Application | Comment | Organism |
---|---|---|
medicine | cathepsin S is a potential therapeutic target for regulation of major histocompatibility complex class II immune responses, possibly resulting in treatments for autoimmune diseases and allergic asthma | Mus musculus |
medicine | cathepsin S is a potential therapeutic target for regulation of major histocompatibility complex class II immune responses, possibly resulting in treatments for autoimmune diseases and allergic asthma | Homo sapiens |
medicine | cathepsin S is a potential therapeutic target for regulation of major histocompatibility complex class II immune responses, possibly resulting in treatments for autoimmune diseases and allergic asthma | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expression in baculovirally infected Sf9 insect cells along with humanized forms truncated by eight residues at the amino-terminus | Mus musculus |
expression in baculovirally infected Sf9 insect cells along with humanized forms truncated by eight residues at the amino-terminus | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | addition of a carboxy-terminal hexahistidine purification tag has no effect on the kinetic characterization of any of the enzyme forms against butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin substrate | Mus musculus |
additional information | addition of a carboxy-terminal hexahistidine purification tag has no effect on the kinetic characterization of any of the enzyme forms against butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin substrate | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
E64 | - |
Homo sapiens | |
E64 | - |
Mus musculus | |
E64 | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | - |
? | - |
? | |
additional information | Mus musculus | cathepsin S is implicated as a key enzyme in the processing of major histocompatability complex class II molecules | ? | - |
? | |
additional information | Rattus norvegicus | cathepsin S is implicated as a key enzyme in the processing of major histocompatability complex class II molecules | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | butyloxycarbonyl-Val-Leu-Lys + 7-amino-4-methylcoumarin | - |
? | |
butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O | - |
Rattus norvegicus | butyloxycarbonyl-Val-Leu-Lys + 7-amino-4-methylcoumarin | - |
? | |
additional information | - |
Homo sapiens | ? | - |
? | |
additional information | cathepsin S is implicated as a key enzyme in the processing of major histocompatability complex class II molecules | Mus musculus | ? | - |
? | |
additional information | cathepsin S is implicated as a key enzyme in the processing of major histocompatability complex class II molecules | Rattus norvegicus | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Mus musculus | |
additional information | - |
additional information | - |
Homo sapiens | |
additional information | - |
additional information | - |
Rattus norvegicus | |
30 | - |
butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin | - |
Rattus norvegicus | |
65 | - |
butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin | - |
Rattus norvegicus |