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Literature summary for 3.4.24.86 extracted from
- Neuronal localization of the TNFalpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques (2001), J. Neurobiol., 49, 40-46.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| lipopolysaccharide | - |
Homo sapiens |  |
| phorbol ester | - |
Mus musculus | |
| phorbol ester | - |
Homo sapiens | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| TACE transfected CHO cells | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Mus musculus | 5737 | - |
| cytoplasm | - |
Homo sapiens | 5737 | - |
| Golgi apparatus | - |
Mus musculus | 5794 | - |
| Golgi apparatus | - |
Homo sapiens | 5794 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 85000 | - |
proteolytically mature TACE, immunoblotting | Mus musculus |
| 110000 | - |
pro TACE, immunoblotting | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
Ntera2/cl.D1, human embryonal carcinoma cell line | - |
| Homo sapiens | - |
MonoMac 6 cells | - |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocyte | - |
Mus musculus | - |
| brain | - |
Mus musculus | - |
| brain | neocortex, cerebellum, pyramidal neurons of the cerebral cortex and granular cell layer neurons in the hippocampus | Homo sapiens | - |
| embryo | - |
Mus musculus | - |
| embryo | - |
Homo sapiens | - |
| macrophage | - |
Mus musculus | - |
| macrophage | - |
Homo sapiens | - |
| microglia | - |
Mus musculus | - |
| monocyte | - |
Mus musculus | - |
| monocyte | - |
Homo sapiens | - |
| neuron | - |
Mus musculus | - |
| neuron | - |
Homo sapiens | - |
| oligodendrocyte | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-amyloid precursor protein + H2O | Alzheimer amyloid precursor protein | Homo sapiens | ? | - |
? | |
| beta-amyloid precursor protein + H2O | APP | Homo sapiens | ? | - |
? | |
| proTNF-alpha + H2O | - |
Mus musculus | soluble TNF-alpha | - |
? | |
| proTNF-alpha + H2O | - |
Homo sapiens | soluble TNF-alpha | - |
? | |
| transforming growth factor alpha + H2O | - |
Mus musculus | ? | - |
? | |
| transforming growth factor alpha + H2O | - |
Homo sapiens | ? | - |
? | |
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Release 2023.1 (January 2023)
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