Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.27 extracted from

  • Cheng, X.W.; Kuzuya, M.; Nakamura, K.; Di, Q.; Liu, Z.; Sasaki, T.; Kanda, S.; Jin, H.; Shi, G.P.; Murohara, T.; Yokota, M.; Iguchi, A.
    Localization of cysteine protease, cathepsin S, to the surface of vascular smooth muscle cells by association with integrin alphanubeta3 (2006), Am. J. Pathol., 168, 685-694.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.27

Activating Compound

Activating Compound Comment Organism Structure
additional information IFN-gamma and interleukin-1beta induce cathepsin S expression in smooth muscle plasma membranes Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cystatin C specific endogenous inhibitor, potency against smooth muscle cell invasion, overview Homo sapiens
E64 potency against smooth muscle cell invasion, overview Homo sapiens
GM6001
-
 Homo sapiens
N-morpholinurea-leucine-homophenylalanine-vinylsulfone-phenyl i.e. LHVS, specific inhibitor, potency against smooth muscle cell invasion, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface of vascular smooth muscle cells, by association with integrin alphanybeta3, surface distribution Homo sapiens 9986
-
additional information the enzyme is highly expressed in artherosclerotic and neointimal lesions, active Cat S co-localizes with integrins Homo sapiens
-
-
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Collagen type I + H2O Homo sapiens degradation in plasma membranes ?
-
 ?
Elastin + H2O Homo sapiens degradation in plasma membranes ?
-
 ?
additional information Homo sapiens Cat S is involved in degradtion of extracellular matrix and smooth muscle cell invasion, but not in adhesion and migration, overview, the enzyme shows elastolytic and collagenolytic activities on smooth muscle cell plasma membranes, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta smooth muscle cells Homo sapiens
-
smooth muscle cell SMC, vascular, from aorta Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Collagen type I + H2O degradation Homo sapiens ?
-
 ?
Collagen type I + H2O degradation in plasma membranes Homo sapiens ?
-
 ?
Elastin + H2O degradation in plasma membranes Homo sapiens ?
-
 ?
additional information Cat S is involved in degradtion of extracellular matrix and smooth muscle cell invasion, but not in adhesion and migration, overview, the enzyme shows elastolytic and collagenolytic activities on smooth muscle cell plasma membranes, overview Homo sapiens ?
-
 ?
additional information active Cat S co-localizes with integrins, e.g. integrin alphanubeta3 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Cat S
-
 Homo sapiens