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Literature summary for 3.1.1.1 extracted from

  • Hosokawa, M.; Furihata, T.; Yaginuma, Y.; Yamamoto, N.; Watanabe, N.; Tsukada, E.; Ohhata, Y.; Kobayashi, K.; Satoh, T.; Chiba, K.
    Structural organization and characterization of the regulatory element of the human carboxylesterase (CES1A1 and CES1A2) genes (2008), Drug Metab. Pharmacokinet., 23, 73-84.
    View publication on PubMed
Search for more literature for 3.1.1.1

Protein Variants

Protein Variants Comment Organism
additional information deletion of the region from -432 to -243, which contains the C/EBP-binding site of the CES1A1 promoter, causes a 2.0fold decrease in activity and further deletion to -218 results in no significant effect on activity, deletion of the region from -218 to -112, which contains the GC box (Sp1-A), causes a 9.0fold decrease in activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P23141
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Homo sapiens
-
liver highest expression in liver Homo sapiens
-
lung
-
 Homo sapiens
-
additional information the mRNA expression levels of CES1A1 in small intestine and testis are low, and the level is very low in the brain, CES1A2 mRNA is not detected in small intestine Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl acetate + H2O
-
 Homo sapiens 4-nitrophenol + acetate
-
 ?

Synonyms

Synonyms Comment Organism
CES1A isozyme Homo sapiens