Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Mus musculus | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ii protein + H2O | Mus musculus | inhibition of Ii degradation in enzyme-deficient cells leads to accumulation of Ii degradation intermediates in endosomal/lysosomal compartments | Ii fragments | - |
? | |
Ii protein + H2O | Mus musculus C57BL/6 | inhibition of Ii degradation in enzyme-deficient cells leads to accumulation of Ii degradation intermediates in endosomal/lysosomal compartments | Ii fragments | - |
? | |
additional information | Mus musculus | cathepsin S in professional antigen-presenting cells, APC, controls MHC class II-mediated antigen presentation by epithelial cells in vivo, and plays a critical role in invariant chain degradation | ? | - |
? | |
additional information | Mus musculus C57BL/6 | cathepsin S in professional antigen-presenting cells, APC, controls MHC class II-mediated antigen presentation by epithelial cells in vivo, and plays a critical role in invariant chain degradation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6 mice | - |
Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-cell | - |
Mus musculus | - |
bone marrow | - |
Mus musculus | - |
dendritic cell | - |
Mus musculus | - |
epithelial cell | - |
Mus musculus | - |
intestine | epithelial cell | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ii protein + H2O | inhibition of Ii degradation in enzyme-deficient cells leads to accumulation of Ii degradation intermediates in endosomal/lysosomal compartments | Mus musculus | Ii fragments | - |
? | |
Ii protein + H2O | Ii invariant chain | Mus musculus | Ii fragments | - |
? | |
Ii protein + H2O | inhibition of Ii degradation in enzyme-deficient cells leads to accumulation of Ii degradation intermediates in endosomal/lysosomal compartments | Mus musculus C57BL/6 | Ii fragments | - |
? | |
Ii protein + H2O | Ii invariant chain | Mus musculus C57BL/6 | Ii fragments | - |
? | |
additional information | cathepsin S in professional antigen-presenting cells, APC, controls MHC class II-mediated antigen presentation by epithelial cells in vivo, and plays a critical role in invariant chain degradation | Mus musculus | ? | - |
? | |
additional information | cathepsin S in professional antigen-presenting cells, APC, controls MHC class II-mediated antigen presentation by epithelial cells in vivo, and plays a critical role in invariant chain degradation | Mus musculus C57BL/6 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cat S | - |
Mus musculus |