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Literature summary for 3.4.24.86 extracted from

  • Baumgart, A.; Seidl, S.; Vlachou, P.; Michel, L.; Mitova, N.; Schatz, N.; Specht, K.; Koch, I.; Schuster, T.; Grundler, R.; Kremer, M.; Fend, F.; Siveke, J.; Peschel, C.; Duyster, J.; Dechow, T.
    ADAM17 regulates epidermal growth factor receptor expression through the activation of Notch1 in non-small cell lung cancer (2010), Cancer Res., 70, 5368-5378.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Notch 1 + H2O Homo sapiens ADAM17 is required for Notch1 receptor proteolysis in NSCLC cells in vitro and in vivo ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
NCI-H1650 cell
-
Homo sapiens
-
NCI-H1975 cell
-
Homo sapiens
-
NCI-H2170 cell
-
Homo sapiens
-
NCI-H292 cell
-
Homo sapiens
-
NCI-H358 cell
-
Homo sapiens
-
NCI-H520 cell
-
Homo sapiens
-
non-small cell lung cancer cell
-
Homo sapiens
-
U-266 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Notch 1 + H2O ADAM17 is required for Notch1 receptor proteolysis in NSCLC cells in vitro and in vivo Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
ADAM17
-
Homo sapiens

General Information

General Information Comment Organism
malfunction ADAM17 knockdown leads to a dramatic cell growth suppression in NCI-H292 cells Homo sapiens
physiological function ADAM17 regulates epidermal growth factor receptor expression through the activation of Notch1 in non-small cell lung cancer. ADAM17 mediates cell growth, survival, and tumorigenicity by epidermal growth factor receptor-independent mechanisms Homo sapiens