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adipose tissue
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atherosclerotic plaque
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TACE expression measured by immunohistochemical analysis is observed in 183 of 383 breast carcinomas. TACE expression is predominantly seen in tumors with high levels of released human epidermal growth factor-4 receptor intracellular domain (4ICD) and membranous human epidermal growth factor-4 receptor
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metalloproteases ADAM-9, ADAM-15, and ADAM-17 are upregulated in advanced human atherosclerotic lesions in samples from carotid, aortic, and femoral territories compared to samples from internal thoracic artery free of atherosclerotic plaques. ADAM-9, ADAM-15, and ADAM-17-expressing cells colocalize with CD68-positive cells of monocytic origin in the atherosclerotic plaques, in the carotid territory, cells expressing the ADAMs codistribute also with smooth muscle cells
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metalloproteases ADAM-9, ADAM-15, and ADAM-17 are upregulated in advanced human atherosclerotic lesions in samples from carotid, aortic, and femoral territories compared to samples from internal thoracic artery free of atherosclerotic plaques. ADAM-9, ADAM-15, and ADAM-17-expressing cells colocalize with CD68-positive cells of monocytic origin in the atherosclerotic plaques, in the femoral territory, cells expressing the ADAMs codistribute also with CD31-positive endothelial cells
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both ADAM10, EC 3.4.24.81, and ADAM17 are present during all stages of spermatogenesis
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granulosa cells of bovine preovulatory follicles
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ADAM-17, TIMP-3 and fractalkine are constitutively expressed
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ADAM17 proteolytic targets, amphiregulin, transforming growth factor (TGF-alpha), syndecan-1 (SDC1), and tumor necrosis factor receptor 1 (TNFR1), are shed from HVECs in response to staphylococcal superantigen toxic shock syndrome toxin TSST-1. ADAM17, but not related ADAM10, is required for amphiregulin, TGF-alpha, and TNFR1 shedding. Both ADAM10 and ADAM17 contribute to SDC1 shedding and IL-8 production by HVECs in response to TSST-1
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within the hypothalamus, TACE is most abundantly expressed in astrocytes of the median eminence, specific changes in TACE activity are required for the normal timimg of puberty. TACE is a component of the neuron-to-glia signaling process used by glutamatergic neurons to control female sexual development
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large cell anaplastic lymphoma cell line
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CD30-positive Hodgkins lymphoma cell line
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CD30-positive Hodgkins lymphoma cell line
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hepatic stellate cell line
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TACE protein is localized to mononuclear cells (MNC), which infiltrate the liver from the spleen after hepatectomy. The kinetics of TACE expression is in accordance with the number of TACE-staining mononuclear cells and synchronizes with those of transforming growth factor-alpha. TACE-staining mononuclear cells partially overlapp with CD3+ T lymphocytes
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neuroblastoma cell line
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sural nerve biopsies from Guillain-Barre syndrome patients. ADAM-17-expressing T cells can be localized primarily within the epi- and perineurium, whereas in control sections from patients with non-inflammatory neuropathies, no axpression can be depected. The enzyme may contribute to the pathogenesis of inflammatory demyelination of the peripheral nervous system
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TACE expression measured by immunohistochemical analysis is observed in 39 of 217 ovarian carcinomas.TACE expression is predominantly seen in tumors with high levels of released human epidermal growth factor-4 receptor intracellular domain (4ICD) and membranous human epidermal growth factor-4 receptor
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ADAM17/TACE mRNA is expressed in 10 of 10 PDAC tissues. ADAM17/TACE mRNA expression is down-regulated in pancreatic cancer cells arrested in G2 -M phase. Critical involvement of ADAM17/TACE in the invasion behavior of pancreatic cancer cells
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ADAM17/TACE mRNA is expressed in 10 of 10 PDAC tissues. ADAM17/TACE expression is a later event in progression of pancreatic intraepithelial neoplasia to pancreatic ductal adenocarcinoma
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Villous explant cultures or cytotrophoblastic cells are used. Preadministration of TACE inhibitor in villous explant cultures or transfection of cytotrophoblastic cells with TACE-specific small interference RNA decreases the shedding of heparin-binding epidermal growth factor-like growth factor and amphiregulin. Hypoxia (2% O2) causes an increase in the levels of TACE mRNA and protein in villous explants and primary cytotrophoblastic cells in vitro
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TACE expression measured by immunohistochemical analysis is observed in 16 of 24 and 17 of 24 hormone-sensitive and hormone-insensitive prostate carcinomas. TACE expression is predominantly seen in tumors with high levels of released human epidermal growth factor-4 receptor intracellular domain (4ICD) and membranous human epidermal growth factor-4 receptor
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CD30-negative acute lymphoblastic leukemia cell line
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both ADAM10, EC 3.4.24.81, and ADAM17 are present during all stages of spermatogenesis
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marrow stromal cell-brain microvascular endothelial cell contact coculture and indirect co-culture of marrow stromal cell and brain microvascular endothelial cell
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primary cellular source of ADAM-17 in inflamed peripheral nervous system (experimental autoimmune neuritis). Not all T lymphocytes within the inflamed peripheral nervous system express ADAM-17. No ADAM-17 expressing cells are found in nerves from control animals
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atherosclerotic lesions of apolipoprotein E-deficient mice
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metalloproteases ADAM-9, ADAM-15, and ADAM-17 are upregulated in advanced human atherosclerotic lesions in samples from carotid, abdominal aortic, and femoral territories compared to samples from internal thoracic artery free of atherosclerotic plaques. ADAM-9, ADAM-15, and ADAM-17-expressing cells colocalize with CD68-positive cells of monocytic origin in the atherosclerotic plaques
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intraluminal thrombus of human abdominal aortic aneurysm
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atherosclerotic lesions of apolipoprotein E-deficient mice
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peripheral blood T-cells
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peripheral blood T-cells
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cellular suppression of TNF-alpha is measured using human whole blood (WBA) stimulated with lipopolysaccharide (LPS)
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neocortex, cerebellum, pyramidal neurons of the cerebral cortex and granular cell layer neurons in the hippocampus
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fetal brain
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the expression of TACE is increased in intermittent and prolonged hyperoxia
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mutated sublines M1 and M2. M1 contains only one expressible TACE allele encoding an M435I point mutation in the catalytic center of the protease, and M2 cells produce two TACE variants with distinct point mutations in the catalytic domain (C22Y) and the cysteine-rich/disintegrin domain (C600Y)
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marrow stromal cell-brain microvascular endothelial cell contact coculture and indirect co-culture of marrow stromal cell and brain microvascular endothelial cell
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corneal epithelial cell
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non-neoplastic salivary gland epithelial cells
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salivary gland epithelial cell
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glandular epithelial cells
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dermal fibroblasts
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638979, 638988, 638991, 638992, 638995, 639001, 639003, 639004, 639006, 639011, 639012, 669269, 669572, 711143 brenda
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embryonic fibroblast
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embryonic fibroblast
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TACE amounts in gingival crevicular fluid are higher in persons with chronic and aggressive periodontitis than in those with gingivitis or in healthy persons. TACE concentrations in gingival crevicular fluid are higher in persons with chronic and aggressive periodontitis than in those with gingivitis, although not significantly higher than in healthy persons. Persons with chronic periodontitis receiving immunosuppressive treatment exhibit over 10fold lower TACE levels than the other periodontitis groups. TACE is positively correlated with probing pocket depth, clinical attachment levels, and receptor activator of NF-kappaB ligand concentrations in gingival crevicular fluid
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expression of TACE in liver and spleen tissues after 70% partial hepatectomy is a time-dependent alteration, reaching a maximal level between 24 and 48 h and remaining elevated for more than 168 h
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adenocarcinoma cells
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skeletal muscle, smooth muscle cells
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ADAM17/TACE mRNA is expressed in 3 of 10 normal pancreatic tissues, 6 of 8 samples from patients with chronic pancreatitis
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by analyzing villous samples representing different gestational ages, it is shown that TACE is continuously expressed in the placentas throughout gestation and that the levels of TACE are positively correlated with the levels of TGF-alpha, heparin-binding epidermal growth factor-like growth factor, and amphiregulin
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human salivary gland cells are used
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non-neoplastic salivary gland epithelial cells
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both ADAM10, EC 3.4.24.81, and ADAM17 are present during all stages of spermatogenesis. Protein level and cell surface localization strongly dropp in Dark segments as compared with the rest of the segments
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