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Literature summary for 3.1.1.1 extracted from

  • Wei, Y.; Peng, A.Y.; Huang, J.
    Inhibition of porcine liver carboxylesterase by phosphorylated flavonoids (2013), Chem. Biol. Interact., 204, 75-79.
    View publication on PubMed
Search for more literature for 3.1.1.1

Inhibitors

Inhibitors Comment Organism Structure
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one
-
 Sus scrofa
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
-
 Sus scrofa
2-[3,4-bis[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-3,5,7-triyl hexaethyl tris(phosphate)
-
 Sus scrofa
2-[3,4-bis[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-5,7-diyl tetraethyl bis(phosphate)
-
 Sus scrofa
2-[3-[(diethoxyphosphoryl)oxy]-4-methoxyphenyl]-4-oxo-3,4-dihydro-2H-chromene-5,7-diyl tetraethyl bis(phosphate)
-
 Sus scrofa
2-[4-[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-5,7-diyl tetraethyl bis(phosphate)
-
 Sus scrofa
3-[4-[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-5,7-diyl tetraethyl bis(phosphate)
-
 Sus scrofa
4-[7-[(diethoxyphosphoryl)oxy]-4-oxo-4H-chromen-3-yl]phenyl diethyl phosphate
-
 Sus scrofa
4-[7-[(diethoxyphosphoryl)oxy]-5-hydroxy-4-oxo-4H-chromen-2-yl]benzene-1,2-diyl tetraethyl bis(phosphate)
-
 Sus scrofa
4-[7-[(diethoxyphosphoryl)oxy]-5-hydroxy-4-oxo-4H-chromen-2-yl]phenyl diethyl phosphate
-
 Sus scrofa
4-[7-[(diethoxyphosphoryl)oxy]-5-hydroxy-4-oxo-4H-chromen-3-yl]phenyl diethyl phosphate
-
 Sus scrofa
4-[7-[(dimethoxyphosphoryl)oxy]-5-hydroxy-4-oxo-4H-chromen-2-yl]phenyl dimethyl phosphate
-
 Sus scrofa
5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
-
 Sus scrofa
5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl dimethyl phosphate
-
 Sus scrofa
diethyl 4-oxo-2-phenyl-4H-chromen-6-yl phosphate
-
 Sus scrofa
diethyl 4-oxo-2-phenyl-4H-chromen-7-yl phosphate
-
 Sus scrofa
diethyl 5-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl phosphate
-
 Sus scrofa
diethyl 5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl phosphate
-
 Sus scrofa
diethyl 7-hydroxy-4-oxo-2-phenyl-4H-chromen-5-yl phosphate
-
 Sus scrofa
dimethyl 4-oxo-2-phenyl-4H-chromen-6-yl phosphate
-
 Sus scrofa
dimethyl 4-oxo-2-phenyl-4H-chromen-7-yl phosphate
-
 Sus scrofa
tetraethyl 4-oxo-2-phenyl-4H-chromene-5,7-diyl bis(phosphate)
-
 Sus scrofa
tetraethyl 5-hydroxy-4-oxo-2-phenyl-4H-chromene-6,7-diyl bis(phosphate)
-
 Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl acetate + H2O
-
 Sus scrofa 4-nitrophenol + acetate
-
 ?

Synonyms

Synonyms Comment Organism
CaE
-
 Sus scrofa
carboxylesterase 1
-
 Sus scrofa
CES
-
 Sus scrofa
Est1
-
 Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00000158
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa 4-[7-[(diethoxyphosphoryl)oxy]-5-hydroxy-4-oxo-4H-chromen-3-yl]phenyl diethyl phosphate
0.00000179
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa diethyl 5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl phosphate
0.00000249
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa 4-[7-[(diethoxyphosphoryl)oxy]-5-hydroxy-4-oxo-4H-chromen-2-yl]phenyl diethyl phosphate
0.00000372
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa 3-[4-[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-5,7-diyl tetraethyl bis(phosphate)
0.00000454
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa 4-[7-[(diethoxyphosphoryl)oxy]-4-oxo-4H-chromen-3-yl]phenyl diethyl phosphate
0.00000893
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa 2-[3,4-bis[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-5,7-diyl tetraethyl bis(phosphate)
0.0000158
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa 2-[4-[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-5,7-diyl tetraethyl bis(phosphate)
0.0000194
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa 2-[3-[(diethoxyphosphoryl)oxy]-4-methoxyphenyl]-4-oxo-3,4-dihydro-2H-chromene-5,7-diyl tetraethyl bis(phosphate)
0.0000217
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa tetraethyl 4-oxo-2-phenyl-4H-chromene-5,7-diyl bis(phosphate)
0.000024
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa 4-[7-[(diethoxyphosphoryl)oxy]-5-hydroxy-4-oxo-4H-chromen-2-yl]benzene-1,2-diyl tetraethyl bis(phosphate)
0.0000255
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa 5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl dimethyl phosphate
0.0000323
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa tetraethyl 5-hydroxy-4-oxo-2-phenyl-4H-chromene-6,7-diyl bis(phosphate)
0.0000662
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa 2-[3,4-bis[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-3,5,7-triyl hexaethyl tris(phosphate)
0.00025
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa diethyl 4-oxo-2-phenyl-4H-chromen-6-yl phosphate
0.00033
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa diethyl 7-hydroxy-4-oxo-2-phenyl-4H-chromen-5-yl phosphate
0.00036
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa 4-[7-[(dimethoxyphosphoryl)oxy]-5-hydroxy-4-oxo-4H-chromen-2-yl]phenyl dimethyl phosphate
0.00056
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa dimethyl 4-oxo-2-phenyl-4H-chromen-7-yl phosphate
0.00392
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa diethyl 4-oxo-2-phenyl-4H-chromen-7-yl phosphate
0.00487
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one
0.00745
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa dimethyl 4-oxo-2-phenyl-4H-chromen-6-yl phosphate
0.022
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
0.0415
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa diethyl 5-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl phosphate
0.0474
-
 in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C Sus scrofa 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one