Literature summary for 3.1.1.1 extracted from

Zhu, H.J.; Appel, D.I.; Johnson, J.A.; Chavin, K.D.; Markowitz, J.S.
Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril (2009), Biochem. Pharmacol., 77, 1266-1272.

Search for more literature for 3.1.1.1

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Flp-In-293 cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
G143E	the mutant does not hydrolyze trandolapril	Homo sapiens
additional information	mutant enzyme Asp260fs is an essentially dysfunctional enzyme with regard to the hydrolysis of trandolapril	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.639	-	trandolapril	wild type enzyme, in PBS containing 10 mM HEPES, pH 7.4, at 37°C	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Homo sapiens	-	-
additional information	isozyme CES1 is not expressed in human intestinal microsomes	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
intestine	isozyme CES2	Homo sapiens	-
liver	isozyme CES1	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
trandolapril + H2O	trandolapril is a CES1 selective substrate while CES2 exerts little to no catalytic activity towards this compound	Homo sapiens	trandolaprilat + ?	-	?

Synonyms

Synonyms	Comment	Organism
CES1	isozyme	Homo sapiens
CES2	isozyme	Homo sapiens

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Release 2023.1 (January 2023)