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Literature summary for 3.4.22.27 extracted from

  • Fonovic, U.P.; Jevnikar, Z.; Kos, J.
    Cathepsin S generates soluble CX3CL1 (fractalkine) in vascular smooth muscle cells (2013), Biol. Chem., 394, 1349-1352.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome co-localized with CX3CL1 Homo sapiens 5768
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CX3CL1 + H2O Homo sapiens cathepsin S is able to cleave membrane-anchored CX3CL1, releasing a 55-kDa fragment to the medium ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P25774
-
-

Source Tissue

Source Tissue Comment Organism Textmining
vascular smooth muscle cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CX3CL1 + H2O cathepsin S is able to cleave membrane-anchored CX3CL1, releasing a 55-kDa fragment to the medium Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
cathepsin S
-
Homo sapiens

General Information

General Information Comment Organism
physiological function by cleaving membrane-anchored CX3CL1 cathepsin S regulates the adhesion of vascular smooth muscle cells and the capture of monocytes to the sites of atherogenesis Homo sapiens