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3.4.24.86: ADAM 17 endopeptidase

This is an abbreviated version!
For detailed information about ADAM 17 endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.86

Reaction

Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-/-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains =

Synonyms

(TACE/ADAM17/CD156q), (TACE:ADAM17), a disintegrin and metallo protease domain 17, a disintegrin and metalloprotease 17, a disintegrin and metalloprotease-17, a disintegrin and metalloproteinase 17, a disintegrin and metalloproteinase-17, ADAM-17, ADAM17, ADAM17 proteinase, ADAM17/tumor necrosis factor-alpha (TNF-A)converting enzyme, ADAMTS-2, CD156, H-TACE, human TACE B, metalloprotease TACE, metalloprotease-disintegrin tumour necrosis factor alpha convertase, metalloproteinase ADAM17, pro tumor necrosis factor cleavage enzyme, pro-tumor necrosis factor-alpha-processing enzyme, proteinase, pro-tumor necrosis factor (9CI), sheddase, TACE, TACE proteinase, TACE/ADAM17, TNF converting enzyme, TNF-alpha convertase, TNF-alpha converting enzyme, TNF-alpha processing protease, TNFalpha converting enzyme, tumor necrosis factor alpha convertase, tumor necrosis factor alpha converting enzyme, tumor necrosis factor alpha-converting enzyme, tumor necrosis factor-alpha converting enzyme, tumor necrosis factor-alpha-converting enzyme, tumour necrosis factor alpha-converting enzyme, tumour necrosis factor-alpha converting enzyme

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.86 ADAM 17 endopeptidase

Source Tissue

Source Tissue on EC 3.4.24.86 - ADAM 17 endopeptidase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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adipose tissue
Manually annotated by BRENDA team
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atherosclerotic plaque
Manually annotated by BRENDA team
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TACE expression measured by immunohistochemical analysis is observed in 183 of 383 breast carcinomas. TACE expression is predominantly seen in tumors with high levels of released human epidermal growth factor-4 receptor intracellular domain (4ICD) and membranous human epidermal growth factor-4 receptor
Manually annotated by BRENDA team
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metalloproteases ADAM-9, ADAM-15, and ADAM-17 are upregulated in advanced human atherosclerotic lesions in samples from carotid, aortic, and femoral territories compared to samples from internal thoracic artery free of atherosclerotic plaques. ADAM-9, ADAM-15, and ADAM-17-expressing cells colocalize with CD68-positive cells of monocytic origin in the atherosclerotic plaques, in the carotid territory, cells expressing the ADAMs codistribute also with smooth muscle cells
Manually annotated by BRENDA team
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metalloproteases ADAM-9, ADAM-15, and ADAM-17 are upregulated in advanced human atherosclerotic lesions in samples from carotid, aortic, and femoral territories compared to samples from internal thoracic artery free of atherosclerotic plaques. ADAM-9, ADAM-15, and ADAM-17-expressing cells colocalize with CD68-positive cells of monocytic origin in the atherosclerotic plaques, in the femoral territory, cells expressing the ADAMs codistribute also with CD31-positive endothelial cells
Manually annotated by BRENDA team
both ADAM10, EC 3.4.24.81, and ADAM17 are present during all stages of spermatogenesis
Manually annotated by BRENDA team
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granulosa cells of bovine preovulatory follicles
Manually annotated by BRENDA team
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ADAM-17, TIMP-3 and fractalkine are constitutively expressed
Manually annotated by BRENDA team
ADAM17 proteolytic targets, amphiregulin, transforming growth factor (TGF-alpha), syndecan-1 (SDC1), and tumor necrosis factor receptor 1 (TNFR1), are shed from HVECs in response to staphylococcal superantigen toxic shock syndrome toxin TSST-1. ADAM17, but not related ADAM10, is required for amphiregulin, TGF-alpha, and TNFR1 shedding. Both ADAM10 and ADAM17 contribute to SDC1 shedding and IL-8 production by HVECs in response to TSST-1
Manually annotated by BRENDA team
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within the hypothalamus, TACE is most abundantly expressed in astrocytes of the median eminence, specific changes in TACE activity are required for the normal timimg of puberty. TACE is a component of the neuron-to-glia signaling process used by glutamatergic neurons to control female sexual development
Manually annotated by BRENDA team
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large cell anaplastic lymphoma cell line
Manually annotated by BRENDA team
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CD30-positive Hodgkin’s lymphoma cell line
Manually annotated by BRENDA team
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CD30-positive Hodgkin’s lymphoma cell line
Manually annotated by BRENDA team
hepatic stellate cell line
Manually annotated by BRENDA team
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TACE protein is localized to mononuclear cells (MNC), which infiltrate the liver from the spleen after hepatectomy. The kinetics of TACE expression is in accordance with the number of TACE-staining mononuclear cells and synchronizes with those of transforming growth factor-alpha. TACE-staining mononuclear cells partially overlapp with CD3+ T lymphocytes
Manually annotated by BRENDA team
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neuroblastoma cell line
Manually annotated by BRENDA team
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sural nerve biopsies from Guillain-Barre syndrome patients. ADAM-17-expressing T cells can be localized primarily within the epi- and perineurium, whereas in control sections from patients with non-inflammatory neuropathies, no axpression can be depected. The enzyme may contribute to the pathogenesis of inflammatory demyelination of the peripheral nervous system
Manually annotated by BRENDA team
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TACE expression measured by immunohistochemical analysis is observed in 39 of 217 ovarian carcinomas.TACE expression is predominantly seen in tumors with high levels of released human epidermal growth factor-4 receptor intracellular domain (4ICD) and membranous human epidermal growth factor-4 receptor
Manually annotated by BRENDA team
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ADAM17/TACE mRNA is expressed in 10 of 10 PDAC tissues. ADAM17/TACE mRNA expression is down-regulated in pancreatic cancer cells arrested in G2 -M phase. Critical involvement of ADAM17/TACE in the invasion behavior of pancreatic cancer cells
Manually annotated by BRENDA team
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ADAM17/TACE mRNA is expressed in 10 of 10 PDAC tissues. ADAM17/TACE expression is a later event in progression of pancreatic intraepithelial neoplasia to pancreatic ductal adenocarcinoma
Manually annotated by BRENDA team
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Villous explant cultures or cytotrophoblastic cells are used. Preadministration of TACE inhibitor in villous explant cultures or transfection of cytotrophoblastic cells with TACE-specific small interference RNA decreases the shedding of heparin-binding epidermal growth factor-like growth factor and amphiregulin. Hypoxia (2% O2) causes an increase in the levels of TACE mRNA and protein in villous explants and primary cytotrophoblastic cells in vitro
Manually annotated by BRENDA team
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TACE expression measured by immunohistochemical analysis is observed in 16 of 24 and 17 of 24 hormone-sensitive and hormone-insensitive prostate carcinomas. TACE expression is predominantly seen in tumors with high levels of released human epidermal growth factor-4 receptor intracellular domain (4ICD) and membranous human epidermal growth factor-4 receptor
Manually annotated by BRENDA team
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CD30-negative acute lymphoblastic leukemia cell line
Manually annotated by BRENDA team
both ADAM10, EC 3.4.24.81, and ADAM17 are present during all stages of spermatogenesis
Manually annotated by BRENDA team
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marrow stromal cell-brain microvascular endothelial cell contact coculture and indirect co-culture of marrow stromal cell and brain microvascular endothelial cell
Manually annotated by BRENDA team
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primary cellular source of ADAM-17 in inflamed peripheral nervous system (experimental autoimmune neuritis). Not all T lymphocytes within the inflamed peripheral nervous system express ADAM-17. No ADAM-17 expressing cells are found in nerves from control animals
Manually annotated by BRENDA team