Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.24.86: ADAM 17 endopeptidase

This is an abbreviated version!
For detailed information about ADAM 17 endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.86

Reaction

Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-/-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains =

Synonyms

(TACE/ADAM17/CD156q), (TACE:ADAM17), a disintegrin and metallo protease domain 17, a disintegrin and metalloprotease 17, a disintegrin and metalloprotease-17, a disintegrin and metalloproteinase 17, a disintegrin and metalloproteinase-17, ADAM-17, ADAM17, ADAM17 proteinase, ADAM17/tumor necrosis factor-alpha (TNF-A)converting enzyme, ADAMTS-2, CD156, H-TACE, human TACE B, metalloprotease TACE, metalloprotease-disintegrin tumour necrosis factor alpha convertase, metalloproteinase ADAM17, pro tumor necrosis factor cleavage enzyme, pro-tumor necrosis factor-alpha-processing enzyme, proteinase, pro-tumor necrosis factor (9CI), sheddase, TACE, TACE proteinase, TACE/ADAM17, TNF converting enzyme, TNF-alpha convertase, TNF-alpha converting enzyme, TNF-alpha processing protease, TNFalpha converting enzyme, tumor necrosis factor alpha convertase, tumor necrosis factor alpha converting enzyme, tumor necrosis factor alpha-converting enzyme, tumor necrosis factor-alpha converting enzyme, tumor necrosis factor-alpha-converting enzyme, tumour necrosis factor alpha-converting enzyme, tumour necrosis factor-alpha converting enzyme

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.86 ADAM 17 endopeptidase

Natural Substrates Products

Natural Substrates Products on EC 3.4.24.86 - ADAM 17 endopeptidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Alzheimer's disease amyloid precursor protein + H2O
?
show the reaction diagram
-
TACE is involved in shedding of Alzheimer's disease amyloid precursor protein
-
-
?
amphiregulin + H2O
?
show the reaction diagram
amyloid precursor protein + H2O
soluble amyloid precursor protein alpha fragment + C83
show the reaction diagram
-
-
-
?
angiotensin-converting enzyme type 2 + H2O
?
show the reaction diagram
-
-
-
-
?
angiotensin-converting enzyme-2 + H2O
?
show the reaction diagram
-
ADAM-17 is responsible for the ACE2 shedding
-
-
?
AREG + H2O
?
show the reaction diagram
-
-
-
-
?
betacellulin + H2O
?
show the reaction diagram
-
-
-
?
CD23 + H2O
?
show the reaction diagram
CD26L + H2O
?
show the reaction diagram
-
-
-
-
?
CD44 + H2O
?
show the reaction diagram
-
-
-
?
CX3CL1 + H2O
?
show the reaction diagram
-
-
-
?
CXCR2 + H2O
?
show the reaction diagram
-
-
-
?
discoidin domain receptor 1 + H2O
?
show the reaction diagram
-
-
-
?
epidermal growth factor receptor + H2O
?
show the reaction diagram
-
-
-
-
?
epiregulin + H2O
?
show the reaction diagram
FLT-3L + H2O
?
show the reaction diagram
-
-
-
-
?
glycoprotein Ibalpha + H2O
?
show the reaction diagram
GPIba + H2O
?
show the reaction diagram
-
-
-
-
?
growth factor alpha + H2O
?
show the reaction diagram
-
-
-
-
?
HB-EGF + H2O
?
show the reaction diagram
heparin-binding EGF-like growth factor + H2O
?
show the reaction diagram
-
-
-
-
?
heregulin + H2O
?
show the reaction diagram
-
-
-
?
ICAM-1 + H2O
?
show the reaction diagram
-
-
-
-
?
intercellular adhesion molecule 1 + H2O
soluble intercellular adhesion molecule 1 + ?
show the reaction diagram
-
-
-
?
intercellular adhesion molecule-1 + H2O
?
show the reaction diagram
-
ADAM-17 mediates shedding of intercellular adhesion molecule-1. The shedding of intercellular adhesion molecule-1 reduces the adhesive capacity of the cells. the cleavage site in the intercellular adhesion molecule-1 is not sequence-specific, but appears to be nonselective
-
-
?
interleukin 1 receptor + H2O
?
show the reaction diagram
-
-
-
?
interleukin 1alpha/beta + H2O
?
show the reaction diagram
-
-
-
?
interleukin 6 + H2O
?
show the reaction diagram
-
-
-
?
interleukin 6 receptor + H2O
?
show the reaction diagram
-
-
-
?
interleukin 6 receptor + H2O
soluble interleukin 6 receptor + ?
show the reaction diagram
-
-
-
?
interleukin-1 receptor II + H2O
?
show the reaction diagram
-
-
-
?
interleukin-6 receptor + H2O
?
show the reaction diagram
-
-
-
?
interleukin-6 receptor + H2O
soluble interleukin-6 receptor + ?
show the reaction diagram
-
-
-
-
?
junctional adhesion molecule A + H2O
?
show the reaction diagram
-
-
-
?
L-selectin + H2O
?
show the reaction diagram
MHC class I polypeptide-related sequence A + H2O
soluble MHC class I polypeptide-related sequence A + ?
show the reaction diagram
-
-
-
?
N-cadherin + H2O
?
show the reaction diagram
-
-
-
?
NCAM + H2O
?
show the reaction diagram
-
-
-
?
Notch 1 + H2O
?
show the reaction diagram
-
ADAM17 is required for Notch1 receptor proteolysis in NSCLC cells in vitro and in vivo
-
-
?
Notch1 + H2O
?
show the reaction diagram
-
-
-
-
?
p55 TNF-alpha RI + H2O
?
show the reaction diagram
-
-
-
-
?
p75 neurotrophin receptor + H2O
?
show the reaction diagram
p75 TNF-alpha RII + H2O
?
show the reaction diagram
-
-
-
-
?
preadipocyte factor 1 + H2O
?
show the reaction diagram
-
TACE is the major protease responsible for conversion of membrane-bound Pref-1 to the biologically active diffusible form
-
-
?
pro-EGF receptor + H2O
EGF receptor + ?
show the reaction diagram
-
-
-
-
?
pro-interleukin-6 receptor + H2O
interleukin-6 receptor + ?
show the reaction diagram
-
-
-
-
?
pro-L-selectin + H2O
L-selectin + ?
show the reaction diagram
-
-
-
-
?
pro-Notch 1 + H2O
Notch 1 + ?
show the reaction diagram
-
-
-
-
?
pro-TGF-alpha + H2O
soluble TGF-alpha + ?
show the reaction diagram
pro-TNF-alpha + H2O
soluble TNF-alpha + ?
show the reaction diagram
protein tyrosine kinase 7 + H2O
?
show the reaction diagram
-
-
-
?
proTGF-alpha + H2O
soluble TGF-alpha
show the reaction diagram
-
-
-
-
?
proTNF-alpha + H2O
soluble TNF-alpha + 9000 Da membrane-bound fragment of TNF-alpha
show the reaction diagram
-
-
-
-
?
proTNF-alpha + H2O
soluble TNF-alpha + ?
show the reaction diagram
-
-
-
-
?
RA175/SynCAM1 + H2O
?
show the reaction diagram
-
neuronal RA175/SynCAM1 isoforms, members of the immunoglobulin family 4, are processed by TACE
-
-
?
receptor tyrosine kinase c-Kit + H2O
?
show the reaction diagram
-
ADAM-17 controls mast cell survival by regulating shedding and surface expression of c-Kit
-
-
?
soluble intercellular cell adhesion molecule 1 + H2O
?
show the reaction diagram
-
-
-
?
soluble interleukin 6 receptor + H2O
?
show the reaction diagram
-
-
-
?
soluble tumor necrosis factor receptor 1 + H2O
?
show the reaction diagram
-
-
-
?
soluble vascular cell adhesion molecule 1 + H2O
?
show the reaction diagram
-
-
-
?
syndecan-1 + H2O
?
show the reaction diagram
-
-
-
?
syndecan-4 + H2O
?
show the reaction diagram
-
-
-
?
TGFalpha + H2O
?
show the reaction diagram
-
-
-
?
TNF receptor 1a + H2O
?
show the reaction diagram
-
-
-
?
TNF-alpha + H2O
?
show the reaction diagram
-
ranitidine enhances TNF-alpha production after lipopolysaccharide treatment through augmented p38 activation, and this seems to occur through TACE
-
-
?
TNF-alpha + H2O
soluble TNF-alpha
show the reaction diagram
TNFalpha + H2O
?
show the reaction diagram
-
-
-
?
transforming growth factor alpha + H2O
?
show the reaction diagram
-
-
-
?
tumor necrosis factor alpha + H2O
?
show the reaction diagram
-
-
-
?
tumor necrosis factor alpha receptor I + H2O
?
show the reaction diagram
-
-
-
?
vasorin + H2O
soluble vasorin + ?
show the reaction diagram
-
-
-
-
?
additional information
?
-