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(+)-1,2-O-isopropylidenglycerol caprylate + H2O
(+)-1,2-O-isopropylidenglycerol + caprylate
(+)-menthylacetate + H2O
(+)-menthol + acetate
-
enzyme is highly enantioselective for (+)-menthylacetate
-
-
?
(+)-trans 4-nitrophenyl crysanthemate + H2O
(+)-trans-crysanthemic acid + 4-nitrophenol
-
-
-
-
?
(+)-trans-ethyl crysanthemate + H2O
(+)-trans-crysanthemic acid + ethanol
-
-
-
-
?
(+/-)-1,2-O-isopropylidenglycerol butanoate + H2O
(+/-)-1,2-O-isopropylidenglycerol + butanoate
(+/-)-3-endo-acetyloxy-1,8-cineole + H2O
(1S,3S,4R)-(+)-3-acetyloxy-1,8-cineole + (1R,3R,4S)-(-)-3-hydroxy-1,8-cineole
-
-
-
-
?
(-)-1,2-O-isopropylidenglycerol caprylate + H2O
(-)-1,2-O-isopropylidenglycerol + caprylate
(-)-cocaine + H2O
O-benzoylecgonine + methanol
CE-1 catalyzed hydrolysis of (-)-cocaine, reaction mechanism of cocaine hydrolysis catalyzed by CE-1, overview. Two reaction steps: a single-step acylation process and a single-step deacylation process. In the transition states of both single-step processes, the cocaine NH group joins the oxyanion hole to form an additional hydrogen bond with the negatively charged carbonyl oxygen atom of the cocaine. The transition states are stabilized by both intermolecular and intramolecular hydrogen bonds with the methyl ester of cocaine, specifically the carbonyl oxygen atom. The rate-limiting transition state is associated with the acylation process
-
-
?
(1R)-1-phenylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
?
-
-
-
?
(1R)-bioresmethrin + H2O
?
(1RS)-cis-permethrin + H2O
cis-dichlorochrysamthemic acid + 3-phenoxybenzyl alcohol
(1RS)-trans-permethrin + H2O
trans-dichlorochrysamthemic acid + 3-phenoxybenzyl alcohol
(1S)-1-phenylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
?
-
-
-
?
(2R)-butan-2-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
?
-
-
-
?
(2R)-fenvalerate + H2O
?
-
-
-
?
(2S)-butan-2-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
?
-
-
-
?
(2S)-fenvalerate + H2O
?
-
-
-
?
(alphaR)(2R)-fenvalerate + H2O
?
-
-
-
?
(alphaR)(2S)-fenvalerate + H2O
?
-
-
-
?
(alphaS)(2R)-fenvalerate + H2O
?
-
-
-
?
(E)-2-(2-(6-((4-acetoxybenzyl)oxy)-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indolium + H2O
(E)-2-(2-(6-hydroxy-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indol-1-ium + 4-methylphenol + acetate
(E)-2-hexenyl acetate + H2O
(E)-2-hexenol + acetate
-
-
-
-
?
(E)-2-hexenyl butyrate + H2O
(E)-2-hexenol + butyrate
-
-
-
-
?
(R)-2-(3-benzoylphenyl)propanoic methyl ester + H2O
methanol + (R)-2-(3-benzoylphenyl)propanoate
when tested with the racemic substrate, the enzyme leads to the production of the R-configured acid with an enantiomeric excess of 80% at the conversion rate of 20% in 32 h
-
-
?
(R)-cyano(6-methoxy-2-naphthyl)methyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
-
-
-
?
(R)-cyano(6-methoxy-2-naphthyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
-
-
-
?
(R)-cyano(6-methoxy-2-naphthyl)methyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
-
-
-
?
(R)-cyano(6-methoxy-2-naphthyl)methyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
-
-
-
?
(R)-cyano(6-methoxynaphthalen-2-yl)methyl (1R,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(1R,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + (2R)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile
-
-
-
?
(R)-cyano(6-methoxynaphthalen-2-yl)methyl (1R,3S)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(1S,2S,3S)-2-(2,2-dichloroethenyl)-3-methylcyclopropanecarboxylate + (2R)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile
-
-
-
?
(R)-cyano(6-methoxynaphthalen-2-yl)methyl (1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + (2S)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile
-
-
-
?
(R)-cyano(6-methoxynaphthalen-2-yl)methyl (1S,3S)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(1S,3S)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + (2S)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile
-
-
-
?
(R)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoate + H2O
(2R)-2-(4-chlorophenyl)-3-methylbutanoic acid + (2R)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile
-
-
-
?
(R)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid + H2O
(2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid
-
-
-
?
(R)-cyano(6-methoxynaphthalen-2-yl)methyl (2S)-2-(4-chlorophenyl)-3-methylbutanoate + H2O
(2S)-2-(4-chlorophenyl)-3-methylbutanoic acid + (2R)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile
-
-
-
?
(R)-ketoprofen ethyl ester + H2O
(R)-ketoprofen + ethanol
-
(R)-ketoprofen or (S)-ketoprofen is produced by esterase hydrolysis of the ester bond of (R,S)-ketoprofen ethyl ester
-
-
?
(R)-naproxen methyl ester + H2O
(R)-naproxen + methanol
-
-
-
-
?
(R)-propranolyl 2-methyl-n-valerate + H2O
(R)-propranolol + 2-methylpentanoate
(R)-propranolyl 2-methylbutanoate + H2O
(R)-propranolol + 2-methylbutanoate
(R)-propranolyl 3-methylbutanoate + H2O
(R)-propranolol + 3-methylbutanoate
(R)-propranolyl 3-methylpentanoate + H2O
(R)-propranolol + 3-methylpentanoate
(R)-propranolyl hexanoate + H2O
(R)-propranolol + hexanoate
(R)-propranolyl n-valerate + H2O
(R)-propranolol + pentanoate
(S)-1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone + H2O
(2S)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline + (isoquinolin-5-yloxy)acetic acid
(S)-cyano(6-methoxy-2-naphthyl)methyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
-
-
-
?
(S)-cyano(6-methoxy-2-naphthyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
-
-
-
?
(S)-cyano(6-methoxy-2-naphthyl)methyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
-
-
-
?
(S)-cyano(6-methoxy-2-naphthyl)methyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
-
-
-
?
(S)-cyano(6-methoxynaphthalen-2-yl)methyl (1R,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(1R,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + (2S)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile
-
-
-
?
(S)-cyano(6-methoxynaphthalen-2-yl)methyl (1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + (2S)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile
-
-
-
?
(S)-cyano(6-methoxynaphthalen-2-yl)methyl (1S,3S)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(1S,3S)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + (2S)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile
-
-
-
?
(S)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoate + H2O
(2R)-2-(4-chlorophenyl)-3-methylbutanoic acid + (2S)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile
-
-
-
?
(S)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid + H2O
(2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid
-
-
-
?
(S)-cyano(6-methoxynaphthalen-2-yl)methyl (2S)-2-(4-chlorophenyl)-3-methylbutanoate + H2O
(2S)-2-(4-chlorophenyl)-3-methylbutanoic acid + (2S)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile
-
-
-
?
(S)-ibuprofen methyl ester + H2O
(S)-ibuprofen + methanol
(S)-ketoprofen ethyl ester + H2O
(S)-ketoprofen + ethanol
(S)-naproxen methyl ester + H2O
(S)-naproxen + methanol
(S)-propranolol 3-methylpentanoate + H2O
(S)-propranolol + 3-methylpentanoate
(S)-propranolyl 2-methylbutanoate + H2O
(S)-propranolol + 2-methylbutanoate
(S)-propranolyl 2-methylpentanoate + H2O
(S)-propranolol + 2-methylpentanoate
(S)-propranolyl 3-methylbutanoate + H2O
(S)-propranolol + 3-methylbutanoate
(S)-propranolyl hexanoate + H2O
(S)-propranolol + hexanoate
(S)-propranolyl n-valerate + H2O
(S)-propranolol + pentanoate
(Z)-3-hexenyl acetate + H2O
(Z)-3-hexenol + acetate
(Z)-3-hexenyl butyrate + H2O
(Z)-3-hexenol + butyrate
-
-
-
-
?
(Z)-3-hexenyl caproate + H2O
(Z)-3-hexenol + caproate
-
-
-
-
?
(Z9,E11)-tetradec-9,11-enyl acetate + H2O
(Z9,E11)-tetradec-9,11-en-1-ol + acetate
-
about 40% hydrolysis (native enzyme), 7.63% hydrolysis (recombinant enzyme)
-
-
?
(Z9,E12)-tetradec-9,12-enyl acetate + H2O
(Z9,E11)-tetradec-9,12-en-1-ol + acetate
-
about 40% hydrolysis (native enzyme), 8.98% hydrolysis (recombinant enzyme)
-
-
?
1,2-dioctanoyl-glycerol + H2O
octanoate + glycerol
-
-
-
-
?
1,2-O-dilauryl-rac-glycero-3-glutaric acid-resorufin ester + H2O
?
1,3-dioctanoyl-glycerol + H2O
octanoate + glycerol
-
-
-
-
?
1,4-diacetoxybenzene + H2O
?
-
-
-
-
?
1-chloro-3-(1-naphthyloxy)-2-propanol acylester + H2O
(R)-1-chloro-3-(1-naphthyloxy)-2-propanol + carboxylic acid
-
-
high stereoselectivity
-
?
1-monocaprylylglycerol + H2O
caprylic acid + glycerol
1-monodecanoyl-glycerol + H2O
decanoate + glycerol
-
-
-
-
?
1-monolauroyl-glycerol + H2O
lauric acid + glycerol
1-monomyristoyl-glycerol + H2O
myristic acid + glycerol
1-monooctanoyl-glycerol + H2O
octanoate + glycerol
-
-
-
-
?
1-monooleyl glycerol + H2O
oleic acid + glycerol
-
-
-
-
?
1-monopalmitin + H2O
palmitic acid + glycerol
-
3.8% of the activity with tributyrin
-
-
?
1-monostearin + H2O
stearic acid + glycerol
-
1.6% of the activity with tributyrin
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
1-naphthyl butanoate + H2O
1-naphthol + butanoate
1-naphthyl butyrate + H2O
1-naphthol + butyrate
1-naphthyl caprylate + H2O
1-naphthol + caprylate
-
14% of the activity with 1-naphthyl acetate
-
-
?
1-naphthyl laurate + H2O
1-naphthol + laurate
-
9% of the activity with 1-naphthyl acetate
-
-
?
1-naphthyl oleate + H2O
1-naphthol + oleate
-
2% of the activity with 1-naphthyl acetate
-
-
?
1-naphthyl propionate + H2O
1-naphthol + propionate
2'-ethylcarbonate-linked paclitaxel + H2O
paclitaxel + propanoate
2,2-dimethylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
?
-
-
-
?
2,4-dinitrophenyl butyrate + H2O
2,4-dinitrophenol + butyrate
2-acetoxy-5-(alpha-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine + H2O
2-[2-oxo-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)ethanone + ?
-
also called prasugrel, the hydrolysis is at least 25times greater with CE2 than CE1
also called R-95913
-
?
2-carboxyethyl-3-cyano-5-methylhexanoic acid ethyl ester + H2O
(3S)-2-carboxyethyl-3-cyano-5-methylhexanoic acid + ethanol
-
-
-
?
2-deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine + H2O
decitabine + ?
-
-
-
-
?
2-methylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
?
-
-
-
?
2-monopalmitin + H2O
palmitic acid + glycerol
-
2.6% of the activity with tributyrin
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
2-naphthyl butyrate + H2O
2-naphthol + butyrate
-
-
-
-
?
2-naphthyl propionate + H2O
2-naphthol + propionate
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
2-nitrophenyl butyrate + H2O
2-nitrophenol + butyrate
2-nitrophenyl laurate + H2O
2-nitrophenol + laurate
-
-
-
-
?
2-nitrophenylpropionate + H2O
2-nitrophenol + propionate
-
-
-
-
?
2-octanyl acetate + H2O
2-octanol + acetate
2-phenethyl acetate + H2O
2-phenylethanol + acetate
-
-
-
-
?
2-phenyl-3-butyn-2-yl acetate
2-phenyl-3-butyn-2-ol + acetate
-
-
-
?
2-phenyl-3-butyn-2-yl acetate + H2O
2-phenyl-3-butyn-2-ol + acetate
2-phenyloxazolin-5-one + H2O
?
2-thionaphthyl acetate + H2O
2-thionaphthol + acetate
-
-
-
-
?
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate + 2 H2O
anordiol + 2 propanoate
i.e anordrin
-
-
?
3'-D-phenylalanyl-gemcitabine + H2O
D-phenylalanine + gemcitabine
-
-
-
-
?
3'-D-valyl-gemcitabine + H2O
D-valine + gemcitabine
-
-
-
-
?
3'-L-isoleucyl-gemcitabine + H2O
L-isoleucine + gemcitabine
-
-
-
-
?
3'-L-phenylalanyl-gemcitabine + H2O
L-phenylalanine + gemcitabine
-
-
-
-
?
3'-L-valyl-gemcitabine + H2O
L-valine + gemcitabine
-
-
-
-
?
3-acetoxypyridine + H2O
?
-
-
-
-
?
3-methyl-1-pentyn-3-yl acetate + H2O
3-methyl-1-pentyn-3-ol + acetate
3-nitrophenyl acetate + H2O
3-nitrophenol + acetate
-
-
-
-
?
3-nitrophenyl butyrate + H2O
3-nitrophenol + butyrate
3-O-(4-ethylbenzoyl)-3-hydroxyflavone + H2O
3-hydroxylflavone + 4-ethylbenzoate
-
-
-
?
3-phenoxybenzyl (1R,3R)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(1R,3R)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylic acid + (3-phenoxyphenyl)methanol
3-phenoxybenzyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid + (3-phenoxyphenyl)methanol
3-phenoxybenzyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid + (3-phenoxyphenyl)methanol
3-phenoxybenzyl (1S,3S)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(1S,3S)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylic acid + (3-phenoxyphenyl)methanol
4'-chloroacetanilide + H2O
?
-
-
-
-
?
4-aminobenzoic acid butyl ester + H2O
4-aminobenzoic acid + butanol
-
-
-
-
?
4-aminobenzoic acid ethyl ester + H2O
4-aminobenzoic acid + ethanol
-
-
-
-
?
4-aminobenzoic acid propyl ester + H2O
4-aminobenzoic acid + propanol
-
-
-
-
?
4-hydroxyphenyl acetate + H2O
4-hydroxyphenol + acetate
-
-
-
-
?
4-methylbenzyl acetate + H2O
4-methylbenzyl alcohol + acetate
-
-
-
-
?
4-methylumbelliferyl (2E)-but-2-enoate + H2O
4-methylumbelliferone + (2E)-but-2-enoic acid
-
-
-
-
?
4-methylumbelliferyl 3-phenoxybutanoate + H2O
4-methylumbelliferone + 3-phenoxybutanoate
-
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferol + acetate
4-methylumbelliferyl acetate + H2O
4-methylumbelliferone + acetate
4-methylumbelliferyl butanoate + H2O
4-methylumbelliferol + butanoate
-
enzyme activity in decreasing order: 4-methylumbelliferyl butanoate, 4-methylumbelliferyl heptanoate, 4-methylumbelliferyl oleate
-
-
?
4-methylumbelliferyl butanoate + H2O
4-methylumbelliferone + butanoate
-
-
-
-
?
4-methylumbelliferyl butyrate + H2O
4-methylumbelliferol + butyrate
4-methylumbelliferyl butyrate + H2O
4-methylumbelliferone + butyrate
4-methylumbelliferyl cyclopentane carboxylate + H2O
4-methylumbelliferone + cyclopentane carboxylate
-
-
-
-
?
4-methylumbelliferyl heptanoate + H2O
4-methylumbelliferol + heptanoate
4-methylumbelliferyl heptanoate + H2O
4-methylumbelliferone + heptanoate
4-methylumbelliferyl hexanoate + H2O
4-methylumbelliferone + hexanoate
-
-
-
-
?
4-methylumbelliferyl laurate + H2O
4-methylumbelliferol + laurate
-
-
-
?
4-methylumbelliferyl laurate + H2O
4-methylumbelliferone + laurate
-
best substrate
-
-
?
4-methylumbelliferyl octanoate + H2O
4-methylumbelliferol + octanoate
-
-
-
?
4-methylumbelliferyl octanoate + H2O
4-methylumbelliferone + octanoate
4-methylumbelliferyl oleate + H2O
4-methylumbelliferol + oleate
4-methylumbelliferyl p-trimethylammoniocinnamate chloride + H2O
4-methylumbelliferol + p-trimethylammoniocinnamate chloride
4-methylumbelliferyl palmitate + H2O
4-methylumbelliferol + palmitate
4-methylumbelliferyl palmitate + H2O
4-methylumbelliferone + palmitate
4-methylumbelliferyl pentanoate + H2O
4-methylumbelliferone + pentanoate
-
-
-
-
?
4-methylumbelliferyl propionate + H2O
4-methylumbelliferone + propionate
-
-
-
-
?
4-nitroacetanilide + H2O
?
-
-
-
-
?
4-nitrobenzoic acid methyl ester + H2O
4-nitrobenzoic acid + methanol
-
ratio of the rates of hydrolysis in liver to intestine 5.5
-
-
?
4-nitrophenol acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl 2-chloropropionate + H2O
4-nitrophenol + (S)-2-chloropropionic acid
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
4-nitrophenyl caprate + H2O
4-nitrophenol + caprate
4-nitrophenyl caprate + H2O
4-nitrophenol + capric acid
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
4-nitrophenyl chrysanthemate + H2O
4-nitrophenol + chrysanthemate
-
-
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
4-nitrophenyl heptanoate + H2O
4-nitrophenol + heptanoate
-
-
-
?
4-nitrophenyl hexadecanoate + H2O
4-nitrophenol + hexadecanoate
4-nitrophenyl hexadecanoate + H2O
4-nitrophenol + palmitate
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
4-nitrophenyl laurate + H2O
4-nitrophenol + lauric acid
4-nitrophenyl methylphosphonate + H2O
4-nitrophenol + methylphosphonate
-
-
-
-
?
4-nitrophenyl myristate + H2O
4-nitrophenol + myristate
4-nitrophenyl myristate + H2O
4-nitrophenol + myristic acid
4-nitrophenyl nonanoate + H2O
4-nitrophenol + nonanoate
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitic acid
-
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
4-nitrophenyl propanoate + H2O
4-nitrophenol + propanoate
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
4-nitrophenyl stearate + H2O
4-nitrophenol + stearate
-
-
-
?
4-nitrophenyl tetradecanoate + H2O
4-nitrophenol + tetradecanoate
4-nitrophenyl valerate + H2O
4-nitrophenol + valerate
4-nitrophenylacetate + H2O
4-nitrophenol + acetate
-
-
-
?
5'-D-phenylalanyl-2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole + H2O
D-phenylalanine + 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole
-
-
-
-
?
5'-D-phenylalanyl-gemcitabine + H2O
D-phenylalanine + gemcitabine
-
-
-
-
?
5'-D-valyl-gemcitabine + H2O
D-valine + gemcitabine
-
-
-
-
?
5'-L-isoleucyl-gemcitabine + H2O
L-isoleucine + gemcitabine
-
-
-
-
?
5'-L-phenylalanyl-2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole + H2O
L-phenylalanine + 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole
-
-
-
-
?
5'-L-phenylalanyl-gemcitabine + H2O
L-phenylalanine + gemcitabine
-
-
-
-
?
5'-L-valyl-gemcitabine + H2O
L-valine + gemcitabine
-
-
-
-
?
5'-O-cinnamoyl-2'-deoxy-5-fluorouridine + H2O
cinnamic acid + 2'-deoxy-5-fluorouridine
-
-
-
-
?
5'-O-L-phenylalanyl-2'-deoxy-5-fluorouridine + H2O
L-phenylalanine + 2'-deoxy-5-fluorouridine
-
-
-
-
?
5-methyl-2-(propan-2-yl)cyclohexyl acetate + H2O
?
6-methoxy-alpha-methyl-2-naphthaleneacetic acid methyl ester
(S)-naproxen + methanol
-
i.e. naproxen methyl ester
high stereoselectivity
-
?
6-monoacetylmorphine + H2O
morphine + acetate
hCE1 can metabolize the conversion of heroin to both 6-monoacetylmorphine and morphine. hCE1 is able to catalyze both reactions, but it is more efficient at the hydrolysis of heroin to 6-monoacetylmorphine, the first step of heroin metabolism
-
-
?
7-acetoxy-3-(2-benzothiazolyl)-4-cyanocoumarin + H2O
?
low activity
-
?
7-amino cephalosporanic acid + H2O
?
-
-
-
-
?
7-aminocephalosporanic acid + H2O
(6R,7R)-7-amino-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid + acetate
-
-
-
-
?
7-ethyl-10-(4-(1-piperidino)-1-amino)carbonyloxycampothecin + H2O
7-ethyl-10-hydroxycampothecin + 4-aminopiperidine-1-carboxylic acid
-
i.e. NPC
-
-
?
7-ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycampothecin + H2O
7-ethyl-10-hydroxycampothecin + 1,4'-bipiperidine-1'-carboxylic acid
-
i.e. irinotecan, CPT-11
-
-
?
7-ethyl-10-(4-N-(5-aminopentanoic acid)-1-piperidino)carbonyloxycampothecin + H2O
7-ethyl-10-hydroxycampothecin + 4-((4-carboxybutyl)amino)piperidine-1-carboxylic acid
-
i.e. APC
-
-
?
7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin + H2O
7-ethyl-10-hydroxycampothecin + ?
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin + H2O
7-ethyl-10-hydroxy-camptothecin + ?
7-[4-octylcarboxy-(3-hydroxy-3-methyl)-butyloxy]-coumarin + H2O
?
-
-
-
-
?
acetanilide + H2O
acetate + aniline
-
-
-
-
?
acetylsalicylic acid + H2O
acetate + salicylate
CES2A1-specific substrate
-
-
?
acetylsalicylic acid + H2O
salicylic acid + acetate
alpha-cypermethrin + H2O
?
-
-
-
?
alpha-naphthyl acetate + H2O
1-naphthol + acetate
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
alpha-naphthyl butanoate + H2O
alpha-naphthol + butanoate
-
enzyme activity increases from acetate to propionate to butanoate substrate
-
-
?
alpha-naphthyl butyrate + H2O
alpha-naphthol + butyrate
alpha-naphthyl caprate + H2O
alpha-naphthol + caprate
-
-
-
?
alpha-naphthyl caproate + H2O
alpha-naphthol + caproate
-
-
-
?
alpha-naphthyl caprylate + H2O
alpha-naphthol + caprylate
alpha-naphthyl nonanoate + H2O
alpha-naphthol + nonanoate
low activity
-
?
alpha-naphthyl propionate + H2O
1-naphthol + propionate
best substrate
-
?
alpha-naphthyl propionate + H2O
alpha-naphthol + propionate
alpha-naphthyl valerate + H2O
alpha-naphthol + valerate
-
-
?
ampicillin + H2O
?
-
-
-
-
?
Amplex red + H2O
resorufin + acetate
anisamidobutyric acid + H2O
?
-
-
-
-
?
anisilic acid + H2O
?
-
-
-
-
?
aspirin + H2O
acetate + salicylate
benazepril + H2O
?
-
-
-
-
?
benzoyl-Gly-farnesyl-L-cysteine methyl ester + H2O
?
-
-
-
-
?
benzyl (trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate) + H2O
benzol + trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate
-
i.e. benzyl cetraxate
-
?
benzyl acetate + H2O
benzyl alcohol + acetate
benzyl propionate + H2O
benzyl alcohol + propionate
-
-
-
-
?
benzyloxycarbonyl-D-Tyr-p-nitrophenyl ester + H2O
benzyloxycarbonyl-D-Tyr + 4-nitrophenol
benzyloxycarbonyl-Gly-p-nitrophenyl ester + H2O
benzyloxycarbonyl-Gly + 4-nitrophenol
-
-
-
-
?
benzyloxycarbonyl-L-Ala-p-nitrophenyl ester + H2O
benzyloxycarbonyl-L-Ala + 4-nitrophenol
-
-
-
-
?
benzyloxycarbonyl-L-Tyr-p-nitrophenyl ester + H2O
benzyloxycarbonyl-L-Tyr + 4-nitrophenol
beta-naphthyl acetate + H2O
beta-naphthol + acetate
beta-naphthyl butyrate + H2O
beta-naphthol + butyrate
-
-
?
beta-naphthyl caproate + H2O
beta-naphthol + caproate
low activity
-
?
beta-naphthyl propionate + H2O
2-naphthol + propionate
best substrate
-
?
beta-naphthyl valerate + H2O
beta-naphthol + valerate
-
-
?
beta-phenethyl acetate + H2O
?
-
-
-
-
?
beta-thionaphthyl acetate + H2O
beta-thionaphthol + acetate
-
-
-
-
?
betamethasone valerate + H2O
betamethasone + valerate
-
ratio of the rates of hydrolysis in liver to intestine 0.21
-
-
?
bifenthrin + H2O
?
-
-
-
?
bis(2-ethylhexyl)phthalate + H2O
?
-
-
-
-
?
bisphenyl carbonate + H2O
?
-
-
-
-
?
butyl 2-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenoxy)propanoate + H2O
2-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenoxy)propanoic acid + butanol
i.e. fluazifop butyl
-
-
?
butyl 2-(4-[[5-(trifluoromethyl)pyridin-2-yl]oxy]phenoxy)propanoate + H2O
fluazifop-P + butanol
butyl 2-[4-(4-cyano-2-fluorophenoxy)phenoxy]propanoate + H2O
cyhalofop + butanol
butyl 4-aminobenzoate + H2O
4-aminobenzoate + butanol
butyl acetate + H2O
butanol + acetate
butyl benzoate + H2O
benzoate + butanol
butyl octanoate + H2O
butanol + octanoate
-
-
?
butyl paraben + H2O
butanol + 4-hydroxybenzoate
-
-
-
?
butyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
?
-
-
-
?
butyrylthiocholine + H2O
butyric acid + thiocholine
camostat mesilate + H2O
?
-
-
-
-
?
capric acid + glycerol
1-monocaprin + H2O
-
PLE-catalyzed esterification of capric acid with glycerol in reverse micelles. The most suitable structure of reverse micelles is comprised of isooctane (reaction medium) and bis(2-ethylhexyl) sodium sulfosuccinate ( anionic surfactant) with 0.1 of R-value ([water]/[surfactant]) and 3.0 of G/F-value ([glycerol]/[fatty acid]) for the PLE-catalyzed esterification. PLE mainly produces 1-monocaprin without any other products (di- and/or tricaprins of subsequent reactions). The degree of esterification at equilibrium state (after 4 h from the initiation) is 62.7% under optimum conditions. Method optimization, overview
-
-
?
capric acid + sn-glycerol
1-monocaprin
-
the carboxylesterase performs also the esterification reaction using capric acid and glycerol as substrates resulting in formation of 1-monocaprin, product analysis by HPLC and method optimization, overview
-
-
?
capsaicin + H2O
?
-
-
-
-
?
carboxyfluorescein diacetate + H2O
?
-
-
-
-
?
carboxyfluorescein diacetate + H2O
carboxyfluorescein + acetate
-
-
-
-
?
cefazolin + H2O
(6R,7R)-7-amino-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid + (1H-tetrazol-1-yl)acetic acid
-
-
-
-
?
cefazolin + H2O
?
67% conversion
-
-
?
cefoperazone + H2O
(2R)-2-[(4-ethyl-2,3-dioxopiperazinyl)carbonylamino]-2-(4-hydroxyphenyl)acetic acid + 1-methyl-1H-tetrazole-5-thiol + ?
83% conversion
-
-
?
cefotaxime + H2O
?
16% conversion
-
-
?
ceftriaxone + H2O
?
18% conversion
-
-
?
cephaloridine + H2O
(6R,7R)-7-amino-8-oxo-3-[(pyridin-1-ium-1-yl)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate + (thiophen-2-yl)acetic acid
-
-
-
-
?
cephalothin + H2O
acetate + deacetylcephalothin
-
-
-
-
?
chlorpyrifos + H2O
?
-
poor substrate
-
-
?
cholesterol ester + H2O
?
cholesterol oleate + H2O
cholesterol + oleate
cholesteryl oleate + H2O
cholesterol + oleate
-
-
-
-
?
clodinafop-propargyl + H2O
? + prop-2-yn-1-ol
-
-
-
-
?
clofibrate + H2O
clofibric acid + ethanol
-
-
-
?
clopidogrel + H2O
(2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoic acid + methanol
clopidogrel + H2O
clopidogrel carboxylic acid + methanol
-
-
-
?
cocaine + H2O
benzoylecgonine + methanol
cocaine + H2O
ecgonine methyl ester + benzoate
cocaine + H2O
O-benzoylecgonine + methanol
CPT-11 + H2O
SN-38 + 1,4'-bipiperidine-1'-carboxylic acid + CO2
cyano(3-phenoxyphenyl)methyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
hydroxy(3-phenoxyphenyl)acetonitrile + 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
-
-
-
?
cyano(6-methoxy-2-naphthyl)methyl 2,2,3,3-tetramethylcyclopropanecarboxylate + H2O
hydroxy(6-methoxy-2-naphthyl)acetonitrile + 2,2,3,3-tetramethylcyclopropanecarboxylic acid
-
-
-
?
cyano(6-methoxy-2-naphthyl)methyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
hydroxy(6-methoxy-2-naphthyl)acetonitrile + 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
-
-
-
?
cyano(6-methoxy-2-naphthyl)methyl butanoate + H2O
hydroxy(6-methoxy-2-naphthyl)acetonitrile + butanoate
-
-
-
?
cyano(6-methoxynaphthalen-2-yl)methyl (2S)-2-(4-chlorophenyl)-3-methylbutanoic acid + H2O
(2R)-2-(4-chlorophenyl)-3-methylbutanoic acid + hydroxy(6-methoxy-2-naphthyl)acetonitrile
-
-
-
?
cyano(6-methoxynaphthalen-2-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylic acid + H2O
hydroxy(6-methoxy-2-naphthyl)acetonitrile + 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylic acid
-
-
-
?
cyclic poly(ethylene terephthalate) trimer + H2O
?
cyclohexyl 4-nitrophenyl methylphosphonate + H2O
?
-
-
-
-
?
D-glucose pentaacetate + H2O
? + acetate
-
-
-
-
?
D-methyl phenidate + H2O
?
-
-
-
?
D-methylphenidate + H2O
methanol + phenyl(piperidin-2-yl)acetate
-
-
-
-
?
D-Tyr ethyl ester + H2O
D-Tyr + ethanol
-
-
-
-
?
D-xylose tetraacetate + H2O
? + acetate
-
-
-
-
?
delapril + H2O
N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-N-(2,3-dihydro-1H-inden-2-yl)glycine + ethanol
-
-
-
-
?
deltamethrin + H2O
3-phenoxybenzaldehyde + (1R,3R)-3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropanecarboxylate + cyanide
derapril + H2O
N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-N-(2,3-dihydro-1H-inden-2-yl)glycine + ethanol
dibutyl phthalate + H2O
?
-
-
-
?
dicaprin + H2O
?
-
-
-
-
?
diethyl (6-methoxynaphthalen-2-yl)(methyl)propanedioate + H2O
ethanol + (2S)-3-ethoxy-2-(6-methoxynaphthalen-2-yl)-2-methyl-3-oxopropanoic acid
diethyl methyl(phenyl)propanedioate + H2O
ethanol + (2S)-3-ethoxy-2-methyl-3-oxo-2-phenylpropanoic acid
diethyl succinate + H2O
?
-
-
-
-
?
diethyl-4-methylumbelliferyl phosphate + H2O
?
-
-
-
?
diltiazem + H2O
?
-
-
-
-
?
dimethyl cis-cyclohex-4-ene-1,2-dicarboxylate + H2O
methyl hydrogen (1S,2R)-cyclohex-4-ene-1,2-dicarboxylate + methanol
-
enantioselectivity, 98% at 25°C, 96% at 50°C
94-97% of the R-enantiomer
ir
DL-methyl 2-chloropropionate + H2O
?
DL-methylphenidate + H2O
methanol + phenyl(piperidin-2-yl)acetate
-
-
-
-
?
enalapril + H2O
?
-
-
-
-
?
epsilon-caprolactone + H2O
6-hydroxyhexanoate
the enzyme catalyzes a ring-opening polymerization of epsilon-caprolactone
-
-
?
epsilon-cypermethrin + H2O
?
-
-
-
?
estrone acetate + H2O
estrone + acetate
-
-
-
-
?
ethanol + acetate
ethyl acetate + H2O
ethanol + acetyl-CoA
ethyl acetate + CoA
ester formation
-
?
ethanol + butyrate
ethyl butanoate + H2O
ester formation
-
?
ethyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate + H2O
ethanol + (2S)-2-(6-methoxynaphthalen-2-yl)propanoate
ethyl (2S)-2-phenylpropanoate + H2O
ethanol + (2S)-2-phenylpropanoate
ethyl (4-nitrophenyl)acetate + H2O
ethanol + (4-nitrophenyl)acetate
-
-
-
-
?
ethyl (naphthalen-2-yl)acetate + H2O
(naphthalen-2-yl)acetate + ethanol
-
-
-
-
?
ethyl (trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate) + H2O
ethanol + trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate
ethyl 2-(4-((6-chloro-1,3-benzothiazol-2-yl)oxy)phenoxy)propanoate + H2O
2-(4-((6-chloro-1,3-benzothiazol-2-yl)oxy)phenoxy)propanoic acid + ethanol
i.e. fenthiaprop ethyl
-
-
?
ethyl 2-(4-((6-chloro-1,3-benzoxazol-2-yl)oxy)phenoxy)propanoate + H2O
2-(4-((6-chloro-1,3-benzoxazol-2-yl)oxy)phenoxy)propanoic acid + ethanol
i.e. fenoxaprop ethyl
-
-
?
ethyl 2-hydroxy-4-phenylbutanoate + H2O
2-hydroxy-4-phenylbutanoate + ethanol
-
enantiopreference for (S)-isomer with enantiomeric excess of 80%
-
?
ethyl 2-[4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy]propanoate
fenoxaprop-P + ethanol
ethyl 2-[4-[(6-chloroquinoxalin-2-yl)oxy]phenoxy]propanoate + H2O
quizalofop-P + ethanol
ethyl 3,4-dihydroxybenzoate + H2O
ethanol + 3,4-dihydroxybenzoate
-
low activity
-
?
ethyl 3-hydroxybenzoate + H2O
ethanol + 3-hydroxybenzoate
-
-
-
?
ethyl 3-methoxybenzoate + H2O
ethanol + 3-methoxybenzoate
-
-
-
?
ethyl 4-aminobenzoate + H2O
4-aminobenzoate + ethanol
ethyl 4-hydroxybenzoate + H2O
ethanol + 4-hydroxybenzoate
-
-
-
?
ethyl 4-methoxybenzoate + H2O
ethanol + 4-methoxybenzoate
-
-
-
?
ethyl 4-nitrophenyl methylphosphonate + H2O
?
-
-
-
-
?
ethyl acetate + H2O
ethanol + acetate
ethyl benzoate + H2O
ethanol + benzoate
-
-
-
?
ethyl bromoacetate + H2O
ethanol + bromoacetate
-
-
-
-
?
ethyl butanoate + H2O
butanoate + ethanol
-
-
-
-
?
ethyl butanoate + H2O
ethanol + butanoate
ethyl butyrate + H2O
ethanol + butanoate
ethyl butyrate + H2O
ethanol + butyrate
ethyl butyrylacetate + H2O
?
-
-
-
-
?
ethyl caproate + H2O
ethanol + caproate
-
-
-
?
ethyl caprylate + H2O
ethanol + caprylate
-
-
-
-
?
ethyl cetraxate + H2O
ethanol + cetraxate
-
-
-
-
?
ethyl chloroacetate + H2O
ethanol + chloroacetate
-
-
-
-
?
ethyl D-pantothenate + H2O
ethanol + D-pantothenate
-
-
-
?
ethyl DL-beta-acetylthioisobutyrate + H2O
?
ethyl fexofenadine + H2O
fexofenadine + ethanol
ethyl fluoroacetate + H2O
ethanol + fluoroacetate
-
-
-
-
?
ethyl hexanoate + H2O
ethanol + hexanoate
ethyl iodoacetate + H2O
ethanol + iodoacetate
-
-
-
-
?
ethyl L-pantothenate + H2O
ethanol + L-pantothenate
-
-
-
?
ethyl laurate + H2O
ethanol + laurate
-
-
?
ethyl myristate + H2O
ethanol + myristate
-
-
?
ethyl octanoate + H2O
ethanol + octanoate
-
-
?
ethyl paraben + H2O
ethanol + 4-hydroxybenzoate
ethyl pelargonate + H2O
ethanol + pelargonate
-
-
?
ethyl pentanoate + H2O
ethanol + pentanoate
ethyl propionate + H2O
ethanol + propionate
ethyl thiolacetate + H2O
ethanol + ethanethioic S-acid
-
-
-
-
?
ethyl valerate + H2O
ethanol + valerate
-
-
-
?
ethyl valerate + H2O
ethanol + valeric acid
-
-
-
?
ethylene glycol dibenzoate + H2O
?
fenitrothion + H2O
?
-
poor substrate
-
-
?
fenofibrate + H2O
?
-
-
-
?
fenofibrate + H2O
fenofibric acid + propan-2-ol
-
-
-
?
fenpropathrin + H2O
?
-
-
-
?
fluorescein diacetate + H2O
?
fluorescein diacetate + H2O
fluorescein + acetate
geranyl acetate + H2O
geraniol + acetate
-
-
-
-
?
glucose pentaacetate + H2O
?
glyceryl tributyrate + H2O
?
glyceryl tridecanoate + H2O
?
glyceryl trihexanoate + H2O
?
activity with mutant enzyme expressed from the gene that has a deletion of about 60 residues at the N terminus
-
-
?
glyceryl trioctanoate + H2O
?
activity with mutant enzyme expressed from the gene that has a deletion of about 60 residues at the N terminus
-
-
?
glyceryl trioleate + H2O
?
heptyl acetate + H2O
heptanol + acetate
heroin + H2O
6-monoacetylmorphine + acetate
hexyl acetate + H2O
hexanol + acetate
hexyl valerate + H2O
hexanol + valeric acid
-
-
-
?
hostacaine + H2O
?
-
-
-
-
?
hydrocinnamoyl farnesyl-L-cysteine methyl ester + H2O
N-(3-phenylpropanoyl)-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine + methanol
-
-
-
-
?
hydroxyethylflurbiprofen + H2O
ethanol + flurbiprofen
hydroxypropylflurbiprofen + H2O
propanol + flurbiprofen
imidapril + H2O
imidaprilat + ?
imidapril + H2O
imidaprilat + ethanol
-
-
-
?
indoxyl acetate + H2O
indol-3-ol + acetate
irinotecan + H2O
7-ethyl-10-hydroxycampothecin + 1,4'-bipiperidine-1'-carboxylic acid
irinotecan + H2O
SN-38 + 1,4'-bipiperidine-1'-carboxylic acid
-
-
-
?
isobutyl 4-nitrophenyl methylphosphonate + H2O
4-nitrophenol + isobutyl methylphosphonate
-
-
-
-
?
isobutyl 4-nitrophenyl methylphosphonate + H2O
?
-
-
-
-
?
isobutyl acetate + H2O
isobutanol + acetate
-
-
-
?
isocarbophos + H2O
?
-
-
-
-
?
isopentyl octanoate + H2O
isopentanol + octanoate
-
-
?
isopropyl (trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate) + H2O
isopropanol + trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate
isopropyl 4-nitrophenyl methylphosphonate + H2O
?
-
-
-
-
?
isopropyl acetate + H2O
isopropanol + acetate
isopropyl cetraxate + H2O
isopropanol + cetraxate
-
-
-
-
?
isopropyl octanoate + H2O
isopropanol + octanoate
-
-
?
ispopropenyl acetate + H2O
isopropenol + acetate
-
-
-
-
?
ketoprofen ethyl ester + H2O
ketoprofen + ethanol
-
-
-
-
?
ketoprofen ethyl ester + H2O
R-ketoprofen + ethanol
-
-
R-isomer is main product of keratinocyte enzyme
-
?
L-methyl phenidate + H2O
?
-
-
-
?
L-phenylalanine butyl ester + H2O
L-phenylalanine + butanol
-
-
-
-
?
L-phenylalanine ethyl ester + H2O
L-phenylalanine + ethanol
-
-
-
-
?
L-Tyr ethyl ester + H2O
L-Tyr + ethanol
lambda-cyhalothrin + H2O
3-phenoxybenzyl alcohol + lambda-cyhalothric acid
-
-
-
-
?
lidocaine + H2O
2,6-xylidine + N,N-diethylglycine
linalyl acetate + H2O
linalool + acetate
malathion + H2O
malathion alpha-monocarboxylic acid + malathion beta-monocarboxylic acid
-
-
-
-
?
methanethiol + acetyl-CoA
methanethioacetate + coenzyme A
ester formation
-
?
methyl (-)-2-(3-benzoylphenyl)propionate + H2O
(-)-2-(3-benzoylphenyl)propionate + methanol
-
-
-
?
methyl (trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate) + H2O
methanol + trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate
methyl 1H-indole-3-carboxylate + H2O
methanol + 1H-indole-3-carboxylate
-
-
-
?
methyl 2-(4-(2,4-dichlorophenoxy)phenoxy)propanoate + H2O
2-(4-(2,4-dichlorophenoxy)phenoxy)propanoic acid + methanol
i.e. Diclofop methyl
-
-
?
methyl 2-(4-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy]phenoxy)propanoate + H2O
haloxyfop-P + methanol
methyl 2-aminobenzoate + H2O
methanol + 2-aminobenzoate
-
-
-
?
methyl 2-hydroxybenzoate + H2O
methanol + 2-hydroxybenzoate
-
very low activity
-
?
methyl 2-methylbutyrate + H2O
2-methylbutanoic acid + methanol
-
substrate of mutant L233P
-
-
?
methyl 2-tetrahydrofuroate + H2O
tetrahydrofuran-2-carboxylic acid + methanol
-
substrate of mutant L233P
-
-
?
methyl 2-[4-(2,4-dichlorophenoxy)phenoxy]propanoate + H2O
diclofop + methanol
methyl 3,5-dihydroxybenzoate + H2O
methanol + 3-hydroxybenzoate
-
low activity
-
?
methyl 3-(4-hydroxyphenyl)propionate + H2O
methanol + 3-(4-hydroxyphenyl)propionate
-
-
-
?
methyl 3-cyclohexene-1-carboxylic acid + H2O
3-cyclohexene-1-carboxylic acid + methanol
-
substrate of mutant L233P
-
-
?
methyl 3-hydroxybenzoate + H2O
methanol + 3-hydroxybenzoate
-
-
-
?
methyl 3-phenyloxirane-2-carboxylate + H2O
3-phenyloxirane-2-carboxylic acid + methanol
-
substrate of mutant L233S
-
-
?
methyl 4-aminobenzoate + H2O
4-aminobenzoate + methanol
methyl 4-aminobenzoate + H2O
methanol + 4-aminobenzoate
-
-
-
?
methyl 4-nitrobenzoate + H2O
4-nitrobenzoate + methanol
-
specific substrate for isoform ES1
-
-
?
methyl acetate
methanol + acetate
-
poor substrate
-
-
?
methyl acetate + H2O
methanol + acetate
methyl benzoate + H2O
methanol + benzoate
-
low activity
-
?
methyl butanoate + H2O
methanol + butanoate
methyl butyrate + H2O
methanol + butanoate
preferred substrate. The enzyme preferentially hydrolyzes esters of short-chain fatty acids (C2C4) and especially those of medium chain (C5C6) fatty acids with short chain alcohols
-
-
?
methyl butyrate + H2O
methanol + butyrate
methyl caprate + H2O
methanol + decanoate
-
-
-
-
?
methyl cetraxate + H2O
methanol + cetraxate
-
-
-
-
?
methyl D-pantothenate + H2O
methanol + D-pantothenate
-
-
-
?
methyl decanoate + H2O
methanol + decanoic acid
-
-
-
?
methyl DL-beta-acetylthioisobutyrate + H2O
D-beta-acetylthioisobutyrate + methanol
methyl hexanoate + H2O
methanol + hexanoate
methyl hexanoate + H2O
methanol + hexanoic acid
-
-
-
?
methyl L-pantothenate + H2O
methanol + L-pantothenate
-
-
-
?
methyl laurate + H2O
methanol + lauric acid
-
-
-
?
methyl myristate + H2O
methanol + myristic acid
-
-
-
?
methyl octanoate + H2O
methanol + octanoate
methyl octanoate + H2O
methanol + octanoic acid
-
-
-
?
methyl paraben + H2O
methanol + 4-hydroxybenzoate
methyl paraoxon + H2O
?
-
-
-
-
?
methyl propionate + H2O
methanol + propionate
methyl salicylate + H2O
methanol + salicylate
-
-
-
-
?
methyl salicylate + H2O
salicylic acid + methanol
-
ratio of the rates of hydrolysis in liver to intestine 15.3
-
-
?
methyl vanillate + H2O
methanol + vanillate
-
-
-
?
methyl-(-)-3-(4-methoxyphenyl) oxirane carboxylate + H2O
?
-
substrate of mutant L233S
-
-
?
methyl-2,4-dichlorophenoxyacetate + H2O
2,4-dichlorophenoxyacetic acid + methanol
-
i.e. 2,4-D-methyl
activation of pro-herbicide to phytotoxic acid. Isoform CXE12 is the major carboxyesterase responsible for activation
-
?
methylprednisolone 21-hemisuccinate + H2O
?
methylumbelliferyl acetate + H2o
methylumbelliferone + acetate
-
-
-
-
?
monobutyl phthalate + H2O
phthalate + butanol
monocaprin + H2O
glycerol + caproate
-
-
-
-
?
monoelaidin + H2O
elaidic acid + glycerol
-
-
-
-
?
monoethylglycylxylidine + H2O
2,6-xylidene + N-ethylglycine
CES1A-specific substrate
-
-
?
monoolein + H2O
glycerol + oleic acid
monopalmitoin + H2O
glycerol + palmitoleic acid
-
-
-
-
?
monopentyl phthalate + H2O
phthalate + pentanol
monopropyl phthalate + H2O
phthalate + propanol
mycophenolate + H2O
mycophenolic acid + 2-(morpholin-4-yl)ethanol
-
-
-
?
mycophenolate mofetil + H2O
mycophenolic acid + mofetil
-
prodrug, activation
-
-
?
N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester + H2O
?
N-acetyl L-phenylalanine ethyl ester + H2O
N-acetyl L-phenylalanine + ethanol
-
-
-
-
?
N-acetyl-DL-phenylalanine beta-naphthyl ester + H2O
N-acetyl-DL-phenylalanine + beta-naphthol
N-acetyl-L-Ala-1-naphthyl ester + H2O
N-acetyl-L-Ala + 1-naphthol
-
-
-
-
?
N-acetyl-L-phenylalanine methyl ester + H2O
N-acetyl-L-phenylalanine + methanol
-
-
-
-
?
N-acetyldapsone + H2O
dapsone + acetate
-
-
-
?
n-butyl acetate + H2O
n-butanol + acetate
-
-
-
-
?
n-butyl benzoate + H2O
n-butanol + benzoate
-
-
-
?
n-butyl n-butyrate + H2O
n-butanol + n-butyrate
n-butyryl salicylate + H2O
n-butanol + salicylate
-
-
-
-
?
n-decanoyl salicylate + H2O
? + salicylate
-
-
-
-
?
N-ethylglycine xylidide + H2O
?
-
-
-
-
?
n-heptyl acetate + H2O
n-heptanol + acetate
-
-
-
-
?
n-hexanoyl salicylate + H2O
n-hexanol + salicylate
-
-
-
-
?
n-hexyl acetate + H2O
n-hexanol + acetate
n-octanoyl salicylate + H2O
? + salicylate
-
-
-
-
?
n-octyl acetate + H2O
n-octanol + acetate
-
-
-
-
?
n-pentyl acetate + H2O
n-pentanol + acetate
-
-
-
-
?
n-propionyl salicylate + H2O
n-propionate + salicylate
-
-
-
-
?
N-propyl acetate + H2O
n-propanol + acetate
-
-
-
-
?
n-propyl D-pantothenate + H2O
n-propanol + D-pantothenate
-
-
-
?
n-propyl L-pantothenate + H2O
n-propanol + L-pantothenate
-
best substrate
-
?
n-propyl salicylate + H2O
n-propanol + salicylate
-
-
-
-
?
n-valeryl salicylate + H2O
n-pentanol + salicylate
-
-
-
-
?
naphthyl acetate + H2O
naphthol + acetate
nitrocefin + H2O
?
-
i.e. 3-(2,4-dinitrosyl)-(6R,7R)-7-(2-thienylacetamido)-ceph-3-em-4-carboxylic acid
-
-
?
nonyl acetate + H2O
nonanol + acetate
-
-
-
-
?
O-butyryl propranolol + H2O
butanoate + propranolol
octyl acetate + H2O
octanol + acetate
oleoyl-CoA + H2O
oleic acid + CoA
oseltamivir + H2O
oseltamivir carboxylate + ethanol
-
-
-
?
oxybutynin + H2O
2-cyclohexyl-2-phenylglycolic acid + 4-(diethylamino)but-2-yn-1-ol
-
-
-
?
oxybutynin + H2O
2-cyclohexyl-2-phenylglycolic acid + ?
-
-
-
?
oxybutynin + H2O
?
-
-
-
-
?
p-nitrophenol butanoate + H2O
p-nitrophenol + butanoate
-
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
p-nitrophenyl butanoate + H2O
p-nitrophenol + butanoate
p-nitrophenyl butyrate
p-nitrophenol + butyrate
p-nitrophenyl butyrate + H2O
p-nitrophenol + butanoate
-
-
-
?
p-nitrophenyl caprate
p-nitrophenol + caprate
p-nitrophenyl caproate
p-nitrophenol + caproate
p-nitrophenyl caproate + H2O
p-nitrophenol + caproate
p-nitrophenyl caprylate + H2O
p-nitrophenol + caprylate
-
-
-
-
?
p-nitrophenyl decanoate
p-nitrophenol + octanoate
p-nitrophenyl hexanoate + H2O
p-nitrophenol + hexanoate
p-nitrophenyl laurate
p-nitrophenol + laurate
-
-
-
?
p-nitrophenyl myristate + H2O
p-nitrophenol + myristate
-
-
-
-
?
p-nitrophenyl octanoate
p-nitrophenol + octanoate
p-nitrophenyl palmitate
p-nitrophenol + palmitate
-
-
-
?
p-nitrophenyl palmitate + H2O
p-nitrophenol + palmitate
p-nitrophenyl pentanoate + H2O
p-nitrophenol + pentanoate
-
and substrates with longer acyl chains, hydrolysis proceeds in biophasic manner
-
-
?
p-nitrophenyl propionate
p-nitrophenol + propionate
-
-
-
?
p-nitrophenyl stearate
p-nitrophenol + stearate
-
-
-
?
p-nitrophenyl stearate + H2O
p-nitrophenol + stearate
-
50% of the activity with p-nitrophenyl decanoate
-
-
?
p-nitrophenyl valerate + H2O
p-nitrophenol + valeric acid
p-tolyl octanoate + H2O
p-toluol + octanoate
-
-
?
palmitin + H2O
?
-
-
-
-
?
palmitoyl-CoA
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
palmitic acid + CoA
paraoxon + H2O
diethylphosphate + 4-nitrophenol
penicillin G + H2O
6-aminopenicillanic acid + phenylacetic acid
-
-
-
-
?
pentyl acetate + H2O
pentanol + acetate
pentyl octanoate + H2O
pentanol + octanoate
-
-
?
pentyl PABC-Doxazolidine + H2O
PABC-Doxazolidine + pentanol
-
-
-
-
?
pentyl valerate + H2O
pentanol + valeric acid
not hydrolysed in the absence of Triton X-100
-
-
?
phenacetin + H2O
?
-
-
-
?
phenolphthalein dibutyrate + H2O
?
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
phenyl butyrate + H2O
phenol + butyrate
phenyl formate + H2O
phenol + formate
phenyl pentanoate + H2O
phenol + pentanoate
phenyl pivalate + H2O
phenol + pivalate
phenyl valerate + H2O
valerate + phenol
-
-
-
-
?
phenylthioacetate + H2O
?
phenylthioacetate + H2O
thiophenol + acetate
phenylthiobutyrate + H2O
thiophenol + butyrate
-
-
-
-
?
phenylthioisobutyrate + H2O
thiophenol + isobutyrate
-
-
-
-
?
phenylthiopentanoate + H2O
thiophenol + pentanoate
-
-
-
-
?
phenylthiopropionate + H2O
thiophenol + propionate
-
-
-
-
?
polyisoprenylated methylated protein + H2O
?
-
-
-
-
?
pranlukast + H2O
?
-
effectively hydrolyzed by carboxylesterase pI 6.2 but not by the pI 6.0 enzyme
-
-
?
prilocaine + H2O
o-toluidine + N-propylalanine
-
-
-
?
procaine + H2O
4-aminobenzoic acid + 2-(diethylamino)ethanol
-
-
-
?
proline-beta-naphthylamide + H2O
?
prop-2-yn-1-yl 2-(4-((5-chloro-3-fluoropyridin-2-yl)oxy)phenoxy)propanoate + H2O
2-(4-((5-chloro-3-fluoropyridin-2-yl)oxy)phenoxy)propanoic acid + prop-2-yn-1-ol
i.e. clodinafop propargyl
-
-
?
propanil + H2O
3,4-dichloroaniline + propanoate
-
-
-
?
propoxur + H2O
?
-
poor substrate
-
-
?
propyl 4-aminobenzoate + H2O
4-aminobenzoate + propanol
propyl acetate + H2O
propanol + acetate
propyl paraben + H2O
propanol + 4-hydroxybenzoate
rac-2-acetoxy-2-(2'-chlorophenyl) acetate + H2O
?
Rac-ibuprofen methyl ester + H2O
Rac-ibuprofen + methanol
-
-
-
-
?
ramipril + H2O
?
-
-
-
-
?
resorufine-butyrate + H2O
?
low activity
-
?
retinyl palmitate + H2O
retinol + palmitate
S-acetylthiocholine iodide + H2O
thiocholine iodide + acetate
-
low activity
-
-
?
S-butyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]ethanethioate + H2O
?
-
-
-
?
S-butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
-
low activity
-
-
?
S-methyl thiobutanoate + H2O
methanol + thiobutanoate
activity with mutant enzyme expressed from the gene that has a deletion of about 60 residues at the N terminus
-
-
?
S-methyl thiobutyrate + H2O
?
-
-
-
?
sarin + H2O
?
-
CE1 exhibits a 5fold preference for the PS isomer of a sarin analog
-
-
?
sec-butyl acetate + H2O
sec-butanol + acetate
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
-
?
t-butyl acetate + H2O
t-butanol + acetate
-
-
-
?
t-butyl-gamma-(t-butoxycarbonylamino)-butyrate + H2O
?
-
effective removal of t-butyl protecting group in organic synthesis
-
?
temephos + H2O
?
-
poor substrate
-
-
?
temocapril + H2O
(2S)-2-[[(2S,6R)-4-(carboxymethyl)-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-6-yl]amino]-4-phenylbutanoic acid + ethanol
-
ratio of the rates of hydrolysis in liver to intestine 734
-
-
?
temocapril + H2O
temocaprilat + ethanol
-
-
-
?
tert-butyl acetate + H2O
tert-butanol + acetate
-
-
-
?
trandolapril + H2O
?
-
-
-
-
?
trandolapril + H2O
trandolaprilat + ?
-
trandolapril is a CES1 selective substrate while CES2 exerts little to no catalytic activity towards this compound
-
-
?
trans-cypermethrin + H2O
?
trans-methyl cinnamate + H2O
methanol + cinnamate
-
very low activity
-
?
trans-permethrin + H2O
(1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid + (3-phenoxyphenyl)methanol
-
-
-
-
?
triacetin + H2O
acetic acid + glycerol
tributyrin + H2O
butanoate + glycerol
tributyrylglycerol + H2O
butyrate + glycerol
tricaproin + H2O
?
-
poor substrate
-
-
?
tricaproin + H2O
caproic acid + glycerol
tricaprylin + H2O
?
-
poor substrate
-
-
?
tricaprylin + H2O
caprylic acid + glycerol
-
8.1% of the activity with tributyrin
-
-
?
trinotecan + H2O
?
-
-
-
-
?
triolein + H2O
oleic acid + glycerol
-
-
-
-
?
tripropionin + H2O
propanoic acid + glycerol
tripropionin + H2O
propionic acid + glycerol
-
-
-
?
Tween 20 + H2O
?
-
-
-
-
?
Tween 80 + H2O
?
-
-
-
-
?
vinyl acetate + H2O
vinyl alcohol + acetate
vinyl butanoate + H2O
vinyl alcohol + butanoate
vinyl butyrate + H2O
vinyl alcohol + butyrate
vinyl caproate + H2O
vinyl alcohol + caproate
-
-
-
-
?
vinyl caprylate + H2O
vinyl alcohol + caprylate
-
-
-
-
?
vinyl hexanoate + H2O
vinyl alcohol + hexanoate
vinyl laurate + H2O
vinyl alcohol + laurate
vinyl octanoate + H2O
vinyl alcohol + octanoate
-
-
?
vinyl propionate + H2O
vinyl alcohol + propionate
xylan + H2O
?
-
polymeric xylan, low activity by the wild-type enzyme, no activity by enzyme mutant NaM1H2
-
-
?
additional information
?
-
(+)-1,2-O-isopropylidenglycerol caprylate + H2O
(+)-1,2-O-isopropylidenglycerol + caprylate
-
-
-
-
?
(+)-1,2-O-isopropylidenglycerol caprylate + H2O
(+)-1,2-O-isopropylidenglycerol + caprylate
-
-
-
-
?
(+)-1,2-O-isopropylidenglycerol caprylate + H2O
(+)-1,2-O-isopropylidenglycerol + caprylate
-
-
-
-
?
(+/-)-1,2-O-isopropylidenglycerol butanoate + H2O
(+/-)-1,2-O-isopropylidenglycerol + butanoate
-
-
-
-
?
(+/-)-1,2-O-isopropylidenglycerol butanoate + H2O
(+/-)-1,2-O-isopropylidenglycerol + butanoate
-
no substrate for isoform CesB
-
-
?
(+/-)-1,2-O-isopropylidenglycerol butanoate + H2O
(+/-)-1,2-O-isopropylidenglycerol + butanoate
-
-
-
-
?
(+/-)-1,2-O-isopropylidenglycerol butanoate + H2O
(+/-)-1,2-O-isopropylidenglycerol + butanoate
-
no substrate for isoform CesB
-
-
?
(+/-)-1,2-O-isopropylidenglycerol butanoate + H2O
(+/-)-1,2-O-isopropylidenglycerol + butanoate
-
-
-
-
?
(+/-)-1,2-O-isopropylidenglycerol butanoate + H2O
(+/-)-1,2-O-isopropylidenglycerol + butanoate
-
no substrate for isoform CesB
-
-
?
(-)-1,2-O-isopropylidenglycerol caprylate + H2O
(-)-1,2-O-isopropylidenglycerol + caprylate
-
-
-
-
?
(-)-1,2-O-isopropylidenglycerol caprylate + H2O
(-)-1,2-O-isopropylidenglycerol + caprylate
-
no substrate for isoform CesB
-
-
?
(-)-1,2-O-isopropylidenglycerol caprylate + H2O
(-)-1,2-O-isopropylidenglycerol + caprylate
-
-
-
-
?
(-)-1,2-O-isopropylidenglycerol caprylate + H2O
(-)-1,2-O-isopropylidenglycerol + caprylate
-
-
-
-
?
(1R)-bioresmethrin + H2O
?
-
substrate for isoform hCE1, not for hCE2
-
-
?
(1R)-bioresmethrin + H2O
?
-
-
-
-
?
(1RS)-cis-permethrin + H2O
cis-dichlorochrysamthemic acid + 3-phenoxybenzyl alcohol
-
isoforms hCE1 and hCE2 hydrolyze trans-permethrin 8- and 28fold more efficiently than cis-permethrin, resp.
-
-
?
(1RS)-cis-permethrin + H2O
cis-dichlorochrysamthemic acid + 3-phenoxybenzyl alcohol
-
-
-
-
?
(1RS)-cis-permethrin + H2O
cis-dichlorochrysamthemic acid + 3-phenoxybenzyl alcohol
-
-
-
-
?
(1RS)-trans-permethrin + H2O
trans-dichlorochrysamthemic acid + 3-phenoxybenzyl alcohol
-
isoforms hCE1 and hCE2 hydrolyze trans-permethrin 8- and 28fold more efficiently than cis-permethrin, resp.
-
-
?
(1RS)-trans-permethrin + H2O
trans-dichlorochrysamthemic acid + 3-phenoxybenzyl alcohol
-
-
-
-
?
(1RS)-trans-permethrin + H2O
trans-dichlorochrysamthemic acid + 3-phenoxybenzyl alcohol
-
-
-
-
?
(E)-2-(2-(6-((4-acetoxybenzyl)oxy)-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indolium + H2O
(E)-2-(2-(6-hydroxy-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indol-1-ium + 4-methylphenol + acetate
-
-
-
-
?
(E)-2-(2-(6-((4-acetoxybenzyl)oxy)-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indolium + H2O
(E)-2-(2-(6-hydroxy-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indol-1-ium + 4-methylphenol + acetate
-
-
-
-
?
(R)-propranolyl 2-methyl-n-valerate + H2O
(R)-propranolol + 2-methylpentanoate
-
-
-
?
(R)-propranolyl 2-methyl-n-valerate + H2O
(R)-propranolol + 2-methylpentanoate
-
-
-
?
(R)-propranolyl 2-methylbutanoate + H2O
(R)-propranolol + 2-methylbutanoate
-
-
-
?
(R)-propranolyl 2-methylbutanoate + H2O
(R)-propranolol + 2-methylbutanoate
-
-
-
?
(R)-propranolyl 3-methylbutanoate + H2O
(R)-propranolol + 3-methylbutanoate
-
-
-
?
(R)-propranolyl 3-methylbutanoate + H2O
(R)-propranolol + 3-methylbutanoate
-
-
-
?
(R)-propranolyl 3-methylpentanoate + H2O
(R)-propranolol + 3-methylpentanoate
-
-
-
?
(R)-propranolyl 3-methylpentanoate + H2O
(R)-propranolol + 3-methylpentanoate
-
-
-
?
(R)-propranolyl hexanoate + H2O
(R)-propranolol + hexanoate
-
-
-
?
(R)-propranolyl hexanoate + H2O
(R)-propranolol + hexanoate
-
-
-
?
(R)-propranolyl n-valerate + H2O
(R)-propranolol + pentanoate
-
-
-
?
(R)-propranolyl n-valerate + H2O
(R)-propranolol + pentanoate
-
-
-
?
(S)-1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone + H2O
(2S)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline + (isoquinolin-5-yloxy)acetic acid
-
-
-
-
?
(S)-1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone + H2O
(2S)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline + (isoquinolin-5-yloxy)acetic acid
-
cleavage of the amide bond, inhibited by bis(p-nitrophenyl) phosphate
-
-
?
(S)-1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone + H2O
(2S)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline + (isoquinolin-5-yloxy)acetic acid
-
-
-
-
?
(S)-1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone + H2O
(2S)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline + (isoquinolin-5-yloxy)acetic acid
-
cleavage of the amide bond, inhibited by bis(p-nitrophenyl) phosphate
-
-
?
(S)-ibuprofen methyl ester + H2O
(S)-ibuprofen + methanol
-
the enzyme has S-form specificity for ibuprofen
-
-
?
(S)-ibuprofen methyl ester + H2O
(S)-ibuprofen + methanol
-
the enzyme has S-form specificity for ibuprofen
-
-
?
(S)-ketoprofen ethyl ester + H2O
(S)-ketoprofen + ethanol
-
the wild-type enzyme shows low enantioselectivity toward (S)-ketoprofen ethyl ester. Mutant enzymes V138G and V138G/L200R shows improved enantioselectivity toward (S)-ketoprofen ethyl ester. The enantioselectivity of V138G and V138G/L200R is greatly improved in Tween 80
-
-
?
(S)-ketoprofen ethyl ester + H2O
(S)-ketoprofen + ethanol
enantioselective activity, best substrate
-
?
(S)-ketoprofen ethyl ester + H2O
(S)-ketoprofen + ethanol
enantioselective activity, best substrate
-
?
(S)-naproxen methyl ester + H2O
(S)-naproxen + methanol
-
-
-
-
?
(S)-naproxen methyl ester + H2O
(S)-naproxen + methanol
-
i.e. (+)-(S)-2-(6-methoxy-2-naphthyl)propionic acid, 98% enantiomeric excess
-
?
(S)-naproxen methyl ester + H2O
(S)-naproxen + methanol
-
the enzyme yields highly optically pure (S) naproxen
-
-
?
(S)-naproxen methyl ester + H2O
(S)-naproxen + methanol
-
the enzyme yields highly optically pure (S) naproxen
-
-
?
(S)-propranolol 3-methylpentanoate + H2O
(S)-propranolol + 3-methylpentanoate
-
-
-
?
(S)-propranolol 3-methylpentanoate + H2O
(S)-propranolol + 3-methylpentanoate
-
-
-
?
(S)-propranolyl 2-methylbutanoate + H2O
(S)-propranolol + 2-methylbutanoate
-
-
-
?
(S)-propranolyl 2-methylbutanoate + H2O
(S)-propranolol + 2-methylbutanoate
-
-
-
?
(S)-propranolyl 2-methylpentanoate + H2O
(S)-propranolol + 2-methylpentanoate
-
-
-
?
(S)-propranolyl 2-methylpentanoate + H2O
(S)-propranolol + 2-methylpentanoate
-
-
-
?
(S)-propranolyl 3-methylbutanoate + H2O
(S)-propranolol + 3-methylbutanoate
-
-
-
?
(S)-propranolyl 3-methylbutanoate + H2O
(S)-propranolol + 3-methylbutanoate
-
-
-
?
(S)-propranolyl hexanoate + H2O
(S)-propranolol + hexanoate
-
-
-
?
(S)-propranolyl hexanoate + H2O
(S)-propranolol + hexanoate
-
-
-
?
(S)-propranolyl n-valerate + H2O
(S)-propranolol + pentanoate
-
-
-
?
(S)-propranolyl n-valerate + H2O
(S)-propranolol + pentanoate
-
-
-
?
(Z)-3-hexenyl acetate + H2O
(Z)-3-hexenol + acetate
-
-
-
-
?
(Z)-3-hexenyl acetate + H2O
(Z)-3-hexenol + acetate
-
nearly 100% hydrolysis (native enzyme), 89.2% hydrolysis (recombinant enzyme)
-
-
?
1,2-O-dilauryl-rac-glycero-3-glutaric acid-resorufin ester + H2O
?
-
-
-
?
1,2-O-dilauryl-rac-glycero-3-glutaric acid-resorufin ester + H2O
?
-
-
-
?
1-monocaprylylglycerol + H2O
caprylic acid + glycerol
-
-
-
-
?
1-monocaprylylglycerol + H2O
caprylic acid + glycerol
-
27% of the activity with tributyrin
-
-
?
1-monolauroyl-glycerol + H2O
lauric acid + glycerol
-
-
-
-
?
1-monolauroyl-glycerol + H2O
lauric acid + glycerol
-
10.0% of the activity with tributyrin
-
-
?
1-monomyristoyl-glycerol + H2O
myristic acid + glycerol
-
-
-
-
?
1-monomyristoyl-glycerol + H2O
myristic acid + glycerol
-
11.6% of the activity with tributyrin
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl butanoate + H2O
1-naphthol + butanoate
-
-
-
-
?
1-naphthyl butanoate + H2O
1-naphthol + butanoate
-
54% of the activity with 1-naphthyl acetate
-
-
?
1-naphthyl butyrate + H2O
1-naphthol + butyrate
-
-
-
-
?
1-naphthyl butyrate + H2O
1-naphthol + butyrate
-
-
-
-
?
1-naphthyl butyrate + H2O
1-naphthol + butyrate
-
-
-
-
?
1-naphthyl butyrate + H2O
1-naphthol + butyrate
-
-
-
-
?
1-naphthyl butyrate + H2O
1-naphthol + butyrate
-
-
-
-
?
1-naphthyl propionate + H2O
1-naphthol + propionate
-
-
-
-
?
1-naphthyl propionate + H2O
1-naphthol + propionate
-
-
-
-
?
1-naphthyl propionate + H2O
1-naphthol + propionate
-
-
-
-
?
1-naphthyl propionate + H2O
1-naphthol + propionate
-
-
-
-
?
2'-ethylcarbonate-linked paclitaxel + H2O
paclitaxel + propanoate
-
-
-
-
?
2'-ethylcarbonate-linked paclitaxel + H2O
paclitaxel + propanoate
-
-
-
-
?
2'-ethylcarbonate-linked paclitaxel + H2O
paclitaxel + propanoate
-
-
-
-
?
2,4-dinitrophenyl butyrate + H2O
2,4-dinitrophenol + butyrate
-
-
-
-
?
2,4-dinitrophenyl butyrate + H2O
2,4-dinitrophenol + butyrate
-
-
-
-
?
2,4-dinitrophenyl butyrate + H2O
2,4-dinitrophenol + butyrate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
substrate of mutant L233G
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
substrate of mutant L233G
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl propionate + H2O
2-naphthol + propionate
-
-
-
-
?
2-naphthyl propionate + H2O
2-naphthol + propionate
-
-
-
-
?
2-naphthyl propionate + H2O
2-naphthol + propionate
-
-
-
-
?
2-naphthyl propionate + H2O
2-naphthol + propionate
-
-
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
-
-
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
-
crude enzyme extract
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
-
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
-
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
-
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
-
-
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
-
-
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
-
-
-
?
2-nitrophenyl butyrate + H2O
2-nitrophenol + butyrate
-
-
-
-
?
2-nitrophenyl butyrate + H2O
2-nitrophenol + butyrate
-
-
-
-
?
2-nitrophenyl butyrate + H2O
2-nitrophenol + butyrate
-
-
-
-
?
2-nitrophenyl butyrate + H2O
2-nitrophenol + butyrate
-
-
-
-
?
2-nitrophenyl butyrate + H2O
2-nitrophenol + butyrate
-
-
-
-
?
2-nitrophenyl butyrate + H2O
2-nitrophenol + butyrate
-
-
-
-
?
2-octanyl acetate + H2O
2-octanol + acetate
the mutant enzyme R11G/L36P/V225A/I551L/A564T treated twice with acetone has a 9fold increase for enantioselectivity in resolution of 2-octanyl acetate relative to that purified by Ni-chelating column, but the wild-type enzyme is less sensitive to acetone in terms of enantioselectivity
-
-
?
2-octanyl acetate + H2O
2-octanol + acetate
the mutant enzyme R11G/L36P/V225A/I551L/A564T treated twice with acetone has a 9fold increase for enantioselectivity in resolution of 2-octanyl acetate relative to that purified by Ni-chelating column, but the wild-type enzyme is less sensitive to acetone in terms of enantioselectivity
-
-
?
2-phenyl-3-butyn-2-yl acetate + H2O
2-phenyl-3-butyn-2-ol + acetate
-
model substrate for study of enantioselectivity in the enzyme reaction, overview
-
?
2-phenyl-3-butyn-2-yl acetate + H2O
2-phenyl-3-butyn-2-ol + acetate
-
model substrate for study of enantioselectivity in the enzyme reaction, low enantioselectivity, overview
-
?
2-phenyloxazolin-5-one + H2O
?
-
-
-
-
?
2-phenyloxazolin-5-one + H2O
?
-
-
-
-
?
2-phenyloxazolin-5-one + H2O
?
-
-
-
-
?
3-methyl-1-pentyn-3-yl acetate + H2O
3-methyl-1-pentyn-3-ol + acetate
-
-
-
?
3-methyl-1-pentyn-3-yl acetate + H2O
3-methyl-1-pentyn-3-ol + acetate
-
model substrate for study of enantioselectivity in the enzyme reaction, no enantioselectivity by the wild-type enzyme, overview
-
?
3-methyl-1-pentyn-3-yl acetate + H2O
3-methyl-1-pentyn-3-ol + acetate
-
model substrate for study of enantioselectivity in the enzyme reaction, low enantioselectivity, overview
-
?
3-nitrophenyl butyrate + H2O
3-nitrophenol + butyrate
-
-
-
-
?
3-nitrophenyl butyrate + H2O
3-nitrophenol + butyrate
-
-
-
-
?
3-phenoxybenzyl (1R,3R)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(1R,3R)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylic acid + (3-phenoxyphenyl)methanol
-
i.e. 1R-cis-NRDC157
-
-
?
3-phenoxybenzyl (1R,3R)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(1R,3R)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylic acid + (3-phenoxyphenyl)methanol
-
i.e. 1R-cis-NRDC157
-
-
?
3-phenoxybenzyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid + (3-phenoxyphenyl)methanol
-
i.e. 1R-trans-permethrin, strong chiral preference for the 1S over the 1R isomers of permethrin
-
-
?
3-phenoxybenzyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid + (3-phenoxyphenyl)methanol
-
i.e. 1R-trans-permethrin, strong chiral preference for the 1S over the 1R isomers of permethrin
-
-
?
3-phenoxybenzyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid + (3-phenoxyphenyl)methanol
-
i.e. 1S-trans-permethrin, strong chiral preference for the 1S over the 1R isomers of permethrin
-
-
?
3-phenoxybenzyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid + (3-phenoxyphenyl)methanol
-
i.e. 1S-trans-permethrin, strong chiral preference for the 1S over the 1R isomers of permethrin
-
-
?
3-phenoxybenzyl (1S,3S)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(1S,3S)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylic acid + (3-phenoxyphenyl)methanol
-
i.e. 1S-cis-NRDC157
-
-
?
3-phenoxybenzyl (1S,3S)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(1S,3S)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylic acid + (3-phenoxyphenyl)methanol
-
i.e. 1S-cis-NRDC157
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferol + acetate
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferol + acetate
-
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferol + acetate
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferol + acetate
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferol + acetate
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferol + acetate
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferol + acetate
-
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferone + acetate
-
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferone + acetate
-
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferone + acetate
-
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferone + acetate
-
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferone + acetate
-
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferone + acetate
-
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferone + acetate
-
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferone + acetate
-
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferone + acetate
-
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferone + acetate
-
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferone + acetate
-
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferone + acetate
-
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferone + acetate
-
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferone + acetate
-
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferone + acetate
-
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferone + acetate
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferone + acetate
-
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferone + acetate
-
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferone + acetate
-
-
-
-
?
4-methylumbelliferyl butyrate + H2O
4-methylumbelliferol + butyrate
-
-
-
?
4-methylumbelliferyl butyrate + H2O
4-methylumbelliferol + butyrate
-
-
-
-
?
4-methylumbelliferyl butyrate + H2O
4-methylumbelliferol + butyrate
high activity
-
?
4-methylumbelliferyl butyrate + H2O
4-methylumbelliferol + butyrate
-
-
-
?
4-methylumbelliferyl butyrate + H2O
4-methylumbelliferone + butyrate
-
-
-
-
?
4-methylumbelliferyl butyrate + H2O
4-methylumbelliferone + butyrate
-
-
-
-
?
4-methylumbelliferyl butyrate + H2O
4-methylumbelliferone + butyrate
-
-
-
-
?
4-methylumbelliferyl butyrate + H2O
4-methylumbelliferone + butyrate
-
hydrolysis is 50% compared to 4-methylumbelliferyl acetate
-
-
?
4-methylumbelliferyl butyrate + H2O
4-methylumbelliferone + butyrate
-
-
-
-
?
4-methylumbelliferyl butyrate + H2O
4-methylumbelliferone + butyrate
-
-
-
-
?
4-methylumbelliferyl heptanoate + H2O
4-methylumbelliferol + heptanoate
-
-
-
?
4-methylumbelliferyl heptanoate + H2O
4-methylumbelliferol + heptanoate
-
enzyme activity in decreasing order: 4-methylumbelliferyl butanoate, 4-methylumbelliferyl heptanoate, 4-methylumbelliferyl oleate
-
-
?
4-methylumbelliferyl heptanoate + H2O
4-methylumbelliferol + heptanoate
-
-
-
?
4-methylumbelliferyl heptanoate + H2O
4-methylumbelliferol + heptanoate
-
-
-
-
?
4-methylumbelliferyl heptanoate + H2O
4-methylumbelliferone + heptanoate
-
-
-
-
?
4-methylumbelliferyl heptanoate + H2O
4-methylumbelliferone + heptanoate
-
-
-
-
?
4-methylumbelliferyl heptanoate + H2O
4-methylumbelliferone + heptanoate
-
-
-
?
4-methylumbelliferyl octanoate + H2O
4-methylumbelliferone + octanoate
-
-
-
-
?
4-methylumbelliferyl octanoate + H2O
4-methylumbelliferone + octanoate
-
-
-
-
?
4-methylumbelliferyl oleate + H2O
4-methylumbelliferol + oleate
-
-
-
-
?
4-methylumbelliferyl oleate + H2O
4-methylumbelliferol + oleate
-
-
-
-
?
4-methylumbelliferyl oleate + H2O
4-methylumbelliferol + oleate
-
enzyme activity in decreasing order: 4-methylumbelliferyl butanoate, 4-methylumbelliferyl heptanoate, 4-methylumbelliferyl oleate
-
-
?
4-methylumbelliferyl p-trimethylammoniocinnamate chloride + H2O
4-methylumbelliferol + p-trimethylammoniocinnamate chloride
-
-
-
-
?
4-methylumbelliferyl p-trimethylammoniocinnamate chloride + H2O
4-methylumbelliferol + p-trimethylammoniocinnamate chloride
-
-
-
-
?
4-methylumbelliferyl palmitate + H2O
4-methylumbelliferol + palmitate
-
-
-
?
4-methylumbelliferyl palmitate + H2O
4-methylumbelliferol + palmitate
-
-
-
?
4-methylumbelliferyl palmitate + H2O
4-methylumbelliferone + palmitate
-
-
-
-
?
4-methylumbelliferyl palmitate + H2O
4-methylumbelliferone + palmitate
-
hydrolysis is 7% compared to 4-methylumbelliferyl acetate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
r
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
converted twice as fast as the corresponding palmitate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
high activity
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
92% of the activity with 4-nitrophenyl butanoate
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
about 30% activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
about 30% activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
best substrate
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
Est55, 30% of the activity with 4-nitrophenyl butanoate, Est30, 20% of the activity with 4-nitrophenyl caproate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
ratio of the rates of hydrolysis in liver to intestine 2.1
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
substrate for both isoform CES1 and CES2
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
best substrate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
15% of the activity with 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
15% of the activity with 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
at 37°C, 14% of the activity with pentanoyl-CoA
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
specific activity is less than 10% compared to the activity with caprylate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
hydrolysis at about 70% compared to activity with 4-nitrophenyl pentanoate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
at 37°C, 14% of the activity with pentanoyl-CoA
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
specific activity is less than 10% compared to the activity with caprylate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
hydrolysis at about 70% compared to activity with 4-nitrophenyl pentanoate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
8.8% of the activity with 4-nitrophenyl pentanoate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
the acyl-length selectivity of the proteins against 4-nitrophenyl ester substrates in the order of decreasing efficiency: C8, C6, C4, C3, C2
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
the acyl-length selectivity of the proteins against 4-nitrophenyl ester substrates in the order of decreasing efficiency: C8, C6, C4, C3, C2
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
89% activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
89% activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
about 55% of the activity with 4-nitrophenyl butanoate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
about 55% of the activity with 4-nitrophenyl butanoate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
best substrate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
best substrate of mutants M211V, M211T, M211S and M211S/R215L
-
r
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
Est30, 65% of the activity with 4-nitrophenyl caproate
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
best substrate
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
hydrolysis at about 90% compared to activity with 4-nitrophenyl pentanoate
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
83% of the activity with 4-nitrophenyl pentanoate
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
the acyl-length selectivity of the proteins against 4-nitrophenyl ester substrates in the order of decreasing efficiency: C8, C6, C4, C3, C2
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
the acyl-length selectivity of the proteins against 4-nitrophenyl ester substrates in the order of decreasing efficiency: C8, C6, C4, C3, C2
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
best substrate
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
high level of activity with 4-nitrophenyl butyrate (100%)
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
high level of activity with 4-nitrophenyl butyrate (100%)
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
highest activity
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
best 4-nitrophenyl ester substrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
highest activity (100%)
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
highest activity (100%)
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
4-nitrophenyl propionate and 4-nitrophenyl butyrate are the best substrates
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
best substrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
about 80% activity compared to 4-nitrophenyl caprylate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
about 80% activity compared to 4-nitrophenyl caprylate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
best substrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
best substrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
about 60% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
about 60% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
no activity with wild-type enzyme Mhg but with enzyme L233 mutants
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
no activity with wild-type enzyme Mhg but with enzyme L233 mutants
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
best substrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
best substrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
weak
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
at 37°C, 74% of the activity with pentanoyl-CoA
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
specific activity is about 80% compared to the activity with caprylate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
at 37°C, 74% of the activity with pentanoyl-CoA
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
specific activity is about 80% compared to the activity with caprylate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
most preferable substrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
most preferable substrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
most efficient hydrolysis with 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
most efficient hydrolysis with 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
highest activity
-
-
?
4-nitrophenyl caprate + H2O
4-nitrophenol + caprate
-
-
-
-
?
4-nitrophenyl caprate + H2O
4-nitrophenol + caprate
-
-
-
?
4-nitrophenyl caprate + H2O
4-nitrophenol + caprate
-
-
-
?
4-nitrophenyl caprate + H2O
4-nitrophenol + capric acid
-
-
-
-
?
4-nitrophenyl caprate + H2O
4-nitrophenol + capric acid
-
Est55, 1.6% of the activity with 4-nitrophenyl butanoate, Est30, 32% of the activity with 4-nitrophenyl caproate
-
-
?
4-nitrophenyl caprate + H2O
4-nitrophenol + capric acid
-
-
-
?
4-nitrophenyl caprate + H2O
4-nitrophenol + capric acid
-
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
-
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
65% of the activity with 4-nitrophenyl butanoate
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
about 55% activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
-
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
-
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
Est55, 97% of the activity with 4-nitrophenyl butanoate, activation energy 35.7 kJ/mol. Est30, activation energy 101.9 kJ/mol
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
no activity with wild-type enzyme Mhg but with enzyme mutant L233G
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
no activity with wild-type enzyme Mhg but with enzyme mutant L233G
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
the enzyme shows the highest activity with p-nitrophenyl caproate
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
the enzyme shows the highest activity with p-nitrophenyl caproate
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
82% of the activity with 4-nitrophenyl butanoate
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
82% of the activity with 4-nitrophenyl butanoate
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
-
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
-
-
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
-
45% of the activity with 4-nitrophenyl butanoate
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
-
highest activity
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
-
Est55, 13% of the activity with 4-nitrophenyl butanoate, Est30, 50% of the activity with 4-nitrophenyl caproate
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
maximal activity
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
maximal activity
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
-
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
-
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
the enzyme shows the highest specific activity with p-nitrophenyl caprylate
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
the enzyme shows the highest specific activity with p-nitrophenyl caprylate
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
-
-
-
r
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
-
-
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
about 30% activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
65% activity compared to 4-nitrophenyl caprylate
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
65% activity compared to 4-nitrophenyl caprylate
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
-
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
-
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
-
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
-
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
-
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
specific activity is about 50% compared to the activity with caprylate
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
hydrolysis at about 50% compared to activity with 4-nitrophenyl pentanoate
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
-
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
specific activity is about 50% compared to the activity with caprylate
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
1.8% of the activity with 4-nitrophenyl pentanoate
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
-
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
-
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
-
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
-
14% activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
about 10% of the activity with 4-nitrophenyl butanoate
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
about 10% of the activity with 4-nitrophenyl butanoate
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
-
-
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
4-nitrophenyl decanoate is the most readily hydrolyzed substrate. The activity decreases sharply with increasing the chain length, being 4-nitrophenyldecanoate hydrolyzed at five times the rate of 4-nitrophenyl hexadecanoate
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
preference for medium chain-length esters
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
-
-
-
-
?
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
switch of substrate specificity of hyperthermophilic promiscuous acylaminoacyl peptidase by combination of protein and solvent engineering into a specific carboxylesterase
-
-
?
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
switch of substrate specificity of hyperthermophilic promiscuous acylaminoacyl peptidase by combination of protein and solvent engineering into a specific carboxylesterase
-
-
?
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
-
-
-
?
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
-
-
-
r
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
-
-
-
-
?
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
-
-
-
?
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
about 20% activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
-
-
-
?
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
medium-chain 4-nitrophenyl esters are the preferred substrates, whereas 4-nitrophenyl esters of longer chain fatty acids are poor substrates
-
-
?
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
-
-
-
?
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
-
-
-
?
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
-
-
-
?
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
activity with mutant enzyme expressed from the gene that has a deletion of about 60 residues at the N terminus
-
-
?
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
hydrolysis at about 30% compared to activity with 4-nitrophenyl pentanoate
-
-
?
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
-
-
-
?
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
activity with mutant enzyme expressed from the gene that has a deletion of about 60 residues at the N terminus
-
-
?
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
0.8% of the activity with 4-nitrophenyl pentanoate
-
-
?
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
-
-
-
?
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
-
-
-
?
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
-
-
-
?
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
-
-
-
?
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
4-nitrophenyl decanoate is the most readily hydrolyzed substrate. The activity decreases sharply with increasing the chain length, being 4-nitrophenyldecanoate hydrolyzed at five times the rate of 4-nitrophenyl hexadecanoate
-
-
?
4-nitrophenyl dodecanoate + H2O
4-nitrophenol + dodecanoate
preference for medium chain-length esters
-
-
?
4-nitrophenyl hexadecanoate + H2O
4-nitrophenol + hexadecanoate
-
-
-
r
4-nitrophenyl hexadecanoate + H2O
4-nitrophenol + hexadecanoate
-
-
-
-
?
4-nitrophenyl hexadecanoate + H2O
4-nitrophenol + hexadecanoate
-
-
-
?
4-nitrophenyl hexadecanoate + H2O
4-nitrophenol + hexadecanoate
hydrolysis at less than 10% compared to activity with 4-nitrophenyl pentanoate
-
-
?
4-nitrophenyl hexadecanoate + H2O
4-nitrophenol + hexadecanoate
-
-
-
?
4-nitrophenyl hexadecanoate + H2O
4-nitrophenol + hexadecanoate
4-nitrophenyl decanoate is the most readily hydrolyzed substrate. The activity decreases sharply with increasing the chain length, being 4-nitrophenyldecanoate hydrolyzed at five times the rate of 4-nitrophenyl hexadecanoate
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
best substrate of the wild-type enzyme
-
r
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
lower activity
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
about 30% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
about 30% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
medium-chain 4-nitrophenyl esters are the preferred substrates, whereas 4-nitrophenyl esters of longer chain fatty acids are poor substrates
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
best substrate
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
at 37°C, 69% of the activity with pentanoyl-CoA
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
activity with mutant enzyme expressed from the gene that has a deletion of about 60 residues at the N terminus
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
hydrolysis at about 90% compared to activity with 4-nitrophenyl pentanoate
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
activity with mutant enzyme expressed from the gene that has a deletion of about 60 residues at the N terminus
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
75.4% of the activity with 4-nitrophenyl pentanoate
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
31.6% of the activity with 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
31.5% of the activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
the acyl-length selectivity of the proteins against 4-nitrophenyl ester substrates in the order of decreasing efficiency: C8, C6, C4, C3, C2
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
31.6% of the activity with 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
31.5% of the activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
the acyl-length selectivity of the proteins against 4-nitrophenyl ester substrates in the order of decreasing efficiency: C8, C6, C4, C3, C2
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
78% activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
about 65% of the activity with 4-nitrophenyl butanoate
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
about 65% of the activity with 4-nitrophenyl butanoate
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
37% activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
37% activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
30-35% of the activity with 4-nitrophenyl butanoate
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
58% activity compared to 4-nitrophenyl caprylate
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
specific activity is about 10% compared to the activity with caprylate
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
specific activity is about 10% compared to the activity with caprylate
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + lauric acid
-
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + lauric acid
-
Est55, 0.6% of the activity with 4-nitrophenyl butanoate, Est30, 12% of the activity with 4-nitrophenyl caproate
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + lauric acid
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + lauric acid
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + lauric acid
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + lauric acid
-
-
-
-
?
4-nitrophenyl myristate + H2O
4-nitrophenol + myristate
-
-
-
-
?
4-nitrophenyl myristate + H2O
4-nitrophenol + myristate
36% activity compared to 4-nitrophenyl caprylate
-
-
?
4-nitrophenyl myristate + H2O
4-nitrophenol + myristate
-
-
-
?
4-nitrophenyl myristate + H2O
4-nitrophenol + myristic acid
-
-
-
?
4-nitrophenyl myristate + H2O
4-nitrophenol + myristic acid
-
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
acetone is utilized to purify wild-type and mutant enzymes to improve their activity and enantioselectivity
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
acetone is utilized to purify wild-type and mutant enzymes to improve their activity and enantioselectivity
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
r
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
low activity
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
about 45% activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
about 45% activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
about 5% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
about 5% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
medium-chain 4-nitrophenyl esters are the preferred substrates, whereas 4-nitrophenyl esters of longer chain fatty acids are poor substrates
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
hydrolysis at about 75% compared to activity with 4-nitrophenyl pentanoate
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
11.5% of the activity with 4-nitrophenyl pentanoate
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
16.7% of the activity with 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
16.7% of the activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
the acyl-length selectivity of the proteins against 4-nitrophenyl ester substrates in the order of decreasing efficiency: C8, C6, C4, C3, C2
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
16.7% of the activity with 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
16.7% of the activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
the acyl-length selectivity of the proteins against 4-nitrophenyl ester substrates in the order of decreasing efficiency: C8, C6, C4, C3, C2
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
46% activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
about 30% of the activity with 4-nitrophenyl butanoate
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
about 30% of the activity with 4-nitrophenyl butanoate
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
low activity by mutant NaM1H2, not by wild-type enzyme
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
-
5% activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
-
5% activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
-
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
-
-
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
-
low activity
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
12% activity compared to 4-nitrophenyl caprylate
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
-
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
low activity
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
low activity
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
-
-
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
-
-
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
-
-
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
-
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
-
-
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
79% of the activity with 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
-
?
4-nitrophenyl propanoate + H2O
4-nitrophenol + propanoate
-
Est55, 50% of the activity with 4-nitrophenyl butanoate, Est30, 45% of the activity with 4-nitrophenyl caproate
-
-
?
4-nitrophenyl propanoate + H2O
4-nitrophenol + propanoate
about 95% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl propanoate + H2O
4-nitrophenol + propanoate
about 95% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl propanoate + H2O
4-nitrophenol + propanoate
-
-
-
?
4-nitrophenyl propanoate + H2O
4-nitrophenol + propanoate
-
-
-
?
4-nitrophenyl propanoate + H2O
4-nitrophenol + propanoate
hydrolysis at about 85% compared to activity with 4-nitrophenyl pentanoate
-
-
?
4-nitrophenyl propanoate + H2O
4-nitrophenol + propanoate
the acyl-length selectivity of the proteins against 4-nitrophenyl ester substrates in the order of decreasing efficiency: C8, C6, C4, C3, C2
-
-
?
4-nitrophenyl propanoate + H2O
4-nitrophenol + propanoate
the acyl-length selectivity of the proteins against 4-nitrophenyl ester substrates in the order of decreasing efficiency: C8, C6, C4, C3, C2
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
about 70% activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
about 70% activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
4-nitrophenyl propionate and 4-nitrophenyl butyrate are the best substrates
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
18% of the activity with 4-nitrophenyl pentanoate
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
77% of the activity with 4-nitrophenyl butanoate
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
77% of the activity with 4-nitrophenyl butanoate
-
?
4-nitrophenyl tetradecanoate + H2O
4-nitrophenol + tetradecanoate
-
-
-
r
4-nitrophenyl tetradecanoate + H2O
4-nitrophenol + tetradecanoate
-
-
-
-
?
4-nitrophenyl tetradecanoate + H2O
4-nitrophenol + tetradecanoate
hydrolysis at less tha 10% compared to activity with 4-nitrophenyl pentanoate
-
-
?
4-nitrophenyl tetradecanoate + H2O
4-nitrophenol + tetradecanoate
-
-
-
?
4-nitrophenyl tetradecanoate + H2O
4-nitrophenol + tetradecanoate
4-nitrophenyl decanoate is the most readily hydrolyzed substrate. The activity decreases sharply with increasing the chain length, being 4-nitrophenyldecanoate hydrolyzed at five times the rate of 4-nitrophenyl hexadecanoate
-
-
?
4-nitrophenyl tetradecanoate + H2O
4-nitrophenol + tetradecanoate
preference for medium chain-length esters
-
-
?
4-nitrophenyl valerate + H2O
4-nitrophenol + valerate
-
-
-
?
4-nitrophenyl valerate + H2O
4-nitrophenol + valerate
-
-
-
-
?
4-nitrophenyl valerate + H2O
4-nitrophenol + valerate
-
-
-
-
?
4-nitrophenyl valerate + H2O
4-nitrophenol + valerate
-
high activity
-
-
?
4-nitrophenyl valerate + H2O
4-nitrophenol + valerate
-
-
-
-
?
4-nitrophenyl valerate + H2O
4-nitrophenol + valerate
-
-
?
4-nitrophenyl valerate + H2O
4-nitrophenol + valerate
-
-
-
-
?
4-nitrophenyl valerate + H2O
4-nitrophenol + valerate
-
-
-
-
?
4-nitrophenyl valerate + H2O
4-nitrophenol + valerate
-
-
-
-
?
5-methyl-2-(propan-2-yl)cyclohexyl acetate + H2O
?
-
substrate of mutant L233P
-
-
?
5-methyl-2-(propan-2-yl)cyclohexyl acetate + H2O
?
-
substrate of mutant L233P
-
-
?
7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin + H2O
7-ethyl-10-hydroxycampothecin + ?
-
i.e. irinotecan, CPT-11, prodrug
i.e. SN-38, topoisomerase inhibitor used in cancer therapy
-
?
7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin + H2O
7-ethyl-10-hydroxycampothecin + ?
-
i.e. irinotecan, CPT-11, prodrug
i.e. SN-38, topoisomerase inhibitor used in cancer therapy
-
?
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin + H2O
7-ethyl-10-hydroxy-camptothecin + ?
-
activation of the prodrug, i.e. CPT-11 or irinotecan, a commercial topoisomerase I inhibitor commonly used for treatment of colorectal tumors
i.e. SN-38
?
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin + H2O
7-ethyl-10-hydroxy-camptothecin + ?
-
i.e. CPT-11 or irinotecan, a commercial topoisomerase I inhibitor commonly used for treatment of colorectal tumors
i.e. SN-38
?
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin + H2O
7-ethyl-10-hydroxy-camptothecin + ?
-
isozyme CE-2 is responsible for activation of the prodrug
i.e. SN-38
?
acetylsalicylic acid + H2O
salicylic acid + acetate
-
ratio of the rates of hydrolysis in liver to intestine 0.94
-
-
?
acetylsalicylic acid + H2O
salicylic acid + acetate
-
-
-
?
alpha-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
alpha-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
B3SST1; B3SST2
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
high activity
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
enzyme activity increases from acetate to propionate to butanoate substrate
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
preferred substrate for the enzyme from the malathion-suceptible strain
-
?
alpha-naphthyl butyrate + H2O
alpha-naphthol + butyrate
-
-
-
?
alpha-naphthyl butyrate + H2O
alpha-naphthol + butyrate
-
-
-
?
alpha-naphthyl butyrate + H2O
alpha-naphthol + butyrate
-
-
?
alpha-naphthyl butyrate + H2O
alpha-naphthol + butyrate
-
-
-
-
?
alpha-naphthyl butyrate + H2O
alpha-naphthol + butyrate
-
-
-
?
alpha-naphthyl caprylate + H2O
alpha-naphthol + caprylate
-
-
-
?
alpha-naphthyl caprylate + H2O
alpha-naphthol + caprylate
-
-
-
?
alpha-naphthyl propionate + H2O
alpha-naphthol + propionate
-
-
-
?
alpha-naphthyl propionate + H2O
alpha-naphthol + propionate
-
enzyme activity increases from acetate to propionate to butanoate substrate
-
-
?
Amplex red + H2O
resorufin + acetate
Amplex red is readily converted to resorufin by a carboxylesterase without requiring H2O2, horseradish peroxidase, or oxygen
-
-
?
Amplex red + H2O
resorufin + acetate
Amplex red is readily converted to resorufin by a carboxylesterase without requiring H2O2, horseradish peroxidase, or oxygen
-
-
?
aspirin + H2O
acetate + salicylate
-
no activity
-
-
ir
aspirin + H2O
acetate + salicylate
-
-
-
-
ir
aspirin + H2O
acetate + salicylate
-
-
-
-
ir
benzyl acetate + H2O
benzyl alcohol + acetate
-
-
-
-
?
benzyl acetate + H2O
benzyl alcohol + acetate
-
-
-
-
?
benzyloxycarbonyl-D-Tyr-p-nitrophenyl ester + H2O
benzyloxycarbonyl-D-Tyr + 4-nitrophenol
-
-
-
-
?
benzyloxycarbonyl-D-Tyr-p-nitrophenyl ester + H2O
benzyloxycarbonyl-D-Tyr + 4-nitrophenol
-
-
-
-
?
benzyloxycarbonyl-D-Tyr-p-nitrophenyl ester + H2O
benzyloxycarbonyl-D-Tyr + 4-nitrophenol
-
-
-
-
?
benzyloxycarbonyl-L-Tyr-p-nitrophenyl ester + H2O
benzyloxycarbonyl-L-Tyr + 4-nitrophenol
-
-
-
-
?
benzyloxycarbonyl-L-Tyr-p-nitrophenyl ester + H2O
benzyloxycarbonyl-L-Tyr + 4-nitrophenol
-
-
-
-
?
benzyloxycarbonyl-L-Tyr-p-nitrophenyl ester + H2O
benzyloxycarbonyl-L-Tyr + 4-nitrophenol
-
-
-
-
?
benzyloxycarbonyl-L-Tyr-p-nitrophenyl ester + H2O
benzyloxycarbonyl-L-Tyr + 4-nitrophenol
-
-
-
-
?
beta-naphthyl acetate + H2O
beta-naphthol + acetate
-
-
-
?
beta-naphthyl acetate + H2O
beta-naphthol + acetate
-
-
-
?
beta-naphthyl acetate + H2O
beta-naphthol + acetate
Culex sp.
-
-
-
-
?
beta-naphthyl acetate + H2O
beta-naphthol + acetate
-
-
-
?
beta-naphthyl acetate + H2O
beta-naphthol + acetate
-
-
-
-
?
beta-naphthyl acetate + H2O
beta-naphthol + acetate
-
-
-
-
?
beta-naphthyl acetate + H2O
beta-naphthol + acetate
-
-
-
?
bioresmethrin + H2O
?
-
-
-
-
?
bioresmethrin + H2O
?
-
-
-
-
?
bioresmethrin + H2O
?
-
-
-
?
butanilicain + H2O
?
-
-
-
-
?
butanilicain + H2O
?
-
i.e. N-butylglycyl-2-chloro-6-methylanilide
-
-
?
butyl 2-(4-[[5-(trifluoromethyl)pyridin-2-yl]oxy]phenoxy)propanoate + H2O
fluazifop-P + butanol
-
-
-
?
butyl 2-(4-[[5-(trifluoromethyl)pyridin-2-yl]oxy]phenoxy)propanoate + H2O
fluazifop-P + butanol
i.e. fluazifop-P-butyl
-
-
?
butyl 2-[4-(4-cyano-2-fluorophenoxy)phenoxy]propanoate + H2O
cyhalofop + butanol
-
-
-
?
butyl 2-[4-(4-cyano-2-fluorophenoxy)phenoxy]propanoate + H2O
cyhalofop + butanol
i.e. cyhalofop-butyl
-
-
?
butyl 4-aminobenzoate + H2O
4-aminobenzoate + butanol
-
-
-
?
butyl 4-aminobenzoate + H2O
4-aminobenzoate + butanol
-
-
-
?
butyl acetate + H2O
butanol + acetate
-
-
-
?
butyl acetate + H2O
butanol + acetate
the enzyme preferentially hydrolyzes esters of short-chain fatty acids (C2C4) and especially those of medium chain (C5C6) fatty acids with short chain alcohols
-
-
?
butyl acetate + H2O
butanol + acetate
-
-
?
butyl acetate + H2O
butanol + acetate
-
-
-
?
butyl benzoate + H2O
benzoate + butanol
-
at 5-6% of the rate of monobutyl phthalate
-
-
?
butyl benzoate + H2O
benzoate + butanol
-
at 5-6% of the rate of monobutyl phthalate
-
-
?
butyrylthiocholine + H2O
butyric acid + thiocholine
-
activity of serum enzyme, no activity of liver enzyme
-
-
?
butyrylthiocholine + H2O
butyric acid + thiocholine
-
-
-
-
?
camptothecin-11 + H2O
?
-
i.e. CPT-11, an anti-tumor agent
-
-
?
camptothecin-11 + H2O
?
-
i.e. CPT-11
-
-
?
camptothecin-11 + H2O
?
-
i.e. CPT-11, an anti-tumor agent
-
-
?
camptothecin-11 + H2O
?
-
i.e. CPT-11
-
-
?
capecitabin + H2O
?
-
-
-
-
?
capecitabin + H2O
?
-
-
-
-
?
capecitabin + H2O
?
-
-
-
?
capecitabin + H2O
?
-
-
-
-
?
capecitabin + H2O
?
-
-
-
-
?
capecitabin + H2O
?
-
-
-
-
?
cholesterol ester + H2O
?
-
-
-
-
?
cholesterol ester + H2O
?
-
-
-
-
?
cholesterol ester + H2O
?
-
-
-
-
?
cholesterol oleate + H2O
cholesterol + oleate
-
-
-
-
?
cholesterol oleate + H2O
cholesterol + oleate
-
-
-
-
?
cilazapril + H2O
?
-
-
-
-
?
cilazapril + H2O
?
-
-
-
-
?
cilazapril + H2O
?
-
-
-
?
cilazapril + H2O
?
-
-
-
-
?
cilazapril + H2O
?
-
-
-
-
?
cilazapril + H2O
?
-
-
-
-
?
cis-cypermethrin + H2O
?
-
-
-
?
cis-cypermethrin + H2O
?
-
-
-
?
cis-cypermethrin + H2O
?
-
-
-
?
cis-permethrin + H2O
?
-
-
-
?
cis-permethrin + H2O
?
-
-
-
?
clopidogrel + H2O
(2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoic acid + methanol
-
-
-
-
?
clopidogrel + H2O
(2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoic acid + methanol
-
an anti-thrombogenic agent
-
-
?
clopidogrel + H2O
(2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoic acid + methanol
-
-
-
-
?
clopidogrel + H2O
(2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoic acid + methanol
-
an anti-thrombogenic agent
-
-
?
cocaine + H2O
benzoylecgonine + methanol
the enzyme mainly performs methyl ester hydrolysis. Spontaneous degradation of cocaine will start in a buffer with pH 7.0 at room temperature
-
-
?
cocaine + H2O
benzoylecgonine + methanol
the enzyme mainly performs methyl ester hydrolysis. Spontaneous degradation of cocaine will start in a buffer with pH 7.0 at room temperature
-
-
?
cocaine + H2O
benzoylecgonine + methanol
the enzyme mainly performs methyl ester hydrolysis. Spontaneous degradation of cocaine will start in a buffer with pH 7.0 at room temperature
-
-
?
cocaine + H2O
benzoylecgonine + methanol
the enzyme mainly performs methyl ester hydrolysis. Spontaneous degradation of cocaine will start in a buffer with pH 7.0 at room temperature
-
-
?
cocaine + H2O
benzoylecgonine + methanol
the enzyme mainly performs methyl ester hydrolysis. Spontaneous degradation of cocaine will start in a buffer with pH 7.0 at room temperature
-
-
?
cocaine + H2O
benzoylecgonine + methanol
the enzyme mainly performs methyl ester hydrolysis. Spontaneous degradation of cocaine will start in a buffer with pH 7.0 at room temperature
-
-
?
cocaine + H2O
benzoylecgonine + methanol
the enzyme mainly performs methyl ester hydrolysis. Spontaneous degradation of cocaine will start in a buffer with pH 7.0 at room temperature
-
-
?
cocaine + H2O
benzoylecgonine + methanol
the enzyme mainly performs methyl ester hydrolysis. Spontaneous degradation of cocaine will start in a buffer with pH 7.0 at room temperature
-
-
?
cocaine + H2O
benzoylecgonine + methanol
the enzyme mainly performs methyl ester hydrolysis. Spontaneous degradation of cocaine will start in a buffer with pH 7.0 at room temperature
-
-
?
cocaine + H2O
benzoylecgonine + methanol
the enzyme mainly performs methyl ester hydrolysis. Spontaneous degradation of cocaine will start in a buffer with pH 7.0 at room temperature
-
-
?
cocaine + H2O
ecgonine methyl ester + benzoate
-
specific substrate for isozyme CES1
-
-
?
cocaine + H2O
ecgonine methyl ester + benzoate
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
cocaine + H2O
ecgonine methyl ester + benzoate
-
specific substrate for isozyme CES1
-
-
?
cocaine + H2O
ecgonine methyl ester + benzoate
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
cocaine + H2O
ecgonine methyl ester + benzoate
specific substrate for isozyme CES1
-
-
?
cocaine + H2O
ecgonine methyl ester + benzoate
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
cocaine + H2O
ecgonine methyl ester + benzoate
-
specific substrate for isozyme CES1
-
-
?
cocaine + H2O
ecgonine methyl ester + benzoate
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
cocaine + H2O
ecgonine methyl ester + benzoate
-
specific substrate for isozyme CES1
-
-
?
cocaine + H2O
ecgonine methyl ester + benzoate
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
cocaine + H2O
ecgonine methyl ester + benzoate
-
specific substrate for isozyme CES1
-
-
?
cocaine + H2O
ecgonine methyl ester + benzoate
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
cocaine + H2O
O-benzoylecgonine + methanol
-
-
-
-
?
cocaine + H2O
O-benzoylecgonine + methanol
-
-
-
-
?
cocaine + H2O
O-benzoylecgonine + methanol
-
-
-
-
?
cocaine + H2O
O-benzoylecgonine + methanol
the enzyme is site- and stereospecific for hydrolysis and transesterification of the methyl ester linkage on R-cocaine
-
-
?
cocaine + H2O
O-benzoylecgonine + methanol
CE-1 is responsible for the methyl ester hydrolysis of cocaine
-
-
?
CPT-11 + H2O
SN-38 + 1,4'-bipiperidine-1'-carboxylic acid + CO2
-
other name irinotecan
-
-
?
CPT-11 + H2O
SN-38 + 1,4'-bipiperidine-1'-carboxylic acid + CO2
-
other name irinotecan
-
-
?
CPT-11 + H2O
SN-38 + 1,4'-bipiperidine-1'-carboxylic acid + CO2
-
-
-
-
?
CPT-11 + H2O
SN-38 + 1,4'-bipiperidine-1'-carboxylic acid + CO2
-
CPT-11 is also named irinotecan, i.e. 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin. Human intestine carboxylesterase demonstrates the most efficient kinetic parameters for CPT-11 hydrolysis to the active metabolite SN-38
-
-
?
CPT-11 + H2O
SN-38 + 1,4'-bipiperidine-1'-carboxylic acid + CO2
-
other name irinotecan
-
-
?
CPT-11 + H2O
SN-38 + 1,4'-bipiperidine-1'-carboxylic acid + CO2
-
-
-
-
?
CPT-11 + H2O
SN-38 + ?
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
CPT-11 + H2O
SN-38 + ?
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
CPT-11 + H2O
SN-38 + ?
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
CPT-11 + H2O
SN-38 + ?
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
CPT-11 + H2O
SN-38 + ?
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
CPT-11 + H2O
SN-38 + ?
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
cyclic poly(ethylene terephthalate) trimer + H2O
?
-
-
-
-
?
cyclic poly(ethylene terephthalate) trimer + H2O
?
-
-
-
-
?
cypermethrin + H2O
?
-
-
-
?
cypermethrin + H2O
?
-
-
-
?
deltamethrin + H2O
3-phenoxybenzaldehyde + (1R,3R)-3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropanecarboxylate + cyanide
-
-
-
-
?
deltamethrin + H2O
3-phenoxybenzaldehyde + (1R,3R)-3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropanecarboxylate + cyanide
-
-
-
?
deltamethrin + H2O
3-phenoxybenzaldehyde + (1R,3R)-3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropanecarboxylate + cyanide
-
-
-
?
derapril + H2O
N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-N-(2,3-dihydro-1H-inden-2-yl)glycine + ethanol
-
-
-
?
derapril + H2O
N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-N-(2,3-dihydro-1H-inden-2-yl)glycine + ethanol
-
-
-
-
?
diethyl (6-methoxynaphthalen-2-yl)(methyl)propanedioate + H2O
ethanol + (2S)-3-ethoxy-2-(6-methoxynaphthalen-2-yl)-2-methyl-3-oxopropanoic acid
-
-
-
?
diethyl (6-methoxynaphthalen-2-yl)(methyl)propanedioate + H2O
ethanol + (2S)-3-ethoxy-2-(6-methoxynaphthalen-2-yl)-2-methyl-3-oxopropanoic acid
-
-
-
?
diethyl methyl(phenyl)propanedioate + H2O
ethanol + (2S)-3-ethoxy-2-methyl-3-oxo-2-phenylpropanoic acid
-
-
-
?
diethyl methyl(phenyl)propanedioate + H2O
ethanol + (2S)-3-ethoxy-2-methyl-3-oxo-2-phenylpropanoic acid
-
-
-
?
diolein + H2O
?
-
-
-
-
?
diolein + H2O
?
-
-
-
-
?
DL-methyl 2-chloropropionate + H2O
?
25% of the activity with methyl DL-beta-acetylthioisobutyrate
-
-
?
DL-methyl 2-chloropropionate + H2O
?
as active as with methyl DL-beta-acetylthioisobutyrate
-
-
?
DL-methyl 2-chloropropionate + H2O
?
25% of the activity with methyl DL-beta-acetylthioisobutyrate
-
-
?
DL-methyl 2-chloropropionate + H2O
?
as active as with methyl DL-beta-acetylthioisobutyrate
-
-
?
ethanol + acetate
ethyl acetate + H2O
-
esterification reaction
-
?
ethanol + acetate
ethyl acetate + H2O
ester formation
-
?
ethyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate + H2O
ethanol + (2S)-2-(6-methoxynaphthalen-2-yl)propanoate
-
-
-
?
ethyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate + H2O
ethanol + (2S)-2-(6-methoxynaphthalen-2-yl)propanoate
-
-
-
?
ethyl (2S)-2-phenylpropanoate + H2O
ethanol + (2S)-2-phenylpropanoate
-
-
-
?
ethyl (2S)-2-phenylpropanoate + H2O
ethanol + (2S)-2-phenylpropanoate
-
-
-
?
ethyl (trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate) + H2O
ethanol + trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate
-
i.e. ethyl cetraxate
-
?
ethyl (trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate) + H2O
ethanol + trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate
-
i.e. ethyl cetraxate
-
?
ethyl 2-[4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy]propanoate
fenoxaprop-P + ethanol
-
-
-
?
ethyl 2-[4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy]propanoate
fenoxaprop-P + ethanol
i.e. fenoxaprop-P-ethyl
-
-
?
ethyl 2-[4-[(6-chloroquinoxalin-2-yl)oxy]phenoxy]propanoate + H2O
quizalofop-P + ethanol
-
-
-
?
ethyl 2-[4-[(6-chloroquinoxalin-2-yl)oxy]phenoxy]propanoate + H2O
quizalofop-P + ethanol
i.e. quizalofop-P-ethyl
-
-
?
ethyl 4-aminobenzoate + H2O
4-aminobenzoate + ethanol
-
-
-
?
ethyl 4-aminobenzoate + H2O
4-aminobenzoate + ethanol
-
-
-
?
ethyl acetate + H2O
ethanol + acetate
-
-
-
?
ethyl acetate + H2O
ethanol + acetate
-
-
-
-
?
ethyl acetate + H2O
ethanol + acetate
-
-
-
-
?
ethyl acetate + H2O
ethanol + acetate
-
-
?
ethyl acetate + H2O
ethanol + acetate
-
-
?
ethyl acetate + H2O
ethanol + acetate
-
-
-
?
ethyl acetate + H2O
ethanol + acetate
-
-
-
?
ethyl acetate + H2O
ethanol + acetate
-
-
-
-
?
ethyl acetate + H2O
ethanol + acetate
-
-
-
?
ethyl acetate + H2O
ethanol + acetate
-
-
-
?
ethyl acetate + H2O
ethanol + acetate
-
-
-
?
ethyl butanoate + H2O
ethanol + butanoate
-
-
?
ethyl butanoate + H2O
ethanol + butanoate
-
-
-
?
ethyl butyrate + H2O
ethanol + butanoate
the enzyme preferentially hydrolyzes esters of short-chain fatty acids (C2C4) and especially those of medium chain (C5C6) fatty acids with short chain alcohols
-
-
?
ethyl butyrate + H2O
ethanol + butanoate
-
-
-
?
ethyl butyrate + H2O
ethanol + butyrate
-
-
-
-
?
ethyl butyrate + H2O
ethanol + butyrate
-
-
-
-
?
ethyl butyrate + H2O
ethanol + butyrate
-
-
-
-
?
ethyl butyrate + H2O
ethanol + butyrate
-
-
-
-
?
ethyl butyrate + H2O
ethanol + butyrate
-
-
-
-
?
ethyl DL-beta-acetylthioisobutyrate + H2O
?
40% of the activity with methyl DL-beta-acetylthioisobutyrate
-
-
?
ethyl DL-beta-acetylthioisobutyrate + H2O
?
40% of the activity with methyl DL-beta-acetylthioisobutyrate
-
-
?
ethyl fexofenadine + H2O
fexofenadine + ethanol
-
-
-
?
ethyl fexofenadine + H2O
fexofenadine + ethanol
-
-
-
?
ethyl hexanoate + H2O
ethanol + hexanoate
-
-
?
ethyl hexanoate + H2O
ethanol + hexanoate
-
-
-
?
ethyl hexanoate + H2O
ethanol + hexanoate
-
-
?
ethyl paraben + H2O
ethanol + 4-hydroxybenzoate
-
best substrate
-
?
ethyl paraben + H2O
ethanol + 4-hydroxybenzoate
-
best substrate
-
?
ethyl pentanoate + H2O
ethanol + pentanoate
-
-
?
ethyl pentanoate + H2O
ethanol + pentanoate
-
-
-
?
ethyl propionate + H2O
ethanol + propionate
-
-
-
?
ethyl propionate + H2O
ethanol + propionate
the enzyme preferentially hydrolyzes esters of short-chain fatty acids (C2C4) and especially those of medium chain (C5C6) fatty acids with short chain alcohols
-
-
?
ethyl propionate + H2O
ethanol + propionate
-
-
-
-
?
ethyl propionate + H2O
ethanol + propionate
-
-
?
ethyl propionate + H2O
ethanol + propionate
-
-
-
-
?
ethylene glycol dibenzoate + H2O
?
-
-
-
?
ethylene glycol dibenzoate + H2O
?
-
-
-
?
fenvalerate + H2O
?
-
-
-
?
fenvalerate + H2O
?
-
-
-
?
fenvalerate + H2O
?
-
-
-
?
fluorescein diacetate + H2O
?
-
-
-
?
fluorescein diacetate + H2O
?
-
specific probe substrate for isoform CES2
-
-
?
fluorescein diacetate + H2O
?
-
-
-
-
?
fluorescein diacetate + H2O
fluorescein + acetate
-
-
-
?
fluorescein diacetate + H2O
fluorescein + acetate
-
-
-
-
?
glucose pentaacetate + H2O
?
-
-
-
-
?
glucose pentaacetate + H2O
?
-
-
-
-
?
glyceryl tributyrate + H2O
?
-
-
-
-
?
glyceryl tributyrate + H2O
?
-
-
-
?
glyceryl tributyrate + H2O
?
activity with mutant enzyme expressed from the gene that has a deletion of about 60 residues at the N terminus
-
-
?
glyceryl tributyrate + H2O
?
activity with mutant enzyme expressed from the gene that has a deletion of about 60 residues at the N terminus
-
-
?
glyceryl tridecanoate + H2O
?
activity with mutant enzyme expressed from the gene that has a deletion of about 60 residues at the N terminus
-
-
?
glyceryl tridecanoate + H2O
?
activity with mutant enzyme expressed from the gene that has a deletion of about 60 residues at the N terminus
-
-
?
glyceryl trioleate + H2O
?
-
-
-
-
?
glyceryl trioleate + H2O
?
-
-
-
?
glyceryl trioleate + H2O
?
activity with mutant enzyme expressed from the gene that has a deletion of about 60 residues at the N terminus
-
-
?
glyceryl trioleate + H2O
?
activity with mutant enzyme expressed from the gene that has a deletion of about 60 residues at the N terminus
-
-
?
heptyl acetate + H2O
heptanol + acetate
-
-
-
-
?
heptyl acetate + H2O
heptanol + acetate
-
lower activity
-
-
?
heroin + H2O
6-monoacetylmorphine + acetate
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
heroin + H2O
6-monoacetylmorphine + acetate
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
heroin + H2O
6-monoacetylmorphine + acetate
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
heroin + H2O
6-monoacetylmorphine + acetate
hCE1 can metabolize the conversion of heroin to both 6-monoacetylmorphine and morphine. hCE1 is able to catalyze both reactions, but it is more efficient at the hydrolysis of heroin to 6-monoacetylmorphine, the first step of heroin metabolism
-
-
?
heroin + H2O
6-monoacetylmorphine + acetate
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
heroin + H2O
6-monoacetylmorphine + acetate
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
heroin + H2O
6-monoacetylmorphine + acetate
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
hexyl acetate + H2O
hexanol + acetate
-
-
?
hexyl acetate + H2O
hexanol + acetate
-
-
-
-
?
hydroxyethylflurbiprofen + H2O
ethanol + flurbiprofen
-
-
-
-
?
hydroxyethylflurbiprofen + H2O
ethanol + flurbiprofen
-
-
-
-
?
hydroxyethylflurbiprofen + H2O
ethanol + flurbiprofen
-
-
-
-
?
hydroxyethylflurbiprofen + H2O
ethanol + flurbiprofen
-
-
-
-
?
hydroxypropylflurbiprofen + H2O
propanol + flurbiprofen
-
-
-
-
?
hydroxypropylflurbiprofen + H2O
propanol + flurbiprofen
-
-
-
-
?
hydroxypropylflurbiprofen + H2O
propanol + flurbiprofen
-
-
-
-
?
hydroxypropylflurbiprofen + H2O
propanol + flurbiprofen
-
-
-
-
?
imidapril + H2O
?
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
imidapril + H2O
?
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
imidapril + H2O
?
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
imidapril + H2O
?
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
imidapril + H2O
?
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
imidapril + H2O
?
-
-
-
-
?
imidapril + H2O
?
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
imidapril + H2O
imidaprilat + ?
-
-
-
?
imidapril + H2O
imidaprilat + ?
-
-
-
-
?
indoxyl acetate + H2O
indol-3-ol + acetate
-
-
-
-
?
indoxyl acetate + H2O
indol-3-ol + acetate
-
-
-
-
?
irinotecan + H2O
7-ethyl-10-hydroxycampothecin + 1,4'-bipiperidine-1'-carboxylic acid
antitumor prodrug, poor substrate
-
-
?
irinotecan + H2O
7-ethyl-10-hydroxycampothecin + 1,4'-bipiperidine-1'-carboxylic acid
antitumor prodrug, poor substrate
-
-
?
irinotecan + H2O
?
-
other name CPT-11
-
-
?
irinotecan + H2O
?
-
other name CPT-11
-
-
?
irinotecan + H2O
?
-
other name CPT-11
-
-
?
irinotecan + H2O
?
-
-
-
-
?
isopropyl (trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate) + H2O
isopropanol + trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate
-
i.e. propyl cetraxate
-
?
isopropyl (trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate) + H2O
isopropanol + trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate
-
i.e. propyl cetraxate
-
?
isopropyl acetate + H2O
isopropanol + acetate
-
-
-
-
?
isopropyl acetate + H2O
isopropanol + acetate
-
-
-
?
L-Tyr ethyl ester + H2O
L-Tyr + ethanol
-
-
-
-
?
L-Tyr ethyl ester + H2O
L-Tyr + ethanol
-
-
-
-
?
lidocaine + H2O
2,6-xylidine + N,N-diethylglycine
-
-
-
?
lidocaine + H2O
2,6-xylidine + N,N-diethylglycine
the CES1A substrate lidocaine is metabolized to 2,6-xylidine via a MEGX intermediate
-
-
?
linalyl acetate + H2O
linalool + acetate
-
-
-
?
linalyl acetate + H2O
linalool + acetate
-
model substrate for study of enantioselectivity in the enzyme reaction, overview
-
?
linalyl acetate + H2O
linalool + acetate
-
model substrate for study of enantioselectivity in the enzyme reaction, low enantioselectivity, overview
-
?
malathion + H2O
?
i.e. S-(1,2-dicarbethoxyethyl)-O,O-dimethyldithiophosphate
-
-
?
malathion + H2O
?
i.e. S-(1,2-dicarbethoxyethyl)-O,O-dimethyldithiophosphate
-
-
?
malathion + H2O
?
-
poor substrate
-
-
?
malathion + H2O
?
Culex sp.
-
-
-
-
?
malathion + H2O
?
-
-
-
?
malathion + H2O
?
-
-
-
?
malathion + H2O
?
-
preferred substrate for the malathion esterase from the malathion-resistant strain
-
?
meperidine + H2O
?
-
specific substrate for isozyme CES1
-
-
?
meperidine + H2O
?
-
specific substrate for isozyme CES1
-
-
?
meperidine + H2O
?
specific substrate for isozyme CES1
-
-
?
meperidine + H2O
?
-
specific substrate for isozyme CES1
-
-
?
meperidine + H2O
?
-
specific substrate for isozyme CES1
-
-
?
meperidine + H2O
?
-
specific substrate for isozyme CES1
-
-
?
methyl (trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate) + H2O
methanol + trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate
-
i.e. methyl cetraxate
-
?
methyl (trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate) + H2O
methanol + trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate
-
i.e. methyl cetraxate
-
?
methyl 2-(4-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy]phenoxy)propanoate + H2O
haloxyfop-P + methanol
-
-
-
?
methyl 2-(4-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy]phenoxy)propanoate + H2O
haloxyfop-P + methanol
i.e. haloxyfop-P-methyl
-
-
?
methyl 2-[4-(2,4-dichlorophenoxy)phenoxy]propanoate + H2O
diclofop + methanol
-
-
-
?
methyl 2-[4-(2,4-dichlorophenoxy)phenoxy]propanoate + H2O
diclofop + methanol
i.e. diclofop-methyl
-
-
?
methyl 4-aminobenzoate + H2O
4-aminobenzoate + methanol
-
-
-
?
methyl 4-aminobenzoate + H2O
4-aminobenzoate + methanol
-
-
-
?
methyl acetate + H2O
methanol + acetate
-
-
-
?
methyl acetate + H2O
methanol + acetate
the enzyme preferentially hydrolyzes esters of short-chain fatty acids (C2C4) and especially those of medium chain (C5C6) fatty acids with short chain alcohols
-
-
?
methyl acetate + H2O
methanol + acetate
-
-
-
-
?
methyl acetate + H2O
methanol + acetate
-
-
-
?
methyl acetate + H2O
methanol + acetate
-
-
-
?
methyl butanoate + H2O
methanol + butanoate
-
-
-
-
?
methyl butanoate + H2O
methanol + butanoate
-
-
-
-
?
methyl butyrate + H2O
methanol + butyrate
-
-
-
?
methyl butyrate + H2O
methanol + butyrate
-
-
-
-
?
methyl butyrate + H2O
methanol + butyrate
-
-
-
-
?
methyl butyrate + H2O
methanol + butyrate
-
-
-
-
?
methyl butyrate + H2O
methanol + butyrate
-
-
-
-
?
methyl butyrate + H2O
methanol + butyrate
-
-
-
-
?
methyl butyrate + H2O
methanol + butyrate
-
-
-
-
?
methyl butyrate + H2O
methanol + butyrate
-
-
-
-
?
methyl butyrate + H2O
methanol + butyrate
-
-
-
-
?
methyl butyrate + H2O
methanol + butyrate
-
-
-
-
?
methyl DL-beta-acetylthioisobutyrate + H2O
D-beta-acetylthioisobutyrate + methanol
produces D-beta-acetylthioisobutyrate with a degree of conversion of 49.5% and an enantiomeric excess value of 97.2% at an optimum pH of about 8-10 and an optimum temperature of about 57 to 67°C
-
-
?
methyl DL-beta-acetylthioisobutyrate + H2O
D-beta-acetylthioisobutyrate + methanol
produces D-beta-acetylthioisobutyrate with a degree of conversion of 49.5% and an enantiomeric excess value of 97.2% at an optimum pH of about 8-10 and an optimum temperature of about 57 to 67°C
-
-
?
methyl hexanoate + H2O
methanol + hexanoate
-
-
-
?
methyl hexanoate + H2O
methanol + hexanoate
the enzyme preferentially hydrolyzes esters of short-chain fatty acids (C2C4) and especially those of medium chain (C5C6) fatty acids with short chain alcohols
-
-
?
methyl hexanoate + H2O
methanol + hexanoate
-
-
-
-
?
methyl hexanoate + H2O
methanol + hexanoate
-
-
-
-
?
methyl octanoate + H2O
methanol + octanoate
-
-
-
-
?
methyl octanoate + H2O
methanol + octanoate
-
-
?
methyl octanoate + H2O
methanol + octanoate
-
-
-
-
?
methyl paraben + H2O
methanol + 4-hydroxybenzoate
-
-
-
?
methyl paraben + H2O
methanol + 4-hydroxybenzoate
-
-
-
?
methyl propionate + H2O
methanol + propionate
-
-
-
?
methyl propionate + H2O
methanol + propionate
the enzyme preferentially hydrolyzes esters of short-chain fatty acids (C2C4) and especially those of medium chain (C5C6) fatty acids with short chain alcohols
-
-
?
methyl propionate + H2O
methanol + propionate
-
no activity
-
-
?
methyl propionate + H2O
methanol + propionate
-
hydrolyzed at highest rate among the fatty acid methyl esters
-
-
?
methyl propionate + H2O
methanol + propionate
-
hydrolyzed at highest rate among the fatty acid methyl esters
-
-
?
methylphenidate + H2O
?
-
specific substrate for isozyme CES1
-
-
?
methylphenidate + H2O
?
-
specific substrate for isozyme CES1
-
-
?
methylphenidate + H2O
?
specific substrate for isozyme CES1
-
-
?
methylphenidate + H2O
?
-
specific substrate for isozyme CES1
-
-
?
methylphenidate + H2O
?
-
specific substrate for isozyme CES1
-
-
?
methylphenidate + H2O
?
-
specific substrate for isozyme CES1
-
-
?
methylprednisolone 21-hemisuccinate + H2O
?
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
methylprednisolone 21-hemisuccinate + H2O
?
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
methylprednisolone 21-hemisuccinate + H2O
?
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
methylprednisolone 21-hemisuccinate + H2O
?
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
methylprednisolone 21-hemisuccinate + H2O
?
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
methylprednisolone 21-hemisuccinate + H2O
?
-
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
monobutyl phthalate + H2O
phthalate + butanol
-
-
-
-
?
monobutyl phthalate + H2O
phthalate + butanol
-
-
-
-
?
monoolein + H2O
glycerol + oleic acid
-
-
-
-
?
monoolein + H2O
glycerol + oleic acid
-
-
-
-
?
monopentyl phthalate + H2O
phthalate + pentanol
-
at 50% of the rate of monobutyl phthalate
-
-
?
monopentyl phthalate + H2O
phthalate + pentanol
-
at 50% of the rate of monobutyl phthalate
-
-
?
monopropyl phthalate + H2O
phthalate + propanol
-
at 12-19% of the rate of monobutyl phthalate
-
-
?
monopropyl phthalate + H2O
phthalate + propanol
-
at 12-19% of the rate of monobutyl phthalate
-
-
?
N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester + H2O
?
-
specific enzyme substrate
-
-
?
N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester + H2O
?
-
specific enzyme substrate
-
-
?
N-acetyl-DL-phenylalanine beta-naphthyl ester + H2O
N-acetyl-DL-phenylalanine + beta-naphthol
NAPBNE, a chromogenic substrate of chymotrypsin-like enzymes
-
-
?
N-acetyl-DL-phenylalanine beta-naphthyl ester + H2O
N-acetyl-DL-phenylalanine + beta-naphthol
NAPBNE, a chromogenic substrate of chymotrypsin-like enzymes
-
-
?
n-butyl n-butyrate + H2O
n-butanol + n-butyrate
-
-
-
-
?
n-butyl n-butyrate + H2O
n-butanol + n-butyrate
-
-
-
-
?
n-hexyl acetate + H2O
n-hexanol + acetate
-
-
-
-
?
n-hexyl acetate + H2O
n-hexanol + acetate
-
-
-
-
?
naphthyl acetate + H2O
naphthol + acetate
-
-
-
?
naphthyl acetate + H2O
naphthol + acetate
-
-
-
-
?
naphthyl acetate + H2O
naphthol + acetate
-
-
-
-
?
naphthyl acetate + H2O
naphthol + acetate
-
-
-
-
?
O-butyryl propranolol + H2O
butanoate + propranolol
-
-
-
-
?
O-butyryl propranolol + H2O
butanoate + propranolol
-
preferential hydrolysis of R-isomer by liver enzyme
-
-
?
O-butyryl propranolol + H2O
butanoate + propranolol
-
preferential hydrolysis of R-isomer by liver and intestine enzyme, non-enantioselective
-
-
?
O-butyryl propranolol + H2O
butanoate + propranolol
-
preferential hydrolysis of S-isomer by liver enzyme
-
-
?
octyl acetate + H2O
octanol + acetate
-
-
-
?
octyl acetate + H2O
octanol + acetate
-
lower activity
-
-
?
oleoyl-CoA + H2O
oleic acid + CoA
-
-
-
?
oleoyl-CoA + H2O
oleic acid + CoA
-
-
-
-
?
oseltamivir + H2O
?
-
specific substrate for isozyme CES1
-
-
?
oseltamivir + H2O
?
-
specific substrate for isozyme CES1
-
-
?
oseltamivir + H2O
?
-
-
-
-
?
oseltamivir + H2O
?
specific substrate for isozyme CES1
-
-
?
oseltamivir + H2O
?
-
an anti-viral drug
-
-
?
oseltamivir + H2O
?
-
specific substrate for isozyme CES1
-
-
?
oseltamivir + H2O
?
-
specific substrate for isozyme CES1
-
-
?
oseltamivir + H2O
?
-
-
-
-
?
oseltamivir + H2O
?
-
an anti-viral drug
-
-
?
oseltamivir + H2O
?
-
specific substrate for isozyme CES1
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
-
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
-
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
hydrolysis proceeds in linear manner, 15% of the reaction rate with p-nitrophenyl butyrate
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
hydrolysis proceeds in linear manner, 15% of the reaction rate with p-nitrophenyl butyrate
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
-
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
-
-
-
?
p-nitrophenyl butanoate + H2O
p-nitrophenol + butanoate
-
-
-
-
?
p-nitrophenyl butanoate + H2O
p-nitrophenol + butanoate
-
-
-
-
?
p-nitrophenyl butanoate + H2O
p-nitrophenol + butanoate
-
-
-
-
?
p-nitrophenyl butanoate + H2O
p-nitrophenol + butanoate
-
-
-
-
?
p-nitrophenyl butyrate
p-nitrophenol + butyrate
-
-
-
?
p-nitrophenyl butyrate
p-nitrophenol + butyrate
-
-
-
-
?
p-nitrophenyl butyrate
p-nitrophenol + butyrate
-
-
-
-
?
p-nitrophenyl caprate
p-nitrophenol + caprate
-
-
-
?
p-nitrophenyl caprate
p-nitrophenol + caprate
-
-
-
-
?
p-nitrophenyl caproate
p-nitrophenol + caproate
-
-
-
?
p-nitrophenyl caproate
p-nitrophenol + caproate
-
-
-
-
?
p-nitrophenyl caproate
p-nitrophenol + caproate
-
-
-
-
?
p-nitrophenyl caproate + H2O
p-nitrophenol + caproate
-
-
-
-
?
p-nitrophenyl caproate + H2O
p-nitrophenol + caproate
-
-
-
-
?
p-nitrophenyl decanoate
p-nitrophenol + octanoate
-
-
-
-
?
p-nitrophenyl decanoate
p-nitrophenol + octanoate
-
-
-
-
?
p-nitrophenyl hexanoate + H2O
p-nitrophenol + hexanoate
-
-
-
-
?
p-nitrophenyl hexanoate + H2O
p-nitrophenol + hexanoate
-
-
-
?
p-nitrophenyl octanoate
p-nitrophenol + octanoate
-
-
-
-
?
p-nitrophenyl octanoate
p-nitrophenol + octanoate
-
-
-
-
?
p-nitrophenyl palmitate + H2O
p-nitrophenol + palmitate
-
-
-
?
p-nitrophenyl palmitate + H2O
p-nitrophenol + palmitate
-
50% of the activity with p-nitrophenyl decanoate
-
-
?
p-nitrophenyl palmitate + H2O
p-nitrophenol + palmitate
-
-
-
-
?
p-nitrophenyl valerate + H2O
p-nitrophenol + valeric acid
-
79% of the reaction rate with p-nitrophenyl butyrate
-
-
?
p-nitrophenyl valerate + H2O
p-nitrophenol + valeric acid
-
-
-
-
?
p-nitrophenyl valerate + H2O
p-nitrophenol + valeric acid
-
-
-
-
?
palmitoyl-CoA + H2O
palmitic acid + CoA
weak
-
-
?
palmitoyl-CoA + H2O
palmitic acid + CoA
-
-
-
-
?
paraoxon + H2O
diethylphosphate + 4-nitrophenol
-
-
-
-
?
paraoxon + H2O
diethylphosphate + 4-nitrophenol
-
-
-
-
?
paraoxon + H2O
diethylphosphate + 4-nitrophenol
-
-
-
-
?
pentyl acetate + H2O
pentanol + acetate
-
-
-
-
?
pentyl acetate + H2O
pentanol + acetate
-
-
-
?
permethrin + H2O
?
-
the cis-form of permethrin is favorably hydrolyzed by isozyme HCE2, whereas the trans-form is comparably hydrolyzed by HCE1 and HCE2
-
-
?
permethrin + H2O
?
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
the enzyme preferentially hydrolyzes esters of short-chain fatty acids (C2C4) and especially those of medium chain (C5C6) fatty acids with short chain alcohols
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl butyrate + H2O
phenol + butyrate
-
-
-
-
?
phenyl butyrate + H2O
phenol + butyrate
-
-
-
-
?
phenyl butyrate + H2O
phenol + butyrate
-
-
-
-
?
phenyl butyrate + H2O
phenol + butyrate
-
-
-
-
?
phenyl butyrate + H2O
phenol + butyrate
-
-
-
-
?
phenyl butyrate + H2O
phenol + butyrate
-
-
-
-
?
phenyl butyrate + H2O
phenol + butyrate
-
-
-
-
?
phenyl formate + H2O
phenol + formate
-
-
-
-
?
phenyl formate + H2O
phenol + formate
-
-
-
-
?
phenyl formate + H2O
phenol + formate
-
-
-
-
?
phenyl pentanoate + H2O
phenol + pentanoate
-
-
-
-
?
phenyl pentanoate + H2O
phenol + pentanoate
-
-
-
-
?
phenyl pentanoate + H2O
phenol + pentanoate
-
-
-
-
?
phenyl pivalate + H2O
phenol + pivalate
-
-
-
-
?
phenyl pivalate + H2O
phenol + pivalate
-
-
-
-
?
phenyl pivalate + H2O
phenol + pivalate
-
-
-
-
?
phenylthioacetate + H2O
?
-
-
-
?
phenylthioacetate + H2O
?
-
-
-
?
phenylthioacetate + H2O
thiophenol + acetate
-
-
-
-
?
phenylthioacetate + H2O
thiophenol + acetate
-
-
?
phenylthioacetate + H2O
thiophenol + acetate
-
-
?
procaine + H2O
?
-
-
-
?
procaine + H2O
?
-
-
-
-
?
proline-beta-naphthylamide + H2O
?
-
-
-
?
proline-beta-naphthylamide + H2O
?
-
-
-
?
propyl 4-aminobenzoate + H2O
4-aminobenzoate + propanol
-
-
-
?
propyl 4-aminobenzoate + H2O
4-aminobenzoate + propanol
-
-
-
?
propyl acetate + H2O
propanol + acetate
-
-
?
propyl acetate + H2O
propanol + acetate
-
-
-
?
propyl paraben + H2O
propanol + 4-hydroxybenzoate
-
-
-
?
propyl paraben + H2O
propanol + 4-hydroxybenzoate
-
-
-
?
quinapril + H2O
?
-
-
-
-
?
quinapril + H2O
?
-
-
-
-
?
quinapril + H2O
?
-
-
-
?
quinapril + H2O
?
-
-
-
-
?
quinapril + H2O
?
-
-
-
-
?
quinapril + H2O
?
-
-
-
-
?
rac-2-acetoxy-2-(2'-chlorophenyl) acetate + H2O
?
-
-
-
-
?
rac-2-acetoxy-2-(2'-chlorophenyl) acetate + H2O
?
-
-
-
-
?
retinyl palmitate + H2O
retinol + palmitate
-
-
-
-
?
retinyl palmitate + H2O
retinol + palmitate
-
-
-
?
retinyl palmitate + H2O
retinol + palmitate
-
-
?
temocapril + H2O
?
-
specific substrate for isozyme CES1
-
-
?
temocapril + H2O
?
-
specific substrate for isozyme CES1
-
-
?
temocapril + H2O
?
weak
-
-
?
temocapril + H2O
?
specific substrate for isozyme CES1
-
-
?
temocapril + H2O
?
-
specific substrate for isozyme CES1
-
-
?
temocapril + H2O
?
-
specific substrate for isozyme CES1
-
-
?
temocapril + H2O
?
-
-
-
-
?
temocapril + H2O
?
-
specific substrate for isozyme CES1
-
-
?
trans-cypermethrin + H2O
?
-
-
-
?
trans-cypermethrin + H2O
?
-
-
-
?
trans-permethrin + H2O
?
-
-
-
-
?
trans-permethrin + H2O
?
-
-
-
?
trans-permethrin + H2O
?
-
-
-
?
trans-permethrin + H2O
?
-
-
-
?
trans-permethrin + H2O
?
-
-
-
?
triacetin + H2O
?
-
-
-
-
?
triacetin + H2O
?
-
-
-
-
?
triacetin + H2O
?
-
-
-
-
?
triacetin + H2O
?
-
-
-
?
triacetin + H2O
?
-
-
-
-
?
triacetin + H2O
?
-
-
-
?
triacetin + H2O
acetic acid + glycerol
-
-
-
-
?
triacetin + H2O
acetic acid + glycerol
about 65% of the activity with tributyrin
-
-
?
triacetin + H2O
acetic acid + glycerol
-
-
-
-
?
triacetin + H2O
acetic acid + glycerol
-
-
-
-
?
triacetin + H2O
acetic acid + glycerol
-
-
-
?
triacetin + H2O
acetic acid + glycerol
-
-
-
-
?
triacetin + H2O
acetic acid + glycerol
-
-
-
-
?
tributyrin + H2O
?
-
-
-
-
?
tributyrin + H2O
?
-
-
-
-
?
tributyrin + H2O
?
hydrolyzed at a lower rate than short and medium chain fatty acid esters
-
-
?
tributyrin + H2O
?
-
-
-
-
?
tributyrin + H2O
?
-
-
-
?
tributyrin + H2O
?
-
-
-
?
tributyrin + H2O
?
-
-
-
?
tributyrin + H2O
?
-
-
-
-
?
tributyrin + H2O
?
-
-
-
-
?
tributyrin + H2O
?
-
-
-
?
tributyrin + H2O
?
-
-
-
-
?
tributyrin + H2O
?
-
-
-
?
tributyrin + H2O
?
-
-
-
?
tributyrin + H2O
?
no activity with triolein, suggesting that this lipolytic enzyme is not a true lipase
-
-
?
tributyrin + H2O
?
no activity with triolein, suggesting that this lipolytic enzyme is not a true lipase
-
-
?
tributyrin + H2O
?
-
-
-
-
?
tributyrin + H2O
butanoate + glycerol
-
-
-
-
?
tributyrin + H2O
butanoate + glycerol
-
-
-
?
tributyrin + H2O
butanoate + glycerol
-
-
-
?
tributyrin + H2O
butanoate + glycerol
-
-
-
-
?
tributyrin + H2O
butanoate + glycerol
-
-
-
-
?
tributyrin + H2O
butanoate + glycerol
-
-
-
-
?
tributyrylglycerol + H2O
butyrate + glycerol
-
-
-
-
?
tributyrylglycerol + H2O
butyrate + glycerol
-
-
-
-
?
tributyrylglycerol + H2O
butyrate + glycerol
-
-
-
-
?
tributyrylglycerol + H2O
butyrate + glycerol
-
-
-
-
?
tributyrylglycerol + H2O
butyrate + glycerol
-
-
-
-
?
tributyrylglycerol + H2O
butyrate + glycerol
-
-
-
-
?
tributyrylglycerol + H2O
butyrate + glycerol
-
-
-
-
?
tricaproin + H2O
caproic acid + glycerol
-
-
-
-
?
tricaproin + H2O
caproic acid + glycerol
-
19.2% of the activity with tributyrin
-
-
?
triolein + H2O
?
-
-
-
-
?
triolein + H2O
?
-
-
-
-
?
tripropionin + H2O
?
-
-
-
-
?
tripropionin + H2O
?
-
-
-
-
?
tripropionin + H2O
?
-
-
-
?
tripropionin + H2O
?
-
-
-
-
?
tripropionin + H2O
?
-
-
-
-
?
tripropionin + H2O
propanoic acid + glycerol
-
-
-
-
?
tripropionin + H2O
propanoic acid + glycerol
-
-
-
-
?
vinyl acetate + H2O
vinyl alcohol + acetate
-
-
-
-
?
vinyl acetate + H2O
vinyl alcohol + acetate
-
-
-
-
?
vinyl acetate + H2O
vinyl alcohol + acetate
30.5% of the activity with vinyl butyrate
-
-
?
vinyl acetate + H2O
vinyl alcohol + acetate
-
-
-
-
?
vinyl acetate + H2O
vinyl alcohol + acetate
-
-
-
-
?
vinyl acetate + H2O
vinyl alcohol + acetate
-
-
?
vinyl acetate + H2O
vinyl alcohol + acetate
-
-
-
-
?
vinyl acetate + H2O
vinyl alcohol + acetate
-
-
-
-
?
vinyl butanoate + H2O
vinyl alcohol + butanoate
-
-
-
-
?
vinyl butanoate + H2O
vinyl alcohol + butanoate
-
-
-
-
?
vinyl butanoate + H2O
vinyl alcohol + butanoate
-
-
-
-
?
vinyl butanoate + H2O
vinyl alcohol + butanoate
-
-
-
-
?
vinyl butanoate + H2O
vinyl alcohol + butanoate
-
-
-
-
?
vinyl butanoate + H2O
vinyl alcohol + butanoate
-
-
-
-
?
vinyl butyrate + H2O
vinyl alcohol + butyrate
-
-
-
?
vinyl butyrate + H2O
vinyl alcohol + butyrate
-
-
?
vinyl butyrate + H2O
vinyl alcohol + butyrate
-
-
-
?
vinyl hexanoate + H2O
vinyl alcohol + hexanoate
68% of the activity with vinyl butyrate
-
-
?
vinyl hexanoate + H2O
vinyl alcohol + hexanoate
-
-
?
vinyl laurate + H2O
vinyl alcohol + laurate
-
-
-
-
?
vinyl laurate + H2O
vinyl alcohol + laurate
-
-
-
-
?
vinyl laurate + H2O
vinyl alcohol + laurate
-
-
-
-
?
vinyl propionate + H2O
vinyl alcohol + propionate
-
-
-
-
?
vinyl propionate + H2O
vinyl alcohol + propionate
-
-
-
-
?
vinyl propionate + H2O
vinyl alcohol + propionate
55% of the activity with vinyl butyrate
-
-
?
vinyl propionate + H2O
vinyl alcohol + propionate
-
-
-
-
?
vinyl propionate + H2O
vinyl alcohol + propionate
-
-
-
-
?
vinyl propionate + H2O
vinyl alcohol + propionate
-
-
?
vinyl propionate + H2O
vinyl alcohol + propionate
-
-
-
?
vinyl propionate + H2O
vinyl alcohol + propionate
-
-
-
-
?
vinyl propionate + H2O
vinyl alcohol + propionate
-
-
-
-
?
additional information
?
-
-
the enzyme does not attack cephalosporin C, N-acetyl-glucosamine, acetyl deoxyadenosine, aryl-ferulates and aryl-coumorates
-
-
?
additional information
?
-
enzyme hydrolyzes a range of carboxylester substrates with acyl groups ranging from C2 to C16, with a preference for butyryl moieties
-
-
?
additional information
?
-
-
enzyme hydrolyzes a range of carboxylester substrates with acyl groups ranging from C2 to C16, with a preference for butyryl moieties
-
-
?
additional information
?
-
-
substrate specificities of wild-type and mutant enzymes, reverse reaction in performed in organic solvents
-
?
additional information
?
-
-
substrate specificity of wild-type and mutant enzymes
-
?
additional information
?
-
substrate preference in decreasing order: clodinafop propargyl, fenoxaprop ethyl, fluazifop butyl, diclofop methyl, fenthioprop ethyl
-
-
?
additional information
?
-
-
substrate preference in decreasing order: clodinafop propargyl, fenoxaprop ethyl, fluazifop butyl, diclofop methyl, fenthioprop ethyl
-
-
?
additional information
?
-
-
carboxylesterase has serine residue in active site and -SH groups in specific sites which are required for its activity
-
-
?
additional information
?
-
-
carboxylesterase has serine residue in active site and -SH groups in specific sites which are required for its activity
-
-
?
additional information
?
-
the Aquamicrobium strain FPB-1 is capable of efficiently degrading AOPP herbicides
-
-
?
additional information
?
-
the enzyme hydrolyzes aryloxyphenoxypropionate herbicides, mass spectrometry analysis of metabolite generated during fluazifop-P-butyl degradation by strain FPB-1, overview
-
-
?
additional information
?
-
no activity detected with methyl myristate. Tributyrin is hydrolyzed by LipA at a lower rate than short and medium chain fatty acid esters and 4-nitrophenyl acetate is converted twice as fast as the corresponding palmitate
-
-
?
additional information
?
-
the enzyme preferentially hydrolyzes esters of short-chain fatty acids (C2C4) and especially those of medium chain (C5C6) fatty acids with short chain alcohols. Methyl esters are hydrolyzed faster than the corresponding ethyl esters. Butyrate is the preferred chain length for the carboxylic acid. No activity with esters of hydroxy-substituted fatty acids such as 3-hydroxybutyrate
-
-
?
additional information
?
-
-
the purified esterase is able to hydrolyze synthetic substrates with acyl group chain lengths of C4, C12, and C14 and displays higher activity (85% higher) toward C4 chain-lengths
-
-
?
additional information
?
-
-
the purified esterase is able to hydrolyze synthetic substrates with acyl group chain lengths of C4, C12, and C14 and displays higher activity (85% higher) toward C4 chain-lengths
-
-
?
additional information
?
-
-
dramatic decline in activity with substrates of chain length above C6, no activity with ethyl esters of 2-hydroxy- and 2-methoxybenzoates, phenyl acetate, ferulate, and diethyl esters of terephthalate and phthalate
-
?
additional information
?
-
-
dramatic decline in activity with substrates of chain length above C6, no activity with ethyl esters of 2-hydroxy- and 2-methoxybenzoates, phenyl acetate, ferulate, and diethyl esters of terephthalate and phthalate
-
?
additional information
?
-
for the benzoyl ester hydrolysis of cocaine cf. EC 3.1.1.84. Enzyme PnbA-2 resembles human hCE-1 enzyme in cocaine metabolism, hCE-1 enzyme hydrolyses the methyl ester of cocaine
-
-
?
additional information
?
-
for the benzoyl ester hydrolysis of cocaine cf. EC 3.1.1.84. Enzyme PnbA-2 resembles human hCE-1 enzyme in cocaine metabolism, hCE-1 enzyme hydrolyses the methyl ester of cocaine
-
-
?
additional information
?
-
for the benzoyl ester hydrolysis of cocaine cf. EC 3.1.1.84. Enzyme PnbA-2 resembles human hCE-1 enzyme in cocaine metabolism, hCE-1 enzyme hydrolyses the methyl ester of cocaine
-
-
?
additional information
?
-
for the benzoyl ester hydrolysis of cocaine cf. EC 3.1.1.84. Enzyme PnbA-2 resembles human hCE-1 enzyme in cocaine metabolism, hCE-1 enzyme hydrolyses the methyl ester of cocaine
-
-
?
additional information
?
-
for the benzoyl ester hydrolysis of cocaine cf. EC 3.1.1.84. Enzyme PnbA-2 resembles human hCE-1 enzyme in cocaine metabolism, hCE-1 enzyme hydrolyses the methyl ester of cocaine
-
-
?
additional information
?
-
for the benzoyl ester hydrolysis of cocaine cf. EC 3.1.1.84. Enzyme PnbA-2 resembles human hCE-1 enzyme in cocaine metabolism, hCE-1 enzyme hydrolyses the methyl ester of cocaine
-
-
?
additional information
?
-
for the benzoyl ester hydrolysis of cocaine cf. EC 3.1.1.84. Enzyme PnbA-2 resembles human hCE-1 enzyme in cocaine metabolism, hCE-1 enzyme hydrolyses the methyl ester of cocaine
-
-
?
additional information
?
-
for the benzoyl ester hydrolysis of cocaine cf. EC 3.1.1.84. Enzyme PnbA-2 resembles human hCE-1 enzyme in cocaine metabolism, hCE-1 enzyme hydrolyses the methyl ester of cocaine
-
-
?
additional information
?
-
-
enzyme shows preference for short chain fatty acid substrates
-
?
additional information
?
-
-
enzyme shows preference for short chain fatty acid substrates
-
?
additional information
?
-
esterase BSE01701 can enzymatically resolve inexpensive racemic methyl lactate and generate chiral D-methyl lactate, BSE01701 is utilized to generate optically pure D-methyl lactate through enzymatic kinetic resolution reactions, optimum conditions are 35°C, pH 9.0, and 60 % n-heptane. Enzyme BSE01701 preferentially hydrolyzes 4-nitrophenyl esters with short-chain fatty acids and exhibits its highest activity toward 4-nitrophenyl butyrate. The hydrolysis activities of BSE01701 are much lower when the aliphatic acyl-chain of substrate is longer than C8. BSE01701 is an esterase
-
-
?
additional information
?
-
-
hydrolysis of amino acid esters
-
-
?
additional information
?
-
enzyme activity against tertiary alcohol esters is about 1000fold lower compared with secondary and primary alcohol esters. The enantioselectivity towards esters of tertiary alcohols is very low
-
-
?
additional information
?
-
-
enzyme activity against tertiary alcohol esters is about 1000fold lower compared with secondary and primary alcohol esters. The enantioselectivity towards esters of tertiary alcohols is very low
-
-
?
additional information
?
-
no substrate: triglycerides with chain length of C8 to C18
-
-
?
additional information
?
-
-
no substrate: triglycerides with chain length of C8 to C18
-
-
?
additional information
?
-
no activity with 4-nitrophenyl myristate and 4-nitrophenyl palmitate
-
-
?
additional information
?
-
no activity with 4-nitrophenyl myristate and 4-nitrophenyl palmitate
-
-
?
additional information
?
-
-
no activity with 4-nitrophenyl myristate and 4-nitrophenyl palmitate
-
-
?
additional information
?
-
-
hydrolysis of amino acid esters
-
-
?
additional information
?
-
for the benzoyl ester hydrolysis of cocaine cf. EC 3.1.1.84. Enzyme PnbA-1 resembles human hCE-1 enzyme in cocaine metabolism, hCE-1 enzyme hydrolyses the methyl ester of cocaine
-
-
?
additional information
?
-
for the benzoyl ester hydrolysis of cocaine cf. EC 3.1.1.84. Enzyme PnbA-1 resembles human hCE-1 enzyme in cocaine metabolism, hCE-1 enzyme hydrolyses the methyl ester of cocaine
-
-
?
additional information
?
-
-
triglycerides are not hydrolyzed
-
-
?
additional information
?
-
no activity with alpha-naphthol palmitate, substrate specificity, activity with other nitrophenyl esters, naphthol-AS esters, and HPTS esters, overview
-
?
additional information
?
-
-
no activity with alpha-naphthol palmitate, substrate specificity, activity with other nitrophenyl esters, naphthol-AS esters, and HPTS esters, overview
-
?
additional information
?
-
F1P6W8
substrate specificity, overview
-
-
?
additional information
?
-
substrate specificity, overview
-
-
?
additional information
?
-
-
substrate specificity, overview
-
-
?
additional information
?
-
-
no activity with (S)-1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone in plasma
-
-
?
additional information
?
-
-
the enzyme is involved in organophosphate insecticide resistance
-
-
?
additional information
?
-
-
imaging and detection of carboxylesterase in zebrafish by a near-infrared fluorescence off-on probe, overview
-
-
?
additional information
?
-
-
the enzyme plays an important role in the reproductive biology
-
-
?
additional information
?
-
-
the enzyme also performs transesterification reactions in competition to the hydrolysis, overview
-
?
additional information
?
-
-
the enzyme also performs transesterification reactions in competition to the hydrolysis, overview
-
?
additional information
?
-
-
enzyme shows low thioesterase activity, it cannot use free pimelic acid for pimeloyl-CoA synthesis, enzyme shows a broad substrate specificity with a preference for short chain substrates
-
?
additional information
?
-
enzyme shows low thioesterase activity, it cannot use free pimelic acid for pimeloyl-CoA synthesis, enzyme shows a broad substrate specificity with a preference for short chain substrates
-
?
additional information
?
-
-
the enzyme BioH is involved in biotin biosynthesis
-
?
additional information
?
-
the enzyme BioH is involved in biotin biosynthesis
-
?
additional information
?
-
-
BioHe shows carboxylesterase activity with a preference for short chain fatty acid esters with acyl chain length of up to C6. BioHe BioH also shows low enzymatic activities for thioesterase, lipase, and aminopeptidase, but shows no detectable enzymatic activity for phosphatase, trypsin-like endopeptidase, or perhydrolase
-
-
?
additional information
?
-
no activity with triolein
-
-
?
additional information
?
-
-
no activity with triolein
-
-
?
additional information
?
-
activity decreases when the chain length increases from C8 to C16, the enzyme does not show any activity on longer acyl chain triglycerides than tributyrin
-
-
?
additional information
?
-
-
activity decreases when the chain length increases from C8 to C16, the enzyme does not show any activity on longer acyl chain triglycerides than tributyrin
-
-
?
additional information
?
-
activity decreases when the chain length increases from C8 to C16, the enzyme does not show any activity on longer acyl chain triglycerides than tributyrin
-
-
?
additional information
?
-
enzyme CaesCCR11 has a preference for C4 substrates. Activity toward 4-nitrophenyl esters with longer chain lengths is only slightly detected, suggesting that CaesCCR11 is an esterase
-
-
?
additional information
?
-
enzyme CaesCCR11 has a preference for C4 substrates. Activity toward 4-nitrophenyl esters with longer chain lengths is only slightly detected, suggesting that CaesCCR11 is an esterase
-
-
?
additional information
?
-
-
enzyme CaesCCR11 has a preference for C4 substrates. Activity toward 4-nitrophenyl esters with longer chain lengths is only slightly detected, suggesting that CaesCCR11 is an esterase
-
-
?
additional information
?
-
specific activities on tri-, di- and monoacylglycerols are much lower than those measured with the shorter-chain vinyl esters and decreases with increasing acyl chain length. No detectable activity of the enzyme on vinyl esters and glycerol esters that have acyl chains longer than 12 carbon atoms
-
-
?
additional information
?
-
-
specific activities on tri-, di- and monoacylglycerols are much lower than those measured with the shorter-chain vinyl esters and decreases with increasing acyl chain length. No detectable activity of the enzyme on vinyl esters and glycerol esters that have acyl chains longer than 12 carbon atoms
-
-
?
additional information
?
-
-
preference for the esters of the fluorogenic compounds 4-methyl umbelliferone and fluorescein over naphthyl esters as substrates
-
-
?
additional information
?
-
the enzyme may function as a blood-brain barrier to protect the central nervous system from ester or amide compounds
-
-
?
additional information
?
-
-
the enzyme may function as a blood-brain barrier to protect the central nervous system from ester or amide compounds
-
-
?
additional information
?
-
the enzyme plays an important role in the detoxification of xenobiotic chemicals that contain organophosphate compounds
-
-
?
additional information
?
-
-
the enzyme plays an important role in the detoxification of xenobiotic chemicals that contain organophosphate compounds
-
-
?
additional information
?
-
both enzyme isoforms hydrolyze type I and type II pyrethroids with strong stereoselectivity
-
-
?
additional information
?
-
-
both enzyme isoforms hydrolyze type I and type II pyrethroids with strong stereoselectivity
-
-
?
additional information
?
-
-
isoform hCE2 does not easily form acylated intermediates. The determining factor for the rate of hydrolysis of 4-aminobenzoic acid esters is Km for isoform hCE2, Vmax for isoform hCE1. hCE1 in addition has transesterification abilities
-
-
?
additional information
?
-
-
no substrate for intestine microsomal enzyme: bioresmethrin, deltamethrin
-
-
?
additional information
?
-
-
the enzyme also catalyzes the transesterification of cocaine in the presence of ethanol to the toxic metabolite cocaethylene
-
-
?
additional information
?
-
hCE1 catalyzes the transesterification of cocaine with ethanol to generate cocaethylene. Carboxylesterase 1 (hCE1) is a broad-spectrum bioscavenger that catalyzes the hydrolysis of heroin and cocaine, and the detoxification of organophosphate chemical weapons, such as sarin, soman and tabun. hCE1 prefers methyl ester- or acetyl-type linkages within its small, rigid pocket and bulky groups within the large, flexible pocket. The small, rigid pocket in hCE1 is selective, whereas its large, flexible pocket is promiscuous with regard to substrate specificity. Together, these pockets allow hCE1 to act on structurally distinct compounds containing either large or small alcohol substituent groups
-
-
?
additional information
?
-
-
hCE1 catalyzes the transesterification of cocaine with ethanol to generate cocaethylene. Carboxylesterase 1 (hCE1) is a broad-spectrum bioscavenger that catalyzes the hydrolysis of heroin and cocaine, and the detoxification of organophosphate chemical weapons, such as sarin, soman and tabun. hCE1 prefers methyl ester- or acetyl-type linkages within its small, rigid pocket and bulky groups within the large, flexible pocket. The small, rigid pocket in hCE1 is selective, whereas its large, flexible pocket is promiscuous with regard to substrate specificity. Together, these pockets allow hCE1 to act on structurally distinct compounds containing either large or small alcohol substituent groups
-
-
?
additional information
?
-
-
the enzyme also catalyzes the ethyl transesterification of cocaine with ethanol to form cocaethylene
-
-
?
additional information
?
-
-
carboxylesterases are enzymes that hydrolyze a broad suite of endogenous and exogenous ester-containing compounds to the corresponding alcohol and carboxylic acid
-
-
?
additional information
?
-
-
xenobiotic substrates are pyrethroid insecticides
-
-
?
additional information
?
-
-
no activity with (S)-1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone in plasma
-
-
?
additional information
?
-
-
human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and exhibits a 1700- and 2900fold preference for the PR enantiomers of analogs of soman and cyclosarin, respectively
-
-
?
additional information
?
-
-
imaging and detection of carboxylesterase in living cells by a near-infrared fluorescence off-on probe, overview
-
-
?
additional information
?
-
in comparison with the (-)-cocaine hydrolysis (benzoyl ester) in vivo, the faster (-)-cocaine hydrolysis (methyl ester) in vivo is solely due to the high abundance of CE-1 in the body
-
-
?
additional information
?
-
-
in comparison with the (-)-cocaine hydrolysis (benzoyl ester) in vivo, the faster (-)-cocaine hydrolysis (methyl ester) in vivo is solely due to the high abundance of CE-1 in the body
-
-
?
additional information
?
-
enzyme hCE2 prefers the (S)-isomer configuration. Docking simulations of CES2 and propranolol derivatives. Substrate specifcity, overview
-
-
?
additional information
?
-
-
enzyme hCE2 prefers the (S)-isomer configuration. Docking simulations of CES2 and propranolol derivatives. Substrate specifcity, overview
-
-
?
additional information
?
-
synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases, substrate specificity, overview. No activity with tert-butyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
-
-
?
additional information
?
-
-
synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases, substrate specificity, overview. No activity with tert-butyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
-
-
?
additional information
?
-
-
the CES1A substrate lidocaine is metabolized to 2,6-xylidine via a MEGX intermediate, 2,6-xylidine production is greater with the MEGX substrate than with lidocaine
-
-
?
additional information
?
-
the CES1A substrate lidocaine is metabolized to 2,6-xylidine via a MEGX intermediate, 2,6-xylidine production is greater with the MEGX substrate than with lidocaine
-
-
?
additional information
?
-
no substrate: 4-nitrophenyl myristate, 4-nitrophenol + palmitate
-
-
?
additional information
?
-
-
no substrate: 4-nitrophenyl myristate, 4-nitrophenol + palmitate
-
-
?
additional information
?
-
no activity with 4-nitrophenyl myristate and 4-nitrophenyl palmitate
-
-
?
additional information
?
-
-
no activity with 4-nitrophenyl myristate and 4-nitrophenyl palmitate
-
-
?
additional information
?
-
no substrate: 4-nitrophenyl myristate, 4-nitrophenol + palmitate
-
-
?
additional information
?
-
no activity with 4-nitrophenyl myristate and 4-nitrophenyl palmitate
-
-
?
additional information
?
-
substrate specificity, poor activity with 4-nitrophenyl octanoate, 4-nitrophenyl decanoate, 4-nitrophenyl dodecanoate, and carboxylic esters with chain length above C14
-
?
additional information
?
-
-
substrate specificity, poor activity with 4-nitrophenyl octanoate, 4-nitrophenyl decanoate, 4-nitrophenyl dodecanoate, and carboxylic esters with chain length above C14
-
?
additional information
?
-
substrate specificity, poor activity with 4-nitrophenyl octanoate, 4-nitrophenyl decanoate, 4-nitrophenyl dodecanoate, and carboxylic esters with chain length above C14
-
?
additional information
?
-
-
substrate specificity, poor substrates are ethyl acetate, ethylpropionate, carboxylic esters with chain length above C14, propyl acetate, butyl acetate, and hexanoyl acetate
-
?
additional information
?
-
-
substrate specificity, poor substrates are ethyl acetate, ethylpropionate, carboxylic esters with chain length above C14, propyl acetate, butyl acetate, and hexanoyl acetate
-
?
additional information
?
-
dephosphorylation is the rate-limiting step in the hydrolysis of organophosphates by enzyme LcalphaE7
-
-
?
additional information
?
-
enzyme hCE2 prefers the (S)-isomer configuration. Docking simulations of CES2 and propranolol derivatives. Substrate specifcity, overview
-
-
?
additional information
?
-
-
enzyme hCE2 prefers the (S)-isomer configuration. Docking simulations of CES2 and propranolol derivatives. Substrate specifcity, overview
-
-
?
additional information
?
-
-
enantioselectivity of racemic esters catalyzed by the Mhg mutant variants, mutant substrate specificities, overview
-
-
?
additional information
?
-
-
enantioselectivity of racemic esters catalyzed by the Mhg mutant variants, mutant substrate specificities, overview
-
-
?
additional information
?
-
-
very low activity with methyl or ethyl esters of amino acids
-
?
additional information
?
-
-
very low activity with methyl or ethyl esters of amino acids
-
?
additional information
?
-
-
no substrate: 1-naphthyl acetate
-
-
?
additional information
?
-
-
no substrate: 1-naphthyl acetate
-
-
?
additional information
?
-
-
maked specificity for mid-chain-length fatty acids of 3-8 C-atoms
-
?
additional information
?
-
-
carboxylesterases are enzymes that hydrolyze a broad suite of endogenous and exogenous ester-containing compounds to the corresponding alcohol and carboxylic acid
-
-
?
additional information
?
-
-
the purified enzyme does not hydrolyse insecticide substrates
-
-
?
additional information
?
-
-
enzyme catalyzed the hydrolysis of short-chain phenylacylesters and triglycerides, and shows weak activity toward 2-hydroxy- and 2-nitroanilide
-
-
?
additional information
?
-
-
preference for short chain fatty acid substrates, no activity with 4-nitrophenyl palmitate or triloin triglyceride and other long chain fatty acid substrates
-
?
additional information
?
-
-
the enzyme does not show any activity towards p-nitrophenyl esanoate and p-nitrophenyl dodecanoate
-
-
?
additional information
?
-
-
the enzyme does not show any activity towards p-nitrophenyl esanoate and p-nitrophenyl dodecanoate
-
-
?
additional information
?
-
PA3859 displays similar affinity for 4-nitrophenyl substrates with acyl chains from C8 to C18
-
-
?
additional information
?
-
-
PA3859 displays similar affinity for 4-nitrophenyl substrates with acyl chains from C8 to C18
-
-
?
additional information
?
-
no activity with 2-hydroxyethyl DL-beta-acetylthioisobutyrate
-
-
?
additional information
?
-
no activity with 2-hydroxyethyl DL-beta-acetylthioisobutyrate
-
-
?
additional information
?
-
-
no activity with 2-hydroxyethyl DL-beta-acetylthioisobutyrate
-
-
?
additional information
?
-
hydrolysis of vinyl and aryl esters of chain length C4-C6
-
?
additional information
?
-
-
hydrolysis of vinyl and aryl esters of chain length C4-C6
-
?
additional information
?
-
hydrolysis of vinyl and aryl esters of chain length C4-C6
-
?
additional information
?
-
enzyme EstPS1 degrades various pyrethroid pesticides, the hydrolysis efficiencies are dependent on the pyrethroid molecular structure. EstPS1 degrades all the tested pyrethroid pesticides and hydrolyses the p-nitrophenyl esters of medium- to short-chain fatty acids, indicating that EstPS1 is an esterase with broad specificity. EstPS1 hydrolyzes the pesticides at different hydrolysis rates in the following decreasing order: carbaryl, fenpropathrin, trans-cypermethrin, cis-cypermethrin, fenvalerate, and bifenthrin. High activity with 4-nitrophenyl ester substrates at chain lengths of C2-C8, low activity with substrates of C10 and C12 chain length, no activity with C14 and C16 substrates
-
-
?
additional information
?
-
-
enzyme EstPS1 degrades various pyrethroid pesticides, the hydrolysis efficiencies are dependent on the pyrethroid molecular structure. EstPS1 degrades all the tested pyrethroid pesticides and hydrolyses the p-nitrophenyl esters of medium- to short-chain fatty acids, indicating that EstPS1 is an esterase with broad specificity. EstPS1 hydrolyzes the pesticides at different hydrolysis rates in the following decreasing order: carbaryl, fenpropathrin, trans-cypermethrin, cis-cypermethrin, fenvalerate, and bifenthrin. High activity with 4-nitrophenyl ester substrates at chain lengths of C2-C8, low activity with substrates of C10 and C12 chain length, no activity with C14 and C16 substrates
-
-
?
additional information
?
-
enzyme EstPS1 degrades various pyrethroid pesticides, the hydrolysis efficiencies are dependent on the pyrethroid molecular structure. EstPS1 degrades all the tested pyrethroid pesticides and hydrolyses the p-nitrophenyl esters of medium- to short-chain fatty acids, indicating that EstPS1 is an esterase with broad specificity. EstPS1 hydrolyzes the pesticides at different hydrolysis rates in the following decreasing order: carbaryl, fenpropathrin, trans-cypermethrin, cis-cypermethrin, fenvalerate, and bifenthrin. High activity with 4-nitrophenyl ester substrates at chain lengths of C2-C8, low activity with substrates of C10 and C12 chain length, no activity with C14 and C16 substrates
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
O35535
phylogenetic tree for rat liver carboxylesterases
-
?
additional information
?
-
phylogenetic tree for rat liver carboxylesterases
-
?
additional information
?
-
phylogenetic tree for rat liver carboxylesterases
-
?
additional information
?
-
phylogenetic tree for rat liver carboxylesterases
-
?
additional information
?
-
phylogenetic tree for rat liver carboxylesterases
-
?
additional information
?
-
phylogenetic tree for rat liver carboxylesterases
-
?
additional information
?
-
-
no substrate: cholesteryl oleate
-
-
?
additional information
?
-
poor substrate: deltamethrin, esfenvalerate, alpha-cypermethrin, cis-permethrin
-
-
?
additional information
?
-
-
does not utilize oxybutynin
-
-
?
additional information
?
-
-
no activity with substrate of greater chain length than 6 C-atoms
-
?
additional information
?
-
-
the enzyme removes acetyl residues from xanthan, alginate, glucose pentaacetate, cellobiose octaacetate
-
-
?
additional information
?
-
-
the enzyme removes acetyl residues from xanthan, alginate, glucose pentaacetate, cellobiose octaacetate
-
-
?
additional information
?
-
-
no substrate: tributyrin, triolein
-
-
?
additional information
?
-
-
no hydrolysis of tributyrin and triolein
-
-
?
additional information
?
-
-
no substrate: tributyrin, triolein
-
-
?
additional information
?
-
-
no hydrolysis of tributyrin and triolein
-
-
?
additional information
?
-
-
no activity with triolein
-
-
?
additional information
?
-
the activity of the enzyme is strongly influenced by the chain length of the acyl group. Activity increases up to C6 and then decreases
-
-
?
additional information
?
-
-
the activity of the enzyme is strongly influenced by the chain length of the acyl group. Activity increases up to C6 and then decreases
-
-
?
additional information
?
-
broad substrate specificities toward various p-nitrophenyl esters ranging from C2 to C16. The activity of the enzyme decreases slowly from 4-nitrophenyl hexanoate to 4-nitrophenyl dodecanoate and is very low for 4-nitrophenyl 4-nitrophenyl hexadecanoate
-
-
?
additional information
?
-
-
broad substrate specificities toward various p-nitrophenyl esters ranging from C2 to C16. The activity of the enzyme decreases slowly from 4-nitrophenyl hexanoate to 4-nitrophenyl dodecanoate and is very low for 4-nitrophenyl 4-nitrophenyl hexadecanoate
-
-
?
additional information
?
-
-
no activity with triolein
-
-
?
additional information
?
-
the activity of the enzyme is strongly influenced by the chain length of the acyl group. Activity increases up to C6 and then decreases
-
-
?
additional information
?
-
-
the activity of the enzyme is strongly influenced by the chain length of the acyl group. Activity increases up to C6 and then decreases
-
-
?
additional information
?
-
broad substrate specificities toward various p-nitrophenyl esters ranging from C2 to C16. The activity of the enzyme decreases slowly from 4-nitrophenyl hexanoate to 4-nitrophenyl dodecanoate and is very low for 4-nitrophenyl 4-nitrophenyl hexadecanoate
-
-
?
additional information
?
-
-
broad substrate specificities toward various p-nitrophenyl esters ranging from C2 to C16. The activity of the enzyme decreases slowly from 4-nitrophenyl hexanoate to 4-nitrophenyl dodecanoate and is very low for 4-nitrophenyl 4-nitrophenyl hexadecanoate
-
-
?
additional information
?
-
BioHs shows carboxylesterase activity with a preference for short chain fatty acid esters with acyl chain length of up to C6. BioHs also displays a weak thioesterase activity. Can form a complex with CoA, and may be involved in the condensation of CoA and pimelic acid into pimeloyl-CoA, a precursor in biotin biosynthesis
-
-
?
additional information
?
-
BioHs shows carboxylesterase activity with a preference for short chain fatty acid esters with acyl chain length of up to C6. BioHs also displays a weak thioesterase activity. Can form a complex with CoA, and may be involved in the condensation of CoA and pimelic acid into pimeloyl-CoA, a precursor in biotin biosynthesis
-
-
?
additional information
?
-
the enzyme EstB is active towards dibutyl phthalate, and can cleave some small aromatic ring side chains from cephalosporin derivatives. No activity against cephalosporin C and cefixime. EstB catalyzed the cleavage of the C-S bond found in cephalosporin derivatives to release the corresponding free aromatic ring side chains. EstB is active towards short-chain nitrophenyl esters (i.e. 4-nitrophenyl acetate (C2) and 4-nitrophenyl butyrate (C4)) and towards tributyrin. Substrate specificity of the Sphingobium sp. SM42 esteraseB (EstB) towards cephalosporin antibiotics
-
-
?
additional information
?
-
-
no activity with nonyl acetate and unsaturated substrates with higher chain length, substrate specificity, overview
-
-
?
additional information
?
-
does not hydrolyze ethyl butyrate, trioctanoin, vinyl laurate, acetylcholine, and triglycerides
-
-
?
additional information
?
-
-
does not hydrolyze ethyl butyrate, trioctanoin, vinyl laurate, acetylcholine, and triglycerides
-
-
?
additional information
?
-
esterase-catalysed transesterification of p-nitrophenyl acetate by reaction with alcohol as nucleophile. The enzyme catalyses an acyl-group transfer with triacetin as acyl donor and aniline as acyl acceptor
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-
?
additional information
?
-
-
esterase-catalysed transesterification of p-nitrophenyl acetate by reaction with alcohol as nucleophile. The enzyme catalyses an acyl-group transfer with triacetin as acyl donor and aniline as acyl acceptor
-
-
?
additional information
?
-
no hydrolysis of triolein and ethyl acetate
-
-
?
additional information
?
-
-
no hydrolysis of triolein and ethyl acetate
-
-
?
additional information
?
-
no activity towards various granular polyhydroxyalkanoates
-
-
?
additional information
?
-
no activity towards various granular polyhydroxyalkanoates
-
-
?
additional information
?
-
recombinant enzyme expressed in Escherichia coli and recombinant enzyme expressed in Sulfolobus solfataricus show the same catalytic properties
-
-
?
additional information
?
-
-
recombinant enzyme expressed in Escherichia coli and recombinant enzyme expressed in Sulfolobus solfataricus show the same catalytic properties
-
-
?
additional information
?
-
recombinant enzyme expressed in Escherichia coli and recombinant enzyme expressed in Sulfolobus solfataricus show the same catalytic properties
-
-
?
additional information
?
-
-
enzyme shows high catalytic efficiency hydrolyzing prodrugs containing a phenylalanyl moiety, but is over 100fold less efficient with valyl or isoleucyl prodrugs
-
-
?
additional information
?
-
-
no activity on 4-nitrophenyl ester substrates with an acyl chain length greater than C12. The enzyme has no activity towards casein or trioleoylglycerol
-
-
?
additional information
?
-
-
no activity on 4-nitrophenyl ester substrates with an acyl chain length greater than C12. The enzyme has no activity towards casein or trioleoylglycerol
-
-
?
additional information
?
-
-
the esterase shows high specificity towards short and middle chain-length fatty acyl esters of 4-nitrophenol
-
-
?
additional information
?
-
-
the esterase shows high specificity towards short and middle chain-length fatty acyl esters of 4-nitrophenol
-
-
?
additional information
?
-
no substrate: 4-nitrophenyl palmitate
-
-
?
additional information
?
-
-
no substrate: 4-nitrophenyl palmitate
-
-
?
additional information
?
-
no substrate: 4-nitrophenyl palmitate
-
-
?
additional information
?
-
-
no substrate: 4-nitrophenyl palmitate
-
-
?
additional information
?
-
-
no enzyme activity is detected toward 4-nitrophenyl laurate, 4-nitrophenyl myristate, 4-nitrophenyl palmitate, and 4-nitrophenyl stearate
-
-
?
additional information
?
-
-
CE7 enzymes, like mesophilic CE7 AcXE, Axe1NaM1, possess a unique and narrow specificity for acetylated substrates. Enzyme NaM1 also shows tributyrin-hydrolyzing activity. No activity of the wild-type enzyme with 4-nitrophenol octanoate and 4-nitrophenol palmitate, mutant NaM1H2 shows low activity with 4-nitrophenol octanoate
-
-
?
additional information
?
-
-
in general, CE7 enzymes possess a unique and narrow specificity for acetylated substrates. Enzyme NaM2 shows no tributyrin-hydrolyzing activity
-
-
?
additional information
?
-
-
in general, CE7 enzymes possess a unique and narrow specificity for acetylated substrates. Enzyme NaM3 shows no tributyrin-hydrolyzing activity
-
-
?
additional information
?
-
-
enzyme does not show beta-lactamase activity
-
-
?
additional information
?
-
-
enzyme does not show beta-lactamase activity
-
-
?
additional information
?
-
no activity with 4-nitrophenyl decanoate
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-
?
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(10Z)-hexadecenoic acid
-
-
(2R)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
-
about 30% residual activity at 0.1 mM
(3S)-1-chloro-3-tosylamido-7-amino-2-heptanone
-
73.6% residual activity at 1 mM
(4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
-
-
(4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 1,4'-bipiperidine-1'-carboxylate
-
-
(5Z,8Z,11Z,14Z)-eicosatetraenoic acid
-
-
(6Z,9Z,12Z)-octadecatrienoic acid
-
-
(9Z)-octadecenoic acid
-
-
(9Z)-tetradecenoic acid
-
-
(9Z,12Z)-octadecadienoic acid
-
-
(S)-naproxen
nearly 80% of the initial activity is lost when 2.5 mM of (S)-naproxen is added to the reaction system
1(R)-cis-alpha(S) deltamethrin
-
1,1'-ethane-1,2-diylbis(1H-indole-2,3-dione)
1,1,1,-trifluoro-3-(hexylsulfinyl)propane-2,2-diol
1,1,1,-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
1,1,1-trifluoro-3-(hexyloxy)propane-2,2-diol
1,1,1-trifluoro-3-(hexyloxy)propane-2,2-diol1,1,1-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
1,1,1-trifluoro-3-(hexylsulfanyl)propan-2-one
1,1,1-trifluoro-3-(hexylsulfinyl)propane-2,2-diol
1,1,1-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
1,1,1-trifluoro-3-(octylsulfanyl)propan-2-one
1,1,1-trifluoro-3-(octylsulfinyl)propane-2,2-diol
1,1,1-trifluoro-3-(octylsulfonyl)propane-2,2-diol
1,1,1-trifluoro-3-octylthiol-propan-2-one
-
-
1,1,1-trifluoro-3-[(2-phenylethyl)sulfanyl]propan-2-one
1,1,1-trifluoro-3-[(2-phenylethyl)sulfonyl]propane-2,2-diol
1,1,1-trifluorododecan-2-one
1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione
1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione
1,2-bis(2,3-difluorophenyl)ethane-1,2-dione
1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone
1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone
1,2-bis(2-chlorophenyl)ethane-1,2-dione
1,2-bis(3,4,5-trifluorophenyl)ethane-1,2-dione
1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone
1,2-bis(3,5-difluorophenyl)ethane-1,2-dione
1,2-bis(3-methoxyphenyl)ethane-1,2-dione
1,2-bis(3-nitrophenyl)ethane-1,2-dione
1,2-bis(4-bromo-2-methoxyphenyl)ethane-1,2-dione
1,2-bis(4-bromo-3-nitrophenyl)ethane-1,2-dione
1,2-bis(4-bromothiophen-2-yl)ethane-1,2-dione
1,2-bis(4-chlorophenyl)ethane-1,2-dione
1,2-bis(4-fluorophenyl)ethane-1,2-dione
1,2-bis(4-methoxyphenyl)ethane-1,2-dione
1,2-bis(4-methylphenyl)ethane-1,2-dione
1,2-bis(5-bromothiophen-2-yl)ethane-1,2-dione
1,2-di(furan-2-yl)ethane-1,2-dione
1,2-di(naphthalen-2-yl)ethane-1,2-dione
1,2-di(pyridin-2-yl)ethane-1,2-dione
1,2-di(thiophen-2-yl)ethane-1,2-dione
1,2-di(thiophen-3-yl)ethane-1,2-dione
1,2-dicyclohexylethane-1,2-dione
1,2-difluoro-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
1,2-diphenylethane-1,2-dione
1,4-dibromo-1,4-diphenyl butane-2,3-dione
1-(2,4-dinitrophenyl)-2-phenylethane-1,2-dione
1-(2-bromoethyl)-1H-indole-2,3-dione
1-(2-chlorophenyl)-2-(3,4-dimethoxyphenyl)ethane-1,2-dione
1-(2-iodoethyl)-1H-indole-2,3-dione
1-(3,4-dichlorobenzyl)-1H-indole-2,3-dione
1-(3,4-dimethylphenyl)-2-phenylethane-1,2-dione
1-(4-(4[(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)methyl]benzyl)benzyl)-1H-indole-2,3-dione
1-(4-chlorobenzyl)-1H-indole-2,3-dione
1-(4-chlorophenyl)-2-(4-methylphenyl)ethane-1,2-dione
1-(4-chlorophenyl)-2-phenylethane-1,2-dione
1-(4-methoxyphenyl)-2-phenylethane-1,2-dione
1-(4-methyl-3-nitrophenyl)-2-phenylethane-1,2-dione
1-(4-methylphenyl)-2-phenylethane-1,2-dione
1-(4-nitrophenyl)-2-phenylethane-1,2-dione
1-(pentachlorophenyl)-2-(pentafluorophenyl)ethane-1,2-dione
1-([(2-bromophenyl)amino]methyl)-1H-indole-2,3-dione
1-([(4-chlorophenyl)amino]methyl)-1H-indole-2,3-dione
1-benzyl-1H-indole-2,3-dione
1-chloro-3-tosylamido-4-phenyl-2-butanone
-
-
1-chloro-3-tosylamido-7-amino-2-heptanone
-
-
1-dodecyl-1H-indole-2,3-dione
1-fluoro-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
1-fluoro-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
1-hexadecanesulfonyl chloride
-
irreversible inhibition
1-hexadecyl-1H-indole-2,3-dione
1-methyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
1-phenyl-1H-indole-2,3-dione
1-[(2-naphthylamino)methyl]-1H-indole-2,3-dione
1-[4-(bromomethyl)phenyl]-2-phenylethane-1,2-dione
1-[4-[oxo(phenyl)acetyl]phenyl]-2-phenylethane-1,2-dione
11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid
-
-
11-piperazin-1-yl-dibenzo[b,f][1,4]thiazepine
-
-
13beta,19-dihydroy-3,15-dioxoatis-16-ene-19-O-beta-D-(6'-galloyl)-glucopyranoside
-
13beta,19-dihydroy-3,15-dioxoatis-16-ene-19-O-beta-Dglucopyranoside
-
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoic acid
-
-
15-deoxy-DELTA12,14-prostaglandin J2
-
-
18beta-11-deoxo-olean-12-en-30-oic acid
-
18beta-11-deoxo-olean-12-en-30-oic acid ethyl ester
-
18beta-11-oxo-olean-12-en-30-oic acid ethyl ester
-
18beta-11-oxo-olean-12-en-30-oic acid methyl ester
-
18beta-11-oxo-olean-12-en-30-oic acid-(20-dimethylamino)ethyl ester
-
18beta-3, 11-dioxo-olean-12-en-30-oic acid
-
18beta-3-O-(beta-carboxypropionyl)-11-deoxo-olean-12-en-30-oic acid ethyl ester
-
18beta-3-O-(beta-carboxypropionyl)-11-oxo-olean-12-en-30-oic acid ethyl ester
-
18beta-3-O-acetyl-11-oxo-olean-12-en-30-oic acid
-
18beta-3-O-acetyl-11-oxo-olean-12-en-30-oic acid-(20-dimethylamino)ethyl ester
-
18beta-3-oxo-11-deoxo-olean-12-en-30-oic acid
-
18beta-glycyrrhetinic acid
-
2,2-dimethyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]propanamide
-
-
2,4-dichloro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
-
2,4-difluoro-N-(4-(4-methylphenylsulfonamido)phenyl)benzene sulfonamide
-
-
2,5-difluoro-N-(4-(4-methylphenylsulfonamido)phenyl)benzene sulfonamide
-
-
2,6,6-trimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
2,7,7-trimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one
-
-
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
-
-
2-(4-methoxyphenyl)-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]acetamide
-
-
2-(propan-2-yl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
2-butanol
10% (v/v), 52% inhibition; 10% (w/v), 42% inhibition
2-chloro-3,4-dimethoxybenzil
2-fluoro-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
2-fluoro-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
2-fluorophenanthrene-3,4-dione
-
2-hydroxy-1,2-bis(2,3,4-trifluorophenyl)ethanone
2-hydroxy-1,2-bis(2,3,5-trifluorophenyl)ethanone
2-methoxy-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
2-methyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
2-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]propanamide
-
-
2-[3,4-bis[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-3,5,7-triyl hexaethyl tris(phosphate)
-
-
2-[3,4-bis[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-5,7-diyl tetraethyl bis(phosphate)
-
-
2-[3-[(diethoxyphosphoryl)oxy]-4-methoxyphenyl]-4-oxo-3,4-dihydro-2H-chromene-5,7-diyl tetraethyl bis(phosphate)
-
-
2-[4-[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-5,7-diyl tetraethyl bis(phosphate)
-
-
2-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl]ethanesulfonyl fluoride
-
-
22(R)-hydroxycholesterol
-
slight inhibition of CES1, not CES2
24(S),25-epoxycholesterol
-
inhibits only CES1, not CES2
24(S)-hydroxycholesterol
-
slight inhibition of CES1, not CES2
25-hydroxycholesterol
-
slight inhibition of CES1, not CES2
27-Hydroxycholesterol
-
partially noncompetitive inhibitor of recombinant CES1, impaires intracellular CES1 activity following treatment of intact THP1 cells. No inhibition of CES2
3',4',7-trihydroxyisoflavone
-
3,3-dimethyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]butanamide
-
-
3,4-difluoro-N-(4-(4-methylphenylsulfonamido)phenyl)benzene sulfonamide
-
-
3,4-difluoro-N-(4-(phenylsulfonamido)phenyl)benzene sulfonamide
-
-
3,4-difluoro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
-
3-(butylsulfanyl)-1,1,1-trifluoropropan-2-one
3-(decylsulfanyl)-1,1,1-trifluoropropan-2-one
3-(decylsulfinyl)-1,1,1-trifluoropropane-2,2-diol
3-(decylsulfonyl)-1,1,1-trifluoropropane-2,2-diol
3-(dodecylsulfanyl)-1,1,1-trifluoropropan-2-one
3-(dodecylsulfinyl)-1,1,1-trifluoropropane-2,2-diol
3-(dodecylsulfonyl)-1,1,1-trifluoropropane-2,2-diol
3-butylsulfinyl-1,1,1-trifluoropropane-2,2-diol
3-chloro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
-
3-decylsulfinyl-1,1,1-trifluoropropane-2,2-diol
3-decylsulfonyl-1,1,1-trifluoropropane-2,2-diol
3-dodecylsulfinyl-1,1,1-trifluoropropane-2,2-diol
3-dodecylsulfonyl-1,1,1-trifluoropropane-2,2-diol
3-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]butanamide
-
-
3-O-acetyl-11-oxo-olean-12-en-30-nitrile
-
3-[4-[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-5,7-diyl tetraethyl bis(phosphate)
-
-
4,6-dichloro-1H-indole-2,3-dione
4,6-dimethyl-N1,N3-diphenylbenzene-1,3-disulfonamide
-
-
4,7-dichloro-1H-indole-2,3-dione
4-(N-(4-(4-fluorophenylsulfonamido)phenyl)sulfamoyl)-3-methylbenzoic acid
-
-
4-(N-(4-(4-fluorophenylsulfonamido)phenyl)sulfamoyl)-N-methyl benzamide
-
-
4-(N-(4-(4-fluorophenylsulfonamido)phenyl)sulfamoyl)benzoic acid
-
-
4-bromo-N-(4-ethoxyphenyl)benzene sulfonamide
-
-
4-chloro-N-(4-(4-fluorophenylsulfonamido)phenyl)benzene sulfonamide
-
-
4-chloro-N-(4-(4-methylphenylsulfonamido)phenyl)benzene sulfonamide
-
-
4-chloro-N-(4-ethoxyphenyl)benzene sulfonamide
-
-
4-fluoro-N-(4-(4-methoxy phenylsulfonamido)phenyl)benzene sulfonamide
-
-
4-fluoro-N-(4-(4-methylphenylsulfonamido)phenyl)benzene sulfonamide
-
-
4-fluoro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
-
4-methoxy-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
-
4-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
-
4-nitrophenyl acetate
-
an inhibition of CaE activity by 4-nitrophenyl acetate is observed at substrate concentration higher than 5 mM
4-[7-[(diethoxyphosphoryl)oxy]-4-oxo-4H-chromen-3-yl]phenyl diethyl phosphate
-
-
4-[7-[(diethoxyphosphoryl)oxy]-5-hydroxy-4-oxo-4H-chromen-2-yl]benzene-1,2-diyl tetraethyl bis(phosphate)
-
-
4-[7-[(diethoxyphosphoryl)oxy]-5-hydroxy-4-oxo-4H-chromen-2-yl]phenyl diethyl phosphate
-
-
4-[7-[(diethoxyphosphoryl)oxy]-5-hydroxy-4-oxo-4H-chromen-3-yl]phenyl diethyl phosphate
-
-
4-[7-[(dimethoxyphosphoryl)oxy]-5-hydroxy-4-oxo-4H-chromen-2-yl]phenyl dimethyl phosphate
-
-
4-[oxo(phenyl)acetyl]benzoic acid
4beta,9alpha,16,20-tetrahydroxy-14(13->12)-abeo-12alphaH-1,6-tigliadiene-3,13-dione
competitive inhibition
4beta,9alpha,20-trihydroxy-14(13->12)-abeo-12alphaH-1,6-tigliadiene-3,13-dione
-
5,5'-dithiobis(2-nitrobenzoic)acid
-
5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
5,6,7-trimethoxybaicalein
-
5,6-dihydroxyflavone
a specific hCE2 inhibitor, exhibits reversible, noncompetitive inhibition, 5,6-dihydroxyflavone displays high specificity toward hCE2 over hCE1
5,7,8-trihydroxyflavone
-
5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
-
-
5-bromo-1-(2-methylprop-2-en-1-yl)-1H-indole-2,3-dione
5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl dimethyl phosphate
-
-
5-hydroxy-6-methoxyflavone
-
5-methoxy-3-(4-phenoxyphenyl)-3H-[1,3,4]oxadiazol-2-one
6,6-dimethyl-2-(propan-2-yl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
7,7-dimethyl-2-(propan-2-yl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin
-
i.e. irinotecan or CPT-11, an antitumor prodrug
7-oxocholesterol
-
slight inhibition of CES1, not CES2
8-ethyl 3-methyl 4-hydroxy-4-(trifluoromethyl)-1,4-dihydropyrazolo[5,1-c][1,2,4]triazine-3,8-dicarboxylate
-
8-methyl-1,4-dihydro-2H-naphtho[2,1-c]pyran-9,10-dione
-
8beta-11-oxo-olean-12-en-30-amide
-
8beta-3-O-acetyl-11-oxo-olean-12-en-30-amide
-
Al3+
inhibits at 0.5-5 mM
amlodipine
-
about 40% residual activity at 0.1 mM
apigenin 7-O-methyl ether
-
arachidonic acid
-
most potent fatty acid inhibitor of recombinant CES1 acting by a noncompetitive mechanism, overview. The inhibition is reversible by bovine serum albumin
ascorbic acid
1 mM, 40% residual activity
asulam
-
91.7% residual activity at 1 mM
atorvastatin
-
about 45% residual activity at 0.1 mM
Ba2+
2 mM, 10% inhibition
bendroflumethiazide
-
about 70% residual activity at 0.1 mM
bioresmethrin
-
a pyrethroid insecticide
bis(4-cyanophenyl) phosphate
-
-
bis(4-nitrophenyl) phosphate
bis(4-nitrophenyl) phosphoric acid
-
97% inhibition at 1 mM
bis(4-nitrophenyl)phosphate
-
potent inhibitor
bis(p-nitrophenyl) phosphate
bis-4-nitrophenyl phosphate
bis-4-nitrophenylphosphate
-
-
bis-p-nitrophenyl phosphate
BNPP, a specific inhibitor of CES, inhibits the hydrolysis of ethyl-FXD in rat skin S9 fraction in a dose-dependent manner, 99% inhibition at 1 mM BNPP
bisoprolol
-
about 90% residual activity at 0.1 mM
butan-1-ol
27 mM, complete inhibition
carvedilol
-
about 17% residual activity at 0.1 mM
cephaloridine
-
competitive inhibitor of 4-nitrophenyl butyrate
cephalothin
-
competitive inhibitor of 4-nitrophenyl butyrate
cetyltrimethylammonium bromide
-
complete inhibition
chloroform
50% (v/v), 2 h incubation, 66% loss of activity
chlorpyrifos-methyl
-
the enzyme is totally inhibited by 0.001 mM chlorpyrifos-methyl
chlorpyrifos-methyl oxon
-
the enzyme is totally inhibited by 0.001 mM chlorpyrifos-methyl oxon
cholesterol
-
slight inhibition of CES1, not CES2
clopidogrel
-
about 15% residual activity at 0.1 mM
CoCl2
-
1mM, 34% residual activity
Cr3+
inhibits at 0.5-5 mM
CuCl2
-
1 mM, 59% residual activity
curcumin
-
reversible inhibition
CuSO4
-
1 mM, 23% residual activity, isoform E1, 10% residual activity, isoform E2
deoxycholate
-
50% inhibition at 1%
didehydrolangduin A-20-O-beta-D-glucopyranoside
-
diethyl 4-hydroxy-4-(trifluoromethyl)-1,4-dihydroimidazo[5,1-c][1,2,4]triazine-3,8-dicarboxylate
-
diethyl 4-hydroxy-4-(trifluoromethyl)-1,4-dihydropyrazolo[5,1-c][1,2,4]triazine-3,8-dicarboxylate
-
diethyl 4-nitrophenyl phosphate
diethyl 4-oxo-2-phenyl-4H-chromen-6-yl phosphate
-
-
diethyl 4-oxo-2-phenyl-4H-chromen-7-yl phosphate
-
-
diethyl 5-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl phosphate
-
-
diethyl 5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl phosphate
-
-
diethyl 7-hydroxy-4-oxo-2-phenyl-4H-chromen-5-yl phosphate
-
-
diethyl coumarylphosphate
-
-
Diethyl p-nitrophenyl phosphate
diethylfluorophosphate
0.01 mM, 30°C, 30 min, 75% inhibition
diethylphosphofluoridate
-
-
diethylpyrocarbonate
5 mM,% inhibition
diethylumbelliferyl phosphate
-
diisopropyl fluorophosphate
diisopropyl phosphofluoridate
-
-
diisopropylfluorophosphate
diltiazem
-
about 23% residual activity at 0.1 mM
dimethyl 4-oxo-2-phenyl-4H-chromen-6-yl phosphate
-
-
dimethyl 4-oxo-2-phenyl-4H-chromen-7-yl phosphate
-
-
Dimethyl formamide
-
inactivation
dimethylchlorophosphate
-
dimethylformamide
50% (v/v), 2 h incubation, 72% loss of activity
dimyristoylphosphatidylcholine
-
88% inhibition
dipalmitoylphosphatidylcholine
-
91.5% inhibition
diphenylamine-2-carboxylate
5 mM, 30°C, 30 min, 77% inhibition
dithiobis-(2-nitrobenzoic acid)
-
weak
DMF
-
10% (v/v) and 20% (v/v), strong decrease in activity of wild-type enzyme and mutant enzymes V138G and V138G/L200R
donepezil hydrochloride
-
-
E600
half-inactivation times of 20 s, at an inhibitor:enzyme molar ratio is 10:1
ebelactone A
-
inhibits more than 80% of the enzyme at 1 mM
ebelactone B
-
complete inhibition at 1 mM
ent-16beta,17-dihydroxyatisan-3-one-19-O-beta-D-(6'-galloyl)-glucopyranoside
-
ent-16beta,17-dihydroxyatisan-3-one-19-O-beta-D-glucopyranoside
-
ent-kaurane-16beta,17-diol-3,12-dione-19-O-beta-D-glucopyranoside
-
ent-kaurane-16beta,17-diol-3-one-19-O-beta-D-(6'-galloyl)-glucopyranoside
-
ent-kaurane-16beta,17-diol-3-one-19-O-beta-D-glucopyranoside
-
eplerenone
-
about 80% residual activity at 0.1 mM
ethyl 3-amino-5-(trifluoromethyl)-1,2,4-triazine-6-carboxylate
-
ethyl 4-hydroxy-4-(trifluoromethyl)-1,4-dihydro[1,2,4]triazolo[5,1-c][1,2,4]triazine-3-carboxylate
-
ethyl 7-hydroxy-7-(trifluoromethyl)-4,7-dihydrotetrazolo[5,1-c][1,2,4]triazine-6-carboxylate
-
ethyl butyrate
-
substrate inhibition
ethyl-4-hydroxy-7-methyl-4-nonaluorobuthyl-1,4-dihydropyrazolo[5,1-c][1,2,4]triazine-3-carboxylate
-
ethyl-4-hydroxy-7-methyl-4-trifluoromethyl-1,4-dihydropyrazolo[5,1-c][1,2,4]triazine-3-carboxylate
-
ethyl-4-hydroxy-7-phenyl-4-nonafluorobutyl-1,4-dihydropyrazolo[5,1-c][1,2,4]triazine-3-carboxylate
-
ethyl-4-hydroxy-7-phenyl-4-pentafluoroethyl-1,4-dihydropyrazolo[5,1-c][1,2,4]triazine-3-carboxylate
-
ethyl-4-hydroxy-7-phenyl-4-trifluoromethyl-1,4-dihydropyrazolo[5,1-c][1,2,4]triazine-3-carboxylate
-
ethyl-7-hydroxy-7-nonafluorobutyl-4,7-dihydrotetrazolo[5,1-c][1,2,4]triazine-6-carboxylate
-
ethyl-7-hydroxy-7-nonafluorobutyl-4,7-dihydro[1,2,4]triazolo[5,1-c][1,2,4]triazine-6-carboxylate
-
FeCl2
-
1 mM, 40% residual activity
FeCl3
-
1 mM, 38% residual activity
fischeroside A-16-O-beta-D-glucopyranoside
-
formaldehyde
20% (v/v), 2 h incubation, 81% loss of activity
Furosemide
-
about 78% residual activity at 0.1 mM
glufosinate
-
low to moderate inhibition
-
glycerol
inhibition of mutant enzyme R11G/L36P/V225A/I551L/A564T no matter that it is or is not treated by acetone
HEPES
-
inhibition mechanism, competitive
ingenol-19-O-beta-D-glucopyranoside
-
irbesartan
-
about 75% residual activity at 0.1 mM
isradipine
-
about 18% residual activity at 0.1 mM
L-4-tosylamino-2-phenylethyl chloromethyl ketone
-
inhibits more than 80% of the enzyme at 1 mM
L-Leu-chloromethyl ketone
-
60.4% residual activity at 1 mM
lercanidipine
-
about 78% residual activity at 0.1 mM
lysophosphatidic acid
-
-
mercaptoethanol
5 mM, 15% loss of activity (recombinant enzyme expressed in Sulfolobus solfataricus). 5 mM, 25% loss of activity (recombinant enzyme expressed in Escherichia coli as thioredoxin-free form (EcSisEstA I)). 5 mM, 22% loss of activity (recombinant enzyme expressed in Escherichia coli as a thioredoxin-EstA fusion protein (EcSisEstA II))
methyl 4-hydroxy-4-(nonafluorobutyl)-1,4-dihydro[1,2,4]triazolo[5,1-c][1,2,4]triazine-3-carboxylate
-
methyl 7-(heptafluoropropyl)-7-hydroxy-4,7-dihydrotetrazolo[5,1-c][1,2,4]triazine-6-carboxylate
-
methyl 7-hydroxy-7-(1,1,2,2-tetrafluoroethyl)-4,7-dihydrotetrazolo[5,1-c][1,2,4]triazine-6-carboxylate
-
methyl 7-hydroxy-7-(nonafluorobutyl)-4,7-dihydrotetrazolo[5,1-c][1,2,4]triazine-6-carboxylate
-
methyl-4-hydroxy-7-phenyl-4-nonafluorobutyl-1,4-dihydropyrazolo[5,1-c][1,2,4]triazine-3-carboxylate
-
methyl-7-hydroxy-7-trifluoromethyl-4,7-dihydrotetrazolo[5,1-c][1,2,4]triazine-6-carboxylate
-
mono-4-nitrophenyl phosphoric acid ester
-
25% inhibition at 1 mM, no inhibition at 0.1 mM
N,N'-(1,4-phenylene)bis(2,3-dichlorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(2,4,5-trichlorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(2,5-dichlorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(2,6-difluorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(2-fluorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3,4,5-trifluorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3,4-dichlorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3,4-difluorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3,5-dichlorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3,5-difluorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3-bromobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3-chlorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3-fluorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(4-bromobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(4-chlorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(4-fluoro-2-methylbenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(4-fluorobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-fluoro-1,4-phenylene)bis(4-chlorobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetrafluoro-1,4-phenylene)bis(4-bromobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(3,4-dichlorobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(3,5-dichlorobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(3-bromobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(3-chlorobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(4-bromobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(4-chlorobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(4-fluorobenzene sulfonamide)
-
-
N,N'-(2,5-dibromo-1,4-phenylene)bis(4-chlorobenzene sulfonamide)
-
-
N,N'-(2,5-dibromo-1,4-phenylene)bisbenzene sulfonamide
-
-
N,N'-(2,5-dichloro-1,4-phenylene)bis(4-chlorobenzene sulfonamide)
-
-
N,N'-(2-chloro-1,4-phenylene)dibenzene sulfonamide
-
-
N,N'-(2-methyl-1,4-phenylene)benzene sulfonamide
-
-
N,N'-(2-methylbenzene-1,4-diyl)dibenzenesulfonamide
-
-
N,N'-(disulfanediyldibenzene-4,1-diyl)dimethanesulfonamide
-
-
N,N'-1,4-phenylenebis-2-naphthalene sulfonamide
-
-
N,N'-9H-fluorene-2,7-diylbis(3,4,5-trifluorobenzenesulfonamide)
-
-
N,N'-9H-fluorene-2,7-diylbis(3-bromobenzenesulfonamide)
-
-
N,N'-9H-fluorene-2,7-diylbis(3-chlorobenzenesulfonamide)
-
-
N,N'-9H-fluorene-2,7-diylbis(4-chlorobenzenesulfonamide)
-
-
N,N'-9H-fluorene-2,7-diyldibenzenesulfonamide
-
-
N,N'-benzene-1,4-diyldibenzenesulfonamide
-
-
N-(4-(4-fluoromethylphenylsulfonamido)phenyl)-2,5-dimethylbenzene sulfonamide
-
-
N-(methoxysuccinyl)-L-Ala-L-Ala-L-Pro-L-Val chloromethyl ketone
-
61.8% residual activity at 1 mM
N-alpha-tosyl-L-Lys chloromethyl ketone
-
98.6% residual activity at 1 mM
N-carbobenzyloxy-L-Phe chloromethyl ketone
-
57% residual activity at 1 mM
N-ethylmaleimide
-
slight inhibition
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-2-(thiophen-2-yl)acetamide
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-2-phenoxyacetamide
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-4-(trifluoromethyl)benzamide
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]acetamide
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]butanamide
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]cyclohexanecarboxamide
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]hexanamide
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]pentanamide
-
-
neostigmine
-
serum enzyme is inhibited, liver enzyme is not affected
NiCl2
-
1 mM, 35% residual activity
nimodipine
-
about 70% residual activity at 0.1 mM
O,O'-bis(2-aminoethyl)ethylenglycol-N,N,N',N'-tetraacetic acid
-
-
O-ethyl O-p-nitrophenyl benzene phosphothioate
-
-
organophosphate compounds
-
-
-
organophosphate esters
-
-
-
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoic acid
-
complete inhibition
p-trimethylammoniumanilinium dichloride
-
serum enzyme is inhibited, liver enzyme is not affected
paraoxon-methyl
-
0.0004 mM, complete inhibition
parathion
Culex sp.
-
diacetylmonoxime protects
Pb2+
inhibits at 0.5-5 mM
PEG 6000
-
complete inhibition
phenyl 4-(heptafluoropropyl)-4-hydroxy-1,4-dihydro[1,2,4]triazolo[5,1-c][1,2,4]triazine-3-carboxylate
-
phenyl 7-hydroxy-7-(trifluoromethyl)-4,7-dihydrotetrazolo[5,1-c][1,2,4]triazine-6-carboxylate
-
Phenylarsine oxide
-
10% residual activity at 5 mM
phenylmethanesulfonyl fluoride
0.1 mM, complete inhibition
Phenylmethyl sulfonylfluoride
phenylmethylsulfonyl fluoride
Phenylmethylsulfonylfluoride
Phenylmethylsulphonyl fluoride
-
inhibits at 10 mM
polyphenol extracts from Arenaria serpyllifolia
-
polyphenol extracts from Rhamnus alaternus
-
polyphenol extracts from Thapsia gargantica
-
prasugrel
-
inhibits isozyme CE2 at high concentrations in vitro but not in vivo
prostaglandin F2alpha
-
-
reduced glutathione
-
reversible inhibition
S,S,S-tributyl phosphorotrithioate
-
DEF, dynergist DEF can inhibit the activity of carboxylesterase in insect
S,S,S-tributylphosphorotrithionate
-
-
salicylate
-
of 14 recombinant methyl esterase proteins tested, five show preference for methyl salicylate as a substrate and display salicylate inhibition of methyl salicylate esterase activity in vitro, i.e. AtMES1, -2, -4, -7, and -9
sirolimus
-
about 90% residual activity at 0.1 mM
Sn2+
-
63% inhibition at 25 mM
Sodium cyanide
-
poor inhibition
spironolactone
-
about 70% residual activity at 0.1 mM
tacrolimus
-
about 28% residual activity at 0.1 mM
telmisartan
4-nitrophenyl acetate hydrolysis in human iPS cell-derived enterocytes is significantly inhibited by the CES2A1-specific inhibitor telmisartan
tetraethyl 4-oxo-2-phenyl-4H-chromene-5,7-diyl bis(phosphate)
-
-
tetraethyl 5-hydroxy-4-oxo-2-phenyl-4H-chromene-6,7-diyl bis(phosphate)
-
-
tetraisopropyl diphosphoramide
-
67% inhibition at 0.5 mM
Toluene
20% (v/v), 2 h incubation, 86% loss of activity
tosyl-L-phenylalanine chloromethyl ketone
-
inhibits more than 80% of the enzyme at 1 mM
trans-permethrin
-
a pyrethroid insecticide
trans/cis-permethrin
-
substrate inhibition
tris(p-nitrophenyl)phosphate
-
-
Tween
5% (v/v), 94% inhibition
Tween 50
10% (v/v), 49% inhibition
-
Tween 60
10% (w/v), 49% inhibition
Tween-20
0.1% v/v, 16% loss of activity. 1% v/v, 33% loss of activity
Tween-80
inhibition of wild-type and mutant enzyme R11G/L36P/V225A/I551L/A564T no matter that they are or are not treated by acetone
Urea
5 mM, 16% loss of activity (recombinant enzyme expressed in Sulfolobus solfataricus). 5 mM, 17% loss of activity (recombinant enzyme expressed in Escherichia coli as thioredoxin-free form (EcSisEstA I)). 5 mM, 10% loss of activity (recombinant enzyme expressed in Escherichia coli as a thioredoxin-EstA fusion protein (EcSisEstA II))
valsartan
-
about 90% residual activity at 0.1 mM
1,1'-ethane-1,2-diylbis(1H-indole-2,3-dione)
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1,1'-ethane-1,2-diylbis(1H-indole-2,3-dione)
-
comparison with inhibition of human carboxyesterases hCE1 and hiCE and with acetyl- and butyrylcholinesterase
1,1,1,-trifluoro-3-(hexylsulfinyl)propane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hiCE and rabbit enzyme
1,1,1,-trifluoro-3-(hexylsulfinyl)propane-2,2-diol
comparison with inhibition of human isoforms hiCE and hCE1
1,1,1,-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hiCE and rabbit enzyme
1,1,1,-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
comparison with inhibition of human isoforms hiCE and hCE1
1,1,1-trifluoro-3-(hexyloxy)propane-2,2-diol
-
-
1,1,1-trifluoro-3-(hexyloxy)propane-2,2-diol
-
-
1,1,1-trifluoro-3-(hexyloxy)propane-2,2-diol1,1,1-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hiCE and rabbit enzyme
1,1,1-trifluoro-3-(hexyloxy)propane-2,2-diol1,1,1-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
comparison with inhibition of human isoforms hiCE and hCE1
1,1,1-trifluoro-3-(hexylsulfanyl)propan-2-one
-
-
1,1,1-trifluoro-3-(hexylsulfanyl)propan-2-one
-
-
1,1,1-trifluoro-3-(hexylsulfinyl)propane-2,2-diol
-
-
1,1,1-trifluoro-3-(hexylsulfinyl)propane-2,2-diol
-
-
1,1,1-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
-
-
1,1,1-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
-
-
1,1,1-trifluoro-3-(octylsulfanyl)propan-2-one
-
-
1,1,1-trifluoro-3-(octylsulfanyl)propan-2-one
-
-
1,1,1-trifluoro-3-(octylsulfinyl)propane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hiCE and rabbit enzyme
1,1,1-trifluoro-3-(octylsulfinyl)propane-2,2-diol
-
-
1,1,1-trifluoro-3-(octylsulfinyl)propane-2,2-diol
comparison with inhibition of human isoforms hiCE and hCE1
1,1,1-trifluoro-3-(octylsulfinyl)propane-2,2-diol
-
-
1,1,1-trifluoro-3-(octylsulfonyl)propane-2,2-diol
-
-
1,1,1-trifluoro-3-(octylsulfonyl)propane-2,2-diol
-
-
1,1,1-trifluoro-3-[(2-phenylethyl)sulfanyl]propan-2-one
-
-
1,1,1-trifluoro-3-[(2-phenylethyl)sulfanyl]propan-2-one
-
-
1,1,1-trifluoro-3-[(2-phenylethyl)sulfonyl]propane-2,2-diol
-
-
1,1,1-trifluoro-3-[(2-phenylethyl)sulfonyl]propane-2,2-diol
-
-
1,1,1-trifluorododecan-2-one
-
-
1,1,1-trifluorododecan-2-one
-
-
1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme
1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoforms hCE1 and hCE2
1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme
1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoforms hCE1 and hCE2
1,2-bis(2,3-difluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme
1,2-bis(2,3-difluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoforms hCE1 and hCE2
1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone
comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme
1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone
comparison with inhibition of human isoforms hCE1 and hCE2
1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone
comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme
1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone
comparison with inhibition of human isoforms hCE1 and hCE2
1,2-bis(2-chlorophenyl)ethane-1,2-dione
-
-
1,2-bis(2-chlorophenyl)ethane-1,2-dione
-
-
1,2-bis(3,4,5-trifluorophenyl)ethane-1,2-dione
-
-
1,2-bis(3,4,5-trifluorophenyl)ethane-1,2-dione
-
-
1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone
comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme
1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone
comparison with inhibition of human isoforms hCE1 and hCE2
1,2-bis(3,5-difluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme
1,2-bis(3,5-difluorophenyl)ethane-1,2-dione
-
-
1,2-bis(3,5-difluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoforms hCE1 and hCE2
1,2-bis(3,5-difluorophenyl)ethane-1,2-dione
-
-
1,2-bis(3-methoxyphenyl)ethane-1,2-dione
-
-
1,2-bis(3-methoxyphenyl)ethane-1,2-dione
-
-
1,2-bis(3-nitrophenyl)ethane-1,2-dione
-
-
1,2-bis(3-nitrophenyl)ethane-1,2-dione
-
-
1,2-bis(4-bromo-2-methoxyphenyl)ethane-1,2-dione
-
-
1,2-bis(4-bromo-2-methoxyphenyl)ethane-1,2-dione
-
-
1,2-bis(4-bromo-3-nitrophenyl)ethane-1,2-dione
-
-
1,2-bis(4-bromo-3-nitrophenyl)ethane-1,2-dione
-
-
1,2-bis(4-bromothiophen-2-yl)ethane-1,2-dione
-
-
1,2-bis(4-bromothiophen-2-yl)ethane-1,2-dione
-
-
1,2-bis(4-chlorophenyl)ethane-1,2-dione
-
-
1,2-bis(4-chlorophenyl)ethane-1,2-dione
-
-
1,2-bis(4-fluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme
1,2-bis(4-fluorophenyl)ethane-1,2-dione
-
-
1,2-bis(4-fluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoforms hCE1 and hCE2
1,2-bis(4-fluorophenyl)ethane-1,2-dione
-
-
1,2-bis(4-methoxyphenyl)ethane-1,2-dione
-
-
1,2-bis(4-methoxyphenyl)ethane-1,2-dione
-
-
1,2-bis(4-methylphenyl)ethane-1,2-dione
-
-
1,2-bis(4-methylphenyl)ethane-1,2-dione
-
-
1,2-bis(5-bromothiophen-2-yl)ethane-1,2-dione
-
-
1,2-bis(5-bromothiophen-2-yl)ethane-1,2-dione
-
-
1,2-di(furan-2-yl)ethane-1,2-dione
-
-
1,2-di(furan-2-yl)ethane-1,2-dione
-
-
1,2-di(naphthalen-2-yl)ethane-1,2-dione
-
-
1,2-di(naphthalen-2-yl)ethane-1,2-dione
-
-
1,2-di(pyridin-2-yl)ethane-1,2-dione
-
-
1,2-di(pyridin-2-yl)ethane-1,2-dione
-
-
1,2-di(thiophen-2-yl)ethane-1,2-dione
-
-
1,2-di(thiophen-2-yl)ethane-1,2-dione
-
-
1,2-di(thiophen-3-yl)ethane-1,2-dione
-
-
1,2-di(thiophen-3-yl)ethane-1,2-dione
-
-
1,2-dicyclohexylethane-1,2-dione
-
-
1,2-dicyclohexylethane-1,2-dione
-
-
1,2-diphenylethane-1,2-dione
-
-
1,2-diphenylethane-1,2-dione
-
-
1,4-dibromo-1,4-diphenyl butane-2,3-dione
-
irreversible inhibition
1,4-dibromo-1,4-diphenyl butane-2,3-dione
-
irreversible inhibition
1-(2,4-dinitrophenyl)-2-phenylethane-1,2-dione
-
-
1-(2,4-dinitrophenyl)-2-phenylethane-1,2-dione
-
-
1-(2-bromoethyl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-(2-bromoethyl)-1H-indole-2,3-dione
-
comparison with inhibition of human carboxyesterases hCE1 and hiCE and with acetyl- and butyrylcholinesterase
1-(2-chlorophenyl)-2-(3,4-dimethoxyphenyl)ethane-1,2-dione
-
-
1-(2-chlorophenyl)-2-(3,4-dimethoxyphenyl)ethane-1,2-dione
-
-
1-(2-iodoethyl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-(2-iodoethyl)-1H-indole-2,3-dione
-
comparison with inhibition of human carboxyesterases hCE1 and hiCE and with acetyl- and butyrylcholinesterase
1-(3,4-dichlorobenzyl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-(3,4-dichlorobenzyl)-1H-indole-2,3-dione
-
comparison with inhibition of human carboxyesterases hCE1 and hiCE and with acetyl- and butyrylcholinesterase
1-(3,4-dimethylphenyl)-2-phenylethane-1,2-dione
-
-
1-(3,4-dimethylphenyl)-2-phenylethane-1,2-dione
-
-
1-(4-(4[(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)methyl]benzyl)benzyl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-(4-(4[(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)methyl]benzyl)benzyl)-1H-indole-2,3-dione
-
comparison with inhibition of human carboxyesterases hCE1 and hiCE and with acetyl- and butyrylcholinesterase
1-(4-chlorobenzyl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-(4-chlorobenzyl)-1H-indole-2,3-dione
-
comparison with inhibition of human carboxyesterases hCE1 and hiCE and with acetyl- and butyrylcholinesterase
1-(4-chlorophenyl)-2-(4-methylphenyl)ethane-1,2-dione
-
-
1-(4-chlorophenyl)-2-(4-methylphenyl)ethane-1,2-dione
-
-
1-(4-chlorophenyl)-2-phenylethane-1,2-dione
-
-
1-(4-chlorophenyl)-2-phenylethane-1,2-dione
-
-
1-(4-methoxyphenyl)-2-phenylethane-1,2-dione
-
-
1-(4-methoxyphenyl)-2-phenylethane-1,2-dione
-
-
1-(4-methyl-3-nitrophenyl)-2-phenylethane-1,2-dione
-
-
1-(4-methyl-3-nitrophenyl)-2-phenylethane-1,2-dione
-
-
1-(4-methylphenyl)-2-phenylethane-1,2-dione
-
-
1-(4-methylphenyl)-2-phenylethane-1,2-dione
-
-
1-(4-nitrophenyl)-2-phenylethane-1,2-dione
-
-
1-(4-nitrophenyl)-2-phenylethane-1,2-dione
-
-
1-(pentachlorophenyl)-2-(pentafluorophenyl)ethane-1,2-dione
-
-
1-(pentachlorophenyl)-2-(pentafluorophenyl)ethane-1,2-dione
-
-
1-([(2-bromophenyl)amino]methyl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-([(2-bromophenyl)amino]methyl)-1H-indole-2,3-dione
-
comparison with inhibition of human carboxyesterases hCE1 and hiCE and with acetyl- and butyrylcholinesterase
1-([(4-chlorophenyl)amino]methyl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-([(4-chlorophenyl)amino]methyl)-1H-indole-2,3-dione
-
comparison with inhibition of human carboxyesterases hCE1 and hiCE and with acetyl- and butyrylcholinesterase
1-benzyl-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-benzyl-1H-indole-2,3-dione
-
comparison with inhibition of human carboxyesterases hCE1 and hiCE and with acetyl- and butyrylcholinesterase
1-butanol
-
10% (v/v), complete loss of activity, wild-type enzyme and mutant enzymes V138G and V138G/L200R
1-butanol
-
62% inhibition of BioHe at 30%
1-butanol
5% (v/v), 95% inhibition; 5% (w/v), 95% inhibition
1-butanol
95% inhibition of BioHs at 30%
1-dodecyl-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-dodecyl-1H-indole-2,3-dione
-
comparison with inhibition of human carboxyesterases hCE1 and hiCE and with acetyl- and butyrylcholinesterase
1-hexadecyl-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-hexadecyl-1H-indole-2,3-dione
-
comparison with inhibition of human carboxyesterases hCE1 and hiCE and with acetyl- and butyrylcholinesterase
1-phenyl-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-phenyl-1H-indole-2,3-dione
-
comparison with inhibition of human carboxyesterases hCE1 and hiCE and with acetyl- and butyrylcholinesterase
1-propanol
-
10% (v/v), complete loss of activity, wild-type enzyme and mutant enzymes V138G and V138G/L200R
1-propanol
5% (v/v), 91% inhibition; 5% (w/v), 91% inhibition
1-[(2-naphthylamino)methyl]-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-[(2-naphthylamino)methyl]-1H-indole-2,3-dione
-
comparison with inhibition of human carboxyesterases hCE1 and hiCE and with acetyl- and butyrylcholinesterase
1-[4-(bromomethyl)phenyl]-2-phenylethane-1,2-dione
-
-
1-[4-(bromomethyl)phenyl]-2-phenylethane-1,2-dione
-
-
1-[4-[oxo(phenyl)acetyl]phenyl]-2-phenylethane-1,2-dione
-
-
1-[4-[oxo(phenyl)acetyl]phenyl]-2-phenylethane-1,2-dione
-
-
2-chloro-3,4-dimethoxybenzil
-
blocks hydrolysis of trans-permethrin by isoform hCE2 36 times more efficiently than hCE1
2-chloro-3,4-dimethoxybenzil
-
-
2-chloro-3,4-dimethoxybenzil
-
blocks hydrolysis of trans-permethrin by isoform hCE2 36 times more efficiently than hCE1
2-chloro-3,4-dimethoxybenzil
-
blocks hydrolysis of trans-permethrin by isoform hCE2 36 times more efficiently than hCE1
2-hydroxy-1,2-bis(2,3,4-trifluorophenyl)ethanone
comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme
2-hydroxy-1,2-bis(2,3,4-trifluorophenyl)ethanone
comparison with inhibition of human isoforms hCE1 and hCE2
2-hydroxy-1,2-bis(2,3,5-trifluorophenyl)ethanone
comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme
2-hydroxy-1,2-bis(2,3,5-trifluorophenyl)ethanone
comparison with inhibition of human isoforms hCE1 and hCE2
2-mercaptoethanol
-
-
2-mercaptoethanol
1 mM, 8% inhibition
2-mercaptoethanol
-
94% residual activity
2-mercaptoethanol
-
reversible inhibition
2-propanol
slight inhibition
2-propanol
10% (v/v), 94% inhibition; 5% (w/v), 58% inhibition. 10% (w/v), 94% inhibition
3-(butylsulfanyl)-1,1,1-trifluoropropan-2-one
-
-
3-(butylsulfanyl)-1,1,1-trifluoropropan-2-one
-
-
3-(decylsulfanyl)-1,1,1-trifluoropropan-2-one
-
-
3-(decylsulfanyl)-1,1,1-trifluoropropan-2-one
-
-
3-(decylsulfinyl)-1,1,1-trifluoropropane-2,2-diol
-
-
3-(decylsulfinyl)-1,1,1-trifluoropropane-2,2-diol
-
-
3-(decylsulfonyl)-1,1,1-trifluoropropane-2,2-diol
-
-
3-(decylsulfonyl)-1,1,1-trifluoropropane-2,2-diol
-
-
3-(dodecylsulfanyl)-1,1,1-trifluoropropan-2-one
-
-
3-(dodecylsulfanyl)-1,1,1-trifluoropropan-2-one
-
-
3-(dodecylsulfinyl)-1,1,1-trifluoropropane-2,2-diol
-
-
3-(dodecylsulfinyl)-1,1,1-trifluoropropane-2,2-diol
-
-
3-(dodecylsulfonyl)-1,1,1-trifluoropropane-2,2-diol
-
-
3-(dodecylsulfonyl)-1,1,1-trifluoropropane-2,2-diol
-
-
3-butylsulfinyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hiCE and rabbit enzyme
3-butylsulfinyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoforms hiCE and hCE1
3-decylsulfinyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hiCE and rabbit enzyme
3-decylsulfinyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoforms hiCE and hCE1
3-decylsulfonyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hiCE and rabbit enzyme
3-decylsulfonyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoforms hiCE and hCE1
3-dodecylsulfinyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hiCE and rabbit enzyme
3-dodecylsulfinyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoforms hiCE and hCE1
3-dodecylsulfonyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hiCE and rabbit enzyme
3-dodecylsulfonyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoforms hiCE and hCE1
4,6-dichloro-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
4,6-dichloro-1H-indole-2,3-dione
-
comparison with inhibition of human carboxyesterases hCE1 and hiCE and with acetyl- and butyrylcholinesterase
4,7-dichloro-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
4,7-dichloro-1H-indole-2,3-dione
-
comparison with inhibition of human carboxyesterases hCE1 and hiCE and with acetyl- and butyrylcholinesterase
4-mercuribenzoate
-
-
4-mercuribenzoate
-
complete inhibition at 1 mM, 80% inhibition at 0.1 mM
4-[oxo(phenyl)acetyl]benzoic acid
-
-
4-[oxo(phenyl)acetyl]benzoic acid
-
-
5-bromo-1-(2-methylprop-2-en-1-yl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
5-bromo-1-(2-methylprop-2-en-1-yl)-1H-indole-2,3-dione
-
comparison with inhibition of human carboxyesterases hCE1 and hiCE and with acetyl- and butyrylcholinesterase
5-methoxy-3-(4-phenoxyphenyl)-3H-[1,3,4]oxadiazol-2-one
the inhibitor concentration at which the enzyme activity decreases to 50% after incubation for 5 min is 20 nM
5-methoxy-3-(4-phenoxyphenyl)-3H-[1,3,4]oxadiazol-2-one
half-inactivation time is 15 min, at an inhibitor:enzyme molar ratio of 100:1
acetone
-
20% (v/v), complete loss of activity, wild-type enzyme and mutant enzymes V138G and V138G/L200R
acetone
-
15% inhibition of BioHe at 30%
acetone
slight inhibition
acetone
10% (v/v), 88% inhibition; 10% (w/v), 88% inhibition
acetone
96% inhibition of BioHs at 30%
acetone
50% (v/v), 2 h incubation, 60% loss of activity
acetonitrile
-
20% (v/v), complete loss of activity, wild-type enzyme and mutant enzymes V138G and V138G/L200R
acetonitrile
-
89% inhibition of BioHe at 30%
acetonitrile
15% v/v, 1.8fold activation. 30% v/v, 32% loss of activity
acetonitrile
-
inactivation
acetonitrile
10% (w/v), 61% inhibition; 5% (v/v), 61% inhibition
acetonitrile
97% inhibition of BioHs at 30%
Ag+
strong inhibition at 1 mM
Ag+
-
1 mM, complete inhibition
Ag+
1 mM, more than 70% loss of activity
Ag+
0.5 mM, complete inhibition; strong
Aldicarb
-
-
benzil
comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme
benzil
-
specific CES inhibitor
benzil
-
inhibition of CES1 in THP-1 cells
benzil
-
irreversible inhibition
benzil
comparison with inhibition of human isoforms hCE1 and hCE2
benzil
-
irreversible inhibition
benzil
-
38% residual activity at 1 mM
bis(4-nitrophenyl) phosphate
-
-
bis(4-nitrophenyl) phosphate
-
0.1 mM, 98.6% inhibition
bis(4-nitrophenyl) phosphate
-
-
bis(4-nitrophenyl) phosphate
-
-
bis(4-nitrophenyl) phosphate
-
-
bis(4-nitrophenyl) phosphate
-
-
bis(4-nitrophenyl) phosphate
-
0.01 mM, 30 min, 89% loss of activity of isoenzyme V, 97% loss of activity of isoenzyme I
bis(4-nitrophenyl) phosphate
-
25% inhibition at 1 mM, no inhibition at 0.1 mM
bis(p-nitrophenyl) phosphate
-
a specific inhibitor of carboxylesterases
bis(p-nitrophenyl) phosphate
-
a specific inhibitor of carboxylesterases
bis(p-nitrophenyl) phosphate
-
a specific inhibitor of carboxylesterases
bis(p-nitrophenyl) phosphate
-
a specific inhibitor of carboxylesterases
bis-4-nitrophenyl phosphate
-
irreversible carboxylesterase inhibitor
bis-4-nitrophenyl phosphate
-
irreversible carboxylesterase inhibitor
bis-4-nitrophenyl phosphate
-
irreversible carboxylesterase inhibitor
bis-4-nitrophenyl phosphate
-
irreversible carboxylesterase inhibitor
bis-4-nitrophenyl phosphate
-
irreversible carboxylesterase inhibitor
bis-4-nitrophenyl phosphate
-
bis-4-nitrophenyl phosphate
BNPP; BNPP
bis-4-nitrophenyl phosphate
BNPP
bis-4-nitrophenyl phosphate
-
BNPP, a specific carboxylesterase inhibitor, strong inhibition at 1 mM
bis-4-nitrophenyl phosphate
-
irreversible carboxylesterase inhibitor
bis-4-nitrophenyl phosphate
BNPP, a specific inhibitor of CES, inhibits the hydrolysis of ethyl-FXD in rat skin S9 fraction in a dose-dependent manner, 99% inhibition at 1 mM BNPP
bis-4-nitrophenyl phosphate
BNPP
butanol
-
butanol
strong inhibition
Ca2+
-
-
Ca2+
inhibits at 0.5-5 mM
Ca2+
2 mM, 13% inhibition
Carbaryl
-
-
Carbaryl
-
78% inhibition
chlorpyrifos
-
chlorpyrifos
Culex sp.
-
presence of diacetylmonoxime protects
chlorpyrifos
-
65% inhibition
chlorpyrifos
-
significant inhibition of 56% and 79% after exposure to 0.0012 and 0.0073 mg/l, resp.
chlorpyrifos-oxon
-
-
chlorpyrifos-oxon
-
CaE activity on 4-nitrophenyl valerate is more sensitive to chlorpyrifos-oxon than CaE activity determined by 4-nitrophenyl acetate and alpha-naphthyl acetate
Co2+
-
-
Co2+
-
about 42% residual activity at 5 mM Co2+ after 1 h of incubation
Co2+
inhibits at 0.5-5 mM
Co2+
-
18% inhibition at 25 mM
Co2+
1 mM, 5% inhibition. 10 mM, 27% inhibition
Co2+
5 mM, 38% inhibition
Cu2+
-
-
Cu2+
strong inhibition at 1 mM
Cu2+
inhibits at 0.5-5 mM
Cu2+
-
10 mM Cu2+ reduces the esterase activity by 65%
Cu2+
93.5% inhibition at 5 mM
Cu2+
1 mM, more than 70% loss of activity
Cu2+
-
45% reduced activity
Cu2+
-
over 94% inhibition at 25 mM
Cu2+
-
1 mM, 14% loss of activity
Cu2+
-
30% inhibition of recombinant BioHe at 5-10 mM
Cu2+
1 mM, 15% inhibition. 10 mM, 95% inhibition
Cu2+
5 mM, 57% inhibition; 5 mM, reduces the esterase activity to 43%
Cu2+
-
76% residual activity at 1 mM
decane-5,6-dione
-
-
deltamethrin
-
-
deltamethrin
-
48% inhibition
DFP
-
-
DFP
-
0.01 mM, 99% loss of activity after 5 min
DFP
-
complete inhibition at 1 mM, 80% inhibition at 0.1 mM
dichlorvos
Arg43 plays an important role in the interaction between AFEST and dichlorvos by means of stabilizing the complex. The IC50 of the mutant enzyme R43S to dichlorvos is lower than that of the wild type AFEST by a factor of 1.56
dichlorvos
-
CaE activities on 4-nitrophenyl acetate and alpha-naphthyl acetate are more sensitive to chlorpyrifos-oxon than CaE activity determined by 4-nitrophenyl valerate
diethyl 4-nitrophenyl phosphate
-
i.e. E600, strong inhibitor
diethyl 4-nitrophenyl phosphate
1 mM, 70% inhibition
diethyl 4-nitrophenyl phosphate
-
complete inhibition at 5 mM
diethyl dicarbonate
-
irreversible inhibition
diethyl dicarbonate
1 mM, 19% inhibition
diethyl dicarbonate
-
8% residual activity at 5 mM
Diethyl p-nitrophenyl phosphate
1 mM, 70% inhibition
Diethyl p-nitrophenyl phosphate
-
diethyldicarbonate
-
-
diethyldicarbonate
1.5 mM, 94% inhibition
diethyldicarbonate
-
1 mM, 1.6% residual activity, isoform E1, 2.4% residual activity, isoform E2
diethyldicarbonate
-
weak inhibition
diethyldicarbonate
2.0 mM, 98% inhibition
diethyldicarbonate
5 mM,% inhibition
Digitonin
specifically inhibits isozyme CES1A. The metabolism of MEGX to 2,6-xylidine is inhibited by the CES1A inhibitor digitonin in Caco-2 cells
Digitonin
specifically inhibits CES1
diisopropyl fluorophosphate
-
-
diisopropyl fluorophosphate
irreversible
diisopropyl fluorophosphate
-
irreversible inhibition
diisopropyl fluorophosphate
-
-
diisopropyl fluorophosphate
-
reversible inhibition
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
complete inhibition at 0.01 mM
dioxane
-
dithiothreitol
-
1 mM, 58% residual activity
dithiothreitol
-
1 mM, 35% inhibition
dithiothreitol
1 mM, 14% loss of activity (recombinant enzyme expressed in Sulfolobus solfataricus). 1 mM, 19% loss of activity (recombinant enzyme expressed in Escherichia coli as thioredoxin-free form (EcSisEstA I)). 1 mM, 23% loss of activity (recombinant enzyme expressed in Escherichia coli as a thioredoxin-EstA fusion protein (EcSisEstA II))
dithiothreitol
-
reversible inhibition
DMSO
-
10% (v/v), activity and enantioselectivity of mutant enzyme V138G toward (S)-ketoprofen ethyl ester is greatly increased. 10% (v/v) and 20% (v/v) decreases activity of wild-type and mutant enzyme V138G/L200R
DMSO
30% v/v, 22% loss of activity
DMSO
10% (w/v), 66% inhibition; 5% (v/v), 58% inhibition
DMSO
22% inhibition of BioHs at 30%
dodecane-6,7-dione
-
-
DTT
-
1 mM 12% inhibition
DTT
-
1 mM, 42% inhibition
EDTA
-
-
EDTA
-
10 mM, 20% inhibition
EDTA
-
95% residual activity at 5 mM
EDTA
-
1 mM, 10.8% inhibition
EDTA
-
5 mM, 5 min, slight decrease in activity
EDTA
5 mM, 42% loss of activity (recombinant enzyme expressed in Sulfolobus solfataricus). 5 mM, 69% loss of activity (recombinant enzyme expressed in Escherichia coli as thioredoxin-free form (EcSisEstA I)). 5 mM, 65% loss of activity (recombinant enzyme expressed in Escherichia coli as a thioredoxin-EstA fusion protein (EcSisEstA II))
EDTA
5 mM, 17% inhibition
EDTA
-
81% residual activity
EGTA
-
minimal inhibition
EGTA
-
39% residual activity
eserine
-
eserine sulfate
eserine
-
complete inhibition
eserine
1 mM, 12% inhibition
eserine
5 mM, 30°C, 30 min, 18% inhibition
eserine
10 mM, 19% inhibition
eserine
-
complete inhibition at 1 mM, 80% inhibition at 0.1 mM
eserine
-
reversible inhibition
eserine
-
20% inhibition of CaE activity at 2.5 mM eserine using 4-nitrophenyl valerate as a substrate
ethanol
-
20% (v/v), complete loss of activity, wild-type enzyme and mutant enzymes V138G and V138G/L200R
ethanol
-
16% inhibition of BioHe at 30%
ethanol
-
inhibitory above 10% v/V
ethanol
15% v/v, 1.7fold activation. 30% v/v, 18% loss of activity
ethanol
95% inhibition of BioHs at 30%
ethanol
50% (v/v), 2 h incubation, 67% loss of activity
Fe2+
-
-
Fe2+
-
inhibition at 10 mM
Fe2+
slight inhibition at 1 mM
Fe2+
1 mM, more than 70% loss of activity
Fe2+
-
97% inhibition at 25 mM
Fe2+
-
1 mM, 10% loss of activity
Fe2+
5 mM, 81% inhibition; 5 mM, reduces the esterase activity to 19%
Fe2+
-
51% residual activity at 1 mM
Fe3+
inhibits at 0.5-5 mM
Fe3+
-
inhibition at 10 mM
Fe3+
1 mM, more than 70% loss of activity
Fe3+
-
23% residual activity at 1 mM
Galaxolide
-
synthetic fragrance Galaxolide induces human cancer cell degeneration with a EC50 value of 0.026 mM in neuroblastoma SH-SY5Y cells and 0.058 mM in lung cancer A549 cells
Galaxolide
-
synthetic fragrance Galaxolide
heptane
-
heptane
20% (v/v), 2 h incubation, 88% loss of activity
hexadecane-8,9-dione
-
-
Hg2+
-
-
Hg2+
strong inhibition at 1 mM
Hg2+
inhibits at 0.5-5 mM
Hg2+
-
inhibition at 1 and 10 mM
Hg2+
-
1 mM, complete inhibition
Hg2+
-
1 mM, 50% loss of activity
Hg2+
0.5 mM, complete inhibition; strong
Hg2+
-
complete inhibition at 1 mM, 80% inhibition at 0.1 mM; HgCl2
HgCl2
-
slight inhibition
HgCl2
-
complete inhibition
HgCl2
-
complete inhibition
HgCl2
-
1 mM, 11% residual activity; 1 mM, 89% inhibition
HgCl2
1 mM, 53% inhibition
iodoacetic acid
slight inhibition
Isopropanol
-
20% (v/v), complete loss of activity, wild-type enzyme and mutant enzymes V138G and V138G/L200R
Isopropanol
-
70% inhibition of BioHe at 30%
Isopropanol
15% v/v, 1.4fold activation. 30% v/v, 21% loss of activity
Isopropanol
96% inhibition of BioHs at 30%
K+
slight inhibition at 1 mM
loperamide
-
specific carboxylesterase 2 inhibitor
loperamide
-
specific carboxylesterase 2 inhibitor
loperamide
-
specific carboxylesterase 2 inhibitor
loperamide
-
specific carboxylesterase 2 inhibitor
loperamide
-
specific carboxylesterase 2 inhibitor, does not inhibit isoform CES1
loperamide
-
inhibitor of isoform CES2
loperamide
specifically inhibits CES2
loperamide
-
specific carboxylesterase 2 inhibitor
methanol
-
10% (v/v) and 20% (v/v), strong decrease in activity of wild-type enzyme and mutant enzymes V138G and V138G/L200R
methanol
-
7% inhibition of BioHe at 30%
methanol
10% (v/v), 93% inhibition; 5% (w/v), 94% inhibition
methanol
98% inhibition of BioHs at 30%
methanol
50% (v/v), 2 h incubation, 58% loss of activity
methanol
-
noncompetitive product inhibition
methyl paraoxon
-
-
Mg2+
-
-
Mg2+
inhibits at 0.5-5 mM
Mg2+
slight inhibition at 1 mM
Mg2+
1 mM, 5% loss of activity
Mn2+
-
-
Mn2+
inhibits at 0.5-5 mM
Mn2+
activates at 1 mM, inhibits at 5 mM
Mn2+
1 mM; 10 mM, 12% loss of activity
Mn2+
5 mM, 27% inhibition
Mn2+
-
5 mM, 62% of initial activity
n-hexane
-
20% (v/v), activity and enantioselectivity of mutant enzyme V138G toward (S)-ketoprofen ethyl ester is greatly increased. 10% (v/v), activity of wild-type enzyme and mutant enzyme V138G/L200R is increased
n-hexane
20% (v/v), 2 h incubation, 67% loss of activity
NaF
-
-
NaF
-
5 mM, 50% inhibition
NaF
-
1 mM, 30 min, 55% loss of activity of isoenzyme I, 2% loss of activity of isoenzyme V
NEM
-
-
Ni2+
inhibits at 0.5-5 mM
Ni2+
almost complete inhibition at 1-5 mM
Ni2+
5 mM, 22% inhibition
Ni2+
-
5 mM, 67% of initial activity
octadecane-9,10-dione
-
-
octadecane-9,10-dione
-
-
octane-4,5-dione
-
-
p-chloromercuribenzoate
0.1 mM, strong inhibition; strong
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
complete inhibition
paraoxon
binds covalently to the catalytic serine residue
paraoxon
-
0.1 mM, 98.5% inhibition
paraoxon
Culex sp.
-
presence of diacetylmonoxime protects
paraoxon
-
non-specific CES inhibitor, CES1 protein expression in cells is unaffected by a 24 h paraoxon treatment, suggesting that the reduced hydrolytic activity is due to covalent inhibition of CES1 by oxons and not down-regulation of expression
paraoxon
-
inhibition of CES1 in THP-1 cells
paraoxon
-
fully inhibited by paraoxon
paraoxon
5 mM, 30°C, 30 min, 90% inhibition
paraoxon
0.01 mM, complete inhibition
paraoxon
-
0.001 mM, 30 min, complete inhibition of isoenzyme V, 95% loss of activity of isoenzyme I
paraoxon
-
complete inhibition at 1 mM
paraoxon
-
0.1 mM and 1 mM, complete inhibition
paraoxon
-
reversible inhibition
PCMB
-
-
PCMB
5 mM, 30°C, 30 min, 72% inhibition
pepstatin A
-
phenyl-1,2-butanedione
-
-
phenyl-1,2-butanedione
-
-
phenyl-1,2-heptanedione
-
-
phenyl-1,2-heptanedione
-
-
phenyl-1,2-hexanedione
-
-
phenyl-1,2-hexanedione
-
-
phenyl-1,2-octanedione
-
-
phenyl-1,2-octanedione
-
-
phenyl-1,2-pentanedione
-
-
phenyl-1,2-pentanedione
-
-
phenyl-1,2-propanedione
-
-
phenyl-1,2-propanedione
-
-
Phenylmethyl sulfonylfluoride
-
-
Phenylmethyl sulfonylfluoride
-
-
Phenylmethyl sulfonylfluoride
-
11% residual activity
phenylmethylsulfonyl fluoride
-
phenylmethylsulfonyl fluoride
-
complete inhibition at 5 mM
phenylmethylsulfonyl fluoride
0.08 mM, 97% inhibition
phenylmethylsulfonyl fluoride
-
1 mM, complete inhibition
phenylmethylsulfonyl fluoride
half-inactivation times is 10 s, at an inhibitor:enzyme molar ratio of 10:1
phenylmethylsulfonyl fluoride
-
1 mM, 79% residual activity, isoform E1, 70% residual activity, isoform E2
phenylmethylsulfonyl fluoride
-
complete inhibition
phenylmethylsulfonyl fluoride
-
-
phenylmethylsulfonyl fluoride
-
0.1 mM, 48% residual activity
phenylmethylsulfonyl fluoride
-
complete inhibition above 1 mM
phenylmethylsulfonyl fluoride
-
-
phenylmethylsulfonyl fluoride
-
-
phenylmethylsulfonyl fluoride
-
1 mM, 4% inhibition; 1 mM, 4% residual activity
phenylmethylsulfonyl fluoride
-
1 mM, complete inhibition
phenylmethylsulfonyl fluoride
1 mM, 72% inhibition
phenylmethylsulfonyl fluoride
-
complete inhibition at 1 mM
phenylmethylsulfonyl fluoride
-
complete inhibition at 1 mM
phenylmethylsulfonyl fluoride
-
-
phenylmethylsulfonyl fluoride
-
reversible inhibition
phenylmethylsulfonyl fluoride
-
EstU1 loses approximately 70% of its activity in the presence of 1 mM phenylmethylsulfonyl fluoride
Phenylmethylsulfonylfluoride
-
Phenylmethylsulfonylfluoride
-
-
physostigmine
-
-
physostigmine
0.1 mM, 96% inhibition
physostigmine
-
0.01 mM, 3 min, no loss of activity of isoenzyme V, 95% loss of activity of isoenzyme I
PMSF
-
-
PMSF
-
complete inhibition
PMSF
1 mM, 85% inhibition
PMSF
PMSF targets the serine residue in the active site of enzyme
PMSF
0.025, 94% inhibition
PMSF
1 mM, 28% loss of activity
PMSF
completely inhibited by 1 mM
PMSF
5 mM, complete inhibition
PMSF
1 mM, 79% loss of activity (recombinant enzyme expressed in Sulfolobus solfataricus). 1 mM, 89% loss of activity (recombinant enzyme expressed in Escherichia coli as thioredoxin-free form (EcSisEstA I)). 1 mM, 81% loss of activity (recombinant enzyme expressed in Escherichia coli as a thioredoxin-EstA fusion protein (EcSisEstA II))
PMSF
5 mM, complete inhibition
PMSF
-
0.01 mM, 30 min, 94% loss of activity of isoenzyme V, 27% loss of activity of isoenzyme I
PMSF
-
75% inhibition at 1 mM, 10% inhibition at 0.1 mM
polyphenol extracts from Arenaria serpyllifolia
-
competitive
-
polyphenol extracts from Arenaria serpyllifolia
-
competitive
-
polyphenol extracts from Rhamnus alaternus
-
non competitive
-
polyphenol extracts from Rhamnus alaternus
-
non competitive
-
polyphenol extracts from Thapsia gargantica
-
competitive
-
polyphenol extracts from Thapsia gargantica
-
competitive
-
propan-2-ol
-
competitive
propan-2-ol
weaker effect than propan-1-ol
Propanol
-
Propanol
50% (v/v), 2 h incubation, 59% loss of activity
propoxur
-
-
SDS
strong inhibition at 1% (v/v)
SDS
-
36% residual activity at 0.1% (w/v) after 30 min of incubation
SDS
-
almost complete inhibition at 1%
SDS
-
52% inhibition of recombinant BioHe at 0.2%
SDS
0.1% w/v, 24.2% inhibition
SDS
0.1% v/v, 17% loss of activity. 1% v/v, 68% loss of activity
SDS
almost complete inhibition of recombinant BioHs at 0.2%
SDS
5% (w/v), 90% inhibition
simvastatin
-
complete inhibition at 0.1 mM
simvastatin
strongly inhibits hydrolytic process of anordrin in liver and intestine microsomes; strongly inhibits hydrolytic process of anordrin in liver and intestine microsomes
sodium dodecylsulfate
-
0.1% w/V, 10% residual activity
sodium dodecylsulfate
0.1%, strong inhibition
sodium dodecylsulfate
-
1%, 60 min at 30°C, 59% residual activity
sodium dodecylsulfate
-
0.1%, complete inhibition
sodium dodecylsulfate
-
0.1%, no effect during short-term incubation, complete inhibition after 60 min
sodium dodecylsulfate
-
0.1%, no effect during short-term incubation, complete inhibition after 60 min
soman
enzyme binds stereoselectively, (S)-stereoisomer of soman is preferred 10000fold over the (R)-isomer
tetradecane-7,8-dione
-
-
tetradecane-7,8-dione
-
-
Tonalide
-
synthetic fragrance Tonalide induces human cancer cell degeneration with a EC50 value of 0.098 mM in neuroblastoma SH-SY5Y cells and 0.014 mM in lung cancer A549 cells
Tonalide
-
synthetic fragrance Tonalide
triazophos
-
Trichlorfon
-
-
Triton X-100
-
1%, 60 min at 30°C, 81% residual activity
Triton X-100
10% (v/v), 92% inhibition; 10% (w/v), 92% inhibition
Triton X-100
5% (w/v), 42% inhibition
Triton X-100
-
93.6% inhibition
Tween 20
-
almost complete inhibition at 1%
Tween 20
5% (w/v), 94% inhibition
Tween 20
5% (w/v), 28% inhibition
Tween 80
-
1%, 60 min at 30°C, 76% residual activity
Tween 80
5% (w/v), 8% inhibition
Tween 80
5% (w/v), 38% inhibition
Zn2+
-
-
Zn2+
strong inhibition at 1 mM
Zn2+
-
about 10% residual activity at 5 mM Zn2+ after 1 h of incubation
Zn2+
inhibits at 0.5-5 mM
Zn2+
-
inhibition at 10 mM
Zn2+
complete inhibition at 1-5 mM
Zn2+
-
1 mM, complete inhibition
Zn2+
1 mM, more than 70% loss of activity
Zn2+
-
59% reduced activity
Zn2+
-
46% inhibition at 25 mM
Zn2+
-
1 mM, 75% loss of activity
Zn2+
1 mM, 8% inhibition. 10 mM, 49% inhibition
Zn2+
5 mM, 87% inhibition; 5 mM, reduces the esterase activity to 13%
Zn2+
-
5 mM, 41% of initial activity
ZnCl2
-
slight inhibition
ZnCl2
-
1 mM, 36% residual activity
additional information
-
not inhibitory: Ca2+, EDTA
-
additional information
poor effect by EDTA at 5 mM
-
additional information
phenylmethansulfonfluoride has almost no influence on the activity up to 10 mM; PMSF has almost no influence on the activity of LipA up to 10 mM
-
additional information
-
EDTA, Mg2+, Mn2+, Ca2+, and Ba2+ do not affect the esterase activity, the enzyme is not sensitive to the addition of 1 mM SDS
-
additional information
-
not affected by EDTA, Ca2+, Mg2+, Co2+, Fe3+, Zn2+
-
additional information
-
not inhibitory: EDTA, EGTA, Li+, K+, NH4+, Mg2+, Triton X-100 at 0.1%, dimethylsulfoxide at 15%
-
additional information
not inhibitory: detergents CHAPS, Tween-20, Triton X-100 at 1%, or EDTA, dithiothreitol, 2-mercaptoethanol
-
additional information
-
not inhibitory: detergents CHAPS, Tween-20, Triton X-100 at 1%, or EDTA, dithiothreitol, 2-mercaptoethanol
-
additional information
-
no inhibition by 1% Triton X-100 and !% CHAPS, not affected by Ca2+, Mg2+, Mn2+, Li+, Na+, K+, EDTA, and PMSF
-
additional information
-
substrate inhibition increases with increasing chain length of the fatty acid on the ester
-
additional information
-
not affected by Equitrol exposure
-
additional information
-
no inhibition by DMSO at 10-30%
-
additional information
-
not inhibited by bis(p-nitrophenyl) phosphate
-
additional information
-
unsaturated fatty acids are better inhibitors of CES1 activity than saturated fatty acids, CES2 activity is unaffected by any fatty acid
-
additional information
-
several different scaffolds capable of inhibiting carboxylesterases are e.g. organophosphates, carbamates, trifluoromethyl ketone-containing structures, and aromatic ethane-1,2-diones. Comparison of diverse benzil analogues and dione-based carboxylesterase and trifluoromethyl ketone inhibitors in carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis, overview
-
additional information
-
development and evaluation of a class of benzene sulfonamide inhibitors, quantitative structure-activity relationship, QSAR, modeling, overview
-
additional information
-
no inhibition by clonidine, phenylephrine, risperidone, and paliperidone. Quantitative structure-activity relationship of potential inhibitors, molecular modeling of, overview. Drug-drug interactions with substrate methylphenidate, overview
-
additional information
-
not inhibited by butane-2,3-dione, hexane 3,4-dione, oxanilide, S1,S2-diphenyl ethane bis(thioate), diphenyl ethanedioate, 1,4-diphenylbutane-2,3-dione, and 1-bromo-1,4-diphenyl butane-2,3-dione
-
additional information
-
2,3-butanedione monoxime has no inhibitory effect on CE1
-
additional information
-
not inhibited by 0.1 mM dabigatran exilate, dabigatran, pindolol, labetalol, propranolol, metoprolol, sotalol, and azathioprine
-
additional information
-
inhibitor docking study, overview
-
additional information
tunicamycin leads to decreased levels of secreted hCES2, but the enzyme is still active
-
additional information
-
tunicamycin leads to decreased levels of secreted hCES2, but the enzyme is still active
-
additional information
screening of fiftyeight flavonoids for inhibitory effects against hCE2 using a fluorescence-based method. C3 and C6 hydroxy groups are essential for hCE2 inhibition, while O-glycosylation or C-glycosylation lead to the loss of hCE2 inhibition. Among all tested flavonoids, 5,6-dihydroxyflavone display the most potent inhibitory effect against enzyme hCE2. Analysis of the inhibition mechanism of 5,6-dihydroxyflavone by both experimental and docking simulations, structure-inhibition relationships of flavonoids against hCE2, overview. No or poor inhibition by 6,7-dimethoxybaicalein, myricetin, baicalin, wogonoside, apigenin-7-O-glucronide, cynaroside, myricitrin, isovitexin, daidzin, biochanin A, calycosin-7-glucoside, and 3'-hydroxypuerarin
-
additional information
-
screening of fiftyeight flavonoids for inhibitory effects against hCE2 using a fluorescence-based method. C3 and C6 hydroxy groups are essential for hCE2 inhibition, while O-glycosylation or C-glycosylation lead to the loss of hCE2 inhibition. Among all tested flavonoids, 5,6-dihydroxyflavone display the most potent inhibitory effect against enzyme hCE2. Analysis of the inhibition mechanism of 5,6-dihydroxyflavone by both experimental and docking simulations, structure-inhibition relationships of flavonoids against hCE2, overview. No or poor inhibition by 6,7-dimethoxybaicalein, myricetin, baicalin, wogonoside, apigenin-7-O-glucronide, cynaroside, myricitrin, isovitexin, daidzin, biochanin A, calycosin-7-glucoside, and 3'-hydroxypuerarin
-
additional information
design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterases, molecular docking, overview; design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterases, molecular docking, overview
-
additional information
design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterases, molecular docking, overview; design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterases, molecular docking, overview
-
additional information
-
design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterases, molecular docking, overview; design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterases, molecular docking, overview
-
additional information
synthesis of 1,2-dione-containing abietane analogues for generation of human carboxylesterase inhibitors by a retrosynthetic strategy, molecular docking of ligands to the enzyme's active site, overview
-
additional information
-
synthesis of 1,2-dione-containing abietane analogues for generation of human carboxylesterase inhibitors by a retrosynthetic strategy, molecular docking of ligands to the enzyme's active site, overview
-
additional information
diterpenoids and glycosides are isolated from roots of Euphorbia ebracteolata and their inhibitory potency and structure is determined, NMR spectrometric analysis, overview
-
additional information
-
diterpenoids and glycosides are isolated from roots of Euphorbia ebracteolata and their inhibitory potency and structure is determined, NMR spectrometric analysis, overview
-
additional information
no inhibition of CES1 by loperamide; no inhibition of CES2 by digitonin
-
additional information
no inhibition of CES1 by loperamide; no inhibition of CES2 by digitonin
-
additional information
-
no inhibition of CES1 by loperamide; no inhibition of CES2 by digitonin
-
additional information
1 mM EDTA or 1 mM phenanthroline show little effect on activity
-
additional information
-
1 mM EDTA or 1 mM phenanthroline show little effect on activity
-
additional information
-
no inhibition by NaCl, KCl, MgCl2, MnCl2, CoCl2, NiCl2
-
additional information
-
not inhibitory: EDTA, 2,2-dipyridyl, 1,10-phenanthroline, 8-hydroxyquinoline, Tiron, at 1 mM each
-
additional information
-
exposure to esfenvalerate has little effect on enzyme activity
-
additional information
-
not inhibited by bis(p-nitrophenyl) phosphate
-
additional information
-
several different scaffolds capable of inhibiting carboxylesterases are e.g. organophosphates, carbamates, trifluoromethyl ketone-containing structures, and aromatic ethane-1,2-diones. Comparison of diverse benzil analogues and dione-based and trifluoromethyl ketone carboxylesterase inhibitors in carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis, overview
-
additional information
-
not inhibited by butane-2,3-dione, hexane 3,4-dione, oxanilide, S1,S2-diphenyl ethane bis(thioate), diphenyl ethanedioate, 1,4-diphenylbutane-2,3-dione, and 1-bromo-1,4-diphenyl butane-2,3-dione
-
additional information
-
kidney bean esterase can be inhibited by organophosphate and carbamate pesticides, which can be substituted for acetylcholinesterase, sensitivity and specificity of kidney bean esterase on pesticides, inhibition kinetics, overview. The enzyme inhibition rate decreases in the order BNPP, physostigmine, donepezil hydrochloride, and the inhibition rate of BNPP is significantly higher than that of the latter two at 1 mM
-
additional information
-
the enzyme activity is not affected by the presence of 5.0 mM phenylmethylsulfonyl fluoride
-
additional information
-
not inhibitory: EDTA
-
additional information
-
no inhibition by EDTA
-
additional information
no inhibition by methanol
-
additional information
-
not inhibited by bis(p-nitrophenyl) phosphate
-
additional information
O35535
ethopropazine, a specific inhibitor of butyrylcholinesterase (EC 3.1.1.8), shows no inhibitory effect; ethopropazine, a specific inhibitor of butyrylcholinesterase (EC 3.1.1.8), shows no inhibitory effect
-
additional information
ethopropazine, a specific inhibitor of butyrylcholinesterase (EC 3.1.1.8), shows no inhibitory effect; ethopropazine, a specific inhibitor of butyrylcholinesterase (EC 3.1.1.8), shows no inhibitory effect
-
additional information
-
no inhibition by eserine, CaCl2, p-hydroxymercuribenzoate, imidacloprid, fipronil, and piperonyl butoxide
-
additional information
-
not affected by eserine sulfate, copper sulfate, and p-chloromercurybenzoate
-
additional information
-
not inhibitory: EDTA, CaCl2, MgCl2, CuCl2, CoCl2, FeCl2, MnCl2, N-bromosuccinimide, diethylpyrocarbonate
-
additional information
-
enzyme retains 97% of activity after 60 min in 1 M urea. Not inhibitory: 1% Tween 20, 1% Lubrol
-
additional information
no inhibition by EDTA
-
additional information
-
no inhibition by EDTA
-
additional information
-
enzyme is not significantly inhibited by metals in river water
-
additional information
-
not inhibited by benzyl carbamate
-
additional information
-
inhibitor docking study, overview
-
additional information
synthesis, molecular docking, and biological activity of polyfluoroalkyl dihydroazolo[5,1-c][1,2,4]triazines as selective carboxylesterase inhibitors, modelling and docking simulations, tautomeric forms of dihydroazolo[5,1-c][1,2,4]triazines, overview
-
additional information
-
no inhibition by sodium sulfosuccinate
-
additional information
-
not inhibited by 1 mM EDTA and beta-mercaptoethanol
-
additional information
-
toxic effects of insecticides on the 2 strains: malathion, malaoxon, fenitrothion, primiphos-methyl, DDT, and deltamethrine
-
additional information
-
not inhibitory: phenylmethylsulfonylfluoride, EDTA, Triton X-100, 2-mercaptoethanol
-
additional information
-
not affected by EDTA
-
additional information
-
EstU1 activity is not affected by the presence of EDTA (94% activity at 1 mM)
-
additional information
-
NaM1 activity and thermal stability are not affected by bovine serum albumin or other stabilizing solutes other than NaCl and trehalose
-
additional information
-
not inhibited by carbamates
-
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0.1 - 10
(+)-trans-ethyl crysanthemate
6.5
(1R)-1-phenylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
pH and temperature not specified in the publication
0.0086 - 16.7
(1RS)-cis-permethrin
0.00757 - 9.8
(1RS)-trans-permethrin
2.9
(1S)-1-phenylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
pH and temperature not specified in the publication
10.1
(2R)-butan-2-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
pH and temperature not specified in the publication
48.5
(2S)-butan-2-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
pH and temperature not specified in the publication
8.135
(E)-2-hexenyl acetate
-
pH 7.4, 28°C
4.536
(E)-2-hexenyl butyrate
-
pH 7.4, 28°C
0.0003 - 0.0009
(R)-cyano(6-methoxy-2-naphthyl)methyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
0.0017 - 0.0025
(R)-cyano(6-methoxy-2-naphthyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
0.0019
(R)-cyano(6-methoxy-2-naphthyl)methyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
0.0015 - 0.0017
(R)-cyano(6-methoxy-2-naphthyl)methyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
0.0007 - 0.0009
(R)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid
0.0125 - 0.0132
(R)-propranolyl 2-methylbutanoate
0.0024 - 0.0072
(R)-propranolyl 3-methylbutanoate
0.0106 - 0.012
(R)-propranolyl n-valerate
0.0003 - 0.0025
(S)-cyano(6-methoxy-2-naphthyl)methyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
0.0007 - 0.0028
(S)-cyano(6-methoxy-2-naphthyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
0.0024 - 0.0038
(S)-cyano(6-methoxy-2-naphthyl)methyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
0.0014 - 0.004
(S)-cyano(6-methoxy-2-naphthyl)methyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
0.0008 - 0.002
(S)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid
3.1 - 20.9
(S)-ketoprofen ethyl ester
0.0045 - 0.0149
(S)-propranolyl 2-methylbutanoate
0.004 - 0.009
(S)-propranolyl 3-methylbutanoate
0.0066 - 0.0178
(S)-propranolyl n-valerate
6.265 - 11.4
(Z)-3-hexenyl acetate
3.135
(Z)-3-hexenyl butyrate
-
pH 7.4, 28°C
2.423
(Z)-3-hexenyl caproate
-
pH 7.4, 28°C
0.9
1,4-diacetoxybenzene
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.008 - 1.01
1-naphthyl acetate
1.1
1-naphthyl butanoate
-
pH 7.0, 25°C
0.0076 - 0.33
1-naphthyl butyrate
0.143
1-naphthyl propionate
-
-
0.0088
2'-ethylcarbonate-linked paclitaxel
-
-
4.6
2,2-dimethylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
pH and temperature not specified in the publication
0.0001 - 0.00029
2,4-dinitrophenyl butyrate
0.00925
2-acetoxy-5-(alpha-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
-
isozyme CE1
13.7
2-methylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
pH and temperature not specified in the publication
0.2 - 5
2-naphthyl acetate
0.56
2-naphthyl propionate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.31
2-Nitrophenyl acetate
-
-
0.00024 - 0.1
2-Nitrophenyl butyrate
0.084
2-nitrophenyl propionate
-
-
0.00224 - 0.0169
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate
0.97
3'-D-phenylalanyl-gemcitabine
-
pH 7.4, 37°C
1.43
3'-D-valyl-gemcitabine
-
pH 7.4, 37°C
0.94
3'-L-isoleucyl-gemcitabine
-
pH 7.4, 37°C
0.51
3'-L-phenylalanyl-gemcitabine
-
pH 7.4, 37°C
0.9
3'-L-valyl-gemcitabine
-
pH 7.4, 37°C
1.8
3-acetoxypyridine
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.21
3-nitrophenyl acetate
-
-
1.6
4'-chloroacetanilide
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.11 - 0.13
4-aminobenzoic acid butyl ester
0.356 - 1.198
4-aminobenzoic acid ethyl ester
0.322 - 0.398
4-aminobenzoic acid propyl ester
1.2
4-methylbenzyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.24 - 166.7
4-methylumbelliferyl acetate
0.0167 - 0.738
4-methylumbelliferyl butanoate
0.02108 - 0.16
4-Methylumbelliferyl butyrate
0.000618 - 0.024
4-methylumbelliferyl heptanoate
0.000086 - 0.000117
4-methylumbelliferyl laurate
0.00031 - 0.00634
4-methylumbelliferyl octanoate
0.000024 - 0.000053
4-methylumbelliferyl palmitate
0.65
4-nitroacetanilide
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.013 - 4.47
4-nitrophenyl acetate
0.004 - 127
4-nitrophenyl butanoate
0.00043 - 1.6
4-nitrophenyl butyrate
0.011 - 0.043
4-nitrophenyl caprate
0.008 - 3.8
4-nitrophenyl caproate
0.014 - 0.068
4-nitrophenyl caprylate
0.008 - 4.99
4-nitrophenyl decanoate
0.00075 - 67.6
4-nitrophenyl dodecanoate
0.005 - 4.8
4-nitrophenyl hexadecanoate
0.004 - 44.7
4-nitrophenyl hexanoate
0.01 - 0.6
4-nitrophenyl laurate
0.0086
4-nitrophenyl myristate
-
-
0.0117 - 25.2
4-nitrophenyl octanoate
0.0031 - 0.876
4-nitrophenyl palmitate
0.02 - 2.1
4-nitrophenyl pentanoate
0.139 - 0.348
4-nitrophenyl propanoate
0.0338 - 3.3
4-nitrophenyl propionate
0.009 - 1.054
4-nitrophenyl tetradecanoate
0.034 - 0.36
4-nitrophenyl valerate
0.022 - 2
4-yethylumbelliferyl acetate
0.63
5'-cinnamic acid-floxuridine
-
pH 7.4, 37°C
0.9
5'-D-phenylalanyl-BDCRB
-
pH 7.4, 37°C
0.22
5'-D-phenylalanyl-gemcitabine
-
pH 7.4, 37°C
1.16
5'-D-valyl-gemcitabine
-
pH 7.4, 37°C
0.85
5'-L-isoleucyl-gemcitabine
-
pH 7.4, 37°C
0.46
5'-L-phenylalanine-floxuridine
-
pH 7.4, 37°C
0.91
5'-L-phenylalanyl-BDCRB
-
pH 7.4, 37°C
0.17
5'-L-phenylalanyl-gemcitabine
-
pH 7.4, 37°C
0.96
5'-L-valyl-gemcitabine
-
pH 7.4, 37°C
3.02
7-amino cephalosporanic acid
-
pH 7.0, 25°C
0.46 - 0.51
7-aminocephalosporanic acid
0.0032 - 0.46
7-ethyl-10-(4-(1-piperidino)-1-amino)carbonyloxycampothecin
0.001 - 0.137
7-ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycampothecin
0.27
7-ethyl-10-(4-N-(5-aminopentanoic acid)-1-piperidino)carbonyloxycampothecin
-
pH 7.0, 37°C, isoform CES2
0.0186 - 0.0453
7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin
0.00034 - 0.0043
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin
3.3
Acetylsalicylic acid
in 2.0 mM Tris-HCl, pH 7.6, at 25°C
0.00001 - 0.222
Alpha-naphthyl acetate
0.0702 - 0.126
anisamidobutyric acid
0.0689 - 0.15
anisilic acid
0.0804 - 0.1002
benazepril
0.033
benzoyl-Gly-farnesyl-L-cysteine methyl ester
-
-
1.6
Benzyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.00672 - 25.75
bioresmethrin
0.005
bis(2-ethylhexyl)phthalate
-
-
0.044
bisphenyl carbonate
-
-
0.00043
butyl 2-(4-[[5-(trifluoromethyl)pyridin-2-yl]oxy]phenoxy)propanoate
recombinant His-tagged enzyme, pH 7.0, 37°C
0.00045
butyl 2-[4-(4-cyano-2-fluorophenoxy)phenoxy]propanoate
recombinant His-tagged enzyme, pH 7.0, 37°C
3.4
butyl acetate
pH 7.5, 30°C
0.45
butyl paraben
-
pH 6.8, 30°C
4.4
butyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
pH and temperature not specified in the publication
0.141 - 0.2324
camostat mesilate
0.1336
capsaicin
-
isoenzyme pI 6.0
0.07849
cefazolin
-
at 35°C in 100 mM sodium phosphate (pH 7.0)
1.3 - 2
cholesterol oleate
0.00016
cis-permethrin
pH 7.0, 30°C
0.002 - 0.0091
cyano(3-phenoxyphenyl)methyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
0.0015 - 0.0054
cyano(6-methoxy-2-naphthyl)methyl 2,2,3,3-tetramethylcyclopropanecarboxylate
0.0018 - 0.0021
cyano(6-methoxynaphthalen-2-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylic acid
0.5
cyclic poly(ethylene terephthalate) trimer
-
pH 6.0, 60°C
0.00021
cypermethrin
pH 7.0, 30°C
2.01
D-glucose pentaacetate
-
pH 7.0, 25°C
0.6635
D-methyl phenidate
wild type enzyme
2.16
D-xylose tetraacetate
-
pH 7.0, 25°C
0.00123
deltamethrin
pH 7.0, 30°C
4.65
diethyl succinate
-
-
1.734
enalapril
-
in 100 mM phosphate buffer at 37°C, pH not specified in the publication
0.62
ethyl 2-naphthyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.00039 - 0.00042
ethyl 2-[4-[(6-chloroquinoxalin-2-yl)oxy]phenoxy]propanoate
1.2
ethyl 3-hydroxybenzoate
-
pH 7.0, 37°C
2.3
ethyl 3-methoxybenzoate
-
pH 7.0, 37°C
0.39
ethyl 4-hydroxybenzoate
-
pH 7.0, 37°C
0.42
ethyl 4-nitrophenyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.22
ethyl 4-nitrophenyl methylphosphonate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.11
ethyl benzoate
-
pH 7.0, 37°C
0.0313
ethyl bromoacetate
-
-
0.0025 - 0.185
ethyl butyrate
0.33
ethyl butyrylacetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.12
ethyl cetraxate
-
pH 7.4, 30°C
0.083
ethyl chloroacetate
-
-
16.7
ethyl D-pantothenate
-
pH 7.4, 30°C
0.333
ethyl fluoroacetate
-
-
2.8 - 7.5
ethyl hexanoate
0.0184
ethyl iodoacetate
-
-
18.3
ethyl L-pantothenate
-
pH 7.4, 30°C
6.6 - 19
ethyl pentanoate
10
ethyl propionate
pH 7.5, 30°C
0.66
ethylene glycol dibenzoate
-
pH 7.0, 37°C
0.00091
fenvalerate
pH 7.0, 30°C
0.00194 - 0.00482
fluorescein diacetate
1.086
geranyl acetate
-
pH 7.4, 28°C
0.0558
Glucose pentaacetate
-
-
0.19 - 4.647
hexyl acetate
0.025
hydrocinnamoyl farnesyl-L-cysteine methyl ester
-
-
1.9
indoxyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.7
isobutyl 4-nitrophenyl methylphosphonate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
1.2
isopropyl 4-nitrophenyl methylphosphonate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.17
isopropyl cetraxate
-
pH 7.4, 30°C
1.6
ketoprofen ethyl ester
-
-
0.7757
L-methyl phenidate
wild type enzyme
0.08
L-phenylalanine butyl ester
-
pH 7.4, 37°C
1.18
L-phenylalanine ethyl ester
-
pH 7.4, 37°C
0.00032
methyl 2-(4-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy]phenoxy)propanoate
recombinant His-tagged enzyme, pH 7.0, 37°C
0.00039
methyl 2-[4-(2,4-dichlorophenoxy)phenoxy]propanoate
recombinant His-tagged enzyme, pH 7.0, 37°C
2.49
methyl 3-(4-hydroxyphenyl)propionate
-
pH 7.4, 30°C
0.0026 - 2.18
methyl butyrate
0.38
methyl cetraxate
-
pH 7.4, 30°C
29.4
methyl D-pantothenate
-
pH 7.4, 30°C
105
methyl L-pantothenate
-
pH 7.4, 30°C
0.04 - 0.4
methyl octanoate
0.88
methyl paraben
-
pH 6.8, 30°C
0.42
methyl paraoxon
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
1.67 - 2.7
monobutyl phthalate
1.39 - 2.63
monopentyl phthalate
5.88 - 6.25
monopropyl phthalate
1.03 - 1.2
mycophenolate mofetil
-
pH 7.4, 37°C
0.0236 - 0.0853
N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester
0.4
N-acetyl L-phenylalanine ethyl ester
-
pH 7.4, 37°C
0.211
N-acetyl-L-Ala-1-naphthyl ester
-
-
0.075
n-butyl benzoate
-
pH 7.0, 37°C
0.11
n-butyl n-butyrate
-
-
0.799
n-Butyryl salicylate
-
-
0.132
n-Decanoyl salicylate
-
-
0.679
n-Hexanoyl salicylate
-
-
0.21
n-Octanoyl salicylate
-
-
0.576
n-Propionyl salicylate
-
-
10
n-propyl D-pantothenate
-
pH 7.4, 30°C
12.1
n-propyl L-pantothenate
-
pH 7.4, 30°C
0.983
n-valeryl salicylate
-
-
0.094 - 0.9284
oxybutynin
0.0031 - 119
p-nitrophenyl acetate
0.01 - 0.243
p-nitrophenyl butanoate
0.33 - 0.4
p-nitrophenyl butyrate
0.0005 - 0.25
p-nitrophenyl caproate
0.0047
p-nitrophenyl caprylate
-
60°C, pH 7.5
0.00031
p-nitrophenyl decanoate
-
60°C, pH 7.5
50
p-nitrophenyl hexanoate
pH 7.1, 70°C
0.6
p-nitrophenyl laurate
+/- 0.13
0.0021
p-nitrophenyl myristate
-
60°C, pH 7.5
0.35
p-nitrophenyl propionate
+/- 0.08
0.039
p-nitrophenyl valerate
-
-
0.11
paraoxon
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
7.795
pentyl acetate
-
pH 7.4, 28°C
0.00064 - 0.25
phenyl butyrate
0.00049
phenyl pentanoate
-
-
0.42 - 13
phenylthioacetate
0.71
phenylthiobutyrate
-
-
0.5
phenylthioisobutyrate
-
-
1.1
phenylthiopentanoate
-
-
2
phenylthiopropionate
-
-
0.0512 - 0.061
pranlukast
6
propyl acetate
pH 7.5, 30°C
0.6
propyl paraben
-
pH 6.8, 30°C
0.901
ramipril
-
in 100 mM phosphate buffer at 37°C, pH not specified in the publication
0.00089 - 0.086
retinyl palmitate
2.1
S-butyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]ethanethioate
pH and temperature not specified in the publication
0.229 - 0.4678
temocapril
0.639 - 1.721
trandolapril
0.00011 - 0.014
trans-permethrin
0.4992 - 0.715
trinotecan
3
vinyl laurate
-
pH 7.5, 25°C
additional information
additional information
-
0.1
(+)-trans-ethyl crysanthemate
-
mutant enzyme S61A, pH 7.5, 45°C
0.18
(+)-trans-ethyl crysanthemate
-
mutant enzyme C60A, pH 7.5, 45°C
0.31
(+)-trans-ethyl crysanthemate
-
mutant enzyme S53A, pH 7.5, 45°C
0.33
(+)-trans-ethyl crysanthemate
-
wild type enzyme, pH 7.5, 45°C
10
(+)-trans-ethyl crysanthemate
-
mutant enzyme K62R, pH 7.5, 45°C
0.0086
(1RS)-cis-permethrin
-
isoform hCE2, pH 7.4, 37°C
0.0238
(1RS)-cis-permethrin
-
isoform hCE1, pH 7.4, 37°C
1.93
(1RS)-cis-permethrin
-
hydrolase A, pH 7.4, 37°C
4.96
(1RS)-cis-permethrin
-
hydrolase B, pH 7.4, 37°C
16.7
(1RS)-cis-permethrin
-
pH 7.4, 37°C
0.00757
(1RS)-trans-permethrin
-
isoform hCE2, pH 7.4, 37°C
0.0098
(1RS)-trans-permethrin
-
isoform hCE1, pH 7.4, 37°C
1.96
(1RS)-trans-permethrin
-
pH 7.4, 37°C
6.74
(1RS)-trans-permethrin
-
hydrolase A, pH 7.4, 37°C
9.8
(1RS)-trans-permethrin
-
hydrolase B, pH 7.4, 37°C
0.0003
(R)-cyano(6-methoxy-2-naphthyl)methyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
isoform hCE-1, pH 8.0, 37°C
0.0009
(R)-cyano(6-methoxy-2-naphthyl)methyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
isoform hCE-2, pH 8.0, 37°C
0.0017
(R)-cyano(6-methoxy-2-naphthyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
isoform hCE-1, pH 8.0, 37°C
0.0025
(R)-cyano(6-methoxy-2-naphthyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
isoform hCE-2, pH 8.0, 37°C
0.0019
(R)-cyano(6-methoxy-2-naphthyl)methyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
isoform hCE-1, pH 8.0, 37°C
0.0019
(R)-cyano(6-methoxy-2-naphthyl)methyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
isoform hCE-2, pH 8.0, 37°C
0.0015
(R)-cyano(6-methoxy-2-naphthyl)methyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
isoform hCE-1, pH 8.0, 37°C
0.0017
(R)-cyano(6-methoxy-2-naphthyl)methyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
isoform hCE-2, pH 8.0, 37°C
0.0007
(R)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid
isoform hCE-1, pH 8.0, 37°C
0.0009
(R)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid
isoform hCE-2, pH 8.0, 37°C
0.0125
(R)-propranolyl 2-methylbutanoate
enzyme hCE2, pH and temperature not specified in the publication
0.0132
(R)-propranolyl 2-methylbutanoate
enzyme mfCES2v3, pH and temperature not specified in the publication
0.0024
(R)-propranolyl 3-methylbutanoate
enzyme hCE2, pH and temperature not specified in the publication
0.0072
(R)-propranolyl 3-methylbutanoate
enzyme mfCES2v3, pH and temperature not specified in the publication
0.0106
(R)-propranolyl n-valerate
enzyme mfCES2v3, pH and temperature not specified in the publication
0.012
(R)-propranolyl n-valerate
enzyme hCE2, pH and temperature not specified in the publication
0.0003
(S)-cyano(6-methoxy-2-naphthyl)methyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
isoform hCE-1, pH 8.0, 37°C
0.0025
(S)-cyano(6-methoxy-2-naphthyl)methyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
isoform hCE-2, pH 8.0, 37°C
0.0007
(S)-cyano(6-methoxy-2-naphthyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
isoform hCE-1, pH 8.0, 37°C
0.0028
(S)-cyano(6-methoxy-2-naphthyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
isoform hCE-2, pH 8.0, 37°C
0.0024
(S)-cyano(6-methoxy-2-naphthyl)methyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
isoform hCE-1, pH 8.0, 37°C
0.0038
(S)-cyano(6-methoxy-2-naphthyl)methyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
isoform hCE-2, pH 8.0, 37°C
0.0014
(S)-cyano(6-methoxy-2-naphthyl)methyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
isoform hCE-1, pH 8.0, 37°C
0.004
(S)-cyano(6-methoxy-2-naphthyl)methyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
isoform hCE-2, pH 8.0, 37°C
0.0008
(S)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid
isoform hCE-1, pH 8.0, 37°C
0.002
(S)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid
isoform hCE-2, pH 8.0, 37°C
3.1
(S)-ketoprofen ethyl ester
-
pH 8.0, 80°C, wild-type enzyme
3.9
(S)-ketoprofen ethyl ester
-
pH 6.0, 80°C, mutant enzyme V138G/L200R
20.9
(S)-ketoprofen ethyl ester
-
pH 8.0, 80°C, mutant enzyme V138G
0.0045
(S)-propranolyl 2-methylbutanoate
enzyme mfCES2v3, pH and temperature not specified in the publication
0.0149
(S)-propranolyl 2-methylbutanoate
enzyme hCE2, pH and temperature not specified in the publication
0.004
(S)-propranolyl 3-methylbutanoate
enzyme hCE2, pH and temperature not specified in the publication
0.009
(S)-propranolyl 3-methylbutanoate
enzyme mfCES2v3, pH and temperature not specified in the publication
0.0066
(S)-propranolyl n-valerate
enzyme mfCES2v3, pH and temperature not specified in the publication
0.0178
(S)-propranolyl n-valerate
enzyme hCE2, pH and temperature not specified in the publication
6.265
(Z)-3-hexenyl acetate
-
pH 7.4, 28°C
9.6
(Z)-3-hexenyl acetate
-
Lineweaver-Burk method, in 20 mM Tris buffer (pH 7.4), at 28°C
11.4
(Z)-3-hexenyl acetate
-
non-linear fitting, in 20 mM Tris buffer (pH 7.4), at 28°C
0.008
1-naphthyl acetate
-
-
0.131
1-naphthyl acetate
-
-
0.16
1-naphthyl acetate
-
-
0.25
1-naphthyl acetate
-
-
0.37
1-naphthyl acetate
-
-
0.64
1-naphthyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
1.01
1-naphthyl acetate
-
pH 7.0, 25°C
0.0076
1-naphthyl butyrate
-
-
0.055
1-naphthyl butyrate
-
-
0.18
1-naphthyl butyrate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.33
1-naphthyl butyrate
-
-
0.0001
2,4-dinitrophenyl butyrate
-
-
0.00029
2,4-dinitrophenyl butyrate
-
-
0.2
2-naphthyl acetate
-
recombinant wild-type enzyme, pH 8.5, 30°C
0.4
2-naphthyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.41
2-naphthyl acetate
-
recombinant mutant NaM1H2, pH 8.5, 30°C
1
2-naphthyl acetate
at pH 7.0 and 25°C
0.00024
2-Nitrophenyl butyrate
-
-
0.00043
2-Nitrophenyl butyrate
-
-
0.0005
2-Nitrophenyl butyrate
-
-
0.00141
2-Nitrophenyl butyrate
-
-
0.039
2-Nitrophenyl butyrate
-
-
0.1
2-Nitrophenyl butyrate
-
-
0.00224
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate
intestinal microsomes, pH 7.4, 37°C
0.00283
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate
liver microsomes, pH 7.4, 37°C
0.0136
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate
CES1, pH 7.4, 37°C
0.0169
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate
CES1, pH 7.4, 37°C
0.11
4-aminobenzoic acid butyl ester
-
isoform hCE2, 37°C
0.13
4-aminobenzoic acid butyl ester
-
isoform hCE1, 37°C
0.356
4-aminobenzoic acid ethyl ester
-
isoform hCE1, 37°C
1.198
4-aminobenzoic acid ethyl ester
-
isoform hCE2, 37°C
0.322
4-aminobenzoic acid propyl ester
-
isoform hCE1, 37°C
0.398
4-aminobenzoic acid propyl ester
-
isoform hCE2, 37°C
0.24
4-methylumbelliferyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.47
4-methylumbelliferyl acetate
-
recombinant mutant NaM1H2, pH 8.5, 30°C
166.7
4-methylumbelliferyl acetate
-
recombinant wild-type enzyme, pH 8.5, 30°C
0.0167
4-methylumbelliferyl butanoate
pH 8.0, 25°C
0.738
4-methylumbelliferyl butanoate
-
pH 7.0, 39°C
0.02108
4-Methylumbelliferyl butyrate
pH 7.0, 70°C, mutant enzyme F198A
0.0227
4-Methylumbelliferyl butyrate
-
in 25 mM Tris-HCl (pH 8.0), at 25°C
0.03598
4-Methylumbelliferyl butyrate
pH 7.0, 70°C, mutant enzyme W194A
0.06266
4-Methylumbelliferyl butyrate
pH 7.0, 70°C, wild-type enzyme
0.1
4-Methylumbelliferyl butyrate
-
-
0.16
4-Methylumbelliferyl butyrate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.000618
4-methylumbelliferyl heptanoate
-
in 25 mM Tris-HCl (pH 8.0), at 25°C
0.01064
4-methylumbelliferyl heptanoate
pH 7.0, 70°C, wild-type enzyme
0.01502
4-methylumbelliferyl heptanoate
pH 7.0, 70°C, mutant enzyme W194A
0.0191
4-methylumbelliferyl heptanoate
pH 8.0, 25°C
0.024
4-methylumbelliferyl heptanoate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.000086
4-methylumbelliferyl laurate
-
in 25 mM Tris-HCl (pH 8.0), at 25°C
0.000117
4-methylumbelliferyl laurate
pH 8.0, 25°C
0.00031
4-methylumbelliferyl octanoate
-
in 25 mM Tris-HCl (pH 8.0), at 25°C
0.00634
4-methylumbelliferyl octanoate
pH 8.0, 25°C
0.000024
4-methylumbelliferyl palmitate
pH 8.0, 25°C
0.000053
4-methylumbelliferyl palmitate
-
in 25 mM Tris-HCl (pH 8.0), at 25°C
0.013
4-nitrophenyl acetate
-
pH 7.2, 37°C
0.0215
4-nitrophenyl acetate
pH 8.0, 25°C
0.0229
4-nitrophenyl acetate
isoenzyme hBr3/pTARGET
0.0308
4-nitrophenyl acetate
-
-
0.043
4-nitrophenyl acetate
-
isoenzyme V
0.05
4-nitrophenyl acetate
-
37°C
0.055
4-nitrophenyl acetate
-
-
0.06
4-nitrophenyl acetate
-
pH 8.0, 22°C
0.0768
4-nitrophenyl acetate
-
80°C, pH 8.0, wild-type enzyme
0.077
4-nitrophenyl acetate
pH 7.5, 30°C
0.0853
4-nitrophenyl acetate
-
60°C
0.0932
4-nitrophenyl acetate
mutant enzyme G143E
0.0989
4-nitrophenyl acetate
-
-
0.1 - 0.58
4-nitrophenyl acetate
-
recombinant wild-type enzyme, pH 8.5, 30°C
0.1066
4-nitrophenyl acetate
wild type enzyme
0.125
4-nitrophenyl acetate
-
-
0.125
4-nitrophenyl acetate
-
45°C
0.134
4-nitrophenyl acetate
pH 7.0, 37°C
0.173
4-nitrophenyl acetate
-
isoform CES2, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C
0.183
4-nitrophenyl acetate
-
37°C
0.208
4-nitrophenyl acetate
-
isoform CES1-b, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C
0.22
4-nitrophenyl acetate
-
isoenzyme I
0.261
4-nitrophenyl acetate
pH 7.0, 30°C
0.263
4-nitrophenyl acetate
recombinant refolded His-taggged mutant A270S, pH 7.5, 37°C
0.29
4-nitrophenyl acetate
pH 7.5, 37°C
0.35
4-nitrophenyl acetate
pH 8.0, 80°C
0.365
4-nitrophenyl acetate
isoenzyme HU1/pTARGET
0.389
4-nitrophenyl acetate
recombinant refolded His-taggged mutant S76N, pH 7.5, 37°C
0.417
4-nitrophenyl acetate
recombinant refolded His-taggged mutant D204E, pH 7.5, 37°C
0.42
4-nitrophenyl acetate
-
recombinant mutant N96S, pH 8.5, 30°C
0.43
4-nitrophenyl acetate
-
pH 9.0, 25°C
0.44
4-nitrophenyl acetate
-
-
0.441
4-nitrophenyl acetate
-
isoform CES1-c, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C
0.464
4-nitrophenyl acetate
pH 9.0, 80°C
0.47
4-nitrophenyl acetate
-
pH 7.5, 30°C
0.47
4-nitrophenyl acetate
pH 2.0, 50°C
0.52
4-nitrophenyl acetate
-
pH 7.4, 37°C
0.52
4-nitrophenyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.579
4-nitrophenyl acetate
recombinant refolded His-taggged wild-type enzyme, pH 7.5, 37°C
0.63
4-nitrophenyl acetate
-
recombinant mutant F210L, pH 8.5, 30°C
0.73
4-nitrophenyl acetate
pH 6.0, 35°C, wild-type enzyme
0.76
4-nitrophenyl acetate
-
recombinant mutant NaM1H2, pH 8.5, 30°C
0.761
4-nitrophenyl acetate
-
pH 7.0, 25°C
0.9504
4-nitrophenyl acetate
frameshift mutant enzyme D260fs
0.98
4-nitrophenyl acetate
-
at 25°C
1.2
4-nitrophenyl acetate
pH 6.0, 35°C, mutant enzyme N248A/P256Q/E257G/S283F
1.3
4-nitrophenyl acetate
-
enzyme from human milk
1.3
4-nitrophenyl acetate
-
pH 7.0, 37°C
1.5
4-nitrophenyl acetate
-
enzyme from human pancreas
1.5
4-nitrophenyl acetate
-
mutant enzyme D205N
1.8
4-nitrophenyl acetate
-
mutant enzyme D205A
2.3
4-nitrophenyl acetate
-
-
2.5
4-nitrophenyl acetate
pH 7.0, 70°C
2.5
4-nitrophenyl acetate
70°C, pH 7.2
2.86
4-nitrophenyl acetate
-
-
3.7
4-nitrophenyl acetate
-
pH 6.8, 30°C
4.47
4-nitrophenyl acetate
pH 6.5, 50°C
0.004
4-nitrophenyl butanoate
-
37°C
0.0231
4-nitrophenyl butanoate
-
mutant C408G, pH 8.5
0.0241
4-nitrophenyl butanoate
pH 8.0, temperature not specified in the publication, recombinant enzyme expressed in Escherichia coli as thioredoxin-free form (EcSisEstA I)
0.0242
4-nitrophenyl butanoate
-
wild-type, pH 8.5
0.0254
4-nitrophenyl butanoate
pH 8.0, temperature not specified in the publication, recombinant enzyme expressed in Escherichia coli as a thioredoxin-EstA fusion protein (EcSisEstA II)
0.026
4-nitrophenyl butanoate
-
mutant C408P, pH 8.5
0.0283
4-nitrophenyl butanoate
-
mutant C408V, pH 8.5
0.0327
4-nitrophenyl butanoate
-
80°C, pH 8.0, wild-type enzyme
0.0328
4-nitrophenyl butanoate
-
mutant C408A, pH 8.5
0.0356
4-nitrophenyl butanoate
pH 8.0, temperature not specified in the publication, recombinant enzyme expressed in Sulfolobus solfataricus
0.04
4-nitrophenyl butanoate
-
pH 7.5, 25°C
0.045
4-nitrophenyl butanoate
pH 7.5, 22°C
0.05
4-nitrophenyl butanoate
-
pH 7.5, 25°C
0.092
4-nitrophenyl butanoate
pH 7.0, 30°C
0.097
4-nitrophenyl butanoate
pH 7.5, 30°C
0.097
4-nitrophenyl butanoate
pH 7.0, 37°C
0.0971
4-nitrophenyl butanoate
-
mutant C408S, pH 8.5
0.1287
4-nitrophenyl butanoate
pH 8.0, 25°C
0.164
4-nitrophenyl butanoate
pH 7.1, 70°C
0.28
4-nitrophenyl butanoate
-
pH 7.5, 30°C
0.28
4-nitrophenyl butanoate
-
wild-type, pH 8.0, 25°C
0.38
4-nitrophenyl butanoate
-
pH 8.0, 22°C
0.42
4-nitrophenyl butanoate
-
mutant G244P, pH 8.0, 25°C
0.73
4-nitrophenyl butanoate
-
wild-type enzyme, pH 7.1, 70°C
0.75
4-nitrophenyl butanoate
-
mutant R215L, pH 7.1, 70°C
0.86
4-nitrophenyl butanoate
-
pH 7.0, 25°C
1
4-nitrophenyl butanoate
-
pH 7.5, 25°C
1.06
4-nitrophenyl butanoate
-
mutant M211S/R215L, pH 7.1, 70°C
1.27
4-nitrophenyl butanoate
-
mutant M211V, pH 7.1, 70°C
1.77
4-nitrophenyl butanoate
-
mutant M211S, pH 7.1, 70°C
1.86
4-nitrophenyl butanoate
-
mutant M211T, pH 7.1, 70°C
127
4-nitrophenyl butanoate
pH 7.5, 70°C
0.00043
4-nitrophenyl butyrate
-
-
0.00055
4-nitrophenyl butyrate
-
-
0.0011
4-nitrophenyl butyrate
-
-
0.00449
4-nitrophenyl butyrate
-
-
0.00603
4-nitrophenyl butyrate
-
at 35°C in 100 mM sodium phosphate (pH 7.0)
0.01
4-nitrophenyl butyrate
-
pH 7.2, 37°C
0.011
4-nitrophenyl butyrate
-
pH 8.0, 37°C
0.021
4-nitrophenyl butyrate
70°C, pH 7.1
0.041
4-nitrophenyl butyrate
-
-
0.05
4-nitrophenyl butyrate
pH 6.0, 35°C, mutant enzyme A241N/Q249P/G250E/F276S
0.056
4-nitrophenyl butyrate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.06
4-nitrophenyl butyrate
-
pH 7.0, 37°C
0.0705
4-nitrophenyl butyrate
-
60°C
0.0756
4-nitrophenyl butyrate
-
45°C
0.092
4-nitrophenyl butyrate
pH 7.0, 30°C
0.0983
4-nitrophenyl butyrate
-
37°C
0.13
4-nitrophenyl butyrate
pH 6.0, 35°C, wild-type enzyme
0.13
4-nitrophenyl butyrate
-
recombinant mutant NaM1H2, pH 8.5, 30°C
0.14
4-nitrophenyl butyrate
-
pH 7.4, 37°C
0.18
4-nitrophenyl butyrate
pH 6.0, 35°C, mutant enzyme Q249P/G250E
0.222
4-nitrophenyl butyrate
pH 8.0, 60°C
0.239
4-nitrophenyl butyrate
pH 9.0, 80°C
0.263
4-nitrophenyl butyrate
-
-
0.32
4-nitrophenyl butyrate
pH 6.0, 35°C, wild-type enzyme
0.33
4-nitrophenyl butyrate
pH 7.5, 37°C
0.348
4-nitrophenyl butyrate
-
apparent value, pH 8.0, 60°C
0.48
4-nitrophenyl butyrate
pH 6.0, 35°C, mutant enzyme N248A/P256Q/E257G/S283F
0.5
4-nitrophenyl butyrate
pH 8.5, 35°C, recombinant enzyme
0.53
4-nitrophenyl butyrate
-
0.6
4-nitrophenyl butyrate
pH 2.0, 50°C
0.63
4-nitrophenyl butyrate
pH 7.4, 37°C, mutant enzyme R210A
0.69
4-nitrophenyl butyrate
-
pH 8.5, 40°C
0.7
4-nitrophenyl butyrate
-
recombinant wild-type enzyme, pH 8.5, 30°C
0.93
4-nitrophenyl butyrate
pH 7.4, 37°C, wild-type enzyme
1.27
4-nitrophenyl butyrate
pH 8.0, 80°C
1.6
4-nitrophenyl butyrate
-
-
0.011
4-nitrophenyl caprate
-
-
0.043
4-nitrophenyl caprate
pH 7.0, 37°C
0.008
4-nitrophenyl caproate
-
37°C
0.019
4-nitrophenyl caproate
pH 7.0, 37°C
0.037
4-nitrophenyl caproate
pH 7.0, 30°C
0.077
4-nitrophenyl caproate
pH 7.5, 22°C
0.25
4-nitrophenyl caproate
pH 7.5, 37°C
0.33
4-nitrophenyl caproate
-
pH 7.0, 37°C
3.8
4-nitrophenyl caproate
pH and temperature not specified in the publication
0.014
4-nitrophenyl caprylate
pH 7.0, 37°C
0.017
4-nitrophenyl caprylate
-
37°C
0.028
4-nitrophenyl caprylate
pH 7.4, 37°C, wild-type enzyme
0.043
4-nitrophenyl caprylate
pH 7.4, 37°C, mutant enzyme R210A
0.068
4-nitrophenyl caprylate
pH 7.0, 30°C
0.008
4-nitrophenyl decanoate
-
mutants M211S and M211S/R215L, pH 7.1, 70°C
0.011
4-nitrophenyl decanoate
-
mutant R215L, pH 7.1, 70°C
0.018
4-nitrophenyl decanoate
-
wild-type enzyme, pH 7.1, 70°C
0.019
4-nitrophenyl decanoate
-
mutant M211T, pH 7.1, 70°C
0.0191
4-nitrophenyl decanoate
pH 8.0, temperature not specified in the publication, recombinant enzyme expressed in Escherichia coli as thioredoxin-free form (EcSisEstA I)
0.0203
4-nitrophenyl decanoate
pH 8.0, temperature not specified in the publication, recombinant enzyme expressed in Escherichia coli as a thioredoxin-EstA fusion protein (EcSisEstA II)
0.021
4-nitrophenyl decanoate
-
mutant M211V, pH 7.1, 70°C
0.024
4-nitrophenyl decanoate
pH 8.0, 60°C
0.032
4-nitrophenyl decanoate
-
pH 7.5, 30°C
0.033
4-nitrophenyl decanoate
pH 9.0, 80°C
0.0361
4-nitrophenyl decanoate
pH 8.0, temperature not specified in the publication, recombinant enzyme expressed in Sulfolobus solfataricus
0.651
4-nitrophenyl decanoate
-
80°C, pH 8.0, wild-type enzyme
4.99
4-nitrophenyl decanoate
pH 8.0, 80°C
0.00075
4-nitrophenyl dodecanoate
pH 8.0, 60°C, mutant enzyme W474Q/R526V/T560W
0.00076
4-nitrophenyl dodecanoate
pH 8.0, 60°C, mutant enzyme F488Y/R526V/T560W
0.00101
4-nitrophenyl dodecanoate
pH 8.0, 60°C, mutant enzyme F488W/R526V/T560W
0.00122
4-nitrophenyl dodecanoate
pH 8.0, 60°C, mutant enzyme R526V/T560W
0.00183
4-nitrophenyl dodecanoate
pH 8.0, 60°C, mutant enzyme W474A/R526V/T560W
0.00234
4-nitrophenyl dodecanoate
pH 8.0, 60°C, mutant enzyme W474V/F488G/R526V/T560W
0.00243
4-nitrophenyl dodecanoate
pH 8.0, 60°C, mutant enzyme W474V/R526V/T560W
0.0038
4-nitrophenyl dodecanoate
-
pH 7.5, 30°C
0.00388
4-nitrophenyl dodecanoate
pH 8.0, 60°C, mutant enzyme F488P/R526V/T560W
0.00579
4-nitrophenyl dodecanoate
pH 8.0, 60°C, mutant enzyme F488S/R526V/T560W
0.007
4-nitrophenyl dodecanoate
-
mutant M211T, pH 7.1, 70°C
0.00737
4-nitrophenyl dodecanoate
pH 8.0, 60°C, mutant enzyme F488A/R526V/T560W
0.008
4-nitrophenyl dodecanoate
-
mutant M211S/R215L, pH 7.1, 70°C
0.00834
4-nitrophenyl dodecanoate
pH 8.0, 60°C, mutant enzyme F488G/R526V/T560W
0.00862
4-nitrophenyl dodecanoate
pH 8.0, 60°C, wild-type enzyme
0.01
4-nitrophenyl dodecanoate
-
mutant M211S, pH 7.1, 70°C
0.0118
4-nitrophenyl dodecanoate
pH 8.0, 60°C, mutant enzyme R526V
0.015
4-nitrophenyl dodecanoate
-
mutant M211V, pH 7.1, 70°C
0.015
4-nitrophenyl dodecanoate
pH 9.0, 80°C
0.019
4-nitrophenyl dodecanoate
-
wild-type enzyme, pH 7.1, 70°C
0.021
4-nitrophenyl dodecanoate
-
mutant R215L, pH 7.1, 70°C
0.037
4-nitrophenyl dodecanoate
pH 8.0, 60°C
0.339
4-nitrophenyl dodecanoate
pH 7.0, 30°C
0.654
4-nitrophenyl dodecanoate
-
80°C, pH 8.0, wild-type enzyme
67.5
4-nitrophenyl dodecanoate
pH 7.0, 70°C
67.6
4-nitrophenyl dodecanoate
70°C, pH 7.2
0.005
4-nitrophenyl hexadecanoate
pH 9.0, 80°C
0.0051
4-nitrophenyl hexadecanoate
pH 9.0, 80°C
0.021
4-nitrophenyl hexadecanoate
-
mutant M211S, pH 7.1, 70°C
0.023
4-nitrophenyl hexadecanoate
-
mutant M211T, pH 7.1, 70°C
0.026
4-nitrophenyl hexadecanoate
-
mutant M211V, pH 7.1, 70°C
0.031
4-nitrophenyl hexadecanoate
-
mutant R215L, pH 7.1, 70°C
0.034
4-nitrophenyl hexadecanoate
-
mutant M211S/R215L, pH 7.1, 70°C
0.042
4-nitrophenyl hexadecanoate
-
wild-type enzyme, pH 7.1, 70°C
0.13
4-nitrophenyl hexadecanoate
pH 8.0, 60°C
0.507
4-nitrophenyl hexadecanoate
-
80°C, pH 8.0, wild-type enzyme
4.8
4-nitrophenyl hexadecanoate
pH 7.0, 70°C
4.8
4-nitrophenyl hexadecanoate
70°C, pH 7.2
0.004
4-nitrophenyl hexanoate
-
-
0.01036
4-nitrophenyl hexanoate
pH 8.0, 25°C
0.011
4-nitrophenyl hexanoate
70°C, pH 7.1
0.0126
4-nitrophenyl hexanoate
-
37°C
0.0192
4-nitrophenyl hexanoate
-
45°C
0.021
4-nitrophenyl hexanoate
-
-
0.0219
4-nitrophenyl hexanoate
pH 8.0, temperature not specified in the publication, recombinant enzyme expressed in Escherichia coli as a thioredoxin-EstA fusion protein (EcSisEstA II)
0.0239
4-nitrophenyl hexanoate
pH 8.0, temperature not specified in the publication, recombinant enzyme expressed in Escherichia coli as thioredoxin-free form (EcSisEstA I)
0.0331
4-nitrophenyl hexanoate
pH 8.0, temperature not specified in the publication, recombinant enzyme expressed in Sulfolobus solfataricus
0.034
4-nitrophenyl hexanoate
pH 7.5, 30°C
0.037
4-nitrophenyl hexanoate
pH 7.0, 30°C
0.0375
4-nitrophenyl hexanoate
-
60°C
0.044
4-nitrophenyl hexanoate
pH 7.1, 70°C
0.048
4-nitrophenyl hexanoate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.05
4-nitrophenyl hexanoate
pH 7.1, 70°C, mutant enzyme expressed from the gene that has a deletion of about 60 residues at the N terminus
0.051
4-nitrophenyl hexanoate
pH 8.0, 60°C
0.07
4-nitrophenyl hexanoate
-
wild-type, pH 8.0, 25°C
0.077
4-nitrophenyl hexanoate
-
-
0.09
4-nitrophenyl hexanoate
-
mutant R215L, pH 7.1, 70°C
0.099
4-nitrophenyl hexanoate
-
mutant M211S/R215L, pH 7.1, 70°C
0.12
4-nitrophenyl hexanoate
-
pH 7.5, 30°C
0.13
4-nitrophenyl hexanoate
pH 6.0, 35°C, mutant enzyme N248A/P256Q/E257G/S283F
0.13
4-nitrophenyl hexanoate
pH 6.0, 35°C, wild-type enzyme
0.21
4-nitrophenyl hexanoate
-
mutant M211V, pH 7.1, 70°C
0.22
4-nitrophenyl hexanoate
-
wild-type enzyme, pH 7.1, 70°C
0.25
4-nitrophenyl hexanoate
-
mutant G244P, pH 8.0, 25°C
0.41
4-nitrophenyl hexanoate
-
mutant M211S, pH 7.1, 70°C
0.47
4-nitrophenyl hexanoate
-
-
0.51
4-nitrophenyl hexanoate
-
mutant M211T, pH 7.1, 70°C
0.59
4-nitrophenyl hexanoate
-
3.9
4-nitrophenyl hexanoate
pH 2.0, 50°C
14.5
4-nitrophenyl hexanoate
70°C, pH 7.2
44.7
4-nitrophenyl hexanoate
pH 7.5, 70°C
0.01
4-nitrophenyl laurate
-
-
0.067
4-nitrophenyl laurate
-
-
0.186
4-nitrophenyl laurate
pH 7.0, 37°C
0.339
4-nitrophenyl laurate
pH 7.0, 30°C
0.6
4-nitrophenyl laurate
pH 7.5, 37°C
0.0117
4-nitrophenyl octanoate
pH 7.0, 70°C, mutant enzyme D524N
0.012
4-nitrophenyl octanoate
-
-
0.0165
4-nitrophenyl octanoate
-
37°C
0.022
4-nitrophenyl octanoate
-
mutant M211S/R215L, pH 7.1, 70°C
0.0232
4-nitrophenyl octanoate
pH 7.0, 70°C, wild-type enzyme
0.025
4-nitrophenyl octanoate
-
mutant R215L, pH 7.1, 70°C
0.0254
4-nitrophenyl octanoate
-
45°C
0.0266
4-nitrophenyl octanoate
pH 7.0, 70°C, mutant enzyme D524A
0.028
4-nitrophenyl octanoate
-
wild-type enzyme, pH 7.1, 70°C
0.029
4-nitrophenyl octanoate
pH 8.0, 60°C
0.033
4-nitrophenyl octanoate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.0335
4-nitrophenyl octanoate
-
60°C
0.037
4-nitrophenyl octanoate
-
mutant M211S, pH 7.1, 70°C
0.04
4-nitrophenyl octanoate
-
wild-type, pH 8.0, 25°C
0.051
4-nitrophenyl octanoate
pH 7.1, 70°C
0.06
4-nitrophenyl octanoate
-
mutant M211V, pH 7.1, 70°C
0.0606
4-nitrophenyl octanoate
pH 8.0, 25°C
0.068
4-nitrophenyl octanoate
pH 7.0, 30°C
0.072
4-nitrophenyl octanoate
-
pH 7.5, 30°C
0.1
4-nitrophenyl octanoate
-
mutant M211T, pH 7.1, 70°C
0.119
4-nitrophenyl octanoate
70°C, pH 7.1
0.15
4-nitrophenyl octanoate
-
-
0.152
4-nitrophenyl octanoate
pH 9.0, 80°C
0.153
4-nitrophenyl octanoate
pH 9.0, 80°C
0.19
4-nitrophenyl octanoate
-
recombinant mutant NaM1H2, pH 8.5, 30°C
0.2
4-nitrophenyl octanoate
-
pH 8.0, 50°C
0.289
4-nitrophenyl octanoate
-
80°C, pH 8.0, wild-type enzyme
0.63
4-nitrophenyl octanoate
-
2.64
4-nitrophenyl octanoate
pH 8.0, 80°C
14.5
4-nitrophenyl octanoate
pH 7.0, 70°C
25.2
4-nitrophenyl octanoate
pH 7.5, 70°C
0.0031
4-nitrophenyl palmitate
-
at 70°C
0.0191
4-nitrophenyl palmitate
-
at 150°C
0.227
4-nitrophenyl palmitate
pH 8.0, temperature not specified in the publication, recombinant enzyme expressed in Escherichia coli as thioredoxin-free form (EcSisEstA I)
0.252
4-nitrophenyl palmitate
pH 8.0, temperature not specified in the publication, recombinant enzyme expressed in Escherichia coli as a thioredoxin-EstA fusion protein (EcSisEstA II)
0.61
4-nitrophenyl palmitate
pH 8.0, temperature not specified in the publication, recombinant enzyme expressed in Sulfolobus solfataricus
0.876
4-nitrophenyl palmitate
pH 7, 50°C
0.02
4-nitrophenyl pentanoate
70°C, pH 7.1
0.031
4-nitrophenyl pentanoate
-
-
0.039
4-nitrophenyl pentanoate
-
pH 7.2, 37°C
0.0566
4-nitrophenyl pentanoate
-
45°C
0.071
4-nitrophenyl pentanoate
pH 7.1, 70°C
0.0766
4-nitrophenyl pentanoate
-
60°C
0.079
4-nitrophenyl pentanoate
-
pH 7.5, 30°C
0.08
4-nitrophenyl pentanoate
-
37°C
0.12
4-nitrophenyl pentanoate
pH 7.5, 30°C
0.125
4-nitrophenyl pentanoate
-
-
0.1517
4-nitrophenyl pentanoate
pH 8.0, 25°C
0.53
4-nitrophenyl pentanoate
-
-
2.1
4-nitrophenyl pentanoate
pH 7.0, 70°C
2.1
4-nitrophenyl pentanoate
70°C, pH 7.2
0.139
4-nitrophenyl propanoate
pH 7.0, 30°C
0.348
4-nitrophenyl propanoate
pH 7.1, 70°C
0.0338
4-nitrophenyl propionate
pH 8.0, 25°C
0.05
4-nitrophenyl propionate
-
-
0.0828
4-nitrophenyl propionate
-
60°C
0.106
4-nitrophenyl propionate
70°C, pH 7.1
0.12
4-nitrophenyl propionate
pH 7.5, 30°C
0.137
4-nitrophenyl propionate
-
45°C
0.139
4-nitrophenyl propionate
pH 7.0, 30°C
0.196
4-nitrophenyl propionate
-
37°C
0.35
4-nitrophenyl propionate
pH 7.5, 37°C
0.35
4-nitrophenyl propionate
-
pH 7.0, 37°C
0.37
4-nitrophenyl propionate
pH 6.0, 35°C, wild-type enzyme
0.45
4-nitrophenyl propionate
pH 2.0, 50°C
0.67
4-nitrophenyl propionate
-
pH 7.5, 30°C
0.7
4-nitrophenyl propionate
pH 6.0, 35°C, mutant enzyme N248A/P256Q/E257G/S283F
0.9
4-nitrophenyl propionate
-
-
1.05
4-nitrophenyl propionate
-
-
1.5
4-nitrophenyl propionate
-
pH 8.0, 50°C
3.3
4-nitrophenyl propionate
-
-
0.009
4-nitrophenyl tetradecanoate
pH 9.0, 80°C
0.0094
4-nitrophenyl tetradecanoate
pH 9.0, 80°C
0.017
4-nitrophenyl tetradecanoate
-
mutant M211S, pH 7.1, 70°C
0.019
4-nitrophenyl tetradecanoate
-
mutant M211V, pH 7.1, 70°C
0.02
4-nitrophenyl tetradecanoate
-
mutant M211T, pH 7.1, 70°C
0.022
4-nitrophenyl tetradecanoate
-
mutants R215L and M211S/R215L, pH 7.1, 70°C
0.031
4-nitrophenyl tetradecanoate
-
wild-type enzyme, pH 7.1, 70°C
1.054
4-nitrophenyl tetradecanoate
-
80°C, pH 8.0, wild-type enzyme
0.034
4-nitrophenyl valerate
-
pH 7.0, 37°C
0.1
4-nitrophenyl valerate
-
mutant L362D, 37°C, pH 7.4
0.15
4-nitrophenyl valerate
-
wild-type, 37°C, pH 7.4
0.187
4-nitrophenyl valerate
-
at 25°C
0.19
4-nitrophenyl valerate
-
wild-type, pH 8.0, 25°C
0.26
4-nitrophenyl valerate
-
mutant L362A, 37°C, pH 7.4
0.33
4-nitrophenyl valerate
-
mutant G244P, pH 8.0, 25°C
0.36
4-nitrophenyl valerate
-
mutant L362R, 37°C, pH 7.4
0.022
4-yethylumbelliferyl acetate
-
-
0.0333
4-yethylumbelliferyl acetate
pH 8.0, 25°C
0.0828
4-yethylumbelliferyl acetate
-
in 25 mM Tris-HCl (pH 8.0), at 25°C
0.23
4-yethylumbelliferyl acetate
-
mutant L362D, 37°C, pH 7.4
0.29
4-yethylumbelliferyl acetate
-
wild-type, 37°C, pH 7.4
0.43
4-yethylumbelliferyl acetate
-
mutant L362A, 37°C, pH 7.4
0.45
4-yethylumbelliferyl acetate
-
80°C
0.57
4-yethylumbelliferyl acetate
-
mutant L362R, 37°C, pH 7.4
2
4-yethylumbelliferyl acetate
-
-
0.46
7-aminocephalosporanic acid
-
recombinant wild-type enzyme, pH 8.5, 30°C
0.51
7-aminocephalosporanic acid
-
recombinant mutant NaM1H2, pH 8.5, 30°C
0.0032
7-ethyl-10-(4-(1-piperidino)-1-amino)carbonyloxycampothecin
-
pH 7.0, 37°C, isoform CES2
0.08
7-ethyl-10-(4-(1-piperidino)-1-amino)carbonyloxycampothecin
-
pH 7.0, 37°C, isoform CES1A1
0.46
7-ethyl-10-(4-(1-piperidino)-1-amino)carbonyloxycampothecin
-
pH 7.0, 37°C
0.001
7-ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycampothecin
-
pH 7.0, 37°C, isoform CES2
0.039
7-ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycampothecin
-
pH 7.0, 37°C, isoform CES1A1
0.137
7-ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycampothecin
-
pH 7.0, 37°C
0.0186
7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin
-
wild-type, pH 8.5
0.0206
7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin
-
mutant C408P, pH 8.5
0.0223
7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin
-
mutant C408V, pH 8.5
0.0224
7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin
-
mutant C408G, pH 8.5
0.0453
7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin
-
mutant C408A, pH 8.5
0.00034
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin
-
isozyme CE-2
0.0034
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin
-
liver, pH 7.5, 37°C
0.0038
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin
-
colon carcinoma, pH 7.5, 37°C
0.0043
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin
-
isozyme CE-1
0.00001
Alpha-naphthyl acetate
-
non-specific enzyme, pH 6.9, 25°C
0.0001
Alpha-naphthyl acetate
-
malathion-specific enzyme, pH 6.9, 25°C
0.027
Alpha-naphthyl acetate
-
isozyme ME3, pH 7.0, 27°C
0.048
Alpha-naphthyl acetate
-
isozyme ME2, pH 7.0, 27°C
0.052
Alpha-naphthyl acetate
-
isozyme ME1, pH 7.0, 27°C
0.222
Alpha-naphthyl acetate
-
at 25°C
0.0702
anisamidobutyric acid
-
isoenzyme pI 6.0
0.126
anisamidobutyric acid
-
isoenzyme pI 6.2
0.0689
anisilic acid
-
isoenzyme pI 6.0
0.15
anisilic acid
-
isoenzyme pI 6.2
0.0804
benazepril
-
isoenzyme pI 6.2
0.1002
benazepril
-
isoenzyme pI 6.0
0.00672
bioresmethrin
-
isoform hCE1, pH 7.4, 37°C
25.75
bioresmethrin
-
pH 7.4, 37°C
0.6
butanilicain
-
isoenzyme V
1.6
butanilicain
-
isoenzyme I
0.141
camostat mesilate
-
isoenzyme pI 6.2
0.2324
camostat mesilate
-
isoenzyme pI 6.0
9.64
capric acid
-
pH 10.0, 60°C
16.44
capric acid
-
pH 7.0, 60°C
1.3
cholesterol oleate
-
enzyme from human pancreas
2
cholesterol oleate
-
enzyme from human milk
0.002
cyano(3-phenoxyphenyl)methyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
isoform hCE-1, pH 8.0, 37°C
0.0091
cyano(3-phenoxyphenyl)methyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
isoform hCE-2, pH 8.0, 37°C
0.0015
cyano(6-methoxy-2-naphthyl)methyl 2,2,3,3-tetramethylcyclopropanecarboxylate
isoform hCE-1, pH 8.0, 37°C
0.0054
cyano(6-methoxy-2-naphthyl)methyl 2,2,3,3-tetramethylcyclopropanecarboxylate
isoform hCE-2, pH 8.0, 37°C
0.0018
cyano(6-methoxynaphthalen-2-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylic acid
isoform hCE-1, pH 8.0, 37°C
0.0021
cyano(6-methoxynaphthalen-2-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylic acid
isoform hCE-2, pH 8.0, 37°C
0.0688
delapril
-
isoenzyme pI 6.0
0.1202
delapril
-
isoenzyme pI 6.0
0.028
derapril
-
enzyme from jejunum microsomes
0.033
derapril
-
enzyme from liver microsomes
0.041
derapril
-
enzyme from jejunum cytosol
0.101
derapril
-
enzyme from liver cytosol
0.46
derapril
enzyme from liver microsomes
1.118
derapril
enzyme from liver cytosol
0.0842
diltiazem
-
isoenzyme pI 6.0
0.38
diltiazem
-
isoenzyme pI 6.2
0.00039
ethyl 2-[4-[(6-chloroquinoxalin-2-yl)oxy]phenoxy]propanoate
recombinant His-tagged enzyme, pH 7.0, 37°C
0.00042
ethyl 2-[4-[(6-chloroquinoxalin-2-yl)oxy]phenoxy]propanoate
recombinant His-tagged enzyme, pH 7.0, 37°C
39
ethyl acetate
pH 7.5, 30°C
56
ethyl acetate
in 2.0 mM Tris-HCl, pH 7.6, at 25°C
6.8
ethyl butanoate
pH 7.5, 30°C
62
ethyl butanoate
-
pH 7.5, 30°C
0.0025
ethyl butyrate
-
-
0.0072
ethyl butyrate
-
-
0.0077
ethyl butyrate
-
-
0.0106
ethyl butyrate
-
-
2.8
ethyl hexanoate
pH 7.5, 30°C
7.5
ethyl hexanoate
-
pH 7.5, 30°C
6.6
ethyl pentanoate
pH 7.5, 30°C
19
ethyl pentanoate
-
pH 7.5, 30°C
0.00194
fluorescein diacetate
-
isoform CES1-b, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C
0.00431
fluorescein diacetate
-
isoform CES1-c, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C
0.00482
fluorescein diacetate
-
isoform CES2, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C
0.19
hexyl acetate
pH 7.5, 30°C
4.647
hexyl acetate
-
pH 7.4, 28°C
0.245
imidapril
enzyme from liver microsomes
0.3297
imidapril
-
isoenzyme pI 6.0
0.346
imidapril
-
enzyme from jejunum microsomes
0.382
imidapril
-
enzyme from jejunum cytosol
0.397
imidapril
enzyme from liver cytosol
0.4075
imidapril
-
isoenzyme pI 6.2
0.0062
irinotecan
ratio kcat/Km is 180 per min and mM
0.00625
irinotecan
mutant hCE1m6, ratio kcat/Km is 19.8 per min and mM
0.0828
irinotecan
wild-type, ratio kcat/Km is 0.28 per min and mM
4.21
irinotecan
-
pH 7.4, 37°C
0.00087
malathion
pH 7.0, 30°C
0.0015
malathion
-
malathion-specific enzyme, pH 6.9, 25°C
0.026
malathion
-
non-specific enzyme, pH 6.9, 25°C
39.3
malathion
Culex sp.
-
pH 7.0, 37°C
0.0026
methyl butyrate
-
-
0.0182
methyl butyrate
-
-
0.0589
methyl butyrate
-
-
0.11
methyl butyrate
-
serum enzyme
0.04
methyl octanoate
-
isoenzyme V
0.4
methyl octanoate
-
isoenzyme I
1.67
monobutyl phthalate
-
isoform E1, pH 7.5, 30°C
2.7
monobutyl phthalate
-
isoform E2, pH 7.5, 30°C
1.39
monopentyl phthalate
-
isoform E1, pH 7.5, 30°C
2.63
monopentyl phthalate
-
isoform E2, pH 7.5, 30°C
5.88
monopropyl phthalate
-
isoform E1, pH 7.5, 30°C
6.25
monopropyl phthalate
-
isoform E2, pH 7.5, 30°C
0.0236
N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester
-
pH 7.4, 37°C, in absence of curcumin
0.0853
N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester
-
pH 7.4, 37°C, in presence of curcumin
0.094
oxybutynin
enzyme from liver cytosol
0.123
oxybutynin
enzyme from liver cytosol
0.9284
oxybutynin
-
isoenzyme pI 6.0
0.0031
p-nitrophenyl acetate
isoform hCE-2, pH 8.0, 37°C
0.013
p-nitrophenyl acetate
-
-
0.027
p-nitrophenyl acetate
isoform hCE-1,pH 8.0, 37°C
0.261
p-nitrophenyl acetate
pH 7.0, 30°C
0.29
p-nitrophenyl acetate
+/- 0.04
0.43
p-nitrophenyl acetate
-
-
1.15
p-nitrophenyl acetate
-
60°C, pH 7.5
119
p-nitrophenyl acetate
pH 7.4
0.01
p-nitrophenyl butanoate
-
-
0.243
p-nitrophenyl butanoate
-
60°C, pH 7.5
0.33
p-nitrophenyl butyrate
+/- 0.06
0.4
p-nitrophenyl butyrate
-
-
0.0005
p-nitrophenyl caproate
-
Est55, pH 8.5, 60°C
0.0022
p-nitrophenyl caproate
-
Est30, pH 8.5, 60°C
0.25
p-nitrophenyl caproate
+/- 0.02
0.05
phenyl acetate
-
isoenzyme V
0.43
phenyl acetate
-
isoenzyme I
0.93
phenyl acetate
pH 7.5, 30°C
2.8
phenyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
4
phenyl acetate
-
pH 8.0, 22°C
35
phenyl acetate
-
pH 7.5, 30°C
0.00064
phenyl butyrate
-
-
0.00202
phenyl butyrate
-
-
0.0027
phenyl butyrate
-
-
0.0033
phenyl butyrate
-
-
0.2 - 0.25
phenyl butyrate
-
-
0.42
phenylthioacetate
pH 7.5, 30°C
13
phenylthioacetate
-
pH 7.5, 30°C
0.0512
pranlukast
-
isoenzyme pI 6.0
0.061
pranlukast
-
isoenzyme pI 6.2
0.1177
procaine
-
isoenzyme pI 6.0
0.00089
retinyl palmitate
isozyme ES3, pH 8.0, 37°C
0.0012
retinyl palmitate
isozyme ES10, pH 8.0, 37°C
0.0014
retinyl palmitate
isozyme ES4, pH 8.0, 37°C
0.086
retinyl palmitate
-
pH 5.0, 37°C
0.229
temocapril
-
isoenzyme pI 6.0
0.4678
temocapril
-
isoenzyme pI 6.2
0.639
trandolapril
-
wild type enzyme, in PBS containing 10 mM HEPES, pH 7.4, at 37°C
1.721
trandolapril
-
in 100 mM phosphate buffer at 37°C, pH not specified in the publication
0.00011
trans-permethrin
pH 7.0, 30°C
0.01
trans-permethrin
-
mutant L362R, 37°C, pH 7.4
0.013
trans-permethrin
-
mutant L362A, 37°C, pH 7.4
0.014
trans-permethrin
-
mutant L362D, 37°C, pH 7.4
0.014
trans-permethrin
-
wild-type, 37°C, pH 7.4
0.196
Triacetin
pH 7.5, 22°C
2.2
Triacetin
pH 2.0, 50°C
10
Triacetin
-
pH 7.5, 25°C
12
Triacetin
-
pH 7.5, 25°C
203
Triacetin
in 2.0 mM Tris-HCl, pH 7.6, at 25°C
0.05
tributyrin
-
pH 7.5, 25°C
0.07
tributyrin
-
pH 7.5, 25°C
0.4
tributyrin
-
pH 7.5, 25°C
2.22
tributyrin
pH 7.5, 22°C
7.4
tributyrin
pH 2.0, 50°C
0.4992
trinotecan
-
isoenzyme pI 6.2
0.715
trinotecan
-
isoenzyme pI 6.0
3.9
triolein
-
enzyme from human pancreas
8.3
triolein
-
enzyme from human milk
0.3
tripropionin
-
pH 7.5, 25°C
0.75
tripropionin
-
pH 7.5, 25°C
3.5
tripropionin
pH 2.0, 50°C
15
tripropionin
-
pH 7.5, 25°C
29
tripropionin
in 2.0 mM Tris-HCl, pH 7.6, at 25°C
2.5
vinyl acetate
-
pH 7.5, 25°C
4
vinyl acetate
-
pH 7.5, 25°C
170
vinyl acetate
-
pH 7.5, 25°C
2.5
vinyl butanoate
-
pH 7.5, 25°C
3
vinyl butanoate
-
pH 7.5, 25°C
11
vinyl butanoate
-
pH 7.5, 25°C
6
vinyl propionate
-
pH 7.5, 25°C
7
vinyl propionate
-
pH 7.5, 25°C
68
vinyl propionate
in 2.0 mM Tris-HCl, pH 7.6, at 25°C
70
vinyl propionate
-
pH 7.5, 25°C
additional information
additional information
-
-
additional information
additional information
-
kinetics
-
additional information
additional information
-
kinetics
-
additional information
additional information
-
kinetics
-
additional information
additional information
-
kinetics
-
additional information
additional information
kinetics
-
additional information
additional information
-
kinetics
-
additional information
additional information
kinetics
-
additional information
additional information
-
kinetics
-
additional information
additional information
-
kinetics, wild-type and mutant enzyme
-
additional information
additional information
-
Michaelis-Menten kinetics
-
additional information
additional information
Michaelis-Menten kinetics
-
additional information
additional information
Michaelis-Menten kinetics
-
additional information
additional information
-
Michaelis-Menten kinetics
-
additional information
additional information
Michaelis-Menten kinetics, overview
-
additional information
additional information
Michaelis-Menten kinetics, overview
-
additional information
additional information
-
Michaelis-Menten kinetics, overview
-
additional information
additional information
-
ratio of vmax to Km value is 0.0108 per min for enzyme purified from Escherichia coli, 0.109 per min for enzyme expressed in Pichia pastoris
-
additional information
additional information
-
kinetics of wild-type and mutant enzymes with mycophenolate mofetil, overview
-
additional information
additional information
-
the carboxylesterase-catalyzed esterification of capric acid in the reversed micellar system follows Michaelis-Menten kinetics
-
additional information
additional information
-
Michaelis-Menten kinetics analysis, overview
-
additional information
additional information
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enzyme kinetics, overview. Michaelis-Menten equation can be calculated from Hanes-Woolf equation
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additional information
additional information
kinetic analysis is performed for human CE-1-catalyzed cocaine hydrolysis, Michalis-Menten kinetics, thermodynamics, overview
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additional information
additional information
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kinetic analysis is performed for human CE-1-catalyzed cocaine hydrolysis, Michalis-Menten kinetics, thermodynamics, overview
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additional information
additional information
Michaelis-Menten steady-state kinetic
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additional information
additional information
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Michaelis-Menten steady-state kinetic
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additional information
additional information
reaction kinetics of the enzyme with atorvastatin esters, overview
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additional information
additional information
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reaction kinetics of the enzyme with atorvastatin esters, overview
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