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Literature summary for 3.4.24.86 extracted from
- Tumor necrosis factor-alpha converting enzyme (2002), Int. J. Biochem. Cell Biol., 34, 1-5.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| phorbol ester | - |
Mus musculus |  |
| phorbol ester | - |
Homo sapiens | |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | pharmaceutical industry is attempting to design specific TACE inhibitors to treat inflammatory diseases, may also be beneficial in treating certain cancers | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Homo sapiens |
General Stability
| General Stability | Organism |
|---|---|
| in absence of cell activators the enzyme is long-lived, with a half-life of more than 8h | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| peptide hydroxamate | - |
Homo sapiens | |
| TIMP-3 | tissue inhibitor of metalloproteases-3, CAS: 147783-68-4, 171039-15-9, 13037-60-4 | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | - |
Mus musculus | 9986 | - |
| cell surface | - |
Homo sapiens | 9986 | - |
| cytoplasm | - |
Mus musculus | 5737 | - |
| cytoplasm | - |
Homo sapiens | 5737 | - |
| Golgi apparatus | - |
Mus musculus | 5794 | - |
| Golgi apparatus | - |
Homo sapiens | 5794 | - |
| membrane | membrane-bound | Mus musculus | 16020 | - |
| membrane | membrane-bound | Homo sapiens | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | - |
Mus musculus | |
| Zn2+ | zinc-dependent catalytic domain | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
HUVECs | - |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | - |
Mus musculus | - |
| embryo | - |
Homo sapiens | - |
| fibroblast | - |
Mus musculus | - |
| fibroblast | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-amyloid precursor protein + H2O | - |
Mus musculus | ? | - |
? | |
| beta-amyloid precursor protein + H2O | Alzheimer amyloid precursor protein | Homo sapiens | ? | - |
? | |
| interleukin (IL)-1R-II + H2O | - |
Mus musculus | ? | - |
? | |
| interleukin (IL)-1R-II + H2O | - |
Homo sapiens | ? | - |
? | |
| p55 TNFR1 + H2O | - |
Mus musculus | ? | - |
? | |
| p55 TNFR1 + H2O | - |
Homo sapiens | ? | - |
? | |
| proTNF-alpha + H2O | - |
Mus musculus | soluble TNF-alpha | - |
? | |
| proTNF-alpha + H2O | - |
Homo sapiens | soluble TNF-alpha | - |
? | |
| transforming growth factor alpha + H2O | - |
Mus musculus | ? | - |
? | |
| transforming growth factor alpha + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| (TACE/ADAM17/CD156q) | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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