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Literature summary for 3.4.22.27 extracted from

  • Mason, C.S.; Lamers, M.B.; Henderson, I.M.; Monk, T.; Williams, D.H.
    Baculoviral expression and characterization of rodent cathepsin S (2001), Protein Expr. Purif., 23, 45-54.
    View publication on PubMed

Application

Application Comment Organism
medicine cathepsin S is a potential therapeutic target for regulation of major histocompatibility complex class II immune responses, possibly resulting in treatments for autoimmune diseases and allergic asthma Mus musculus
medicine cathepsin S is a potential therapeutic target for regulation of major histocompatibility complex class II immune responses, possibly resulting in treatments for autoimmune diseases and allergic asthma Homo sapiens
medicine cathepsin S is a potential therapeutic target for regulation of major histocompatibility complex class II immune responses, possibly resulting in treatments for autoimmune diseases and allergic asthma Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expression in baculovirally infected Sf9 insect cells along with humanized forms truncated by eight residues at the amino-terminus Mus musculus
expression in baculovirally infected Sf9 insect cells along with humanized forms truncated by eight residues at the amino-terminus Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information addition of a carboxy-terminal hexahistidine purification tag has no effect on the kinetic characterization of any of the enzyme forms against butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin substrate Mus musculus
additional information addition of a carboxy-terminal hexahistidine purification tag has no effect on the kinetic characterization of any of the enzyme forms against butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin substrate Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
E64
-
Homo sapiens
E64
-
Mus musculus
E64
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens
-
?
-
?
additional information Mus musculus cathepsin S is implicated as a key enzyme in the processing of major histocompatability complex class II molecules ?
-
?
additional information Rattus norvegicus cathepsin S is implicated as a key enzyme in the processing of major histocompatability complex class II molecules ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O
-
Mus musculus butyloxycarbonyl-Val-Leu-Lys + 7-amino-4-methylcoumarin
-
?
butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O
-
Rattus norvegicus butyloxycarbonyl-Val-Leu-Lys + 7-amino-4-methylcoumarin
-
?
additional information
-
Homo sapiens ?
-
?
additional information cathepsin S is implicated as a key enzyme in the processing of major histocompatability complex class II molecules Mus musculus ?
-
?
additional information cathepsin S is implicated as a key enzyme in the processing of major histocompatability complex class II molecules Rattus norvegicus ?
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information
-
Mus musculus
additional information
-
additional information
-
Homo sapiens
additional information
-
additional information
-
Rattus norvegicus
30
-
butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin
-
Rattus norvegicus
65
-
butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin
-
Rattus norvegicus