3.4.24.86: ADAM 17 endopeptidase

This is an abbreviated version!
For detailed information about ADAM 17 endopeptidase, go to the full flat file.

Reaction

Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-/-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains =

Synonyms

(TACE/ADAM17/CD156q), (TACE:ADAM17), a disintegrin and metallo protease domain 17, a disintegrin and metalloprotease 17, a disintegrin and metalloprotease-17, a disintegrin and metalloproteinase 17, a disintegrin and metalloproteinase-17, ADAM-17, ADAM17, ADAM17 proteinase, ADAM17/tumor necrosis factor-alpha (TNF-A)converting enzyme, ADAMTS-2, CD156, H-TACE, human TACE B, metalloprotease TACE, metalloprotease-disintegrin tumour necrosis factor alpha convertase, metalloproteinase ADAM17, pro tumor necrosis factor cleavage enzyme, pro-tumor necrosis factor-alpha-processing enzyme, proteinase, pro-tumor necrosis factor (9CI), sheddase, TACE, TACE proteinase, TACE/ADAM17, TNF converting enzyme, TNF-alpha convertase, TNF-alpha converting enzyme, TNF-alpha processing protease, TNFalpha converting enzyme, tumor necrosis factor alpha convertase, tumor necrosis factor alpha converting enzyme, tumor necrosis factor alpha-converting enzyme, tumor necrosis factor-alpha converting enzyme, tumor necrosis factor-alpha-converting enzyme, tumour necrosis factor alpha-converting enzyme, tumour necrosis factor-alpha converting enzyme

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.86 ADAM 17 endopeptidase

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Results	in table
47	Activating Compound
45	AA Sequence
48	Application
1	CAS Registry Number
33	Cloned(Commentary)
10	Crystallization (Commentary)
3494	Disease/ Diagnostics
22	Expression
47	General Information
4	General Stability
384	IC50 Value
690	Inhibitors
12	kcat/KM [mM/s]
157	Ki Value [mM]
15	KM Value [mM]
90	Localization
18	Metals/Ions
17	Molecular Weight [Da]
102	Natural Substrates/ Products (Substrates)
228	Organism
44	PDB ID
5	pH Optimum
3	Posttranslational Modification
17	Protein Variants
16	Purification (Commentary)
1	Reaction
209	Reference
286	Source Tissue
1	Storage Stability
500	Substrates and Products (Substrate)
5	Subunits
184	Synonyms
4	Temperature Optimum [°C]
14	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.4.24.86 - ADAM 17 endopeptidase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

Homo sapiens

-

638987, 639005, 639006

docking of nine-residue peptide PLAQA-VRSS from proTNF-alpha. The peptide adopts an anti-parallel beta-sheet conformation against a nearby beta-sheet of the protein. In the complexmodel, the side-chains of residues P2 and P2' are largely exposed,and do not form highly favorable interactions

Homo sapiens

P78536

734699

hanging drop vapour diffusion method with 15% polyethylene glycol 4000, 10% 2-propanol, 100 mM sodium citrate (pH 5.6)

Homo sapiens

-

682629

molecular docking studies of inhibitor 2-(N-benzoxycarbonyl)aminoethyl-N-(4-hydroxyamino-4-oxo-2-(isopropylthio)butanoyl)-L-3-phenylalanyl-L-alanyl amide

Homo sapiens

-

712600

TACE mutant V353G is crystallized with the respective inhibitors with a resolution of 1.7 A using the hanging drop method

Homo sapiens

-

699451

X-ray crystal structure of the catalytic domain of TACE

Homo sapiens

-

639007

-

Sus scrofa

-

638987, 639005