Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | the presence of 0.2 mM dithiothreitol is required to maintain cathepsin activity | Ovis aries |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Ovis aries | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Ovis aries | proteolysis of prion protein by cathepsin S generates a soluble-structured intermediate oligomeric form, with potential implications for neurotoxic mechanisms | ? | - |
? | |
prion protein 94-233 + H2O | Ovis aries | in vitro, enzyme causes specific and limited N-terminal truncation of prion protein 94-233 | prion protein 135-233 + prion protein 117-233 + prion protein 114-233 | major soluble fragments, the region of prion protein between S135 and N146 is a major target for selective cleavage cathepsins S | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ovis aries | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
microglia | - |
Ovis aries | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
cathepsin S, a cellular enzyme shows enhanced expression in pathogenic conditions | Ovis aries |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | proteolysis of prion protein by cathepsin S generates a soluble-structured intermediate oligomeric form, with potential implications for neurotoxic mechanisms | Ovis aries | ? | - |
? | |
prion protein 94-233 + H2O | in vitro, enzyme causes specific and limited N-terminal truncation of prion protein 94-233 | Ovis aries | prion protein 135-233 + prion protein 117-233 + prion protein 114-233 | major soluble fragments, the region of prion protein between S135 and N146 is a major target for selective cleavage cathepsins S | ? |
Synonyms | Comment | Organism |
---|---|---|
cathepsin S | - |
Ovis aries |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Ovis aries |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
additional information | - |
cathepsin S is a cysteine protease that is able to work outside the lysosome and in a wide range of pH | Ovis aries |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
assay at | Ovis aries |