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Literature summary for 3.4.24.86 extracted from

  • Xu, H.; Uysal, K.T.; Becherer, J.D.; Arner, P.; Hotamisligil, G.S.
    Altered tumor necrosis factor-alpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha in obesity (2002), Diabetes, 51, 1876-1883.
    View publication on PubMed
Search for more literature for 3.4.24.86

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane-bound Mus musculus 16020
-
membrane membrane-bound Homo sapiens 16020
-
plasma membrane
-
 Mus musculus 5886
-
plasma membrane
-
 Homo sapiens 5886
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 mouse
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte adipose tissue Homo sapiens
-
macrophage
-
 Mus musculus
-
macrophage
-
 Homo sapiens
-
muscle
-
 Mus musculus
-
muscle
-
 Homo sapiens
-
thymocyte
-
 Mus musculus
-
thymocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
75kDaTNFR2 + H2O
-
 Homo sapiens ?
-
 ?
beta-amyloid precursor protein + H2O
-
 Mus musculus ?
-
 ?
beta-amyloid precursor protein + H2O Alzheimer amyloid precursor protein Homo sapiens ?
-
 ?
L-selectin + H2O
-
 Mus musculus ?
-
 ?
L-selectin + H2O
-
 Homo sapiens ?
-
 ?
additional information
-
 Mus musculus ?
-
 ?
additional information TACE is the only enzyme confirmed to process TNF-alpha in vitro and in vivo Homo sapiens ?
-
 ?
proTNF-alpha + H2O
-
 Mus musculus soluble TNF-alpha
-
 ?
proTNF-alpha + H2O
-
 Homo sapiens soluble TNF-alpha
-
 ?
transforming growth factor alpha + H2O
-
 Mus musculus ?
-
 ?
transforming growth factor alpha + H2O
-
 Homo sapiens ?
-
 ?