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Literature summary for 3.1.1.1 extracted from

  • Coppin, C.W.; Jackson, C.J.; Sutherland, T.; Hart, P.J.; Devonshire, A.L.; Russell, R.J.; Oakeshott, J.G.
    Testing the evolvability of an insect carboxylesterase for the detoxification of synthetic pyrethroid insecticides (2012), Insect Biochem. Mol. Biol., 42, 343-352.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli JM109 and BL21 (DE3) cells Lucilia cuprina

Protein Variants

Protein Variants Comment Organism
W251L/D449G the mutant shows a loss of activity for most substrates Lucilia cuprina
W251L/D473N the mutant shows a loss of activity for most substrates Lucilia cuprina
W251L/I140F the mutant shows a loss of activity for most substrates Lucilia cuprina
W251L/I459N the mutant shows a loss of activity for most substrates Lucilia cuprina
W251L/R458C the mutant shows a loss of activity for most substrates Lucilia cuprina
W251L/R461H the mutant shows a loss of activity for most substrates Lucilia cuprina
W251L/R461S the mutations result in improved activity Lucilia cuprina
W251L/S462I the mutant shows a loss of activity for most substrates Lucilia cuprina

Inhibitors

Inhibitors Comment Organism Structure
1(R)-cis-alpha(S) deltamethrin
-
Lucilia cuprina

Organism

Organism UniProt Comment Textmining
Lucilia cuprina Q25252
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-cyano(6-methoxynaphthalen-2-yl)methyl (1R,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + H2O
-
Lucilia cuprina (1R,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + (2R)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile
-
?
(R)-cyano(6-methoxynaphthalen-2-yl)methyl (1R,3S)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + H2O
-
Lucilia cuprina (1S,2S,3S)-2-(2,2-dichloroethenyl)-3-methylcyclopropanecarboxylate + (2R)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile
-
?
(R)-cyano(6-methoxynaphthalen-2-yl)methyl (1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + H2O
-
Lucilia cuprina (1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + (2S)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile
-
?
(R)-cyano(6-methoxynaphthalen-2-yl)methyl (1S,3S)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + H2O
-
Lucilia cuprina (1S,3S)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + (2S)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile
-
?
(R)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoate + H2O
-
Lucilia cuprina (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid + (2R)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile
-
?
(R)-cyano(6-methoxynaphthalen-2-yl)methyl (2S)-2-(4-chlorophenyl)-3-methylbutanoate + H2O
-
Lucilia cuprina (2S)-2-(4-chlorophenyl)-3-methylbutanoic acid + (2R)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile
-
?
(S)-cyano(6-methoxynaphthalen-2-yl)methyl (1R,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + H2O
-
Lucilia cuprina (1R,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + (2S)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile
-
?
(S)-cyano(6-methoxynaphthalen-2-yl)methyl (1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + H2O
-
Lucilia cuprina (1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + (2S)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile
-
?
(S)-cyano(6-methoxynaphthalen-2-yl)methyl (1S,3S)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + H2O
-
Lucilia cuprina (1S,3S)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + (2S)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile
-
?
(S)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoate + H2O
-
Lucilia cuprina (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid + (2S)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile
-
?
(S)-cyano(6-methoxynaphthalen-2-yl)methyl (2S)-2-(4-chlorophenyl)-3-methylbutanoate + H2O
-
Lucilia cuprina (2S)-2-(4-chlorophenyl)-3-methylbutanoic acid + (2S)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile
-
?
deltamethrin + H2O
-
Lucilia cuprina 3-phenoxybenzaldehyde + (1R,3R)-3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropanecarboxylate + cyanide
-
?

Synonyms

Synonyms Comment Organism
E3 carboxylesterase
-
Lucilia cuprina