Application | Comment | Organism |
---|---|---|
medicine | - |
Mus musculus |
medicine | the inhibitor JNJ 10329670 is a candidate for immunosuppressive therapy of allergies and autoimmune diseases, completely reversible inhibition | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed by using the baculovirus expression system | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
JNJ 10329670 | - |
Bos taurus | |
JNJ 10329670 | - |
Canis lupus familiaris | |
JNJ 10329670 | CAS: 400797-24-2, the inhibitor blocks the presentation of tetanus toxoid and giant ragweed by human PBMCs, the inhibitor is a candidate for immunosuppressive therapy of allergies and autoimmune diseases, completely reversible inhibition | Homo sapiens | |
JNJ 10329670 | - |
Mus musculus | |
JNJ 10329670 | - |
Platyrrhini |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | - |
? | - |
? | |
additional information | Canis lupus familiaris | - |
? | - |
? | |
additional information | Homo sapiens | cathepsin S is considered crucial for normal presentation of major histocompatibility complex class II-restricted antigens by antigen presenting cells to CD4+ T cells. It is a key enzyme for the degradation of the class II-associated invariant chain, a process that is required for effective antigen loading of class II molecules | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Canis lupus familiaris | - |
beagle | - |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Platyrrhini | - |
mature female cynomolgus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | - |
Mus musculus | ? | - |
? | |
additional information | - |
Canis lupus familiaris | ? | - |
? | |
additional information | cathepsin S is considered crucial for normal presentation of major histocompatibility complex class II-restricted antigens by antigen presenting cells to CD4+ T cells. It is a key enzyme for the degradation of the class II-associated invariant chain, a process that is required for effective antigen loading of class II molecules | Homo sapiens | ? | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000034 | - |
JNJ 10329670 | pH 5.0 | Homo sapiens | |
0.000124 | - |
JNJ 10329670 | pH 5.0 | Canis lupus familiaris | |
0.000266 | - |
JNJ 10329670 | pH 5.0 | Platyrrhini | |
0.000411 | - |
JNJ 10329670 | pH 5.0 | Bos taurus | |
0.002364 | - |
JNJ 10329670 | pH 5.0 | Mus musculus |