Cloned (Comment) | Organism |
---|---|
DELTAW52-N63 mutant procathepsin S is expressed in HEK 293 cells as a stable protein. However it is not processed to mature cathepsin S as is the wild-type procathepsin S | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
DELTAW52-N63 | the mutant procathepsin S is expressed in HEK 293 cells as a stable protein. However it is not processed to mature cathepsin S as is the wild-type procathepsin S | Homo sapiens |
E44A | mutant procathepsin S shows lysosomal localization | Homo sapiens |
N104Q | no substantial maturation of the mutant has been observed | Homo sapiens |
W52A | mutant enzyme does not show a lysosomal localization | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cathespin S propeptide | tight binding/slow reacting inhibition | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | structural stability and the folding of procathepsin S are considerably dependent on an aromatic stack built by the residue Trp28, Trp31 and Trp52 | Homo sapiens |
proteolytic modification | the propeptide domain of procathepsin S shows chaperone function | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000005 | - |
cathepsin S propeptide | wild-type enzyme | Homo sapiens | |
0.0000003 | - |
cathepsin S propeptide | mutant enzyme E44A | Homo sapiens | |
0.0000013 | - |
cathepsin S propeptide | mutant enzyme R48A | Homo sapiens |