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Literature summary for 3.4.24.86 extracted from

  • Tanabe, Y.; Kasahara, T.; Momoi, T.; Fujita, E.
    Neuronal RA175/SynCAM1 isoforms are processed by tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM17-like proteases (2008), Neurosci. Lett., 444, 16-21.
    View publication on PubMed

Application

Application Comment Organism
molecular biology TACE/ADAM17-like proteases might play a role in synaptic formation to generate specific neuronal connections by processing the excess amount of RA175/SynCAM1, a member of the immunoglobulin family 4, located in the non-synaptic region Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
TAPI-1 TAPI-1 blocks the processing of RA175/SynCAM1, a member of the immunoglobulin family 4. Furthermore, TAPI-1 increases the number of synaptophysin and RA175/SynCAM1 colocalization on the dendrites of neurons Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
RA175/SynCAM1 + H2O Mus musculus neuronal RA175/SynCAM1 isoforms, members of the immunoglobulin family 4, are processed by TACE ?
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?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
RA175/SynCAM1 + H2O neuronal RA175/SynCAM1 isoforms, members of the immunoglobulin family 4, are processed by TACE Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
TACE
-
Mus musculus