Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Notch 1 + H2O | Homo sapiens | ADAM17 is required for Notch1 receptor proteolysis in NSCLC cells in vitro and in vivo | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
NCI-H1650 cell | - |
Homo sapiens | - |
NCI-H1975 cell | - |
Homo sapiens | - |
NCI-H2170 cell | - |
Homo sapiens | - |
NCI-H292 cell | - |
Homo sapiens | - |
NCI-H358 cell | - |
Homo sapiens | - |
NCI-H520 cell | - |
Homo sapiens | - |
non-small cell lung cancer cell | - |
Homo sapiens | - |
U-266 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Notch 1 + H2O | ADAM17 is required for Notch1 receptor proteolysis in NSCLC cells in vitro and in vivo | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAM17 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | ADAM17 knockdown leads to a dramatic cell growth suppression in NCI-H292 cells | Homo sapiens |
physiological function | ADAM17 regulates epidermal growth factor receptor expression through the activation of Notch1 in non-small cell lung cancer. ADAM17 mediates cell growth, survival, and tumorigenicity by epidermal growth factor receptor-independent mechanisms | Homo sapiens |