Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | interferon gamma induces CatS expression | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
the gene encoding Cat S is located on chromosome 1q21 | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
determination of the crystal structure of the enzyme cocrystallized with the irreversible vinyl-sulfone inhibitor APC-2848 or with a reversible dipeptide-nitrile inhibitor, crystal structure determination of the C25S mutant cathepsin S | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C25S | crystal structure determination | Homo sapiens |
additional information | generation of Cat S-deficient knockout mice mutants showing accumulation of MHC class II molecules bound to the 10 kDa fragment of Ii, knockout mice phenotype, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
APC-2848 | irreversible vinyl-sulfone inhibitor | Homo sapiens | |
additional information | reversible inhibition by a dipeptide-nitrile inhibitor | Homo sapiens | |
N-morpholinurea-leucyl-homophenylalanyl-vinylsulfone-phenyl | i.e. LHVS, irreversible inhibition, the inhibitor binds covalently to the active site, in vitro and in vivo inhibition | Homo sapiens | |
N-morpholinurea-leucyl-homophenylalanyl-vinylsulfone-phenyl | i.e. LHVS, irreversible inhibition, the inhibitor binds covalently to the active site | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
24000 | - |
1 * 24000 | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Albumin + H2O | Homo sapiens | degradation | ? | - |
? | |
Collagen + H2O | Homo sapiens | degradation | ? | - |
? | |
Elastin + H2O | Homo sapiens | degradation | ? | - |
? | |
Hemoglobin + H2O | Homo sapiens | degradation | ? | - |
? | |
insulin + H2O | Homo sapiens | degradation | ? | - |
? | |
additional information | Mus musculus | cathepsin S catalyzes a key step in antigen presentation, detailed overview | ? | - |
? | |
additional information | Rattus norvegicus | cathepsin S catalyzes a key step in antigen presentation, detailed overview | ? | - |
? | |
additional information | Bos taurus | cathepsin S catalyzes a key step in antigen presentation, detailed overview | ? | - |
? | |
additional information | Homo sapiens | cathepsin S catalyzes a key step in antigen presentation, detailed overview, Cat S might be involved in psoriasis induction due to an increased interferon gamma level in the epidermis, Cat S is increased in neurons of Alzheimer's disease and Down's syndrome patients, where Cat S facilitates the formation of amyloidbeta from its precursor protein, Cat S might also be involved in asthma, Sjörgren's syndrome, allergen-specific T-cell proliferation in autoimmune processes, and atherosclerosis, overview | ? | - |
? | |
myelin basic protein + H2O | Homo sapiens | degradation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme from lymph node | Bos taurus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
similar to cathepsin L, but with much less activity on Z-Phe-Arg-/-NHMec, and more activity on the Z-Val-Val-Arg-/- compound | the catalytic triad is formed by Cys25, His164, and Asn184, the substrate binding site lies between the N-terminal and the C-terminal domain, cysteine protease mechanism, overview | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A20 cell | B-cell line | Mus musculus | - |
B-cell | - |
Mus musculus | - |
B-cell | - |
Homo sapiens | - |
B-cell | - |
Rattus norvegicus | - |
bone marrow | - |
Homo sapiens | - |
brain | - |
Homo sapiens | - |
brain | grey and white matter | Rattus norvegicus | - |
dendritic cell | - |
Homo sapiens | - |
dendritic cell | - |
Rattus norvegicus | - |
gastric epithelium | - |
Homo sapiens | - |
HaCaT cell | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
HOM2 cell | B lymphoblastoid cell line | Homo sapiens | - |
keratinocyte | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
leukocyte | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
lymph node | - |
Homo sapiens | - |
lymph node | - |
Bos taurus | - |
macrophage | - |
Homo sapiens | - |
macrophage | - |
Rattus norvegicus | - |
microglia | - |
Rattus norvegicus | - |
monocyte | - |
Homo sapiens | - |
monocyte | - |
Rattus norvegicus | - |
additional information | no expression in skeletal muscle | Homo sapiens | - |
neuron | - |
Homo sapiens | - |
neuron | - |
Rattus norvegicus | - |
placenta | - |
Homo sapiens | - |
retina | epithelium piment cells | Homo sapiens | - |
spleen | - |
Homo sapiens | - |
splenocyte | - |
Mus musculus | - |
T-lymphocyte | - |
Homo sapiens | - |
uterine endometrium | - |
Homo sapiens | - |
vermiform appendix | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Albumin + H2O | - |
Homo sapiens | ? | - |
? | |
Albumin + H2O | degradation | Homo sapiens | ? | - |
? | |
Collagen + H2O | - |
Homo sapiens | ? | - |
? | |
Collagen + H2O | degradation | Homo sapiens | ? | - |
? | |
Elastin + H2O | - |
Homo sapiens | ? | - |
? | |
Elastin + H2O | degradation | Homo sapiens | ? | - |
? | |
Hemoglobin + H2O | - |
Homo sapiens | ? | - |
? | |
Hemoglobin + H2O | degradation | Homo sapiens | ? | - |
? | |
insulin + H2O | - |
Homo sapiens | ? | - |
? | |
insulin + H2O | degradation | Homo sapiens | ? | - |
? | |
leupeptin-induced peptide LIP10 + H2O | - |
Mus musculus | ? | - |
? | |
additional information | cathepsin S catalyzes a key step in antigen presentation, detailed overview | Mus musculus | ? | - |
? | |
additional information | cathepsin S catalyzes a key step in antigen presentation, detailed overview | Rattus norvegicus | ? | - |
? | |
additional information | cathepsin S catalyzes a key step in antigen presentation, detailed overview | Bos taurus | ? | - |
? | |
additional information | cathepsin S catalyzes a key step in antigen presentation, detailed overview, Cat S might be involved in psoriasis induction due to an increased interferon gamma level in the epidermis, Cat S is increased in neurons of Alzheimer's disease and Down's syndrome patients, where Cat S facilitates the formation of amyloidbeta from its precursor protein, Cat S might also be involved in asthma, Sjörgren's syndrome, allergen-specific T-cell proliferation in autoimmune processes, and atherosclerosis, overview | Homo sapiens | ? | - |
? | |
additional information | Cat S forms an alpha-beta-CLIP complex, unlike CatB or CatD, from an alpha-beta-Ii molecule in vitro | Mus musculus | ? | - |
? | |
additional information | Cat S forms an alpha-beta-CLIP complex, unlike CatB or CatD, from an alpha-beta-Ii molecule in vitro | Homo sapiens | ? | - |
? | |
myelin basic protein + H2O | - |
Homo sapiens | ? | - |
? | |
myelin basic protein + H2O | degradation | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 24000 | Bos taurus |
Synonyms | Comment | Organism |
---|---|---|
Cat S | - |
Mus musculus |
Cat S | - |
Homo sapiens |
Cat S | - |
Rattus norvegicus |
Cat S | - |
Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
- |
Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4.5 | 7.8 | active range | Homo sapiens |