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Literature summary for 3.4.22.27 extracted from

  • Hamm-Alvarez, S.; Janga, S.; Edman, M.; Madrigal, S.; Shah, M.; Frousiakis, S.; Renduchintala, K.; Zhu, J.; Bricel, S.; Silka, K.; Bach, D.; Heur, M.; Christianakis, S.; Arkfeld, D.; Irvine, J.; Mack, W.; Stohl, W.
    Tear cathepsin s as a candidate biomarker for sjögrens syndrome (2014), Arthritis Rheumatol., 66, 1872-1881.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.27

Application

Application Comment Organism
medicine tear cathepsin S serves as a candidate biomarker for Sjögren's Syndrome Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P25774
-
-

Source Tissue

Source Tissue Comment Organism Textmining
tear
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 the median tear CTSS activity in patients with Sjögren's syndrome is 4.1fold higher than that in patients with other autoimmune diseases, 2.1fold higher than that in patients with nonspecific dry eye disease, and 41.1fold higher than that in healthy control subjects Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CBZ-Val-Val-Arg- 7-amino-4-trifluoromethyl coumarin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
cathepsin S
-
 Homo sapiens
CTSS
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens