Literature summary for 3.4.24.86 extracted from

Xiao, L.; Lin, P.; Lin, F.; Liu, X.; Qin, W.; Zou, H.; Guo, L.; Liu, W.; Wang, S.; Yu, X.
ADAM17 targets MMP-2 and MMP-9 via EGFR-MEK-ERK pathway activation to promote prostate cancer cell invasion (2012), Int. J. Oncol., 40, 1714-1724.

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Application

Application	Comment	Organism
medicine	ADAM17 expression levels are correlated with the invasive ability of androgen-independent prostate cancer cell lines. ADAM17 is overexpressed in cells showing high invasion characteristics, activation of the EGFR-MEK-ERK pathway, up-regulation of MMP-2, MMP-9, and an increased TGF-alpha release into the supernatant. AG1478, PD98059 and antibody against TGF-alpha deactivating the EGFR-MEK-ERK signaling pathway, abolish up-regulation of MMP-2, MMP-9 and prevent cell invasion. Cells with knock-down of ADAM17 by siRNA exhibit low invasive ability, deactivated EGFR-MEK-ERK signaling pathway, reduced TGF-alpha release and down-regulation of MMP-2, MMP-9	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P78536	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
DU-145 cell	-	Homo sapiens	-
PC-3 cell	-	Homo sapiens	-
placenta	-	Homo sapiens	-

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Release 2023.1 (January 2023)