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Literature summary for 3.4.22.27 extracted from

  • Rydzewski, R.M.; Bryant, C.; Oballa, R.; Wesolowski, G.; Rodan, S.B.; Bass, K.E.; Wong, D.H.
    Peptidic 1-cyanopyrrolidines: synthesis and SAR of a series of potent, selective cathepsin inhibitors (2002), Bioorg. Med. Chem., 10, 3277-3284.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(S)-[1-[1-cyano-pyrrolidin-3(R)-ylcarbamoyl]-3-methyl-butyl]-carbamic acid benzyl ester
-
Homo sapiens
(S)-[1-[1-cyano-pyrrolidin-3(S)-ylcarbamoyl]-3-methyl-butyl]-carbamic acid benzyl ester
-
Homo sapiens
1-cyano-(3,4-didehydro)-Pro-Leu methyl ester
-
Homo sapiens
1-cyano-(D)-Pro-(D)-Leu methyl ester
-
Homo sapiens
1-cyano-(D)-Pro-Ala methyl ester
-
Homo sapiens
1-cyano-(D)-Pro-Leu benzyl ester
-
Homo sapiens
1-cyano-(D)-Pro-Leu benzylamide
-
Homo sapiens
1-cyano-(D)-Pro-Leu dimethylamide
-
Homo sapiens
1-cyano-(D)-Pro-Leu methyl ester
-
Homo sapiens
1-cyano-(trans-benzyloxy)prolylleucine methyl ester
-
Homo sapiens
1-cyano-(trans-hydroxy)-Pro-Leu methyl ester
-
Homo sapiens
1-cyano-Pro isoamylamide
-
Homo sapiens
1-cyano-Pro-(D)-Leu methyl ester
-
Homo sapiens
1-cyano-Pro-Ala methyl ester
-
Homo sapiens
1-cyano-Pro-Leu benzyl ester
-
Homo sapiens
1-cyano-Pro-Leu methyl ester
-
Homo sapiens
1-cyano-Pro-Leu-Gly ethyl ester
-
Homo sapiens
1-cyano-Pro-Leu-Leu-Leu methyl ester
-
Homo sapiens
1-cyano-Pro-Phe methyl ester
-
Homo sapiens
1-formyl-(D)-Pro-Leu benzyl ester
-
Homo sapiens
1-iminomethyl-(D)-Pro-Leu benzyl ester
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Val-Val-7-amido-4-methylcoumarin + H2O
-
Homo sapiens benzyloxycarbonyl-Val-Val-Arg + 7-amino-4-methylcoumarin
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information Ki-values above 0.15 mM: 1-iminomethyl-(D)-Pro-Leu benzyl ester, 1-formyl-(D)-Pro-Leu benzyl ester Homo sapiens
0.0000067
-
1-cyano-Pro-Leu-Leu-Leu methyl ester pH 6.5, 23°C Homo sapiens
0.000012
-
1-cyano-(D)-Pro-Leu benzyl ester pH 6.5, 23°C Homo sapiens
0.000014
-
1-cyano-Pro-Leu benzyl ester pH 6.5, 23°C Homo sapiens
0.00003
-
1-cyano-(trans-benzyloxy)prolylleucine methyl ester pH 6.4, 25°C Homo sapiens
0.000033
-
1-cyano-(3,4-didehydro)-Pro-Leu methyl ester pH 6.5, 23°C Homo sapiens
0.000035
-
1-cyano-Pro-Leu-Gly ethyl ester pH 6.5, 23°C Homo sapiens
0.000052
-
1-cyano-Pro-Leu methyl ester pH 6.5, 23°C Homo sapiens
0.000054
-
1-cyano-(trans-hydroxy)-Pro-Leu methyl ester pH 6.5, 23°C Homo sapiens
0.00015
-
1-cyano-(D)-Pro-Leu dimethylamide pH 6.5, 23°C Homo sapiens
0.00024
-
1-cyano-Pro-Phe methyl ester pH 6.5, 23°C Homo sapiens
0.00028
-
1-cyano-Pro isoamylamide pH 6.5, 23°C Homo sapiens
0.00031
-
(S)-[1-[1-cyano-pyrrolidin-3(R)-ylcarbamoyl]-3-methyl-butyl]-carbamic acid benzyl ester pH 6.5, 23°C Homo sapiens
0.00053
-
1-cyano-Pro-Ala methyl ester pH 6.5, 23°C Homo sapiens
0.00054
-
1-cyano-(D)-Pro-Leu methyl ester pH 6.5, 23°C Homo sapiens
0.00097
-
(S)-[1-[1-cyano-pyrrolidin-3(S)-ylcarbamoyl]-3-methyl-butyl]-carbamic acid benzyl ester pH 6.5, 23°C Homo sapiens
0.0011
-
1-cyano-Pro-(D)-Leu methyl ester pH 6.5, 23°C Homo sapiens
0.026
-
1-cyano-(D)-Pro-(D)-Leu methyl ester pH 6.5, 23°C Homo sapiens
0.03
-
1-cyano-(D)-Pro-Leu benzylamide pH 6.5, 23°C Homo sapiens
0.054
-
1-cyano-(D)-Pro-Ala methyl ester pH 6.5, 23°C Homo sapiens