Harris, J.L.; Williams, J.A.; Russo, R.; Tumanut, C.; Roberts, M.J.; Alper, P.B.; He, Y.; Karanewsky, D.S.
Design and synthesis of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 1
Bioorg. Med. Chem. Lett.
15
4979-4984
2005
Homo sapiens
Alper, P.B.; Liu, H.; Chatterjee, A.K.; Nguyen, K.T.; Tully, D.C.; Tumanut, C.; Li, J.; Harris, J.L.; Tuntland, T.; Chang, J.; Gordon, P.; Hollenbeck, T.; Karanewsky, D.S.
Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 2: optimization of P1 and N-aryl
Bioorg. Med. Chem. Lett.
16
1486-1490
2006
Mus musculus
Tully, D.C.; Liu, H.; Alper, P.B.; Chatterjee, A.K.; Epple, R.; Roberts, M.J.; Williams, J.A.; Nguyen, K.T.; Woodmansee, D.H.; Tumanut, C.; Li, J.; Spraggon, G.; Chang, J.; Tuntland, T.; Harris, J.L.; Karanewsky, D.S.
Synthesis and evaluation of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 3: heterocyclic P3
Bioorg. Med. Chem. Lett.
16
1975-1980
2006
Homo sapiens
Tully, D.C.; Liu, H.; Chatterjee, A.K.; Alper, P.B.; Williams, J.A.; Roberts, M.J.; Mutnick, D.; Woodmansee, D.H.; Hollenbeck, T.; Gordon, P.; Chang, J.; Tuntland, T.; Tumanut, C.; Li, J.; Harris, J.L.; Karanewsky, D.S.
Arylaminoethyl carbamates as a novel series of potent and selective cathepsin S inhibitors
Bioorg. Med. Chem. Lett.
16
5107-5111
2006
Rattus norvegicus
Liu, W.; Spero, D.M.
Cysteine protease cathepsin S as a key step in antigen presentation
Drug News Perspect.
17
357-363
2004
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
Boes, M.; van der Wel, N.; Peperzak, V.; Kim, Y.M.; Peters, P.J.; Ploegh, H.
In vivo control of endosomal architecture by class II-associated invariant chain and cathepsin S
Eur. J. Immunol.
35
2552-2562
2005
Mus musculus
Taleb, S.; Lacasa, D.; Bastard, J.P.; Poitou, C.; Cancello, R.; Pelloux, V.; Viguerie, N.; Benis, A.; Zucker, J.D.; Bouillot, J.L.; Coussieu, C.; Basdevant, A.; Langin, D.; Clement, K.
Cathepsin S, a novel biomarker of adiposity: relevance to atherogenesis
FASEB J.
19
1540-1542
2005
Homo sapiens
Vasiljeva, O.; Dolinar, M.; Pungercar, J.R.; Turk, V.; Turk, B.
Recombinant human procathepsin S is capable of autocatalytic processing at neutral pH in the presence of glycosaminoglycans
FEBS Lett.
579
1285-1290
2005
Homo sapiens
Shen, L.; Sigal, L.J.; Boes, M.; Rock, K.L.
Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo
Immunity
21
155-165
2004
Mus musculus
Wang, B.; Sun, J.; Kitamoto, S.; Yang, M.; Grubb, A.; Chapman, H.A.; Kalluri, R.; Shi, G.P.
Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors
J. Biol. Chem.
281
6020-6029
2006
Homo sapiens, Mus musculus, Mus musculus C57BL/6
Beers, C.; Burich, A.; Kleijmeer, M.J.; Griffith, J.M.; Wong, P.; Rudensky, A.Y.
Cathepsin S controls MHC class II-mediated antigen presentation by epithelial cells in vivo
J. Immunol.
174
1205-1212
2005
Mus musculus, Mus musculus C57BL/6
Yang, H.; Kala, M.; Scott, B.G.; Goluszko, E.; Chapman, H.A.; Christadoss, P.
Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis
J. Immunol.
174
1729-1737
2005
Mus musculus, Mus musculus C57BL/6
Rodgers, K.J.; Watkins, D.J.; Miller, A.L.; Chan, P.Y.; Karanam, S.; Brissette, W.H.; Long, C.J.; Jackson, C.L.
Destabilizing role of cathepsin S in murine atherosclerotic plaques
Arterioscler. Thromb. Vasc. Biol.
26
851-856
2006
Homo sapiens, Mus musculus
Rueckrich, T.; Brandenburg, J.; Cansier, A.; Mueller, M.; Stevanovic, S.; Schilling, K.; Wiederanders, B.; Beck, A.; Melms, A.; Reich, M.; Driessen, C.; Kalbacher, H.
Specificity of human cathepsin S determined by processing of peptide substrates and MHC class II-associated invariant chain
Biol. Chem.
387
1503-1511
2006
Homo sapiens (P25774), Homo sapiens
Grice, C.A.; Tays, K.; Khatuya, H.; Gustin, D.J.; Butler, C.R.; Wei, J.; Sehon, C.A.; Sun, S.; Gu, Y.; Jiang, W.; Thurmond, R.L.; Karlsson, L.; Edwards, J.P.
The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors
Bioorg. Med. Chem. Lett.
16
2209-2212
2006
Homo sapiens
Tully, D.C.; Liu, H.; Chatterjee, A.K.; Alper, P.B.; Epple, R.; Williams, J.A.; Roberts, M.J.; Woodmansee, D.H.; Masick, B.T.; Tumanut, C.; Li, J.; Spraggon, G.; Hornsby, M.; Chang, J.; Tuntland, T.; Hollenbeck, T.; Gordon, P.; Harris, J.L.; Karanewsky, D.S.
Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers
Bioorg. Med. Chem. Lett.
16
5112-5117
2006
Rattus norvegicus
Bekkali, Y.; Thomson, D.S.; Betageri, R.; Emmanuel, M.J.; Hao, M.H.; Hickey, E.; Liu, W.; Patel, U.; Ward, Y.D.; Young, E.R.; Nelson, R.; Kukulka, A.; Brown, M.L.; Crane, K.; White, D.; Freeman, D.M.; Labadia, M.E.; Wildeson, J.; Spero, D.M.
Identification of a novel class of succinyl-nitrile-based cathepsin S inhibitors
Bioorg. Med. Chem. Lett.
17
2465-2469
2007
Homo sapiens
Chatterjee, A.K.; Liu, H.; Tully, D.C.; Guo, J.; Epple, R.; Russo, R.; Williams, J.; Roberts, M.; Tuntland, T.; Chang, J.; Gordon, P.; Hollenbeck, T.; Tumanut, C.; Li, J.; Harris, J.L.
Synthesis and SAR of succinamide peptidomimetic inhibitors of cathepsin S
Bioorg. Med. Chem. Lett.
17
2899-2903
2007
Homo sapiens
Gauthier, J.Y.; Black, W.C.; Courchesne, I.; Cromlish, W.; Desmarais, S.; Houle, R.; Lamontagne, S.; Li, C.S.; Masse, F.; McKay, D.J.; Ouellet, M.; Robichaud, J.; Truchon, J.F.; Truong, V.L.; Wang, Q.; Percival, M.D.
The identification of potent, selective, and bioavailable cathepsin S inhibitors
Bioorg. Med. Chem. Lett.
17
4929-4933
2007
Homo sapiens, Mus musculus, Rattus norvegicus
Gupta, S.; Singh, R.K.; Dastidar, S.; Ray, A.
Cysteine cathepsin S as an immunomodulatory target: present and future trends
Expert Opin. Ther. Targets
12
291-299
2008
Homo sapiens
Flannery, T.; McQuaid, S.; McGoohan, C.; McConnell, R.S.; McGregor, G.; Mirakhur, M.; Hamilton, P.; Diamond, J.; Cran, G.; Walker, B.; Scott, C.; Martin, L.; Ellison, D.; Patel, C.; Nicholson, C.; Mendelow, D.; McCormick, D.; Johnston, P.G.
Cathepsin S expression: An independent prognostic factor in glioblastoma tumours - A pilot study
Int. J. Cancer
119
854-860
2006
Homo sapiens
Novinec, M.; Grass, R.N.; Stark, W.J.; Turk, V.; Baici, A.; Lenarcic, B.
Interaction between human cathepsins K, L, and S and elastins: mechanism of elastinolysis and inhibition by macromolecular inhibitors
J. Biol. Chem.
282
7893-7902
2007
Homo sapiens
Chang, W.W.; Wu, H.; Yeh, C.; Wu, C.; Chang, J.
Lysosomal cysteine proteinase cathepsin S as a potential target for anti-cancer therapy
J. Cancer Mol.
3
5-14
2007
Homo sapiens
-
Patterson, A.W.; Wood, W.J.; Hornsby, M.; Lesley, S.; Spraggon, G.; Ellman, J.A.
Identification of selective, nonpeptidic nitrile inhibitors of cathepsin S using the substrate activity screening method
J. Med. Chem.
49
6298-6307
2006
Homo sapiens
Burden, R.E.; Snoddy, P.; Buick, R.J.; Johnston, J.A.; Walker, B.; Scott, C.J.
Recombinant cathepsin S propeptide attenuates cell invasion by inhibition of cathepsin L-like proteases in tumor microenvironment
Mol. Cancer Ther.
7
538-547
2008
Homo sapiens
Akahoshi, N.; Murashima, Y.L.; Himi, T.; Ishizaki, Y.; Ishii, I.
Increased expression of the lysosomal protease cathepsin S in hippocampal microglia following kainate-induced seizures
Neurosci. Lett.
429
136-141
2007
Mus musculus (O70370)
Barclay, J.; Clark, A.K.; Ganju, P.; Gentry, C.; Patel, S.; Wotherspoon, G.; Buxton, F.; Song, C.; Ullah, J.; Winter, J.; Fox, A.; Bevan, S.; Malcangio, M.
Role of the cysteine protease cathepsin S in neuropathic hyperalgesia
Pain
130
225-234
2007
Rattus norvegicus (Q02765)
Clark, A.K.; Yip, P.K.; Grist, J.; Gentry, C.; Staniland, A.A.; Marchand, F.; Dehvari, M.; Wotherspoon, G.; Winter, J.; Ullah, J.; Bevan, S.; Malcangio, M.
Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain
Proc. Natl. Acad. Sci. USA
104
10655-10660
2007
Rattus norvegicus
Kramer, G.; Paul, A.; Kreusch, A.; Schueler, S.; Wiederanders, B.; Schilling, K.
Optimized folding and activation of recombinant procathepsin L and S produced in Escherichia coli
Protein Expr. Purif.
54
147-156
2007
Homo sapiens (P25774)
Cheng, F.C.; Feng, J.J.; Chen, K.H.; Imanishi, H.; Fujishima, M.; Takekoshi, H.; Naoki, Y.; Shimoda, M.
Chlorella powder inhibits the activities of peptidase cathepsin S, PLA2, cyclooxygenase-2, thromboxane synthase, tyrosine phosphatases, tumor necrosis factor-alpha converting enzyme, calpain and kinases
Int. J. Food Sci. Nutr.
60 Suppl 1
89-98
2008
Homo sapiens
de Nooijer, R.; Bot, I.; von der Thuesen, J.H.; Leeuwenburgh, M.A.; Overkleeft, H.S.; Kraaijeveld, A.O.; Dorland, R.; van Santbrink, P.J.; van Heiningen, S.H.; Westra, M.M.; Kovanen, P.T.; Jukema, J.W.; van der Wall, E.E.; van Berkel, T.J.; Shi, G.P.; Biessen, E.A.
Leukocyte cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis
Arterioscler. Thromb. Vasc. Biol.
29
188-194
2009
Mus musculus
Irie, O.; Ehara, T.; Iwasaki, A.; Yokokawa, F.; Sakaki, J.; Hirao, H.; Kanazawa, T.; Teno, N.; Horiuchi, M.; Umemura, I.; Gunji, H.; Masuya, K.; Hitomi, Y.; Iwasaki, G.; Nonomura, K.; Tanabe, K.; Fukaya, H.; Kosaka, T.; Snell, C.R.; Hallett, A.
Discovery of selective and nonpeptidic cathepsin S inhibitors
Bioorg. Med. Chem. Lett.
18
3959-3962
2008
Homo sapiens
Irie, O.; Yokokawa, F.; Ehara, T.; Iwasaki, A.; Iwaki, Y.; Hitomi, Y.; Konishi, K.; Kishida, M.; Toyao, A.; Masuya, K.; Gunji, H.; Sakaki, J.; Iwasaki, G.; Hirao, H.; Kanazawa, T.; Tanabe, K.; Kosaka, T.; Hart, T.W.; Hallett, A.
4-Amino-2-cyanopyrimidines: novel scaffold for nonpeptidic cathepsin S inhibitors
Bioorg. Med. Chem. Lett.
18
4642-4646
2008
Homo sapiens (P25774)
Irie, O.; Kosaka, T.; Kishida, M.; Sakaki, J.; Masuya, K.; Konishi, K.; Yokokawa, F.; Ehara, T.; Iwasaki, A.; Iwaki, Y.; Hitomi, Y.; Toyao, A.; Gunji, H.; Teno, N.; Iwasaki, G.; Hirao, H.; Kanazawa, T.; Tanabe, K.; Hiestand, P.C.; Malcangio, M.; Fox, A.J.; Bevan, S.J.; Yaqoob, M.; Culshaw, A.J.; Hart, T.W.; Hallet, A.
Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-cyanopyrimidines. Part 2
Bioorg. Med. Chem. Lett.
18
5280-5284
2008
Homo sapiens (P25774)
Ayesa, S.; Lindquist, C.; Agback, T.; Benkestock, K.; Classon, B.; Henderson, I.; Hewitt, E.; Jansson, K.; Kallin, A.; Sheppard, D.; Samuelsson, B.
Solid-phase parallel synthesis and SAR of 4-amidofuran-3-one inhibitors of cathepsin S: effect of sulfonamides P3 substituents on potency and selectivity
Bioorg. Med. Chem.
17
1307-1324
2009
Homo sapiens
Leichsenring, A.; Baecker, I.; Wendt, W.; Andriske, M.; Schmitz, B.; Stichel, C.C.; Luebbert, H.
Differential expression of cathepsin S and X in the spinal cord of a rat neuropathic pain model
BMC Neurosci.
9
80
2008
Rattus norvegicus
Wendt, W.; Luebbert, H.; Stichel, C.C.
Upregulation of cathepsin S in the aging and pathological nervous system of mice
Brain Res.
1232
7-20
2008
Mus musculus
Aikawa, E.; Aikawa, M.; Libby, P.; Figueiredo, J.L.; Rusanescu, G.; Iwamoto, Y.; Fukuda, D.; Kohler, R.H.; Shi, G.P.; Jaffer, F.A.; Weissleder, R.
Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease
Circulation
119
1785-1794
2009
Mus musculus
Spielmann, N.; Mutch, D.M.; Rousseau, F.; Tores, F.; Hager, J.; Bertrais, S.; Basdevant, A.; Tounian, P.; Dubern, B.; Galan, P.; Clement, K.
Cathepsin S genotypes are associated with Apo-A1 and HDL-cholesterol in lean and obese French populations
Clin. Genet.
74
155-163
2008
Homo sapiens (P25774), Homo sapiens
Polyakova, O.; Dear, D.; Stern, I.; Martin, S.; Hirst, E.; Bawumia, S.; Nash, A.; Dodson, G.; Bronstein, I.; Bayley, P.M.
Proteolysis of prion protein by cathepsin S generates a soluble beta-structured intermediate oligomeric form, with potential implications for neurotoxic mechanisms
Eur. Biophys. J.
38
209-218
2009
Ovis aries
Seo, H.R.; Bae, S.; Lee, Y.S.
Radiation-induced cathepsin S is involved in radioresistance
Int. J. Cancer
124
1794-1801
2009
Homo sapiens
Luetzner, N.; Kalbacher, H.
Quantifying cathepsin S activity in antigen presenting cells using a novel specific substrate
J. Biol. Chem.
283
36185-36194
2008
Homo sapiens
Markt, P.; McGoohan, C.; Walker, B.; Kirchmair, J.; Feldmann, C.; De Martino, G.; Spitzer, G.; Distinto, S.; Schuster, D.; Wolber, G.; Laggner, C.; Langer, T.
Discovery of novel cathepsin S inhibitors by pharmacophore-based virtual high-throughput screening
J. Chem. Inf. Model.
48
1693-1705
2008
Homo sapiens
Irie, O.; Kosaka, T.; Ehara, T.; Yokokawa, F.; Kanazawa, T.; Hirao, H.; Iwasaki, A.; Sakaki, J.; Teno, N.; Hitomi, Y.; Iwasaki, G.; Fukaya, H.; Nonomura, K.; Tanabe, K.; Koizumi, S.; Uchiyama, N.; Bevan, S.J.; Malcangio, M.; Gentry, C.; Fox, A.J.; Yaqoob, M.; Culshaw, A.J.; Allan Hallett, A.J.
Discovery of orally bioavailable cathepsin S inhibitors for the reversal of neuropathic pain
J. Med. Chem.
51
5502-5505
2008
Homo sapiens, Mus musculus, Rattus norvegicus (Q02765)
Williams, A.S.; Eynott, P.R.; Leung, S.Y.; Nath, P.; Jupp, R.; De Sanctis, G.T.; Resnick, R.; Adcock, I.M.; Chung, K.F.
Role of cathepsin S in ozone-induced airway hyperresponsiveness and inflammation
Pulm. Pharmacol. Ther.
22
27-32
2009
Mus musculus
Minematsu, N.; Nakamura, H.; Furuuchi, M.; Nakajima, T.; Takahashi, S.; Tsujimura, S.; Tateno, H.; Ishizaka, A.
Common functional polymorphisms in the cathepsin S promoter in Japanese subjects: possible contribution to pulmonary emphysema
Respirology
13
498-504
2008
Homo sapiens (P25774), Homo sapiens
Yeh, H.Y.; Klesius, P.H.
Molecular cloning, sequencing and characterization of channel catfish (Ictalurus punctatus, Rafinesque 1818) cathepsin S gene
Vet. Immunol. Immunopathol.
126
382-387
2008
Ictalurus punctatus (B3VCD5), Ictalurus punctatus
Sasaki, T.; Kuzuya, M.; Nakamura, K.; Cheng, X.W.; Hayashi, T.; Song, H.; Hu, L.; Okumura, K.; Murohara, T.; Iguchi, A.; Sato, K.
AT1 blockade attenuates atherosclerotic plaque destabilization accompanied by the suppression of cathepsin S activity in apoE-deficient mice
Atherosclerosis
210
430-437
2010
Mus musculus
Coppini, L.P.; Barros, N.M.; Oliveira, M.; Hirata, I.Y.; Alves, M.F.; Paschoalin, T.; Assis, D.M.; Juliano, M.A.; Puzer, L.; Broemme, D.; Carmona, A.K.
Plasminogen hydrolysis by cathepsin S and identification of derived peptides as selective substrate for cathepsin V and cathepsin L inhibitor
Biol. Chem.
391
561-570
2010
Homo sapiens
Ameriks, M.K.; Axe, F.U.; Bembenek, S.D.; Edwards, J.P.; Gu, Y.; Karlsson, L.; Randal, M.; Sun, S.; Thurmond, R.L.; Zhu, J.
Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements
Bioorg. Med. Chem. Lett.
19
6131-6134
2009
Homo sapiens, Mus musculus
Ameriks, M.K.; Cai, H.; Edwards, J.P.; Gebauer, D.; Gleason, E.; Gu, Y.; Karlsson, L.; Nguyen, S.; Sun, S.; Thurmond, R.L.; Zhu, J.
Pyrazole-based arylalkyne cathepsin S inhibitors. Part II: optimization of cellular potency
Bioorg. Med. Chem. Lett.
19
6135-6139
2009
Homo sapiens
Lee-Dutra, A.; Wiener, D.K.; Arienti, K.L.; Liu, J.; Mani, N.; Ameriks, M.K.; Axe, F.U.; Gebauer, D.; Desai, P.J.; Nguyen, S.; Randal, M.; Thurmond, R.L.; Sun, S.; Karlsson, L.; Edwards, J.P.; Jones, T.K.; Grice, C.A.
Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: part 1
Bioorg. Med. Chem. Lett.
20
2370-2374
2010
Homo sapiens
Wiener, J.J.; Wickboldt, A.T.; Wiener, D.K.; Lee-Dutra, A.; Edwards, J.P.; Karlsson, L.; Nguyen, S.; Sun, S.; Jones, T.K.; Grice, C.A.
Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors. Part 2: Modification of P3, P4, and P5 regions
Bioorg. Med. Chem. Lett.
20
2375-2378
2010
Homo sapiens
Wiener, D.K.; Lee-Dutra, A.; Bembenek, S.; Nguyen, S.; Thurmond, R.L.; Sun, S.; Karlsson, L.; Grice, C.A.; Jones, T.K.; Edwards, J.P.
Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors
Bioorg. Med. Chem. Lett.
20
2379-2382
2010
Homo sapiens
Li, J.; Petrassi, H.; Tumanut, C.; Masick, B.; Trussell, C.; Harris, J.
Substrate optimization for monitoring cathepsin C activity in live cells
Bioorg. Med. Chem.
17
1064-1070
2009
Homo sapiens
Lindahl, C.; Simonsson, M.; Bergh, A.; Thysell, E.; Antti, H.; Sund, M.; Wikstroem, P.
Increased levels of macrophage-secreted cathepsin S during prostate cancer progression in TRAMP mice and patients
Cancer Genomics Proteomics
6
149-159
2009
Mus musculus
Gu, F.F.; Lue, S.Z.; Chen, Y.D.; Zhou, Y.J.; Song, X.T.; Jin, Z.N.; Liu, H.
Relationship between plasma cathepsin S and cystatin C levels and coronary plaque morphology of mild to moderate lesions: an in vivo study using intravascular ultrasound
Chin. Med. Sci.
122
2820-2826
2009
Homo sapiens
Burden, R.E.; Gormley, J.A.; Jaquin, T.J.; Small, D.M.; Quinn, D.J.; Hegarty, S.M.; Ward, C.; Walker, B.; Johnston, J.A.; Olwill, S.A.; Scott, C.J.
Antibody-mediated inhibition of cathepsin S blocks colorectal tumor invasion and angiogenesis
Clin. Cancer Res.
15
6042-6051
2009
Homo sapiens
Wiener, J.J.; Sun, S.; Thurmond, R.L.
Recent advances in the design of cathepsin S inhibitors
Curr. Top. Med. Chem.
10
717-732
2010
Homo sapiens
Schoenefuss, A.; Wendt, W.; Schattling, B.; Schulten, R.; Hoffmann, K.; Stuecker, M.; Tigges, C.; Luebbert, H.; Stichel, C.
Upregulation of cathepsin S in psoriatic keratinocytes
Exp. Dermatol.
19
e80-e88
2009
Homo sapiens
Paraoan, L.; Gray, D.; Hiscott, P.; Garcia-Finana, M.; Lane, B.; Damato, B.; Grierson, I.
Cathepsin S and its inhibitor cystatin C: imbalance in uveal melanoma
Front. Biosci.
14
2504-2513
2009
Homo sapiens
Samokhin, A.O.; Lythgo, P.A.; Gauthier, J.Y.; Percival, M.D.; Broemme, D.
Pharmacological inhibition of cathepsin S decreases atherosclerotic lesions in Apoe-/- mice
J. Cardiovasc. Pharmacol.
56
98-105
2010
Mus musculus
Costantino, C.M.; Ploegh, H.L.; Hafler, D.A.
Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells
J. Immunol.
183
945-952
2009
Homo sapiens
Chen, J.C.; Uang, B.J.; Lyu, P.C.; Chang, J.Y.; Liu, K.J.; Kuo, C.C.; Hsieh, H.P.; Wang, H.C.; Cheng, C.S.; Chang, Y.H.; Chang, M.D.; Chang, W.S.; Lin, C.C.
Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis
J. Med. Chem.
53
4545-4549
2010
Homo sapiens
Clark, A.K.; Yip, P.K.; Malcangio, M.
The liberation of fractalkine in the dorsal horn requires microglial cathepsin S
J. Neurosci.
29
6945-6954
2009
Rattus norvegicus
Lorenz, J.C.; Busacca, C.A.; Feng, X.; Grinberg, N.; Haddad, N.; Johnson, J.; Kapadia, S.; Lee, H.; Saha, A.; Sarvestani, M.; Spinelli, E.M.; Varsolona, R.; Wei, X.; Zeng, X.; Senanayake, C.H.
Large-scale asymmetric synthesis of a cathepsin S inhibitor
J. Org. Chem.
75
1155-1161
2010
Homo sapiens
Deng, X.; Liang, J.T.; Peterson, M.; Rynberg, R.; Cheung, E.; Mani, N.S.
Practical synthesis of a Cathepsin S inhibitor: route identification, purification strategies, and serendipitous discovery of a crystalline salt form
J. Org. Chem.
75
1940-1947
2010
Homo sapiens
Fontanesi, L.; Speroni, C.; Buttazzoni, L.; Scotti, E.; Costa, L.N.; Davoli, R.; Russo, V.
Association between cathepsin L (CTSL) and cathepsin S (CTSS) polymorphisms and meat production and carcass traits in Italian Large White pigs
Meat Sci.
85
331-338
2010
Sus scrofa (F1SS93), Sus scrofa
Oliveira, M.; Torquato, R.J.; Alves, M.F.; Juliano, M.A.; Broemme, D.; Barros, N.M.; Carmona, A.K.
Improvement of cathepsin S detection using a designed FRET peptide based on putative natural substrates
Peptides
31
562-567
2010
Homo sapiens
Baston-Buest, D.M.; Schanz, A.; Buest, S.; Fischer, J.C.; Kruessel, J.S.; Hess, A.P.
The embryos cystatin C and F expression functions as a protective mechanism against the maternal proteinase cathepsin S in mice
Reproduction
139
741-748
2010
Mus musculus
Wilder, C.L.; Park, K.Y.; Keegan, P.M.; Platt, M.O.
Manipulating substrate and pH in zymography protocols selectively distinguishes cathepsins K, L, S, and V activity in cells and tissues
Arch. Biochem. Biophys.
516
52-57
2011
Homo sapiens
Cai, J.; Baugh, M.; Black, D.; Long, C.; Jonathan Bennett, D.; Dempster, M.; Fradera, X.; Gillespie, J.; Andrews, F.; Boucharens, S.; Bruin, J.; Cameron, K.S.; Cumming, I.; Hamilton, W.; Jones, P.S.; Kaptein, A.; Kinghorn, E.; Maidment, M.; Martin, I.; Mitchell, A.; Rankovic, Z.; Robinson, J.; Scullion, P.; Uitdehaag, J.C.; Vink, P.; Westwood, P.; van Zeeland, M.; van Berkom, L.; Bastiani, M.; Meulemans, T.
6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors
Bioorg. Med. Chem. Lett.
20
4350-4354
2010
Homo sapiens
Cai, J.; Bennett, D.J.; Rankovic, Z.; Dempster, M.; Fradera, X.; Gillespie, J.; Cumming, I.; Finlay, W.; Baugh, M.; Boucharens, S.; Bruin, J.; Cameron, K.S.; Hamilton, W.; Kerr, J.; Kinghorn, E.; McGarry, G.; Robinson, J.; Scullion, P.; Uitdehaag, J.C.; van Zeeland, M.; Potin, D.; Saniere, L.; Fouquet, A.; Chevallier, F.; Deronzier, H.; Dorleans, C.; Nicolai, E.
2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors
Bioorg. Med. Chem. Lett.
20
4447-4450
2010
Homo sapiens
Cai, J.; Fradera, X.; van Zeeland, M.; Dempster, M.; Cameron, K.S.; Bennett, D.J.; Robinson, J.; Popplestone, L.; Baugh, M.; Westwood, P.; Bruin, J.; Hamilton, W.; Kinghorn, E.; Long, C.; Uitdehaag, J.C.
4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important
Bioorg. Med. Chem. Lett.
20
4507-4510
2010
Homo sapiens
Kim, N.Y.; Ahn, S.J.; Lee, A.R.; Seo, J.S.; Kim, M.S.; Kim, J.K.; Chung, J.K.; Lee, H.H.
Cloning, expression analysis and enzymatic characterization of cathepsin S from olive flounder (Paralichthys olivaceus)
Comp. Biochem. Physiol. B
157
238-247
2010
Paralichthys olivaceus
Hamm-Alvarez, S.; Janga, S.; Edman, M.; Madrigal, S.; Shah, M.; Frousiakis, S.; Renduchintala, K.; Zhu, J.; Bricel, S.; Silka, K.; Bach, D.; Heur, M.; Christianakis, S.; Arkfeld, D.; Irvine, J.; Mack, W.; Stohl, W.
Tear cathepsin s as a candidate biomarker for sjögrens syndrome
Arthritis Rheumatol.
66
1872-1881
2014
Homo sapiens (P25774), Homo sapiens
Fonovic, U.P.; Jevnikar, Z.; Kos, J.
Cathepsin S generates soluble CX3CL1 (fractalkine) in vascular smooth muscle cells
Biol. Chem.
394
1349-1352
2013
Homo sapiens (P25774)
Kim. M.; Jeon. J.; Song. J.; Suh. K.H.; Kim. Y.H.; Min. K.H.; Lee. K.O.
Synthesis of proline analogues as potent and selective cathepsin S inhibitors
Bioorg. Med. Chem. Lett.
23
3140-3144
2013
Homo sapiens (P25774)
Rauner, M.; Foeger-Samwald, U.; Kurz, M.F.; Bruenner-Kubath, C.; Schamall, D.; Kapfenberger, A.; Varga, P.; Kudlacek, S.; Wutzl, A.; Hoeger, H.; Zysset, P.K.; Shi, G.P.; Hofbauer, L.C.; Sipos, W.; Pietschmann, P.
Cathepsin S controls adipocytic and osteoblastic differentiation, bone turnover, and bone microarchitecture
Bone
64
281-287
2014
Mus musculus (O70370)
Thakur, P.K.; Kumar, M.; Kumar, J.; Gantasala, N.P.; Rao, U.
Structural and functional analysis of cathepsin S of Heterodera spp: a promising candidate for its control
Indian J. Exp. Biol.
52
223-231
2014
Heterodera avenae (O18456), Heterodera avenae
Li, X.; Cheng, X.W.; Hu, L.; Wu, H.; Guo-Ping, H.; Hao, C.N.; Jiang, H.; Zhu, E.; Huang, Z.; Inoue, A.; Sasaki, T.; Du, Q.; Takeshita, K.; Okumura, K.; Murohara, T.; Kuzuya, M.
Cathepsin S activity controls ischemia-induced neovascularization in mice
Int. J. Cardiol.
183
198-208
2015
Homo sapiens (P25774), Homo sapiens, Mus musculus (O70370)
Barry, Z.T.; Platt, M.O.
Cathepsin S cannibalism of cathepsin K as a mechanism to reduce type I collagen degradation
J. Biol. Chem.
287
27723-27730
2012
Homo sapiens (P25774)
Wang, Y.; Liu, X.; Lv, S.; Ren, J.; Ke, F.
Identification and activity of a paralog of cathepsin S from yellow catfish (Pelteobagrus fulvidraco) involved in immune response
Fish Shellfish Immunol.
61
16-23
2017
Tachysurus fulvidraco (A0A248QF88)
Dekita, M.; Wu, Z.; Ni, J.; Zhang, X.; Liu, Y.; Yan, X.; Nakanishi, H.; Takahashi, I.
Cathepsin S is involved in Th17 differentiation through the upregulation of IL-6 by activating PAR-2 after systemic exposure to lipopolysaccharide from Porphyromonas gingivalis
Front. Pharmacol.
8
470
2017
Mus musculus (O70370)
Sun, B.G.; Chi, H.
Cathepsin S of Sciaenops ocellatus identification, transcriptional expression and enzymatic activity
Int. J. Biol. Macromol.
82
76-82
2016
Sciaenops ocellatus (A0A0K0M968), Sciaenops ocellatus
Klinngam, W.; Fu, R.; Janga, S.R.; Edman, M.C.; Hamm-Alvarez, S.F.
Cathepsin S alters the expression of pro-inflammatory cytokines and MMP-9, partially through protease-activated receptor-2, in human corneal epithelial cells
Int. J. Mol. Sci.
19
E3530
2018
Homo sapiens (P25774), Homo sapiens
Oresic Bender, K.; Ofori, L.; van der Linden, W.A.; Mock, E.D.; Datta, G.K.; Chowdhury, S.; Li, H.; Segal, E.; Sanchez Lopez, M.; Ellman, J.A.; Figdor, C.G.; Bogyo, M.; Verdoes, M.
Design of a highly selective quenched activity-based probe and its application in dual color imaging studies of cathepsin S activity localization
J. Am. Chem. Soc.
137
4771-4777
2015
Mus musculus (O70370)
Kumar Vr, S.; Darisipudi, M.N.; Steiger, S.; Devarapu, S.K.; Tato, M.; Kukarni, O.P.; Mulay, S.R.; Thomasova, D.; Popper, B.; Demleitner, J.; Zuchtriegel, G.; Reichel, C.; Cohen, C.D.; Lindenmeyer, M.T.; Liapis, H.; Moll, S.; Reid, E.; Stitt, A.W.; Schott, B.; Gruner, S.; Haap, W.; Ebeling, M.; Hartmann, G.
Cathepsin S cleavage of protease-activated receptor-2 on endothelial cells promotes microvascular diabetes complications
J. Am. Soc. Nephrol.
27
1635-1649
2016
Homo sapiens (P25774), Homo sapiens, Mus musculus (O70370), Mus musculus
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