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Literature summary for 3.4.22.27 extracted from

  • Rueckrich, T.; Brandenburg, J.; Cansier, A.; Mueller, M.; Stevanovic, S.; Schilling, K.; Wiederanders, B.; Beck, A.; Melms, A.; Reich, M.; Driessen, C.; Kalbacher, H.
    Specificity of human cathepsin S determined by processing of peptide substrates and MHC class II-associated invariant chain (2006), Biol. Chem., 387, 1503-1511.
    View publication on PubMed
Search for more literature for 3.4.22.27

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
E-64
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.04
-
 GRWHKISVRWE in 0.1 M citrate buffer, pH 5.5 containing 4 mM dithiothreitol, at 37°C Homo sapiens
0.09
-
 GRWHKLSVRWE in 0.1 M citrate buffer, pH 5.5 containing 4 mM dithiothreitol, at 37°C Homo sapiens
0.17
-
 GRWHKFSVRWE in 0.1 M citrate buffer, pH 5.5 containing 4 mM dithiothreitol, at 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
laminin alpha5-chain + H2O Homo sapiens the laminin-alpha5-chain is cleaved by CatS specifically at the Ser-Val bond ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P25774
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GRWHKFSVRWE + H2O
-
 Homo sapiens ?
-
 ?
GRWHKISVRWE + H2O
-
 Homo sapiens ?
-
 ?
GRWHKLSVRWE + H2O
-
 Homo sapiens ?
-
 ?
GRWHKVSVRWE + H2O
-
 Homo sapiens GRWHKVS + VRWE
-
 ?
laminin alpha5-chain + H2O the laminin-alpha5-chain is cleaved by CatS specifically at the Ser-Val bond Homo sapiens ?
-
 ?
additional information does not cleave GRWHKISVRWE Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CatS
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3
-
 GRWHKISVRWE in 0.1 M citrate buffer, pH 5.5 containing 4 mM dithiothreitol, at 37°C Homo sapiens
11
-
 GRWHKFSVRWE in 0.1 M citrate buffer, pH 5.5 containing 4 mM dithiothreitol, at 37°C Homo sapiens
44
-
 GRWHKLSVRWE in 0.1 M citrate buffer, pH 5.5 containing 4 mM dithiothreitol, at 37°C Homo sapiens