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Literature summary for 3.4.22.27 extracted from

  • Luetzner, N.; Kalbacher, H.
    Quantifying cathepsin S activity in antigen presenting cells using a novel specific substrate (2008), J. Biol. Chem., 283, 36185-36194.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.27

Application

Application Comment Organism
drug development CatS is an appropriate drug target in autoimmune disorders Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
human CatS is obtained by autocatalytic processing of the zymogene expressed in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
E64 cysteine protease inhibitor Homo sapiens
morpholineurea-leucyl-homophenylalanine-vinylsulfone phenyl LHVS, CatS-specific inhibitor at a concentration of 10 nM, other cathepsins are not inhibited Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00048
-
 GRWHIVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00073
-
 GRWHTVG-norleucine-RWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00105
-
 GRWHTVGLKWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00131
-
 GRWHTVGLPWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00142
-
 GRWHFVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.0015
-
 GRWHTVGLIWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.0016
-
 GRWH-norleucine-VGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00171
-
 GRWHTVG-citrulline-RWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00188
-
 GRWHDVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00194
-
 GRWHKVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00198
-
 GRWHTVGIRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.0021
-
 GRWHTFGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00237
-
 GRWHTVGVRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00237
-
 GRWHTVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00244
-
 GRWHTVGRRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00258
-
 GRWHTVFLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00259
-
 GRWHTVGLQWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00276
-
 GRWHVVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.0028
-
 GRWHTVDLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00312
-
 GRWHTVGLHWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00314
-
 GRWHTVGLDWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00324
-
 GRWHPVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00395
-
 GRWHTIGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00418
-
 GRWHT-norleucine-GLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.0048
-
 GRWHTVGFRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00506
-
 GRWHTVTLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00512
-
 GRWHTVILRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00514
-
 GRWHGVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00525
-
 GRWHTVGKRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00527
-
 GRWHTVGLFWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00556
-
 (7-methoxycoumarin-4-yl)-acetyl-GRWPPMGLPWEK(2,4-dinitrophenyl)-D-Arg-NH2
-
 Homo sapiens
0.00591
-
 GRWHTPGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00779
-
 GRWHTMGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.00782
-
 GRWHTKGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.0082
-
 GRWHTVGLRFE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.0082
-
 GRWHTVGLRIE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.0093
-
 GRWHTTGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.01047
-
 GRWHTV-norleucine-LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.01154
-
 GRWHTVGLRRE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.01237
-
 GRWHTDGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.01286
-
 GRWHTGGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.01493
-
 GRWHTVGLRHE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.01648
-
 GRWHTVGLRGE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.01668
-
 GRWHTVGLRDE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.01998
-
 GRWHTVPLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.0249
-
 GRWHTVQLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.02747
-
 GRWHTVKLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens
0.03787
-
 GRWHTVGLRKE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome
-
 Homo sapiens 5768
-
lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens CatS is one of the major proteases involved in antigen processing ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
 Homo sapiens
-
culture condition:antigen-presenting cell
-
 Homo sapiens
-
dendritic cell
-
 Homo sapiens
-
macrophage
-
 Homo sapiens
-
WT-100 cell B-lymphocyte cell line Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 dendritic and B-cells show significantly lower endosomal CatS activity compared with macrophages, the CatS activity in endosomal extracts from macrophages is 10times higher than in the corresponding extracts from B-cell line and even 30times higher than in endosomal fractions from dendritic cells, CatS activity differs not only between the different types of antigen presenting sells but also between endosomal and lysosomal compartments of one cell type Homo sapiens
additional information
-
 macrophage endosomal extracts even show a 600fold higher CatS activity compared with lysosomal extracts Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumarin-4-yl)-acetyl-GRWHPMGAPWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O specific substrate for CatS Homo sapiens (7-methoxycoumarin-4-yl)-acetyl-GRWHPMG + APWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
(7-methoxycoumarin-4-yl)-acetyl-GRWPPMGLPWEK(2,4-dinitrophenyl)-D-Arg-NH2 + H2O specific substrate for CatS Homo sapiens (7-methoxycoumarin-4-yl)-acetyl-GRWPPMG + LPWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWH-norleucine-VGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWH-norleucine-VG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHDVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHDVG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHFVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHFVG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHGVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHGVG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHIVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHIVGL + RWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHKVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHKVG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHPVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHPVG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHT-norleucine-GLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHT-norleucine-G + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTDGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTDG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTFGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTFG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTGGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTGG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTIGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTIG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTKGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTKG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTMGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTMG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTPGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTPG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTTGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTTG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTV-norleucine-LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTV-norleucine + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVDLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVD + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVFLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVF + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVG-citrulline-RWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVG + citrulline-RWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVG-norleucine-RWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVG + norleucine-RWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVGFRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVG + FRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVGIRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVG + IRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVGKRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVG + KRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVGLDWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVG + LDWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVGLFWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVG + LFWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVGLHWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVG + LHWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVGLIWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVG + LIWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVGLKWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVG + LKWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVGLPWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVG + LPWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVGLQWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVG + LQWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVGLRDE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVG + LRDE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVGLRFE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVG + LRFE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVGLRGE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVG + LRGE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVGLRHE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVG + LRHE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVGLRIE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVG + LRIE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVGLRKE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVG + LRKE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVGLRRE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVG + LRRE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 specific substrate for CatS Homo sapiens GRWHTVG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVGRRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVG + RRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVGVRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVG + VRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVILRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVI + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVKLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVK + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVPLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVP + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVQLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVQ + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHTVTLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHTVT + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
 ?
GRWHVVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens GRWHVVG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
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additional information CatS is one of the major proteases involved in antigen processing Homo sapiens ?
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Synonyms

Synonyms Comment Organism
cathepsin S
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 Homo sapiens
CatS
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 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5.666
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 (7-methoxycoumarin-4-yl)-acetyl-GRWPPMGLPWEK(2,4-dinitrophenyl)-D-Arg-NH2
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 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
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 assay at Homo sapiens