3.4.24.86: ADAM 17 endopeptidase

This is an abbreviated version!
For detailed information about ADAM 17 endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.86

3.4.24.86

adam10

ectodomains

sheddase

metalloproteinases

endothelial

phorbol

sirna

amyloid

egf

alzheimer

notch

angiotensin

membrane-anchored

arthritis

amphiregulin

ace2

hb-egf

hydroxamate

timp-3

heparin-binding

l-selectin

trans-signaling

angiotensin-converting

covid-19

alpha-secretase

mmp-2

sars-cov-2

egf-like

juxtamembrane

medicine

prodomains

furin

secretase

tgf-alpha

membrane-proximal

tmprss2

sil-6r

non-amyloidogenic

cxcl16

rhomboid

epiregulin

gamma-secretase

neuregulins

molecular biology

adamalysins

metzincins

membrane-tethered

fractalkine

betacellulin

marimastat

analysis

egfr-dependent

Reaction

Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-/-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains =

Synonyms

(TACE/ADAM17/CD156q), (TACE:ADAM17), a disintegrin and metallo protease domain 17, a disintegrin and metalloprotease 17, a disintegrin and metalloprotease-17, a disintegrin and metalloproteinase 17, a disintegrin and metalloproteinase-17, ADAM-17, ADAM17, ADAM17 proteinase, ADAM17/tumor necrosis factor-alpha (TNF-A)converting enzyme, ADAMTS-2, CD156, H-TACE, human TACE B, metalloprotease TACE, metalloprotease-disintegrin tumour necrosis factor alpha convertase, metalloproteinase ADAM17, pro tumor necrosis factor cleavage enzyme, pro-tumor necrosis factor-alpha-processing enzyme, proteinase, pro-tumor necrosis factor (9CI), sheddase, TACE, TACE proteinase, TACE/ADAM17, TNF converting enzyme, TNF-alpha convertase, TNF-alpha converting enzyme, TNF-alpha processing protease, TNFalpha converting enzyme, tumor necrosis factor alpha convertase, tumor necrosis factor alpha converting enzyme, tumor necrosis factor alpha-converting enzyme, tumor necrosis factor-alpha converting enzyme, tumor necrosis factor-alpha-converting enzyme, tumour necrosis factor alpha-converting enzyme, tumour necrosis factor-alpha converting enzyme

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.86 ADAM 17 endopeptidase

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Results	in table
47	Activating Compound
45	AA Sequence
48	Application
1	CAS Registry Number
33	Cloned(Commentary)
10	Crystallization (Commentary)
3494	Disease/ Diagnostics
22	Expression
47	General Information
4	General Stability
384	IC50 Value
690	Inhibitors
12	kcat/KM [mM/s]
157	Ki Value [mM]
15	KM Value [mM]
90	Localization
18	Metals/Ions
17	Molecular Weight [Da]
102	Natural Substrates/ Products (Substrates)
228	Organism
44	PDB ID
5	pH Optimum
3	Posttranslational Modification
17	Protein Variants
16	Purification (Commentary)
1	Reaction
209	Reference
286	Source Tissue
1	Storage Stability
500	Substrates and Products (Substrate)
5	Subunits
184	Synonyms
4	Temperature Optimum [°C]
14	Turnover Number [1/s]

Localization

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Localization on EC 3.4.24.86 - ADAM 17 endopeptidase

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only the mature form of ADAM-17 associates with the cytoskeleton

cytosolic tail of TACE precedes TACE activation

5829

638982

endoplasmic reticulum

disintegrin and protease regions

additional information

Homo sapiens

ADAM17 localizes to bifurcations in invading sprouts

712928